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Protein

Ectonucleoside triphosphate diphosphohydrolase 6

Gene

Entpd6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides. Hydrolyzes preferentially nucleoside 5'-diphosphates, nucleoside 5'-triphosphates are hydrolyzed only to a minor extent, there is no hydrolysis of nucleoside 5'-monophosphates. The order of activity with different substrates is GDP > IDP >> UDP = CDP >> ADP.

Catalytic activityi

A nucleoside diphosphate + H2O = a nucleoside phosphate + phosphate.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei196Proton acceptorBy similarity1

GO - Molecular functioni

  • guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: RGD
  • nucleoside-diphosphatase activity Source: RGD
  • nucleoside-triphosphatase activity Source: RGD
  • uridine-diphosphatase activity Source: UniProtKB-EC

GO - Biological processi

  • response to calcium ion Source: RGD
  • response to magnesium ion Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium, Magnesium

Enzyme and pathway databases

ReactomeiR-RNO-8850843. Phosphate bond hydrolysis by NTPDase proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Ectonucleoside triphosphate diphosphohydrolase 6 (EC:3.6.1.6)
Short name:
NTPDase 6
Alternative name(s):
CD39 antigen-like 2
Gene namesi
Name:Entpd6
Synonyms:Cd39l2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi619725. Entpd6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 32Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST20
Topological domaini33 – 455LumenalSequence analysisAdd BLAST423

GO - Cellular componenti

  • cell surface Source: RGD
  • extracellular exosome Source: Ensembl
  • extracellular space Source: RGD
  • Golgi apparatus Source: RGD
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002099141 – 455Ectonucleoside triphosphate diphosphohydrolase 6Add BLAST455

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi192N-linked (GlcNAc...)Sequence analysis1
Glycosylationi256N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi297 ↔ 327By similarity
Disulfide bondi387 ↔ 401By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9ER31.
PRIDEiQ9ER31.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007427.
GenevisibleiQ9ER31. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009946.

Structurei

3D structure databases

ProteinModelPortaliQ9ER31.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GDA1/CD39 NTPase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1385. Eukaryota.
COG5371. LUCA.
GeneTreeiENSGT00510000046675.
HOGENOMiHOG000220904.
HOVERGENiHBG018208.
InParanoidiQ9ER31.
KOiK01511.
OMAiGLYELCA.
OrthoDBiEOG091G06ET.
PhylomeDBiQ9ER31.
TreeFamiTF315029.

Family and domain databases

InterProiIPR000407. GDA1_CD39_NTPase.
[Graphical view]
PANTHERiPTHR11782. PTHR11782. 2 hits.
PfamiPF01150. GDA1_CD39. 1 hit.
[Graphical view]
PROSITEiPS01238. GDA1_CD39_NTPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ER31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKIPNHGTL RMTKVAYPLG LCVGLFIYVA YIKWHRASAA QAFFTIAGAA
60 70 80 90 100
SGVRWTQQAF SSPDSATRGH EVFYGIMFDA GSTGTRIHVF QFARPPGETP
110 120 130 140 150
TLTHETFKAL KPGLSAYADD VEKSAQGIQE LLNVAKQHIP YDFWKATPLV
160 170 180 190 200
LKATAGLRLL PGEKAQKLLQ KVKEVFKASP FLVGDDCVSI MNGTDEGVSA
210 220 230 240 250
WITVNFLTGS LKTPGSSSVG MLDLGGGSTQ ITFLPRVEGT LQASPPGHLT
260 270 280 290 300
ALQMFNRTFK LYSYSYLGLG LMSARLAILG GVEGKPAEDD KELVSPCLSP
310 320 330 340 350
RFRGKWEHAE VTYRISGQKA VGLYELCASR VSEVLRNKVH RTEEAQHVDF
360 370 380 390 400
YAFSYYYDLA ASFGLIDAEK GGSLVVGDFE IAAKYVCRTL ETQPPSSPFA
410 420 430 440 450
CMDLTYISLL LHEFGFPGDK VLKLARKIDN VETSWALGAI FHYIDSLKRQ

KVPAL
Length:455
Mass (Da):49,899
Last modified:March 1, 2001 - v1
Checksum:i19A22E8BAEF0F77B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277748 mRNA. Translation: CAC16598.1.
RefSeqiNP_445950.1. NM_053498.1.
XP_006235280.1. XM_006235218.3.
UniGeneiRn.27017.

Genome annotation databases

EnsembliENSRNOT00000009946; ENSRNOP00000009946; ENSRNOG00000007427.
GeneIDi85260.
KEGGirno:85260.
UCSCiRGD:619725. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277748 mRNA. Translation: CAC16598.1.
RefSeqiNP_445950.1. NM_053498.1.
XP_006235280.1. XM_006235218.3.
UniGeneiRn.27017.

3D structure databases

ProteinModelPortaliQ9ER31.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009946.

Proteomic databases

PaxDbiQ9ER31.
PRIDEiQ9ER31.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009946; ENSRNOP00000009946; ENSRNOG00000007427.
GeneIDi85260.
KEGGirno:85260.
UCSCiRGD:619725. rat.

Organism-specific databases

CTDi955.
RGDi619725. Entpd6.

Phylogenomic databases

eggNOGiKOG1385. Eukaryota.
COG5371. LUCA.
GeneTreeiENSGT00510000046675.
HOGENOMiHOG000220904.
HOVERGENiHBG018208.
InParanoidiQ9ER31.
KOiK01511.
OMAiGLYELCA.
OrthoDBiEOG091G06ET.
PhylomeDBiQ9ER31.
TreeFamiTF315029.

Enzyme and pathway databases

ReactomeiR-RNO-8850843. Phosphate bond hydrolysis by NTPDase proteins.

Miscellaneous databases

PROiQ9ER31.

Gene expression databases

BgeeiENSRNOG00000007427.
GenevisibleiQ9ER31. RN.

Family and domain databases

InterProiIPR000407. GDA1_CD39_NTPase.
[Graphical view]
PANTHERiPTHR11782. PTHR11782. 2 hits.
PfamiPF01150. GDA1_CD39. 1 hit.
[Graphical view]
PROSITEiPS01238. GDA1_CD39_NTPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiENTP6_RAT
AccessioniPrimary (citable) accession number: Q9ER31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.