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Protein

Kelch-like protein 41

Gene

Klhl41

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells.By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 41
Alternative name(s):
Kel-like protein 23
Kelch repeat and BTB domain-containing protein 10
Kelch-related protein 1
Sarcosin
Gene namesi
Name:Klhl41
Synonyms:Kbtbd10, Krp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi620852. Klhl41.

Subcellular locationi

GO - Cellular componenti

  • Cul3-RING ubiquitin ligase complex Source: GO_Central
  • cytoplasm Source: RGD
  • cytoskeleton Source: UniProtKB
  • endoplasmic reticulum membrane Source: UniProtKB
  • M band Source: UniProtKB
  • nucleus Source: Ensembl
  • plasma membrane Source: Ensembl
  • pseudopodium Source: RGD
  • ruffle Source: UniProtKB-SubCell
  • sarcoplasmic reticulum membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Membrane, Sarcoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 606606Kelch-like protein 41PRO_0000119089Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei3 – 31PhosphoserineCombined sources

Post-translational modificationi

Ubiquitinated by E3 ubiquitin ligase complex formed by CUL3 and RBX1 and probably targeted for proteasome-independent degradation. Quinone-induced oxidative stress increases its ubiquitination.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9ER30.
PRIDEiQ9ER30.

PTM databases

iPTMnetiQ9ER30.
PhosphoSiteiQ9ER30.

Expressioni

Tissue specificityi

Primarily expressed in skeletal muscle. Also found in heart and lung.

Gene expression databases

BgeeiENSRNOG00000007461.
GenevisibleiQ9ER30. RN.

Interactioni

Subunit structurei

Interacts with NRAP. Part of a complex that contains CUL3, RBX1 and KLHL41. Interacts with LASP1.By similarity2 Publications

Protein-protein interaction databases

IntActiQ9ER30. 1 interaction.
MINTiMINT-4998213.
STRINGi10116.ENSRNOP00000009969.

Structurei

Secondary structure

1
606
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi301 – 3099Combined sources
Beta strandi311 – 3188Combined sources
Turni319 – 3224Combined sources
Beta strandi323 – 3297Combined sources
Beta strandi335 – 3417Combined sources
Beta strandi343 – 3453Combined sources
Beta strandi347 – 3537Combined sources
Beta strandi366 – 3727Combined sources
Turni373 – 3764Combined sources
Beta strandi377 – 3804Combined sources
Beta strandi384 – 3863Combined sources
Beta strandi392 – 3965Combined sources
Beta strandi399 – 4079Combined sources
Turni408 – 4103Combined sources
Beta strandi413 – 4219Combined sources
Turni422 – 4254Combined sources
Beta strandi426 – 4305Combined sources
Beta strandi437 – 4393Combined sources
Beta strandi441 – 4455Combined sources
Beta strandi448 – 4525Combined sources
Beta strandi455 – 4595Combined sources
Beta strandi465 – 4684Combined sources
Turni470 – 4723Combined sources
Beta strandi475 – 4784Combined sources
Beta strandi489 – 4935Combined sources
Beta strandi496 – 5049Combined sources
Beta strandi507 – 51610Combined sources
Turni517 – 5193Combined sources
Beta strandi522 – 5243Combined sources
Beta strandi536 – 5405Combined sources
Beta strandi543 – 5475Combined sources
Beta strandi568 – 5725Combined sources
Turni573 – 5764Combined sources
Beta strandi577 – 5837Combined sources
Helixi586 – 5883Combined sources
Beta strandi592 – 5998Combined sources
Helixi600 – 6023Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WOZX-ray2.00A289-606[»]
ProteinModelPortaliQ9ER30.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9ER30.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 10068BTBPROSITE-ProRule annotationAdd
BLAST
Domaini135 – 237103BACKAdd
BLAST
Repeati346 – 39853Kelch 1Add
BLAST
Repeati399 – 44749Kelch 2Add
BLAST
Repeati448 – 49548Kelch 3Add
BLAST
Repeati497 – 54246Kelch 4Add
BLAST
Repeati544 – 59956Kelch 5Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 5 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IGWS. Eukaryota.
ENOG410XUMT. LUCA.
GeneTreeiENSGT00840000129730.
HOGENOMiHOG000231966.
HOVERGENiHBG052215.
InParanoidiQ9ER30.
KOiK10473.
OMAiFFQLDNV.
OrthoDBiEOG091G0C3Y.
PhylomeDBiQ9ER30.
TreeFamiTF351653.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR030571. KLHL41.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF146. PTHR24412:SF146. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ER30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSQRELAEE LRLYQSTLLQ DGLKDLLEEK KFIDCTLKAG DKSFPCHRLI
60 70 80 90 100
LSACSPYFRE YFLSEIEEEK KKEMALDNVD PAILDLIIKY LYSASIDLND
110 120 130 140 150
GNVQDIFALS SRFQIPSVFT VCVSYLQKRL APGNCLAILR LGLLLDCPRL
160 170 180 190 200
AISAREFVSD RFVQICKEED FMQLSPQELI SVISNDSLNV EKEEVVFEAV
210 220 230 240 250
MKWVRTDKEN RAKNLSEVFD CIRFRLMAEK YFKDHVEKDD IIKSNPEVQK
260 270 280 290 300
KIKVLKDAFA GKLPEPSKSA EKGGTGEVNG DVGDEDLLPG YLNDIPRHGM
310 320 330 340 350
FVKDLILLVN DTAAVAYDPM ENECYLTALA EQIPRNHSSI VTQQNQVYVV
360 370 380 390 400
GGLYVDEENK DQPLQSYFFQ LDNVSSEWVG LPPLPSARCL FGLGEVDDKI
410 420 430 440 450
YVVAGKDLQT EASLDSVLCY DPVAAKWSEV KNLPIKVYGH NVISHNGMIY
460 470 480 490 500
CLGGKTDDKK CTNRVFIYNP KKGDWKDLAP MKTPRSMFGV AIHKGKIVIA
510 520 530 540 550
GGVTEDGLSA SVEAFDLKTN KWEVMTEFPQ ERSSISLVSL AGSLYAIGGF
560 570 580 590 600
AMIQLESKEF APTEVNDIWK YEDDKKEWAG MLKEIRYASG ASCLATRLNL

FKLSKL
Length:606
Mass (Da):68,213
Last modified:March 1, 2001 - v1
Checksum:i08DB54E9298DEACE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ293948 mRNA. Translation: CAC08185.1.
RefSeqiNP_476539.1. NM_057191.1.
UniGeneiRn.28875.

Genome annotation databases

EnsembliENSRNOT00000009969; ENSRNOP00000009969; ENSRNOG00000007461.
GeneIDi117537.
KEGGirno:117537.
UCSCiRGD:620852. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ293948 mRNA. Translation: CAC08185.1.
RefSeqiNP_476539.1. NM_057191.1.
UniGeneiRn.28875.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WOZX-ray2.00A289-606[»]
ProteinModelPortaliQ9ER30.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9ER30. 1 interaction.
MINTiMINT-4998213.
STRINGi10116.ENSRNOP00000009969.

PTM databases

iPTMnetiQ9ER30.
PhosphoSiteiQ9ER30.

Proteomic databases

PaxDbiQ9ER30.
PRIDEiQ9ER30.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009969; ENSRNOP00000009969; ENSRNOG00000007461.
GeneIDi117537.
KEGGirno:117537.
UCSCiRGD:620852. rat.

Organism-specific databases

CTDi10324.
RGDi620852. Klhl41.

Phylogenomic databases

eggNOGiENOG410IGWS. Eukaryota.
ENOG410XUMT. LUCA.
GeneTreeiENSGT00840000129730.
HOGENOMiHOG000231966.
HOVERGENiHBG052215.
InParanoidiQ9ER30.
KOiK10473.
OMAiFFQLDNV.
OrthoDBiEOG091G0C3Y.
PhylomeDBiQ9ER30.
TreeFamiTF351653.

Miscellaneous databases

EvolutionaryTraceiQ9ER30.
PROiQ9ER30.

Gene expression databases

BgeeiENSRNOG00000007461.
GenevisibleiQ9ER30. RN.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR030571. KLHL41.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF146. PTHR24412:SF146. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLH41_RAT
AccessioniPrimary (citable) accession number: Q9ER30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.