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Protein
Submitted name:

Endothelial type gp91-phox

Gene

Cybb

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • NAD(P)H oxidase activity Source: RGD

GO - Biological processi

  • cellular response to cadmium ion Source: RGD
  • cellular response to ethanol Source: RGD
  • cellular response to hypoxia Source: RGD
  • cellular response to L-glutamine Source: RGD
  • hypoxia-inducible factor-1alpha signaling pathway Source: RGD
  • positive regulation of angiogenesis Source: RGD
  • positive regulation of tumor necrosis factor biosynthetic process Source: RGD
  • response to aldosterone Source: RGD
  • response to angiotensin Source: RGD
  • response to drug Source: RGD
  • response to nutrient Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseSAAS annotation

Protein family/group databases

PeroxiBasei5406. RnoNOx02.

Names & Taxonomyi

Protein namesi
Submitted name:
Endothelial type gp91-phoxImported
Gene namesi
Name:CybbImported
Synonyms:gp91-phoxImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi620574. Cybb.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3019HelicalSequence analysisAdd
BLAST
Transmembranei99 – 12123HelicalSequence analysisAdd
BLAST
Transmembranei167 – 19226HelicalSequence analysisAdd
BLAST
Transmembranei204 – 22421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • dendrite Source: RGD
  • endoplasmic reticulum Source: RGD
  • Golgi apparatus Source: RGD
  • intracellular Source: RGD
  • NADPH oxidase complex Source: RGD
  • neuronal cell body Source: RGD
  • nuclear envelope Source: RGD
  • perinuclear region of cytoplasm Source: RGD
  • plasma membrane Source: RGD
  • rough endoplasmic reticulum Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ9ER28.
PRIDEiQ9ER28.

Expressioni

Gene expression databases

GenevisibleiQ9ER28. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031063.

Structurei

3D structure databases

ProteinModelPortaliQ9ER28.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini287 – 397111FAD-binding FR-typeInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains FAD-binding FR-type domain.SAAS annotation
Contains ferric oxidoreductase domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0039. Eukaryota.
ENOG410XNZY. LUCA.
HOGENOMiHOG000216669.
HOVERGENiHBG003760.
KOiK08008.

Family and domain databases

InterProiIPR000778. Cyt_b245_heavy_chain.
IPR013112. FAD-bd_8.
IPR017927. Fd_Rdtase_FAD-bd.
IPR013130. Fe3_Rdtase_TM_dom.
IPR013121. Fe_red_NAD-bd_6.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamiPF08022. FAD_binding_8. 1 hit.
PF01794. Ferric_reduct. 1 hit.
PF08030. NAD_binding_6. 1 hit.
[Graphical view]
PRINTSiPR00466. GP91PHOX.
SUPFAMiSSF63380. SSF63380. 1 hit.
PROSITEiPS51384. FAD_FR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ER28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNWAVNEGL SIFVILVWLG LNVFLFVKYY KVYDDEPKYN YTRKLLGSAL
60 70 80 90 100
ALARAPAACL NFNCMLILLP VCRNLLSFLR GSSACCSTRI RRQLDRNLTF
110 120 130 140 150
HKMVAWMIAL HTAIHTIAHL FNVEWCVNAR VGTSDPYSVA LSNIGDKENE
160 170 180 190 200
EYLNFAREKI KNPEGGLYVA VTRLAGITGI VITLCLILII TSSTKTIRRS
210 220 230 240 250
YFEVFWYTHH LFVIFFIGLA IHGAERIVRG QTSDSLKEHN LDVCADKIKE
260 270 280 290 300
WGKIKECPVP KFAGNPPMTW KWIVGPMFLY LCERLVRFWR SQQKVVITKV
310 320 330 340 350
VTHPFKTIEL QMKKKGFRME VGQYIFVKRP AVSKLEWHPF TLTSAPEEDF
360 370 380 390 400
FSIHIRIVGD WTEGLFKACG CDKQEFQDAW KLPKIAVDGP FGTASEDVFS
410 420 430 440 450
YEVVMLVGAG IGVTPSASIL KSVWYKYCDN ATSLRLKKIY FYWLCRDTHA
460 470 480 490 500
FEWFADLLQL LETQMQERNN ANFLSYNIYL TGWDESQANH FAVHHDEEKD
510 520 530 540 550
VITGLKQKTL YGRPNWDNEF KTIASQHPNT RIGVFLCGPE ALAKTLSKQS
560 570
ISNSESGPRG VHFIFNKENF
Length:570
Mass (Da):65,350
Last modified:March 1, 2001 - v1
Checksum:iDD2AF43E78AD8D19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ295950 mRNA. Translation: CAC09433.1.
RefSeqiNP_076455.1. NM_023965.1.
UniGeneiRn.98491.

Genome annotation databases

GeneIDi66021.
KEGGirno:66021.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ295950 mRNA. Translation: CAC09433.1.
RefSeqiNP_076455.1. NM_023965.1.
UniGeneiRn.98491.

3D structure databases

ProteinModelPortaliQ9ER28.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031063.

Protein family/group databases

PeroxiBasei5406. RnoNOx02.

Proteomic databases

PaxDbiQ9ER28.
PRIDEiQ9ER28.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi66021.
KEGGirno:66021.

Organism-specific databases

CTDi1536.
RGDi620574. Cybb.

Phylogenomic databases

eggNOGiKOG0039. Eukaryota.
ENOG410XNZY. LUCA.
HOGENOMiHOG000216669.
HOVERGENiHBG003760.
KOiK08008.

Gene expression databases

GenevisibleiQ9ER28. RN.

Family and domain databases

InterProiIPR000778. Cyt_b245_heavy_chain.
IPR013112. FAD-bd_8.
IPR017927. Fd_Rdtase_FAD-bd.
IPR013130. Fe3_Rdtase_TM_dom.
IPR013121. Fe_red_NAD-bd_6.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamiPF08022. FAD_binding_8. 1 hit.
PF01794. Ferric_reduct. 1 hit.
PF08030. NAD_binding_6. 1 hit.
[Graphical view]
PRINTSiPR00466. GP91PHOX.
SUPFAMiSSF63380. SSF63380. 1 hit.
PROSITEiPS51384. FAD_FR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9ER28_RAT
AccessioniPrimary (citable) accession number: Q9ER28
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.