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Protein
Submitted name:

Endothelial type gp91-phox

Gene

Cybb

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • NAD(P)H oxidase activity Source: RGD

GO - Biological processi

  • cellular response to cadmium ion Source: RGD
  • cellular response to ethanol Source: RGD
  • cellular response to hypoxia Source: RGD
  • cellular response to L-glutamine Source: RGD
  • hypoxia-inducible factor-1alpha signaling pathway Source: RGD
  • positive regulation of angiogenesis Source: RGD
  • positive regulation of tumor necrosis factor biosynthetic process Source: RGD
  • response to aldosterone Source: RGD
  • response to angiotensin Source: RGD
  • response to drug Source: RGD
  • response to nutrient Source: RGD

Keywordsi

Molecular functionOxidoreductaseSAAS annotation

Protein family/group databases

PeroxiBasei5406 RnoNOx02

Names & Taxonomyi

Protein namesi
Submitted name:
Endothelial type gp91-phoxImported
Gene namesi
Name:CybbImported
Synonyms:gp91-phoxImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi620574 Cybb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 30HelicalSequence analysisAdd BLAST19
Transmembranei99 – 121HelicalSequence analysisAdd BLAST23
Transmembranei167 – 192HelicalSequence analysisAdd BLAST26
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ9ER28

Expressioni

Gene expression databases

GenevisibleiQ9ER28 RN

Structurei

3D structure databases

ProteinModelPortaliQ9ER28
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini287 – 397FAD-binding FR-typeInterPro annotationAdd BLAST111

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0039 Eukaryota
ENOG410XNZY LUCA
HOGENOMiHOG000216669
HOVERGENiHBG003760
KOiK21421

Family and domain databases

InterProiView protein in InterPro
IPR000778 Cyt_b245_heavy_chain
IPR013112 FAD-bd_8
IPR017927 Fd_Rdtase_FAD-bd
IPR013130 Fe3_Rdtase_TM_dom
IPR013121 Fe_red_NAD-bd_6
IPR017938 Riboflavin_synthase-like_b-brl
PfamiView protein in Pfam
PF08022 FAD_binding_8, 1 hit
PF01794 Ferric_reduct, 1 hit
PF08030 NAD_binding_6, 1 hit
PRINTSiPR00466 GP91PHOX
SUPFAMiSSF63380 SSF63380, 1 hit
PROSITEiView protein in PROSITE
PS51384 FAD_FR, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ER28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNWAVNEGL SIFVILVWLG LNVFLFVKYY KVYDDEPKYN YTRKLLGSAL
60 70 80 90 100
ALARAPAACL NFNCMLILLP VCRNLLSFLR GSSACCSTRI RRQLDRNLTF
110 120 130 140 150
HKMVAWMIAL HTAIHTIAHL FNVEWCVNAR VGTSDPYSVA LSNIGDKENE
160 170 180 190 200
EYLNFAREKI KNPEGGLYVA VTRLAGITGI VITLCLILII TSSTKTIRRS
210 220 230 240 250
YFEVFWYTHH LFVIFFIGLA IHGAERIVRG QTSDSLKEHN LDVCADKIKE
260 270 280 290 300
WGKIKECPVP KFAGNPPMTW KWIVGPMFLY LCERLVRFWR SQQKVVITKV
310 320 330 340 350
VTHPFKTIEL QMKKKGFRME VGQYIFVKRP AVSKLEWHPF TLTSAPEEDF
360 370 380 390 400
FSIHIRIVGD WTEGLFKACG CDKQEFQDAW KLPKIAVDGP FGTASEDVFS
410 420 430 440 450
YEVVMLVGAG IGVTPSASIL KSVWYKYCDN ATSLRLKKIY FYWLCRDTHA
460 470 480 490 500
FEWFADLLQL LETQMQERNN ANFLSYNIYL TGWDESQANH FAVHHDEEKD
510 520 530 540 550
VITGLKQKTL YGRPNWDNEF KTIASQHPNT RIGVFLCGPE ALAKTLSKQS
560 570
ISNSESGPRG VHFIFNKENF
Length:570
Mass (Da):65,350
Last modified:March 1, 2001 - v1
Checksum:iDD2AF43E78AD8D19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ295950 mRNA Translation: CAC09433.1
RefSeqiNP_076455.1, NM_023965.1
UniGeneiRn.98491

Genome annotation databases

GeneIDi66021
KEGGirno:66021

Similar proteinsi

Entry informationi

Entry nameiQ9ER28_RAT
AccessioniPrimary (citable) accession number: Q9ER28
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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