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Q9ER26

- KCNS2_RAT

UniProt

Q9ER26 - KCNS2_RAT

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Protein

Potassium voltage-gated channel subfamily S member 2

Gene

Kcns2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity).By similarity

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: RefGenome

GO - Biological processi

  1. protein homooligomerization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199159. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily S member 2
Alternative name(s):
Delayed-rectifier K(+) channel alpha subunit 2
Voltage-gated potassium channel subunit Kv9.2
Gene namesi
Name:Kcns2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi621525. Kcns2.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity
Note: May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 187187CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei188 – 20821Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Topological domaini209 – 23224ExtracellularSequence AnalysisAdd
BLAST
Transmembranei233 – 25321Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Topological domaini254 – 2629CytoplasmicSequence Analysis
Transmembranei263 – 28220Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Topological domaini283 – 29210ExtracellularSequence Analysis
Transmembranei293 – 31321Helical; Name=Segment S4Sequence AnalysisAdd
BLAST
Topological domaini314 – 32815CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei329 – 34921Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Topological domaini350 – 36112ExtracellularSequence AnalysisAdd
BLAST
Intramembranei362 – 38221Pore-forming; Name=Segment H5Sequence AnalysisAdd
BLAST
Topological domaini383 – 3897ExtracellularSequence Analysis
Transmembranei390 – 41021Helical; Name=Segment S6Sequence AnalysisAdd
BLAST
Topological domaini411 – 47767CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 477477Potassium voltage-gated channel subfamily S member 2PRO_0000054086Add
BLAST

Proteomic databases

PRIDEiQ9ER26.

Expressioni

Tissue specificityi

Detected in brain, lung and in pulmonary arteries.

Gene expression databases

GenevestigatoriQ9ER26.

Interactioni

Subunit structurei

Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel proteins (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015707.

Structurei

3D structure databases

ProteinModelPortaliQ9ER26.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi374 – 3796Selectivity filterBy similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231016.
HOVERGENiHBG052230.
InParanoidiQ9ER26.
KOiK04932.
OMAiHGRKMEP.
OrthoDBiEOG7CRTPP.
PhylomeDBiQ9ER26.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ER26-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRQSLWDLS ETDVEDGEIR INVGGFKRRL RSHTLLRFPE TRLGRLLLCH
60 70 80 90 100
SREAILELCD DYDDVQREFY FDRNPELFPY VLHFYHTGKL HVMAELCVFS
110 120 130 140 150
FSQEIEYWGI NEFFIDSCCS YSYHGRKVEP EQEKWDEQSD QESTTSSFDE
160 170 180 190 200
ILAFYNDASK FDGQPLGNFR RQLWLALDNP GYSVLSRVFS VLSILVVLGS
210 220 230 240 250
IITMCLNSLP DFQIPDSQGN PGEDPRFEIV EHFGIAWFTF ELVARFAVAP
260 270 280 290 300
DFLKFFKNAL NLIDLMSIVP FYITLVVNLV VESSPTLANL GRVAQVLRLM
310 320 330 340 350
RIFRILKLAR HSTGLRSLGA TLKYSYKEVG LLLLYLSVGI SIFSVVAYTI
360 370 380 390 400
EKEENEGLAT IPACWWWATV SMTTVGYGDV VPGTTAGKLT ASACILAGIL
410 420 430 440 450
VVVLPITLIF NKFSHFYRRQ KQLESAMRSC DFGDGMKEVP SVNLRDYYAH
460 470
KVKSLMASLT NMSRSSPSEL SLDDSLH
Length:477
Mass (Da):54,317
Last modified:March 1, 2001 - v1
Checksum:i23199B1BBE9C5D5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ296090 mRNA. Translation: CAC14912.1.
RefSeqiNP_076456.1. NM_023966.1.
UniGeneiRn.64498.

Genome annotation databases

EnsembliENSRNOT00000015707; ENSRNOP00000015707; ENSRNOG00000011369.
GeneIDi66022.
KEGGirno:66022.
UCSCiRGD:621525. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ296090 mRNA. Translation: CAC14912.1 .
RefSeqi NP_076456.1. NM_023966.1.
UniGenei Rn.64498.

3D structure databases

ProteinModelPortali Q9ER26.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000015707.

Proteomic databases

PRIDEi Q9ER26.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000015707 ; ENSRNOP00000015707 ; ENSRNOG00000011369 .
GeneIDi 66022.
KEGGi rno:66022.
UCSCi RGD:621525. rat.

Organism-specific databases

CTDi 3788.
RGDi 621525. Kcns2.

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00760000118981.
HOGENOMi HOG000231016.
HOVERGENi HBG052230.
InParanoidi Q9ER26.
KOi K04932.
OMAi HGRKMEP.
OrthoDBi EOG7CRTPP.
PhylomeDBi Q9ER26.
TreeFami TF313103.

Enzyme and pathway databases

Reactomei REACT_199159. Voltage gated Potassium channels.

Miscellaneous databases

NextBioi 614318.
PROi Q9ER26.

Gene expression databases

Genevestigatori Q9ER26.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
Pfami PF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Kv channel subunit expression in rat pulmonary arteries."
    Davies A.R., Kozlowski R.Z.
    Lung 179:147-161(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Brain.

Entry informationi

Entry nameiKCNS2_RAT
AccessioniPrimary (citable) accession number: Q9ER26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3