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Q9ER26

- KCNS2_RAT

UniProt

Q9ER26 - KCNS2_RAT

Protein

Potassium voltage-gated channel subfamily S member 2

Gene

Kcns2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Potassium channel subunit. Modulates channel activity and reduces the ion flow By similarity.By similarity

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: RefGenome

    GO - Biological processi

    1. protein homooligomerization Source: InterPro

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_199159. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily S member 2
    Alternative name(s):
    Delayed-rectifier K(+) channel alpha subunit 2
    Voltage-gated potassium channel subunit Kv9.2
    Gene namesi
    Name:Kcns2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi621525. Kcns2.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity
    Note: May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1.By similarity

    GO - Cellular componenti

    1. voltage-gated potassium channel complex Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 477477Potassium voltage-gated channel subfamily S member 2PRO_0000054086Add
    BLAST

    Proteomic databases

    PRIDEiQ9ER26.

    Expressioni

    Tissue specificityi

    Detected in brain, lung and in pulmonary arteries.

    Gene expression databases

    GenevestigatoriQ9ER26.

    Interactioni

    Subunit structurei

    Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel proteins By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000015707.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ER26.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 187187CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini209 – 23224ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini254 – 2629CytoplasmicSequence Analysis
    Topological domaini283 – 29210ExtracellularSequence Analysis
    Topological domaini314 – 32815CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini350 – 36112ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini383 – 3897ExtracellularSequence Analysis
    Topological domaini411 – 47767CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei362 – 38221Pore-forming; Name=Segment H5Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei188 – 20821Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei233 – 25321Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei263 – 28220Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei293 – 31321Helical; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei329 – 34921Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei390 – 41021Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi374 – 3796Selectivity filterBy similarity

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    GeneTreeiENSGT00740000115408.
    HOGENOMiHOG000231016.
    HOVERGENiHBG052230.
    InParanoidiQ9ER26.
    KOiK04932.
    OMAiHGRKMEP.
    OrthoDBiEOG7CRTPP.
    PhylomeDBiQ9ER26.
    TreeFamiTF313103.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003971. K_chnl_volt-dep_Kv9.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PfamiPF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01494. KV9CHANNEL.
    PR01491. KVCHANNEL.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9ER26-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTRQSLWDLS ETDVEDGEIR INVGGFKRRL RSHTLLRFPE TRLGRLLLCH    50
    SREAILELCD DYDDVQREFY FDRNPELFPY VLHFYHTGKL HVMAELCVFS 100
    FSQEIEYWGI NEFFIDSCCS YSYHGRKVEP EQEKWDEQSD QESTTSSFDE 150
    ILAFYNDASK FDGQPLGNFR RQLWLALDNP GYSVLSRVFS VLSILVVLGS 200
    IITMCLNSLP DFQIPDSQGN PGEDPRFEIV EHFGIAWFTF ELVARFAVAP 250
    DFLKFFKNAL NLIDLMSIVP FYITLVVNLV VESSPTLANL GRVAQVLRLM 300
    RIFRILKLAR HSTGLRSLGA TLKYSYKEVG LLLLYLSVGI SIFSVVAYTI 350
    EKEENEGLAT IPACWWWATV SMTTVGYGDV VPGTTAGKLT ASACILAGIL 400
    VVVLPITLIF NKFSHFYRRQ KQLESAMRSC DFGDGMKEVP SVNLRDYYAH 450
    KVKSLMASLT NMSRSSPSEL SLDDSLH 477
    Length:477
    Mass (Da):54,317
    Last modified:March 1, 2001 - v1
    Checksum:i23199B1BBE9C5D5C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ296090 mRNA. Translation: CAC14912.1.
    RefSeqiNP_076456.1. NM_023966.1.
    UniGeneiRn.64498.

    Genome annotation databases

    EnsembliENSRNOT00000015707; ENSRNOP00000015707; ENSRNOG00000011369.
    GeneIDi66022.
    KEGGirno:66022.
    UCSCiRGD:621525. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ296090 mRNA. Translation: CAC14912.1 .
    RefSeqi NP_076456.1. NM_023966.1.
    UniGenei Rn.64498.

    3D structure databases

    ProteinModelPortali Q9ER26.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000015707.

    Proteomic databases

    PRIDEi Q9ER26.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000015707 ; ENSRNOP00000015707 ; ENSRNOG00000011369 .
    GeneIDi 66022.
    KEGGi rno:66022.
    UCSCi RGD:621525. rat.

    Organism-specific databases

    CTDi 3788.
    RGDi 621525. Kcns2.

    Phylogenomic databases

    eggNOGi COG1226.
    GeneTreei ENSGT00740000115408.
    HOGENOMi HOG000231016.
    HOVERGENi HBG052230.
    InParanoidi Q9ER26.
    KOi K04932.
    OMAi HGRKMEP.
    OrthoDBi EOG7CRTPP.
    PhylomeDBi Q9ER26.
    TreeFami TF313103.

    Enzyme and pathway databases

    Reactomei REACT_199159. Voltage gated Potassium channels.

    Miscellaneous databases

    NextBioi 614318.
    PROi Q9ER26.

    Gene expression databases

    Genevestigatori Q9ER26.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003971. K_chnl_volt-dep_Kv9.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    Pfami PF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01494. KV9CHANNEL.
    PR01491. KVCHANNEL.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Kv channel subunit expression in rat pulmonary arteries."
      Davies A.R., Kozlowski R.Z.
      Lung 179:147-161(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Brain.

    Entry informationi

    Entry nameiKCNS2_RAT
    AccessioniPrimary (citable) accession number: Q9ER26
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3