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Q9ER26

- KCNS2_RAT

UniProt

Q9ER26 - KCNS2_RAT

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Protein

Potassium voltage-gated channel subfamily S member 2

Gene
Kcns2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Potassium channel subunit. Modulates channel activity and reduces the ion flow By similarity.

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: RefGenome

GO - Biological processi

  1. protein homooligomerization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199159. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily S member 2
Alternative name(s):
Delayed-rectifier K(+) channel alpha subunit 2
Voltage-gated potassium channel subunit Kv9.2
Gene namesi
Name:Kcns2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi621525. Kcns2.

Subcellular locationi

Cell membrane; Multi-pass membrane protein By similarity
Note: May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 187187Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei188 – 20821Helical; Name=Segment S1; Reviewed predictionAdd
BLAST
Topological domaini209 – 23224Extracellular Reviewed predictionAdd
BLAST
Transmembranei233 – 25321Helical; Name=Segment S2; Reviewed predictionAdd
BLAST
Topological domaini254 – 2629Cytoplasmic Reviewed prediction
Transmembranei263 – 28220Helical; Name=Segment S3; Reviewed predictionAdd
BLAST
Topological domaini283 – 29210Extracellular Reviewed prediction
Transmembranei293 – 31321Helical; Name=Segment S4; Reviewed predictionAdd
BLAST
Topological domaini314 – 32815Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei329 – 34921Helical; Name=Segment S5; Reviewed predictionAdd
BLAST
Topological domaini350 – 36112Extracellular Reviewed predictionAdd
BLAST
Intramembranei362 – 38221Pore-forming; Name=Segment H5; Reviewed predictionAdd
BLAST
Topological domaini383 – 3897Extracellular Reviewed prediction
Transmembranei390 – 41021Helical; Name=Segment S6; Reviewed predictionAdd
BLAST
Topological domaini411 – 47767Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 477477Potassium voltage-gated channel subfamily S member 2PRO_0000054086Add
BLAST

Proteomic databases

PRIDEiQ9ER26.

Expressioni

Tissue specificityi

Detected in brain, lung and in pulmonary arteries.

Gene expression databases

GenevestigatoriQ9ER26.

Interactioni

Subunit structurei

Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel proteins By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015707.

Structurei

3D structure databases

ProteinModelPortaliQ9ER26.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi374 – 3796Selectivity filter By similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00740000115408.
HOGENOMiHOG000231016.
HOVERGENiHBG052230.
InParanoidiQ9ER26.
KOiK04932.
OMAiHGRKMEP.
OrthoDBiEOG7CRTPP.
PhylomeDBiQ9ER26.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ER26-1 [UniParc]FASTAAdd to Basket

« Hide

MTRQSLWDLS ETDVEDGEIR INVGGFKRRL RSHTLLRFPE TRLGRLLLCH    50
SREAILELCD DYDDVQREFY FDRNPELFPY VLHFYHTGKL HVMAELCVFS 100
FSQEIEYWGI NEFFIDSCCS YSYHGRKVEP EQEKWDEQSD QESTTSSFDE 150
ILAFYNDASK FDGQPLGNFR RQLWLALDNP GYSVLSRVFS VLSILVVLGS 200
IITMCLNSLP DFQIPDSQGN PGEDPRFEIV EHFGIAWFTF ELVARFAVAP 250
DFLKFFKNAL NLIDLMSIVP FYITLVVNLV VESSPTLANL GRVAQVLRLM 300
RIFRILKLAR HSTGLRSLGA TLKYSYKEVG LLLLYLSVGI SIFSVVAYTI 350
EKEENEGLAT IPACWWWATV SMTTVGYGDV VPGTTAGKLT ASACILAGIL 400
VVVLPITLIF NKFSHFYRRQ KQLESAMRSC DFGDGMKEVP SVNLRDYYAH 450
KVKSLMASLT NMSRSSPSEL SLDDSLH 477
Length:477
Mass (Da):54,317
Last modified:March 1, 2001 - v1
Checksum:i23199B1BBE9C5D5C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ296090 mRNA. Translation: CAC14912.1.
RefSeqiNP_076456.1. NM_023966.1.
UniGeneiRn.64498.

Genome annotation databases

EnsembliENSRNOT00000015707; ENSRNOP00000015707; ENSRNOG00000011369.
GeneIDi66022.
KEGGirno:66022.
UCSCiRGD:621525. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ296090 mRNA. Translation: CAC14912.1 .
RefSeqi NP_076456.1. NM_023966.1.
UniGenei Rn.64498.

3D structure databases

ProteinModelPortali Q9ER26.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000015707.

Proteomic databases

PRIDEi Q9ER26.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000015707 ; ENSRNOP00000015707 ; ENSRNOG00000011369 .
GeneIDi 66022.
KEGGi rno:66022.
UCSCi RGD:621525. rat.

Organism-specific databases

CTDi 3788.
RGDi 621525. Kcns2.

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00740000115408.
HOGENOMi HOG000231016.
HOVERGENi HBG052230.
InParanoidi Q9ER26.
KOi K04932.
OMAi HGRKMEP.
OrthoDBi EOG7CRTPP.
PhylomeDBi Q9ER26.
TreeFami TF313103.

Enzyme and pathway databases

Reactomei REACT_199159. Voltage gated Potassium channels.

Miscellaneous databases

NextBioi 614318.
PROi Q9ER26.

Gene expression databases

Genevestigatori Q9ER26.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
Pfami PF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Kv channel subunit expression in rat pulmonary arteries."
    Davies A.R., Kozlowski R.Z.
    Lung 179:147-161(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Brain.

Entry informationi

Entry nameiKCNS2_RAT
AccessioniPrimary (citable) accession number: Q9ER26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: March 1, 2001
Last modified: September 3, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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