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Protein

Potassium voltage-gated channel subfamily S member 2

Gene

Kcns2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_352543. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily S member 2
Alternative name(s):
Delayed-rectifier K(+) channel alpha subunit 2
Voltage-gated potassium channel subunit Kv9.2
Gene namesi
Name:Kcns2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi621525. Kcns2.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

  • Note: May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 or KCNB2.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 184184CytoplasmicBy similarityAdd
BLAST
Transmembranei185 – 20622Helical; Name=Segment S1By similarityAdd
BLAST
Topological domaini207 – 22519ExtracellularBy similarityAdd
BLAST
Transmembranei226 – 24823Helical; Name=Segment S2By similarityAdd
BLAST
Topological domaini249 – 25911CytoplasmicBy similarityAdd
BLAST
Transmembranei260 – 28021Helical; Name=Segment S3By similarityAdd
BLAST
Topological domaini281 – 29010ExtracellularBy similarity
Transmembranei291 – 31121Helical; Voltage-sensor; Name=Segment S4By similarityAdd
BLAST
Topological domaini312 – 32615CytoplasmicBy similarityAdd
BLAST
Transmembranei327 – 34822Helical; Name=Segment S5By similarityAdd
BLAST
Topological domaini349 – 36113ExtracellularBy similarityAdd
BLAST
Intramembranei362 – 37312Helical; Name=Pore helixBy similarityAdd
BLAST
Intramembranei374 – 3818By similarity
Topological domaini382 – 3887ExtracellularBy similarity
Transmembranei389 – 41729Helical; Name=Segment S6By similarityAdd
BLAST
Topological domaini418 – 47760CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 477477Potassium voltage-gated channel subfamily S member 2PRO_0000054086Add
BLAST

Proteomic databases

PRIDEiQ9ER26.

Expressioni

Tissue specificityi

Detected in brain, lung and in pulmonary arteries (PubMed:11891605).1 Publication

Gene expression databases

GenevisibleiQ9ER26. RN.

Interactioni

Subunit structurei

Heterotetramer with KCNB1 and KCNB2. Does not form homomultimers.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015707.

Structurei

3D structure databases

ProteinModelPortaliQ9ER26.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi374 – 3796Selectivity filterBy similarity

Domaini

The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231016.
HOVERGENiHBG052230.
InParanoidiQ9ER26.
KOiK04932.
OMAiQSLWDMS.
OrthoDBiEOG7CRTPP.
PhylomeDBiQ9ER26.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ER26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRQSLWDLS ETDVEDGEIR INVGGFKRRL RSHTLLRFPE TRLGRLLLCH
60 70 80 90 100
SREAILELCD DYDDVQREFY FDRNPELFPY VLHFYHTGKL HVMAELCVFS
110 120 130 140 150
FSQEIEYWGI NEFFIDSCCS YSYHGRKVEP EQEKWDEQSD QESTTSSFDE
160 170 180 190 200
ILAFYNDASK FDGQPLGNFR RQLWLALDNP GYSVLSRVFS VLSILVVLGS
210 220 230 240 250
IITMCLNSLP DFQIPDSQGN PGEDPRFEIV EHFGIAWFTF ELVARFAVAP
260 270 280 290 300
DFLKFFKNAL NLIDLMSIVP FYITLVVNLV VESSPTLANL GRVAQVLRLM
310 320 330 340 350
RIFRILKLAR HSTGLRSLGA TLKYSYKEVG LLLLYLSVGI SIFSVVAYTI
360 370 380 390 400
EKEENEGLAT IPACWWWATV SMTTVGYGDV VPGTTAGKLT ASACILAGIL
410 420 430 440 450
VVVLPITLIF NKFSHFYRRQ KQLESAMRSC DFGDGMKEVP SVNLRDYYAH
460 470
KVKSLMASLT NMSRSSPSEL SLDDSLH
Length:477
Mass (Da):54,317
Last modified:March 1, 2001 - v1
Checksum:i23199B1BBE9C5D5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ296090 mRNA. Translation: CAC14912.1.
RefSeqiNP_076456.1. NM_023966.1.
UniGeneiRn.64498.

Genome annotation databases

EnsembliENSRNOT00000015707; ENSRNOP00000015707; ENSRNOG00000011369.
GeneIDi66022.
KEGGirno:66022.
UCSCiRGD:621525. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ296090 mRNA. Translation: CAC14912.1.
RefSeqiNP_076456.1. NM_023966.1.
UniGeneiRn.64498.

3D structure databases

ProteinModelPortaliQ9ER26.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015707.

Proteomic databases

PRIDEiQ9ER26.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015707; ENSRNOP00000015707; ENSRNOG00000011369.
GeneIDi66022.
KEGGirno:66022.
UCSCiRGD:621525. rat.

Organism-specific databases

CTDi3788.
RGDi621525. Kcns2.

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231016.
HOVERGENiHBG052230.
InParanoidiQ9ER26.
KOiK04932.
OMAiQSLWDMS.
OrthoDBiEOG7CRTPP.
PhylomeDBiQ9ER26.
TreeFamiTF313103.

Enzyme and pathway databases

ReactomeiREACT_352543. Voltage gated Potassium channels.

Miscellaneous databases

NextBioi614318.
PROiQ9ER26.

Gene expression databases

GenevisibleiQ9ER26. RN.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Kv channel subunit expression in rat pulmonary arteries."
    Davies A.R., Kozlowski R.Z.
    Lung 179:147-161(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Wistar.
    Tissue: Brain.

Entry informationi

Entry nameiKCNS2_RAT
AccessioniPrimary (citable) accession number: Q9ER26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: March 1, 2001
Last modified: July 22, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.