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Q9ER26 (KCNS2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily S member 2
Alternative name(s):
Delayed-rectifier K(+) channel alpha subunit 2
Voltage-gated potassium channel subunit Kv9.2
Gene names
Name:Kcns2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length477 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potassium channel subunit. Modulates channel activity and reduces the ion flow By similarity.

Subunit structure

Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel proteins By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Note: May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 By similarity.

Tissue specificity

Detected in brain, lung and in pulmonary arteries.

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similarities

Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.2/KCNS2 sub-subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 477477Potassium voltage-gated channel subfamily S member 2
PRO_0000054086

Regions

Topological domain1 – 187187Cytoplasmic Potential
Transmembrane188 – 20821Helical; Name=Segment S1; Potential
Topological domain209 – 23224Extracellular Potential
Transmembrane233 – 25321Helical; Name=Segment S2; Potential
Topological domain254 – 2629Cytoplasmic Potential
Transmembrane263 – 28220Helical; Name=Segment S3; Potential
Topological domain283 – 29210Extracellular Potential
Transmembrane293 – 31321Helical; Name=Segment S4; Potential
Topological domain314 – 32815Cytoplasmic Potential
Transmembrane329 – 34921Helical; Name=Segment S5; Potential
Topological domain350 – 36112Extracellular Potential
Intramembrane362 – 38221Pore-forming; Name=Segment H5; Potential
Topological domain383 – 3897Extracellular Potential
Transmembrane390 – 41021Helical; Name=Segment S6; Potential
Topological domain411 – 47767Cytoplasmic Potential
Motif374 – 3796Selectivity filter By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ER26 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 23199B1BBE9C5D5C

FASTA47754,317
        10         20         30         40         50         60 
MTRQSLWDLS ETDVEDGEIR INVGGFKRRL RSHTLLRFPE TRLGRLLLCH SREAILELCD 

        70         80         90        100        110        120 
DYDDVQREFY FDRNPELFPY VLHFYHTGKL HVMAELCVFS FSQEIEYWGI NEFFIDSCCS 

       130        140        150        160        170        180 
YSYHGRKVEP EQEKWDEQSD QESTTSSFDE ILAFYNDASK FDGQPLGNFR RQLWLALDNP 

       190        200        210        220        230        240 
GYSVLSRVFS VLSILVVLGS IITMCLNSLP DFQIPDSQGN PGEDPRFEIV EHFGIAWFTF 

       250        260        270        280        290        300 
ELVARFAVAP DFLKFFKNAL NLIDLMSIVP FYITLVVNLV VESSPTLANL GRVAQVLRLM 

       310        320        330        340        350        360 
RIFRILKLAR HSTGLRSLGA TLKYSYKEVG LLLLYLSVGI SIFSVVAYTI EKEENEGLAT 

       370        380        390        400        410        420 
IPACWWWATV SMTTVGYGDV VPGTTAGKLT ASACILAGIL VVVLPITLIF NKFSHFYRRQ 

       430        440        450        460        470 
KQLESAMRSC DFGDGMKEVP SVNLRDYYAH KVKSLMASLT NMSRSSPSEL SLDDSLH 

« Hide

References

[1]"Kv channel subunit expression in rat pulmonary arteries."
Davies A.R., Kozlowski R.Z.
Lung 179:147-161(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ296090 mRNA. Translation: CAC14912.1.
RefSeqNP_076456.1. NM_023966.1.
UniGeneRn.64498.

3D structure databases

ProteinModelPortalQ9ER26.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000015707.

Proteomic databases

PRIDEQ9ER26.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000015707; ENSRNOP00000015707; ENSRNOG00000011369.
GeneID66022.
KEGGrno:66022.
UCSCRGD:621525. rat.

Organism-specific databases

CTD3788.
RGD621525. Kcns2.

Phylogenomic databases

eggNOGCOG1226.
GeneTreeENSGT00740000115408.
HOGENOMHOG000231016.
HOVERGENHBG052230.
InParanoidQ9ER26.
KOK04932.
OMAHGRKMEP.
OrthoDBEOG7CRTPP.
PhylomeDBQ9ER26.
TreeFamTF313103.

Gene expression databases

GenevestigatorQ9ER26.

Family and domain databases

Gene3D1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PfamPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
ProtoNetSearch...

Other

NextBio614318.
PROQ9ER26.

Entry information

Entry nameKCNS2_RAT
AccessionPrimary (citable) accession number: Q9ER26
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families