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Protein

Ataxin-10

Gene

Atxn10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.3 Publications

GO - Molecular functioni

  • enzyme binding Source: RGD
  • identical protein binding Source: RGD

GO - Biological processi

  • cilium assembly Source: Ensembl
  • neuron projection development Source: UniProtKB
  • protein homotrimerization Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ataxin-10
Alternative name(s):
Neuronal beta-catenin-like protein
Spinocerebellar ataxia type 10 protein homolog
Gene namesi
Name:Atxn10
Synonyms:Sca10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi621813. Atxn10.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • cytosol Source: RGD
  • dendrite Source: Ensembl
  • extracellular space Source: Ensembl
  • neuronal cell body Source: Ensembl
  • perinuclear region of cytoplasm Source: UniProtKB
  • plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475Ataxin-10PRO_0000064750Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei12 – 121PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9ER24.
PRIDEiQ9ER24.

PTM databases

iPTMnetiQ9ER24.
PhosphoSiteiQ9ER24.

Expressioni

Tissue specificityi

Ubiquitous distribution. Markedly increased expression in testis, adrenals, and brain.1 Publication

Gene expression databases

GenevisibleiQ9ER24. RN.

Interactioni

Subunit structurei

Interacts with GNB2 (By similarity). Homooligomer. Interacts with OGT in the brain. Interacts with IQCB1 (By similarity).By similarity

GO - Molecular functioni

  • enzyme binding Source: RGD
  • identical protein binding Source: RGD

Protein-protein interaction databases

BioGridi250992. 2 interactions.
STRINGi10116.ENSRNOP00000021071.

Family & Domainsi

Sequence similaritiesi

Belongs to the ataxin-10 family.Curated

Phylogenomic databases

eggNOGiKOG2676. Eukaryota.
ENOG410YBUH. LUCA.
GeneTreeiENSGT00390000010377.
HOGENOMiHOG000034224.
HOVERGENiHBG050622.
InParanoidiQ9ER24.
KOiK19323.
OMAiNNQERVT.
OrthoDBiEOG7WHH9W.
PhylomeDBiQ9ER24.
TreeFamiTF323870.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR019156. Ataxin-10_domain.
[Graphical view]
PfamiPF09759. Atx10homo_assoc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9ER24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPRMPPSR LSGIMVPAPI QDLEALRALT ALFKEQRNRE TAPRTIFQRV
60 70 80 90 100
LDILKKSTQA VELACRDPSQ VEHLASSLQL ITECFRCLRN ACIECSVNQN
110 120 130 140 150
SIRNLDTIGV AVDLVLLFRE LRVEQDSLLT AFRCGLQFLG NVASRNEDSQ
160 170 180 190 200
SIVWVHAFPE LFMSCLNHPD KKIVAYCSMI LFTSLNSERM KDLEENLNIA
210 220 230 240 250
INVIEAHQKH PESEWPFLII TDHFLKSPEL VEAMYGKLSN QERVTLLDIM
260 270 280 290 300
IAKIVGDEQL TKDDISIFLR HAELIANSFV DQCRNVLKLT SEPQTEDKEA
310 320 330 340 350
LVTIRLLDVL CEMTSNTELL GYLQVFPGLM ERVIDVLRVI HSVGKDSTNI
360 370 380 390 400
FSPSDSLKAE GDIEHMTEGF KSHLIRLIGN LCYKNKENQD KVNELDGIPL
410 420 430 440 450
ILDSSNIDDN NPFMMQWVVY AVRNLTEDNS QNQDFIAKME EQGLADASLL
460 470
KKMGFEVEKS GDKLILKSNN DIPPP
Length:475
Mass (Da):53,727
Last modified:March 1, 2001 - v1
Checksum:i530F6E3E498CBB38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ301634 mRNA. Translation: CAC16214.1.
BC062087 mRNA. Translation: AAH62087.1.
RefSeqiNP_579847.1. NM_133313.2.
UniGeneiRn.6524.

Genome annotation databases

EnsembliENSRNOT00000021071; ENSRNOP00000021071; ENSRNOG00000014637.
GeneIDi170821.
KEGGirno:170821.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ301634 mRNA. Translation: CAC16214.1.
BC062087 mRNA. Translation: AAH62087.1.
RefSeqiNP_579847.1. NM_133313.2.
UniGeneiRn.6524.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250992. 2 interactions.
STRINGi10116.ENSRNOP00000021071.

PTM databases

iPTMnetiQ9ER24.
PhosphoSiteiQ9ER24.

Proteomic databases

PaxDbiQ9ER24.
PRIDEiQ9ER24.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021071; ENSRNOP00000021071; ENSRNOG00000014637.
GeneIDi170821.
KEGGirno:170821.

Organism-specific databases

CTDi25814.
RGDi621813. Atxn10.

Phylogenomic databases

eggNOGiKOG2676. Eukaryota.
ENOG410YBUH. LUCA.
GeneTreeiENSGT00390000010377.
HOGENOMiHOG000034224.
HOVERGENiHBG050622.
InParanoidiQ9ER24.
KOiK19323.
OMAiNNQERVT.
OrthoDBiEOG7WHH9W.
PhylomeDBiQ9ER24.
TreeFamiTF323870.

Miscellaneous databases

NextBioi621239.
PROiQ9ER24.

Gene expression databases

GenevisibleiQ9ER24. RN.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR019156. Ataxin-10_domain.
[Graphical view]
PfamiPF09759. Atx10homo_assoc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Ataxin-10, the spinocerebellar ataxia type 10 neurodegenerative disorder protein, is essential for survival of cerebellar neurons."
    Maerz P., Probst A., Lang S., Schwager M., Rose-John S., Otten U., Ozbek S.
    J. Biol. Chem. 279:35542-35550(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, SUBUNIT.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  3. Cited for: INTERACTION WITH OGT, FUNCTION.
  4. "Ataxin 10 induces neuritogenesis via interaction with G-protein beta2 subunit."
    Waragai M., Nagamitsu S., Xu W., Li Y.J., Lin X., Ashizawa T.
    J. Neurosci. Res. 83:1170-1178(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiATX10_RAT
AccessioniPrimary (citable) accession number: Q9ER24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: March 1, 2001
Last modified: January 20, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.