Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ataxin-10

Gene

Atxn10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.3 Publications

GO - Molecular functioni

  • identical protein binding Source: RGD

GO - Biological processi

  • cilium assembly Source: Ensembl
  • neuron projection development Source: UniProtKB
  • protein homotrimerization Source: RGD

Names & Taxonomyi

Protein namesi
Recommended name:
Ataxin-10
Alternative name(s):
Neuronal beta-catenin-like protein
Spinocerebellar ataxia type 10 protein homolog
Gene namesi
Name:Atxn10
Synonyms:Sca10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi621813 Atxn10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000647501 – 475Ataxin-10Add BLAST475

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10Omega-N-methylarginineBy similarity1
Modified residuei12PhosphoserineBy similarity1
Modified residuei430PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ9ER24
PRIDEiQ9ER24

PTM databases

iPTMnetiQ9ER24
PhosphoSitePlusiQ9ER24

Expressioni

Tissue specificityi

Ubiquitous distribution. Markedly increased expression in testis, adrenals, and brain.1 Publication

Gene expression databases

BgeeiENSRNOG00000014637
GenevisibleiQ9ER24 RN

Interactioni

Subunit structurei

Interacts with GNB2 (By similarity). Homooligomer. Interacts with OGT in the brain. Interacts with IQCB1 (By similarity).By similarity

GO - Molecular functioni

  • identical protein binding Source: RGD

Protein-protein interaction databases

BioGridi250992, 2 interactors
STRINGi10116.ENSRNOP00000021071

Family & Domainsi

Sequence similaritiesi

Belongs to the ataxin-10 family.Curated

Phylogenomic databases

eggNOGiKOG2676 Eukaryota
ENOG410YBUH LUCA
GeneTreeiENSGT00390000010377
HOGENOMiHOG000034224
HOVERGENiHBG050622
InParanoidiQ9ER24
KOiK19323
OMAiDICAWES
OrthoDBiEOG091G05RO
PhylomeDBiQ9ER24
TreeFamiTF323870

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR019156 Ataxin-10_domain
PfamiView protein in Pfam
PF09759 Atx10homo_assoc, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits

Sequencei

Sequence statusi: Complete.

Q9ER24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPRMPPSR LSGIMVPAPI QDLEALRALT ALFKEQRNRE TAPRTIFQRV
60 70 80 90 100
LDILKKSTQA VELACRDPSQ VEHLASSLQL ITECFRCLRN ACIECSVNQN
110 120 130 140 150
SIRNLDTIGV AVDLVLLFRE LRVEQDSLLT AFRCGLQFLG NVASRNEDSQ
160 170 180 190 200
SIVWVHAFPE LFMSCLNHPD KKIVAYCSMI LFTSLNSERM KDLEENLNIA
210 220 230 240 250
INVIEAHQKH PESEWPFLII TDHFLKSPEL VEAMYGKLSN QERVTLLDIM
260 270 280 290 300
IAKIVGDEQL TKDDISIFLR HAELIANSFV DQCRNVLKLT SEPQTEDKEA
310 320 330 340 350
LVTIRLLDVL CEMTSNTELL GYLQVFPGLM ERVIDVLRVI HSVGKDSTNI
360 370 380 390 400
FSPSDSLKAE GDIEHMTEGF KSHLIRLIGN LCYKNKENQD KVNELDGIPL
410 420 430 440 450
ILDSSNIDDN NPFMMQWVVY AVRNLTEDNS QNQDFIAKME EQGLADASLL
460 470
KKMGFEVEKS GDKLILKSNN DIPPP
Length:475
Mass (Da):53,727
Last modified:March 1, 2001 - v1
Checksum:i530F6E3E498CBB38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ301634 mRNA Translation: CAC16214.1
BC062087 mRNA Translation: AAH62087.1
RefSeqiNP_579847.1, NM_133313.2
UniGeneiRn.6524

Genome annotation databases

EnsembliENSRNOT00000021071; ENSRNOP00000021071; ENSRNOG00000014637
GeneIDi170821
KEGGirno:170821

Entry informationi

Entry nameiATX10_RAT
AccessioniPrimary (citable) accession number: Q9ER24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health