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Q9ER00 (STX12_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Syntaxin-12
Gene names
Name:Stx12
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) By similarity.

Subunit structure

Associates with the BLOC-1 complex. Interacts with BLOC1S6. Interacts with NAPA and SNAP23. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A By similarity.

Subcellular location

Endosome membrane; Single-pass type IV membrane protein By similarity. Golgi apparatus membrane; Single-pass type IV membrane protein By similarity. Endomembrane system; Single-pass type IV membrane protein; Cytoplasmic side Potential.

Sequence similarities

Belongs to the syntaxin family.

Contains 1 t-SNARE coiled-coil homology domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 274273Syntaxin-12
PRO_0000210224

Regions

Topological domain2 – 250249Cytoplasmic Potential
Transmembrane251 – 27121Helical; Anchor for type IV membrane protein; Potential
Topological domain272 – 2743Vesicular Potential
Domain178 – 24063t-SNARE coiled-coil homology
Coiled coil33 – 13098 Potential

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue1391Phosphoserine Ref.4
Modified residue1421Phosphoserine Ref.4
Modified residue2181Phosphoserine Ref.4
Modified residue2251Phosphoserine Ref.4

Experimental info

Sequence conflict1711A → V in AAH10669. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9ER00 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 443A294A1A1E2905

FASTA27431,195
        10         20         30         40         50         60 
MSYGPLDMYR NPGPSGPQPR DFNSIIQTCS GNIQRISQAT AQIKNLMSQL GTKQDSSKLQ 

        70         80         90        100        110        120 
ENLQQLQHST NQLAKETNEL LKELGSLPLP LSASEQRQQK LQKERLMNDF SSALNNFQVV 

       130        140        150        160        170        180 
QRKVSEKEKE SIARARAGSR LSAEDRQREE QLVSFDSHEE WNQMQSQEEE AAITEQDLEL 

       190        200        210        220        230        240 
IKERETAIRQ LEADILDVNQ IFKDLAMMIH DQGDLIDSIE ANVESSEVHV ERATDQLQRA 

       250        260        270 
AYYQKKSRKK MCILVLVLSV IVTVLVVVIW VASK 

« Hide

References

« Hide 'large scale' references
[1]"Mouse syntaxin12."
Nakamura N., Wada Y., Futai M.
Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Amnion, Cecum and Kidney.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-139; SER-142; SER-218 AND SER-225, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB019211 mRNA. Translation: BAB20282.1.
AK077678 mRNA. Translation: BAC36951.1.
AK078948 mRNA. Translation: BAC37473.1.
AK146544 mRNA. Translation: BAE27249.1.
AK146735 mRNA. Translation: BAE27397.1.
AK167087 mRNA. Translation: BAE39244.1.
BC010669 mRNA. Translation: AAH10669.1.
RefSeqNP_598648.1. NM_133887.4.
UniGeneMm.28237.
Mm.491148.

3D structure databases

ProteinModelPortalQ9ER00.
SMRQ9ER00. Positions 15-139, 184-248.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid221409. 1 interaction.
IntActQ9ER00. 8 interactions.
MINTMINT-1865936.

PTM databases

PhosphoSiteQ9ER00.

Proteomic databases

PaxDbQ9ER00.
PRIDEQ9ER00.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000030698; ENSMUSP00000030698; ENSMUSG00000028879.
GeneID100226.
KEGGmmu:100226.
UCSCuc008vbx.1. mouse.

Organism-specific databases

CTD23673.
MGIMGI:1931027. Stx12.

Phylogenomic databases

eggNOGCOG5325.
GeneTreeENSGT00450000040239.
HOGENOMHOG000188453.
HOVERGENHBG053083.
InParanoidQ9ER00.
KOK13813.
OMAQMQSQEE.
OrthoDBEOG7B31PS.
PhylomeDBQ9ER00.
TreeFamTF315607.

Gene expression databases

BgeeQ9ER00.
CleanExMM_STX12.
GenevestigatorQ9ER00.

Family and domain databases

InterProIPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamPF05739. SNARE. 1 hit.
[Graphical view]
SMARTSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMSSF47661. SSF47661. 1 hit.
PROSITEPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio354343.
PROQ9ER00.
SOURCESearch...

Entry information

Entry nameSTX12_MOUSE
AccessionPrimary (citable) accession number: Q9ER00
Secondary accession number(s): Q3UIV9, Q921T9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot