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Protein

Syntaxin-12

Gene

Stx12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-12
Gene namesi
Name:Stx12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1931027. Stx12.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 250CytoplasmicSequence analysisAdd BLAST249
Transmembranei251 – 271Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini272 – 274VesicularSequence analysis3

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002102242 – 274Syntaxin-12Add BLAST273

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei139PhosphoserineCombined sources1
Modified residuei142PhosphoserineCombined sources1
Modified residuei218PhosphoserineCombined sources1
Modified residuei225PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9ER00.
MaxQBiQ9ER00.
PaxDbiQ9ER00.
PeptideAtlasiQ9ER00.
PRIDEiQ9ER00.

PTM databases

iPTMnetiQ9ER00.
PhosphoSitePlusiQ9ER00.
SwissPalmiQ9ER00.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028879.
CleanExiMM_STX12.
GenevisibleiQ9ER00. MM.

Interactioni

Subunit structurei

Associates with the BLOC-1 complex. Interacts with BLOC1S6. Interacts with NAPA and SNAP23. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi221409. 1 interactor.
IntActiQ9ER00. 8 interactors.
MINTiMINT-1865936.
STRINGi10090.ENSMUSP00000030698.

Structurei

3D structure databases

ProteinModelPortaliQ9ER00.
SMRiQ9ER00.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini178 – 240t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili33 – 130Sequence analysisAdd BLAST98

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0811. Eukaryota.
COG5325. LUCA.
GeneTreeiENSGT00450000040239.
HOGENOMiHOG000188453.
HOVERGENiHBG053083.
InParanoidiQ9ER00.
KOiK13813.
OMAiQMQSQEE.
OrthoDBiEOG091G0HKZ.
PhylomeDBiQ9ER00.
TreeFamiTF315607.

Family and domain databases

InterProiIPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ER00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYGPLDMYR NPGPSGPQPR DFNSIIQTCS GNIQRISQAT AQIKNLMSQL
60 70 80 90 100
GTKQDSSKLQ ENLQQLQHST NQLAKETNEL LKELGSLPLP LSASEQRQQK
110 120 130 140 150
LQKERLMNDF SSALNNFQVV QRKVSEKEKE SIARARAGSR LSAEDRQREE
160 170 180 190 200
QLVSFDSHEE WNQMQSQEEE AAITEQDLEL IKERETAIRQ LEADILDVNQ
210 220 230 240 250
IFKDLAMMIH DQGDLIDSIE ANVESSEVHV ERATDQLQRA AYYQKKSRKK
260 270
MCILVLVLSV IVTVLVVVIW VASK
Length:274
Mass (Da):31,195
Last modified:March 1, 2001 - v1
Checksum:i443A294A1A1E2905
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti171A → V in AAH10669 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019211 mRNA. Translation: BAB20282.1.
AK077678 mRNA. Translation: BAC36951.1.
AK078948 mRNA. Translation: BAC37473.1.
AK146544 mRNA. Translation: BAE27249.1.
AK146735 mRNA. Translation: BAE27397.1.
AK167087 mRNA. Translation: BAE39244.1.
BC010669 mRNA. Translation: AAH10669.1.
CCDSiCCDS18737.1.
RefSeqiNP_598648.1. NM_133887.4.
UniGeneiMm.28237.
Mm.491148.

Genome annotation databases

EnsembliENSMUST00000030698; ENSMUSP00000030698; ENSMUSG00000028879.
GeneIDi100226.
KEGGimmu:100226.
UCSCiuc008vbx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019211 mRNA. Translation: BAB20282.1.
AK077678 mRNA. Translation: BAC36951.1.
AK078948 mRNA. Translation: BAC37473.1.
AK146544 mRNA. Translation: BAE27249.1.
AK146735 mRNA. Translation: BAE27397.1.
AK167087 mRNA. Translation: BAE39244.1.
BC010669 mRNA. Translation: AAH10669.1.
CCDSiCCDS18737.1.
RefSeqiNP_598648.1. NM_133887.4.
UniGeneiMm.28237.
Mm.491148.

3D structure databases

ProteinModelPortaliQ9ER00.
SMRiQ9ER00.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi221409. 1 interactor.
IntActiQ9ER00. 8 interactors.
MINTiMINT-1865936.
STRINGi10090.ENSMUSP00000030698.

PTM databases

iPTMnetiQ9ER00.
PhosphoSitePlusiQ9ER00.
SwissPalmiQ9ER00.

Proteomic databases

EPDiQ9ER00.
MaxQBiQ9ER00.
PaxDbiQ9ER00.
PeptideAtlasiQ9ER00.
PRIDEiQ9ER00.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030698; ENSMUSP00000030698; ENSMUSG00000028879.
GeneIDi100226.
KEGGimmu:100226.
UCSCiuc008vbx.1. mouse.

Organism-specific databases

CTDi23673.
MGIiMGI:1931027. Stx12.

Phylogenomic databases

eggNOGiKOG0811. Eukaryota.
COG5325. LUCA.
GeneTreeiENSGT00450000040239.
HOGENOMiHOG000188453.
HOVERGENiHBG053083.
InParanoidiQ9ER00.
KOiK13813.
OMAiQMQSQEE.
OrthoDBiEOG091G0HKZ.
PhylomeDBiQ9ER00.
TreeFamiTF315607.

Miscellaneous databases

PROiQ9ER00.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028879.
CleanExiMM_STX12.
GenevisibleiQ9ER00. MM.

Family and domain databases

InterProiIPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTX12_MOUSE
AccessioniPrimary (citable) accession number: Q9ER00
Secondary accession number(s): Q3UIV9, Q921T9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.