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Q9ER00

- STX12_MOUSE

UniProt

Q9ER00 - STX12_MOUSE

Protein

Syntaxin-12

Gene

Stx12

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. SNAP receptor activity Source: RefGenome
    3. SNARE binding Source: RefGenome

    GO - Biological processi

    1. cholesterol efflux Source: Ensembl
    2. intracellular protein transport Source: RefGenome
    3. protein stabilization Source: Ensembl
    4. synaptic vesicle exocytosis Source: RefGenome

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Syntaxin-12
    Gene namesi
    Name:Stx12
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1931027. Stx12.

    Subcellular locationi

    GO - Cellular componenti

    1. BLOC-1 complex Source: Ensembl
    2. endosome membrane Source: UniProtKB-SubCell
    3. Golgi membrane Source: UniProtKB-SubCell
    4. integral component of membrane Source: UniProtKB-KW
    5. membrane raft Source: Ensembl
    6. phagocytic vesicle Source: Ensembl
    7. SNARE complex Source: UniProtKB

    Keywords - Cellular componenti

    Endosome, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 274273Syntaxin-12PRO_0000210224Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei139 – 1391Phosphoserine1 Publication
    Modified residuei142 – 1421Phosphoserine1 Publication
    Modified residuei218 – 2181Phosphoserine1 Publication
    Modified residuei225 – 2251Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9ER00.
    PaxDbiQ9ER00.
    PRIDEiQ9ER00.

    PTM databases

    PhosphoSiteiQ9ER00.

    Expressioni

    Gene expression databases

    BgeeiQ9ER00.
    CleanExiMM_STX12.
    GenevestigatoriQ9ER00.

    Interactioni

    Subunit structurei

    Associates with the BLOC-1 complex. Interacts with BLOC1S6. Interacts with NAPA and SNAP23. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A By similarity.By similarity

    Protein-protein interaction databases

    BioGridi221409. 1 interaction.
    IntActiQ9ER00. 8 interactions.
    MINTiMINT-1865936.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ER00.
    SMRiQ9ER00. Positions 15-139, 184-248.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 250249CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini272 – 2743VesicularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei251 – 27121Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini178 – 24063t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili33 – 13098Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the syntaxin family.Curated
    Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5325.
    GeneTreeiENSGT00450000040239.
    HOGENOMiHOG000188453.
    HOVERGENiHBG053083.
    InParanoidiQ9ER00.
    KOiK13813.
    OMAiDGHEEWN.
    OrthoDBiEOG7B31PS.
    PhylomeDBiQ9ER00.
    TreeFamiTF315607.

    Family and domain databases

    InterProiIPR006012. Syntaxin/epimorphin_CS.
    IPR006011. Syntaxin_N.
    IPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    [Graphical view]
    PfamiPF05739. SNARE. 1 hit.
    [Graphical view]
    SMARTiSM00503. SynN. 1 hit.
    SM00397. t_SNARE. 1 hit.
    [Graphical view]
    SUPFAMiSSF47661. SSF47661. 1 hit.
    PROSITEiPS00914. SYNTAXIN. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9ER00-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYGPLDMYR NPGPSGPQPR DFNSIIQTCS GNIQRISQAT AQIKNLMSQL    50
    GTKQDSSKLQ ENLQQLQHST NQLAKETNEL LKELGSLPLP LSASEQRQQK 100
    LQKERLMNDF SSALNNFQVV QRKVSEKEKE SIARARAGSR LSAEDRQREE 150
    QLVSFDSHEE WNQMQSQEEE AAITEQDLEL IKERETAIRQ LEADILDVNQ 200
    IFKDLAMMIH DQGDLIDSIE ANVESSEVHV ERATDQLQRA AYYQKKSRKK 250
    MCILVLVLSV IVTVLVVVIW VASK 274
    Length:274
    Mass (Da):31,195
    Last modified:March 1, 2001 - v1
    Checksum:i443A294A1A1E2905
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti171 – 1711A → V in AAH10669. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB019211 mRNA. Translation: BAB20282.1.
    AK077678 mRNA. Translation: BAC36951.1.
    AK078948 mRNA. Translation: BAC37473.1.
    AK146544 mRNA. Translation: BAE27249.1.
    AK146735 mRNA. Translation: BAE27397.1.
    AK167087 mRNA. Translation: BAE39244.1.
    BC010669 mRNA. Translation: AAH10669.1.
    CCDSiCCDS18737.1.
    RefSeqiNP_598648.1. NM_133887.4.
    UniGeneiMm.28237.
    Mm.491148.

    Genome annotation databases

    EnsembliENSMUST00000030698; ENSMUSP00000030698; ENSMUSG00000028879.
    GeneIDi100226.
    KEGGimmu:100226.
    UCSCiuc008vbx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB019211 mRNA. Translation: BAB20282.1 .
    AK077678 mRNA. Translation: BAC36951.1 .
    AK078948 mRNA. Translation: BAC37473.1 .
    AK146544 mRNA. Translation: BAE27249.1 .
    AK146735 mRNA. Translation: BAE27397.1 .
    AK167087 mRNA. Translation: BAE39244.1 .
    BC010669 mRNA. Translation: AAH10669.1 .
    CCDSi CCDS18737.1.
    RefSeqi NP_598648.1. NM_133887.4.
    UniGenei Mm.28237.
    Mm.491148.

    3D structure databases

    ProteinModelPortali Q9ER00.
    SMRi Q9ER00. Positions 15-139, 184-248.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 221409. 1 interaction.
    IntActi Q9ER00. 8 interactions.
    MINTi MINT-1865936.

    PTM databases

    PhosphoSitei Q9ER00.

    Proteomic databases

    MaxQBi Q9ER00.
    PaxDbi Q9ER00.
    PRIDEi Q9ER00.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030698 ; ENSMUSP00000030698 ; ENSMUSG00000028879 .
    GeneIDi 100226.
    KEGGi mmu:100226.
    UCSCi uc008vbx.1. mouse.

    Organism-specific databases

    CTDi 23673.
    MGIi MGI:1931027. Stx12.

    Phylogenomic databases

    eggNOGi COG5325.
    GeneTreei ENSGT00450000040239.
    HOGENOMi HOG000188453.
    HOVERGENi HBG053083.
    InParanoidi Q9ER00.
    KOi K13813.
    OMAi DGHEEWN.
    OrthoDBi EOG7B31PS.
    PhylomeDBi Q9ER00.
    TreeFami TF315607.

    Miscellaneous databases

    NextBioi 354343.
    PROi Q9ER00.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9ER00.
    CleanExi MM_STX12.
    Genevestigatori Q9ER00.

    Family and domain databases

    InterProi IPR006012. Syntaxin/epimorphin_CS.
    IPR006011. Syntaxin_N.
    IPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    [Graphical view ]
    Pfami PF05739. SNARE. 1 hit.
    [Graphical view ]
    SMARTi SM00503. SynN. 1 hit.
    SM00397. t_SNARE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47661. SSF47661. 1 hit.
    PROSITEi PS00914. SYNTAXIN. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse syntaxin12."
      Nakamura N., Wada Y., Futai M.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Amnion, Cecum and Kidney.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-139; SER-142; SER-218 AND SER-225, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSTX12_MOUSE
    AccessioniPrimary (citable) accession number: Q9ER00
    Secondary accession number(s): Q3UIV9, Q921T9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3