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Protein

Rap guanine nucleotide exchange factor 4

Gene

Rapgef4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi43 – 166cAMP 1Add BLAST124
Nucleotide bindingi356 – 476cAMP 2Add BLAST121

GO - Molecular functioni

  • cAMP binding Source: UniProtKB
  • guanyl-nucleotide exchange factor activity Source: MGI
  • Ras GTPase binding Source: UniProtKB
  • Ras guanyl-nucleotide exchange factor activity Source: UniProtKB

GO - Biological processi

  • calcium ion regulated exocytosis Source: MGI
  • cAMP-mediated signaling Source: MGI
  • insulin secretion Source: MGI
  • regulation of exocytosis Source: MGI
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Biological processi

Exocytosis

Keywords - Ligandi

cAMP, cAMP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-354192. Integrin alphaIIb beta3 signaling.
R-MMU-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-MMU-392517. Rap1 signalling.
R-MMU-422356. Regulation of insulin secretion.

Names & Taxonomyi

Protein namesi
Recommended name:
Rap guanine nucleotide exchange factor 4
Alternative name(s):
Exchange factor directly activated by cAMP 2
Exchange protein directly activated by cAMP 2
Short name:
EPAC 2
cAMP-dependent Rap1 guanine-nucleotide exchange factor
cAMP-regulated guanine nucleotide exchange factor II
Short name:
cAMP-GEFII
Gene namesi
Name:Rapgef4
Synonyms:Cgef2, Epac2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1917723. Rapgef4.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: MGI
  • membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi467L → A: Less than 10% of the wild-type maximal activity. 1 Publication1
Mutagenesisi498Y → F: 2-fold reduction in maximal activity. 1 Publication1
Mutagenesisi569Y → A: 2-fold reduction in maximal activity. 1 Publication1
Mutagenesisi569Y → F: 2-fold reduction in maximal activity. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL3593151.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000688711 – 1011Rap guanine nucleotide exchange factor 4Add BLAST1011

Proteomic databases

PaxDbiQ9EQZ6.
PeptideAtlasiQ9EQZ6.
PRIDEiQ9EQZ6.

PTM databases

iPTMnetiQ9EQZ6.
PhosphoSitePlusiQ9EQZ6.

Expressioni

Tissue specificityi

Expressed in cerebellum, pituitary, adrenal gland and liver.1 Publication

Gene expression databases

BgeeiENSMUSG00000049044.
CleanExiMM_RAPGEF4.
ExpressionAtlasiQ9EQZ6. baseline and differential.
GenevisibleiQ9EQZ6. MM.

Interactioni

Subunit structurei

Interacts with RAP1B, RIMS1 and RIMS2. Probably part of a complex with RIMS2 and GTP-activated RAB3A.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HRASP011123EBI-772212,EBI-350145From a different organism.

GO - Molecular functioni

  • Ras GTPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi208026. 3 interactors.
DIPiDIP-32333N.
IntActiQ9EQZ6. 2 interactors.
STRINGi10090.ENSMUSP00000088336.

Structurei

Secondary structure

11011
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi14 – 19Combined sources6
Beta strandi23 – 25Combined sources3
Helixi28 – 38Combined sources11
Turni42 – 46Combined sources5
Helixi49 – 58Combined sources10
Beta strandi60 – 64Combined sources5
Beta strandi69 – 71Combined sources3
Beta strandi79 – 86Combined sources8
Beta strandi88 – 92Combined sources5
Beta strandi94 – 96Combined sources3
Helixi98 – 100Combined sources3
Beta strandi102 – 107Combined sources6
Helixi115 – 119Combined sources5
Beta strandi124 – 139Combined sources16
Helixi140 – 150Combined sources11
Helixi151 – 153Combined sources3
Turni154 – 157Combined sources4
Turni160 – 162Combined sources3
Helixi202 – 217Combined sources16
Helixi219 – 221Combined sources3
Beta strandi222 – 226Combined sources5
Beta strandi231 – 237Combined sources7
Helixi238 – 247Combined sources10
Beta strandi248 – 250Combined sources3
Helixi255 – 267Combined sources13
Beta strandi270 – 275Combined sources6
Beta strandi282 – 284Combined sources3
Beta strandi286 – 289Combined sources4
Helixi290 – 292Combined sources3
Beta strandi293 – 296Combined sources4
Helixi303 – 310Combined sources8
Helixi329 – 333Combined sources5
Helixi336 – 338Combined sources3
Helixi341 – 351Combined sources11
Helixi355 – 357Combined sources3
Helixi362 – 368Combined sources7
Turni369 – 371Combined sources3
Beta strandi373 – 377Combined sources5
Beta strandi383 – 385Combined sources3
Beta strandi393 – 400Combined sources8
Beta strandi402 – 406Combined sources5
Turni407 – 409Combined sources3
Beta strandi410 – 415Combined sources6
Helixi423 – 428Combined sources6
Beta strandi433 – 438Combined sources6
Beta strandi440 – 449Combined sources10
Helixi450 – 456Combined sources7
Turni457 – 460Combined sources4
Beta strandi465 – 469Combined sources5
Beta strandi472 – 479Combined sources8
Beta strandi498 – 503Combined sources6
Helixi505 – 514Combined sources10
Helixi520 – 522Combined sources3
Helixi523 – 540Combined sources18
Helixi543 – 554Combined sources12
Beta strandi559 – 561Combined sources3
Helixi563 – 588Combined sources26
Helixi589 – 594Combined sources6
Helixi596 – 616Combined sources21
Helixi617 – 620Combined sources4
Helixi622 – 629Combined sources8
Beta strandi668 – 675Combined sources8
Turni677 – 679Combined sources3
Beta strandi681 – 687Combined sources7
Helixi692 – 703Combined sources12
Beta strandi710 – 714Combined sources5
Beta strandi720 – 722Combined sources3
Helixi731 – 733Combined sources3
Beta strandi739 – 743Combined sources5
Helixi745 – 750Combined sources6
Helixi755 – 757Combined sources3
Helixi765 – 768Combined sources4
Helixi773 – 789Combined sources17
Helixi793 – 801Combined sources9
Helixi803 – 805Combined sources3
Helixi811 – 832Combined sources22
Helixi837 – 856Combined sources20
Helixi860 – 871Combined sources12
Helixi873 – 876Combined sources4
Helixi879 – 884Combined sources6
Helixi887 – 898Combined sources12
Helixi903 – 915Combined sources13
Helixi924 – 937Combined sources14
Beta strandi940 – 942Combined sources3
Beta strandi945 – 947Combined sources3
Helixi948 – 964Combined sources17
Beta strandi965 – 967Combined sources3
Beta strandi973 – 975Combined sources3
Helixi981 – 987Combined sources7
Helixi996 – 1006Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1O7FX-ray2.50A1-481[»]
2BYVX-ray2.70E1-1011[»]
3CF6X-ray2.20E324-1011[»]
4F7ZX-ray2.60A1-1011[»]
4MGIX-ray2.80E324-1011[»]
4MGKX-ray2.70E324-1011[»]
4MGYX-ray2.60E324-1011[»]
4MGZX-ray3.00E324-1011[»]
4MH0X-ray2.40E324-1011[»]
ProteinModelPortaliQ9EQZ6.
SMRiQ9EQZ6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9EQZ6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini216 – 291DEPPROSITE-ProRule annotationAdd BLAST76
Domaini496 – 634N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST139
Domaini772 – 1009Ras-GEFPROSITE-ProRule annotationAdd BLAST238

Domaini

The N-terminal nucleotide phosphate binding region cAMP 1 has a much lower affinity for cAMP as compared to cAMP 2.By similarity
The DEP domain is involved in membrane localization independent from regulation by cAMP.By similarity

Sequence similaritiesi

Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 DEP domain.PROSITE-ProRule annotation
Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
Contains 1 Ras-GEF domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2378. Eukaryota.
ENOG410XPX9. LUCA.
GeneTreeiENSGT00860000133664.
HOGENOMiHOG000230545.
HOVERGENiHBG056985.
InParanoidiQ9EQZ6.
KOiK04351.
OMAiTIYDWEL.
OrthoDBiEOG091G0HKG.
TreeFamiTF313184.

Family and domain databases

CDDicd00155. RasGEF. 1 hit.
cd06224. REM. 1 hit.
Gene3Di1.10.10.10. 1 hit.
1.10.840.10. 1 hit.
2.60.120.10. 2 hits.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR000591. DEP_dom.
IPR031189. RAPGEF4.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR014710. RmlC-like_jellyroll.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR23113:SF175. PTHR23113:SF175. 2 hits.
PfamiPF00027. cNMP_binding. 2 hits.
PF00610. DEP. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 2 hits.
SM00049. DEP. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48366. SSF48366. 2 hits.
SSF51206. SSF51206. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS50186. DEP. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9EQZ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVAAHAAHSQ SSAEWIACLD KRPLERSSED VDIIFTRLKG VKAFEKFHPN
60 70 80 90 100
LLRQICLCGY YENLEKGITL FRQGDIGTNW YAVLAGSLDV KVSETSSHQD
110 120 130 140 150
AVTICTLGIG TAFGESILDN TPRHATIVTR ESSELLRIEQ EDFKALWEKY
160 170 180 190 200
RQYMAGLLAP PYGVMETGSN NDRIPDKENT PLIEPHVPLR PAHTITKVPS
210 220 230 240 250
EKILRAGKIL RIAILSRAPH MIRDRKYHLK TYRQCCVGTE LVDWMIQQTS
260 270 280 290 300
CVHSRTQAVG MWQVLLEDGV LNHVDQERHF QDKYLFYRFL DDEREDAPLP
310 320 330 340 350
TEEEKKECDE ELQDTMLLLS QMGPDAHMRM ILRKPPGQRT VDDLEIIYDE
360 370 380 390 400
LLHIKALSHL STTVKRELAG VLIFESHAKG GTVLFNQGEE GTSWYIILKG
410 420 430 440 450
SVNVVIYGKG VVCTLHEGDD FGKLALVNDA PRAASIVLRE DNCHFLRVDK
460 470 480 490 500
EDFNRILRDV EANTVRLKEH DQDVLVLEKV PAGNRAANQG NSQPQQKYTV
510 520 530 540 550
MSGTPEKILE HFLETIRLEP SLNEATDSVL NDFVMMHCVF MPNTQLCPAL
560 570 580 590 600
VAHYHAQPSQ GTEQERMDYA LNNKRRVIRL VLQWAAMYGD LLQEDDVAMA
610 620 630 640 650
FLEEFYVSVS DDARMMAAFK EQLPELEKIV KQISEDAKAP QKKHKVLLQQ
660 670 680 690 700
FNTGDERAQK RQPIRGSDEV LFKVYCIDHT YTTIRVPVAA SVKEVISAVA
710 720 730 740 750
DKLGSGEGLI IVKMNSGGEK VVLKSNDVSV FTTLTINGRL FACPREQFDS
760 770 780 790 800
LTPLPEQEGP TTGTVGTFEL MSSKDLAYQM TTYDWELFNC VHELELIYHT
810 820 830 840 850
FGRHNFKKTT ANLDLFLRRF NEIQFWVVTE VCLCSQLSKR VQLLKKFIKI
860 870 880 890 900
AAHCKEYKNL NSFFAIVMGL SNVAVSRLAL TWEKLPSKFK KFYAEFESLM
910 920 930 940 950
DPSRNHRAYR LTAAKLEPPL IPFMPLLIKD MTFTHEGNKT FIDNLVNFEK
960 970 980 990 1000
MRMIANTART VRYYRSQPFN PDAAQANKNH QDVRSYVRQL NVIDNQRTLS
1010
QMSHRLEPRR P
Note: Produced by alternative promoter usage.
Length:1,011
Mass (Da):115,491
Last modified:March 1, 2001 - v1
Checksum:i449BC537475B03AA
GO
Isoform 2 (identifier: Q9EQZ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-315: Missing.

Note: Produced by alternative promoter usage.
Show »
Length:696
Mass (Da):79,440
Checksum:i4006240D4B85A747
GO
Isoform 3 (identifier: Q9EQZ6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     180-197: Missing.

Note: Produced by alternative splicing of isoform 1. No experimental confirmation available.
Show »
Length:993
Mass (Da):113,489
Checksum:iF503405FD9A9C12F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti313Q → E in BAB23633 (PubMed:16141072).Curated1
Sequence conflicti452D → E in BAB23633 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0076141 – 315Missing in isoform 2. 2 PublicationsAdd BLAST315
Alternative sequenceiVSP_007615180 – 197Missing in isoform 3. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115480 mRNA. Translation: AAD09132.1.
AB021132 mRNA. Translation: BAB18976.1.
AB037668 mRNA. Translation: BAB72180.1.
AK004874 mRNA. Translation: BAB23633.1.
CCDSiCCDS16120.1. [Q9EQZ6-3]
CCDS57176.1. [Q9EQZ6-1]
RefSeqiNP_001191094.1. NM_001204165.1. [Q9EQZ6-1]
NP_001191095.1. NM_001204166.1.
NP_062662.1. NM_019688.2. [Q9EQZ6-3]
UniGeneiMm.196153.

Genome annotation databases

EnsembliENSMUST00000090826; ENSMUSP00000088336; ENSMUSG00000049044. [Q9EQZ6-1]
ENSMUST00000102698; ENSMUSP00000099759; ENSMUSG00000049044. [Q9EQZ6-3]
GeneIDi56508.
KEGGimmu:56508.
UCSCiuc008kbn.2. mouse. [Q9EQZ6-1]
uc008kbo.2. mouse. [Q9EQZ6-3]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115480 mRNA. Translation: AAD09132.1.
AB021132 mRNA. Translation: BAB18976.1.
AB037668 mRNA. Translation: BAB72180.1.
AK004874 mRNA. Translation: BAB23633.1.
CCDSiCCDS16120.1. [Q9EQZ6-3]
CCDS57176.1. [Q9EQZ6-1]
RefSeqiNP_001191094.1. NM_001204165.1. [Q9EQZ6-1]
NP_001191095.1. NM_001204166.1.
NP_062662.1. NM_019688.2. [Q9EQZ6-3]
UniGeneiMm.196153.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1O7FX-ray2.50A1-481[»]
2BYVX-ray2.70E1-1011[»]
3CF6X-ray2.20E324-1011[»]
4F7ZX-ray2.60A1-1011[»]
4MGIX-ray2.80E324-1011[»]
4MGKX-ray2.70E324-1011[»]
4MGYX-ray2.60E324-1011[»]
4MGZX-ray3.00E324-1011[»]
4MH0X-ray2.40E324-1011[»]
ProteinModelPortaliQ9EQZ6.
SMRiQ9EQZ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208026. 3 interactors.
DIPiDIP-32333N.
IntActiQ9EQZ6. 2 interactors.
STRINGi10090.ENSMUSP00000088336.

Chemistry databases

ChEMBLiCHEMBL3593151.

PTM databases

iPTMnetiQ9EQZ6.
PhosphoSitePlusiQ9EQZ6.

Proteomic databases

PaxDbiQ9EQZ6.
PeptideAtlasiQ9EQZ6.
PRIDEiQ9EQZ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090826; ENSMUSP00000088336; ENSMUSG00000049044. [Q9EQZ6-1]
ENSMUST00000102698; ENSMUSP00000099759; ENSMUSG00000049044. [Q9EQZ6-3]
GeneIDi56508.
KEGGimmu:56508.
UCSCiuc008kbn.2. mouse. [Q9EQZ6-1]
uc008kbo.2. mouse. [Q9EQZ6-3]

Organism-specific databases

CTDi11069.
MGIiMGI:1917723. Rapgef4.

Phylogenomic databases

eggNOGiKOG2378. Eukaryota.
ENOG410XPX9. LUCA.
GeneTreeiENSGT00860000133664.
HOGENOMiHOG000230545.
HOVERGENiHBG056985.
InParanoidiQ9EQZ6.
KOiK04351.
OMAiTIYDWEL.
OrthoDBiEOG091G0HKG.
TreeFamiTF313184.

Enzyme and pathway databases

ReactomeiR-MMU-354192. Integrin alphaIIb beta3 signaling.
R-MMU-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-MMU-392517. Rap1 signalling.
R-MMU-422356. Regulation of insulin secretion.

Miscellaneous databases

EvolutionaryTraceiQ9EQZ6.
PROiQ9EQZ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049044.
CleanExiMM_RAPGEF4.
ExpressionAtlasiQ9EQZ6. baseline and differential.
GenevisibleiQ9EQZ6. MM.

Family and domain databases

CDDicd00155. RasGEF. 1 hit.
cd06224. REM. 1 hit.
Gene3Di1.10.10.10. 1 hit.
1.10.840.10. 1 hit.
2.60.120.10. 2 hits.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR000591. DEP_dom.
IPR031189. RAPGEF4.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR014710. RmlC-like_jellyroll.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR23113:SF175. PTHR23113:SF175. 2 hits.
PfamiPF00027. cNMP_binding. 2 hits.
PF00610. DEP. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 2 hits.
SM00049. DEP. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48366. SSF48366. 2 hits.
SSF51206. SSF51206. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS50186. DEP. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPGF4_MOUSE
AccessioniPrimary (citable) accession number: Q9EQZ6
Secondary accession number(s): Q8VIP9, Q9CW52, Q9Z1P0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.