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Q9EQZ6

- RPGF4_MOUSE

UniProt

Q9EQZ6 - RPGF4_MOUSE

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Protein

Rap guanine nucleotide exchange factor 4

Gene
Rapgef4, Cgef2, Epac2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi43 – 166124cAMP 1Add
BLAST
Nucleotide bindingi356 – 476121cAMP 2Add
BLAST

GO - Molecular functioni

  1. cAMP binding Source: UniProtKB
  2. cAMP-dependent protein kinase regulator activity Source: InterPro
  3. guanyl-nucleotide exchange factor activity Source: MGI
  4. protein binding Source: IntAct
  5. Ras GTPase binding Source: UniProtKB
  6. Ras guanyl-nucleotide exchange factor activity Source: UniProtKB

GO - Biological processi

  1. calcium ion-dependent exocytosis Source: MGI
  2. cAMP-mediated signaling Source: MGI
  3. insulin secretion Source: MGI
  4. regulation of exocytosis Source: MGI
  5. regulation of GTPase activity Source: GOC
  6. regulation of Ras GTPase activity Source: GOC
  7. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Biological processi

Exocytosis

Keywords - Ligandi

cAMP, cAMP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Rap guanine nucleotide exchange factor 4
Alternative name(s):
Exchange factor directly activated by cAMP 2
Exchange protein directly activated by cAMP 2
Short name:
EPAC 2
cAMP-dependent Rap1 guanine-nucleotide exchange factor
cAMP-regulated guanine nucleotide exchange factor II
Short name:
cAMP-GEFII
Gene namesi
Name:Rapgef4
Synonyms:Cgef2, Epac2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1917723. Rapgef4.

Subcellular locationi

GO - Cellular componenti

  1. cAMP-dependent protein kinase complex Source: InterPro
  2. cytosol Source: MGI
  3. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi467 – 4671L → A: Less than 10% of the wild-type maximal activity. 1 Publication
Mutagenesisi498 – 4981Y → F: 2-fold reduction in maximal activity. 1 Publication
Mutagenesisi569 – 5691Y → A: 2-fold reduction in maximal activity. 1 Publication
Mutagenesisi569 – 5691Y → F: 2-fold reduction in maximal activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10111011Rap guanine nucleotide exchange factor 4PRO_0000068871Add
BLAST

Proteomic databases

MaxQBiQ9EQZ6.
PaxDbiQ9EQZ6.
PRIDEiQ9EQZ6.

PTM databases

PhosphoSiteiQ9EQZ6.

Expressioni

Tissue specificityi

Expressed in cerebellum, pituitary, adrenal gland and liver.1 Publication

Gene expression databases

ArrayExpressiQ9EQZ6.
BgeeiQ9EQZ6.
CleanExiMM_RAPGEF4.
GenevestigatoriQ9EQZ6.

Interactioni

Subunit structurei

Interacts with RAP1B, RIMS1 and RIMS2. Probably part of a complex with RIMS2 and GTP-activated RAB3A.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HRASP011123EBI-772212,EBI-350145From a different organism.

Protein-protein interaction databases

BioGridi208026. 3 interactions.
DIPiDIP-32333N.
IntActiQ9EQZ6. 2 interactions.

Structurei

Secondary structure

1
1011
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi14 – 196
Beta strandi23 – 253
Helixi28 – 3811
Turni42 – 465
Helixi49 – 5810
Beta strandi60 – 645
Beta strandi69 – 713
Beta strandi79 – 868
Beta strandi88 – 925
Beta strandi94 – 963
Helixi98 – 1003
Beta strandi102 – 1076
Helixi115 – 1195
Beta strandi124 – 13916
Helixi140 – 15011
Helixi151 – 1533
Turni154 – 1574
Turni160 – 1623
Helixi202 – 21716
Helixi219 – 2213
Beta strandi222 – 2265
Beta strandi231 – 2377
Helixi238 – 24710
Beta strandi248 – 2503
Helixi255 – 26713
Beta strandi270 – 2756
Beta strandi282 – 2843
Beta strandi286 – 2894
Helixi290 – 2923
Beta strandi293 – 2964
Helixi303 – 3108
Helixi313 – 33119
Helixi336 – 3383
Helixi341 – 35111
Helixi355 – 3573
Helixi362 – 37110
Beta strandi373 – 3775
Beta strandi383 – 3853
Beta strandi393 – 40614
Turni407 – 4093
Beta strandi410 – 4167
Helixi423 – 4264
Beta strandi433 – 44917
Helixi450 – 45910
Beta strandi463 – 47816
Beta strandi499 – 5035
Helixi505 – 51511
Helixi520 – 5223
Helixi523 – 54018
Helixi543 – 55513
Beta strandi559 – 5613
Helixi563 – 58826
Helixi589 – 5946
Helixi596 – 61116
Turni612 – 6143
Helixi617 – 6204
Helixi622 – 63211
Beta strandi668 – 6758
Turni677 – 6793
Beta strandi681 – 6877
Helixi692 – 70312
Beta strandi709 – 7146
Beta strandi720 – 7223
Beta strandi739 – 7446
Helixi745 – 7473
Beta strandi748 – 7503
Turni755 – 7584
Helixi765 – 7684
Helixi773 – 78917
Helixi793 – 8019
Helixi803 – 8064
Helixi811 – 83222
Helixi837 – 85620
Helixi860 – 86910
Helixi873 – 8764
Helixi879 – 8835
Helixi887 – 89812
Helixi903 – 91412
Helixi924 – 93613
Beta strandi940 – 9478
Helixi948 – 96417
Beta strandi965 – 9673
Beta strandi973 – 9753
Helixi981 – 9888
Helixi996 – 10049

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1O7FX-ray2.50A1-481[»]
2BYVX-ray2.70E1-1011[»]
3CF6X-ray2.20E324-1011[»]
4F7ZX-ray2.60A1-1011[»]
ProteinModelPortaliQ9EQZ6.
SMRiQ9EQZ6. Positions 10-1009.

Miscellaneous databases

EvolutionaryTraceiQ9EQZ6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini216 – 29176DEPAdd
BLAST
Domaini496 – 634139N-terminal Ras-GEFAdd
BLAST
Domaini772 – 1009238Ras-GEFAdd
BLAST

Domaini

The N-terminal nucleotide phosphate binding region cAMP 1 has a much lower affinity for cAMP as compared to cAMP 2 By similarity.
The DEP domain is involved in membrane localization independent from regulation by cAMP By similarity.

Sequence similaritiesi

Contains 1 DEP domain.
Contains 1 Ras-GEF domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0664.
GeneTreeiENSGT00750000117452.
HOGENOMiHOG000230545.
HOVERGENiHBG056985.
InParanoidiQ9EQZ6.
KOiK04351.
OMAiTIYDWEL.
OrthoDBiEOG7ZD1TF.
TreeFamiTF313184.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.840.10. 1 hit.
2.60.120.10. 2 hits.
InterProiIPR002373. cAMP/cGMP_kin.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR000591. DEP_dom.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
IPR014710. RmlC-like_jellyroll.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF00610. DEP. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
PRINTSiPR00103. CAMPKINASE.
SMARTiSM00100. cNMP. 2 hits.
SM00049. DEP. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 2 hits.
SSF51206. SSF51206. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS50186. DEP. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative promoter usage and alternative splicing. Align

Isoform 1 (identifier: Q9EQZ6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVAAHAAHSQ SSAEWIACLD KRPLERSSED VDIIFTRLKG VKAFEKFHPN     50
LLRQICLCGY YENLEKGITL FRQGDIGTNW YAVLAGSLDV KVSETSSHQD 100
AVTICTLGIG TAFGESILDN TPRHATIVTR ESSELLRIEQ EDFKALWEKY 150
RQYMAGLLAP PYGVMETGSN NDRIPDKENT PLIEPHVPLR PAHTITKVPS 200
EKILRAGKIL RIAILSRAPH MIRDRKYHLK TYRQCCVGTE LVDWMIQQTS 250
CVHSRTQAVG MWQVLLEDGV LNHVDQERHF QDKYLFYRFL DDEREDAPLP 300
TEEEKKECDE ELQDTMLLLS QMGPDAHMRM ILRKPPGQRT VDDLEIIYDE 350
LLHIKALSHL STTVKRELAG VLIFESHAKG GTVLFNQGEE GTSWYIILKG 400
SVNVVIYGKG VVCTLHEGDD FGKLALVNDA PRAASIVLRE DNCHFLRVDK 450
EDFNRILRDV EANTVRLKEH DQDVLVLEKV PAGNRAANQG NSQPQQKYTV 500
MSGTPEKILE HFLETIRLEP SLNEATDSVL NDFVMMHCVF MPNTQLCPAL 550
VAHYHAQPSQ GTEQERMDYA LNNKRRVIRL VLQWAAMYGD LLQEDDVAMA 600
FLEEFYVSVS DDARMMAAFK EQLPELEKIV KQISEDAKAP QKKHKVLLQQ 650
FNTGDERAQK RQPIRGSDEV LFKVYCIDHT YTTIRVPVAA SVKEVISAVA 700
DKLGSGEGLI IVKMNSGGEK VVLKSNDVSV FTTLTINGRL FACPREQFDS 750
LTPLPEQEGP TTGTVGTFEL MSSKDLAYQM TTYDWELFNC VHELELIYHT 800
FGRHNFKKTT ANLDLFLRRF NEIQFWVVTE VCLCSQLSKR VQLLKKFIKI 850
AAHCKEYKNL NSFFAIVMGL SNVAVSRLAL TWEKLPSKFK KFYAEFESLM 900
DPSRNHRAYR LTAAKLEPPL IPFMPLLIKD MTFTHEGNKT FIDNLVNFEK 950
MRMIANTART VRYYRSQPFN PDAAQANKNH QDVRSYVRQL NVIDNQRTLS 1000
QMSHRLEPRR P 1011

Note: Produced by alternative promoter usage.

Length:1,011
Mass (Da):115,491
Last modified:March 1, 2001 - v1
Checksum:i449BC537475B03AA
GO
Isoform 2 (identifier: Q9EQZ6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-315: Missing.

Note: Produced by alternative promoter usage.

Show »
Length:696
Mass (Da):79,440
Checksum:i4006240D4B85A747
GO
Isoform 3 (identifier: Q9EQZ6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     180-197: Missing.

Note: Produced by alternative splicing of isoform 1. No experimental confirmation available.

Show »
Length:993
Mass (Da):113,489
Checksum:iF503405FD9A9C12F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 315315Missing in isoform 2. VSP_007614Add
BLAST
Alternative sequencei180 – 19718Missing in isoform 3. VSP_007615Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti313 – 3131Q → E in BAB23633. 1 Publication
Sequence conflicti452 – 4521D → E in BAB23633. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF115480 mRNA. Translation: AAD09132.1.
AB021132 mRNA. Translation: BAB18976.1.
AB037668 mRNA. Translation: BAB72180.1.
AK004874 mRNA. Translation: BAB23633.1.
CCDSiCCDS16120.1. [Q9EQZ6-3]
CCDS57176.1. [Q9EQZ6-1]
RefSeqiNP_001191094.1. NM_001204165.1. [Q9EQZ6-1]
NP_001191095.1. NM_001204166.1.
NP_062662.1. NM_019688.2. [Q9EQZ6-3]
UniGeneiMm.196153.

Genome annotation databases

EnsembliENSMUST00000090826; ENSMUSP00000088336; ENSMUSG00000049044. [Q9EQZ6-1]
ENSMUST00000102698; ENSMUSP00000099759; ENSMUSG00000049044. [Q9EQZ6-3]
GeneIDi56508.
KEGGimmu:56508.
UCSCiuc008kbn.2. mouse. [Q9EQZ6-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF115480 mRNA. Translation: AAD09132.1 .
AB021132 mRNA. Translation: BAB18976.1 .
AB037668 mRNA. Translation: BAB72180.1 .
AK004874 mRNA. Translation: BAB23633.1 .
CCDSi CCDS16120.1. [Q9EQZ6-3 ]
CCDS57176.1. [Q9EQZ6-1 ]
RefSeqi NP_001191094.1. NM_001204165.1. [Q9EQZ6-1 ]
NP_001191095.1. NM_001204166.1.
NP_062662.1. NM_019688.2. [Q9EQZ6-3 ]
UniGenei Mm.196153.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1O7F X-ray 2.50 A 1-481 [» ]
2BYV X-ray 2.70 E 1-1011 [» ]
3CF6 X-ray 2.20 E 324-1011 [» ]
4F7Z X-ray 2.60 A 1-1011 [» ]
ProteinModelPortali Q9EQZ6.
SMRi Q9EQZ6. Positions 10-1009.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 208026. 3 interactions.
DIPi DIP-32333N.
IntActi Q9EQZ6. 2 interactions.

PTM databases

PhosphoSitei Q9EQZ6.

Proteomic databases

MaxQBi Q9EQZ6.
PaxDbi Q9EQZ6.
PRIDEi Q9EQZ6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000090826 ; ENSMUSP00000088336 ; ENSMUSG00000049044 . [Q9EQZ6-1 ]
ENSMUST00000102698 ; ENSMUSP00000099759 ; ENSMUSG00000049044 . [Q9EQZ6-3 ]
GeneIDi 56508.
KEGGi mmu:56508.
UCSCi uc008kbn.2. mouse. [Q9EQZ6-1 ]

Organism-specific databases

CTDi 11069.
MGIi MGI:1917723. Rapgef4.

Phylogenomic databases

eggNOGi COG0664.
GeneTreei ENSGT00750000117452.
HOGENOMi HOG000230545.
HOVERGENi HBG056985.
InParanoidi Q9EQZ6.
KOi K04351.
OMAi TIYDWEL.
OrthoDBi EOG7ZD1TF.
TreeFami TF313184.

Miscellaneous databases

EvolutionaryTracei Q9EQZ6.
NextBioi 312814.
PROi Q9EQZ6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9EQZ6.
Bgeei Q9EQZ6.
CleanExi MM_RAPGEF4.
Genevestigatori Q9EQZ6.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
1.10.840.10. 1 hit.
2.60.120.10. 2 hits.
InterProi IPR002373. cAMP/cGMP_kin.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR000591. DEP_dom.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
IPR014710. RmlC-like_jellyroll.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF00610. DEP. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view ]
PRINTSi PR00103. CAMPKINASE.
SMARTi SM00100. cNMP. 2 hits.
SM00049. DEP. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view ]
SUPFAMi SSF48366. SSF48366. 2 hits.
SSF51206. SSF51206. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
PS50186. DEP. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A brain cAMP-dependent Rap1 guanine-nucleotide exchange factor."
    Gaudriault G.E., Takaya K., Vale W.W.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH RIMS1 AND RIMS2.
  3. "Characterization of the gene EPAC2: structure, chromosomal localization, tissue expression, and identification of the liver-specific isoform."
    Ueno H., Shibasaki T., Iwanaga T., Takahashi K., Yokoyama Y., Liu L.M., Yokoi N., Ozaki N., Matsukura S., Yano H., Seino S.
    Genomics 78:91-98(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE PROMOTER USAGE.
    Tissue: Liver.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Liver.
  5. Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 1-463.
  6. "Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B."
    Rehmann H., Arias-Palomo E., Hadders M.A., Schwede F., Llorca O., Bos J.L.
    Nature 455:124-127(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 324-1011 IN COMPLEX WITH CAMP ANALOG AND RAP1B, SUBUNIT, MUTAGENESIS OF LEU-467; TYR-498 AND TYR-569.

Entry informationi

Entry nameiRPGF4_MOUSE
AccessioniPrimary (citable) accession number: Q9EQZ6
Secondary accession number(s): Q8VIP9, Q9CW52, Q9Z1P0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi