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Q9EQZ6

- RPGF4_MOUSE

UniProt

Q9EQZ6 - RPGF4_MOUSE

Protein

Rap guanine nucleotide exchange factor 4

Gene

Rapgef4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi43 – 166124cAMP 1Add
    BLAST
    Nucleotide bindingi356 – 476121cAMP 2Add
    BLAST

    GO - Molecular functioni

    1. cAMP binding Source: UniProtKB
    2. cAMP-dependent protein kinase regulator activity Source: InterPro
    3. guanyl-nucleotide exchange factor activity Source: MGI
    4. protein binding Source: IntAct
    5. Ras GTPase binding Source: UniProtKB
    6. Ras guanyl-nucleotide exchange factor activity Source: UniProtKB

    GO - Biological processi

    1. calcium ion-dependent exocytosis Source: MGI
    2. cAMP-mediated signaling Source: MGI
    3. insulin secretion Source: MGI
    4. positive regulation of GTPase activity Source: GOC
    5. positive regulation of Ras GTPase activity Source: GOC
    6. regulation of exocytosis Source: MGI
    7. small GTPase mediated signal transduction Source: InterPro

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Keywords - Biological processi

    Exocytosis

    Keywords - Ligandi

    cAMP, cAMP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rap guanine nucleotide exchange factor 4
    Alternative name(s):
    Exchange factor directly activated by cAMP 2
    Exchange protein directly activated by cAMP 2
    Short name:
    EPAC 2
    cAMP-dependent Rap1 guanine-nucleotide exchange factor
    cAMP-regulated guanine nucleotide exchange factor II
    Short name:
    cAMP-GEFII
    Gene namesi
    Name:Rapgef4
    Synonyms:Cgef2, Epac2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1917723. Rapgef4.

    Subcellular locationi

    Cytoplasm. Membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. cAMP-dependent protein kinase complex Source: InterPro
    2. cytosol Source: MGI
    3. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi467 – 4671L → A: Less than 10% of the wild-type maximal activity. 1 Publication
    Mutagenesisi498 – 4981Y → F: 2-fold reduction in maximal activity. 1 Publication
    Mutagenesisi569 – 5691Y → A: 2-fold reduction in maximal activity. 1 Publication
    Mutagenesisi569 – 5691Y → F: 2-fold reduction in maximal activity. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10111011Rap guanine nucleotide exchange factor 4PRO_0000068871Add
    BLAST

    Proteomic databases

    MaxQBiQ9EQZ6.
    PaxDbiQ9EQZ6.
    PRIDEiQ9EQZ6.

    PTM databases

    PhosphoSiteiQ9EQZ6.

    Expressioni

    Tissue specificityi

    Expressed in cerebellum, pituitary, adrenal gland and liver.1 Publication

    Gene expression databases

    ArrayExpressiQ9EQZ6.
    BgeeiQ9EQZ6.
    CleanExiMM_RAPGEF4.
    GenevestigatoriQ9EQZ6.

    Interactioni

    Subunit structurei

    Interacts with RAP1B, RIMS1 and RIMS2. Probably part of a complex with RIMS2 and GTP-activated RAB3A.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HRASP011123EBI-772212,EBI-350145From a different organism.

    Protein-protein interaction databases

    BioGridi208026. 3 interactions.
    DIPiDIP-32333N.
    IntActiQ9EQZ6. 2 interactions.

    Structurei

    Secondary structure

    1
    1011
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi14 – 196
    Beta strandi23 – 253
    Helixi28 – 3811
    Turni42 – 465
    Helixi49 – 5810
    Beta strandi60 – 645
    Beta strandi69 – 713
    Beta strandi79 – 868
    Beta strandi88 – 925
    Beta strandi94 – 963
    Helixi98 – 1003
    Beta strandi102 – 1076
    Helixi115 – 1195
    Beta strandi124 – 13916
    Helixi140 – 15011
    Helixi151 – 1533
    Turni154 – 1574
    Turni160 – 1623
    Helixi202 – 21716
    Helixi219 – 2213
    Beta strandi222 – 2265
    Beta strandi231 – 2377
    Helixi238 – 24710
    Beta strandi248 – 2503
    Helixi255 – 26713
    Beta strandi270 – 2756
    Beta strandi282 – 2843
    Beta strandi286 – 2894
    Helixi290 – 2923
    Beta strandi293 – 2964
    Helixi303 – 3108
    Helixi313 – 33119
    Helixi336 – 3383
    Helixi341 – 35111
    Helixi355 – 3573
    Helixi362 – 37110
    Beta strandi373 – 3775
    Beta strandi383 – 3853
    Beta strandi393 – 40614
    Turni407 – 4093
    Beta strandi410 – 4167
    Helixi423 – 4264
    Beta strandi433 – 44917
    Helixi450 – 45910
    Beta strandi463 – 47816
    Beta strandi499 – 5035
    Helixi505 – 51511
    Helixi520 – 5223
    Helixi523 – 54018
    Helixi543 – 55513
    Beta strandi559 – 5613
    Helixi563 – 58826
    Helixi589 – 5946
    Helixi596 – 61116
    Turni612 – 6143
    Helixi617 – 6204
    Helixi622 – 63211
    Beta strandi668 – 6758
    Turni677 – 6793
    Beta strandi681 – 6877
    Helixi692 – 70312
    Beta strandi709 – 7146
    Beta strandi720 – 7223
    Beta strandi739 – 7446
    Helixi745 – 7473
    Beta strandi748 – 7503
    Turni755 – 7584
    Helixi765 – 7684
    Helixi773 – 78917
    Helixi793 – 8019
    Helixi803 – 8064
    Helixi811 – 83222
    Helixi837 – 85620
    Helixi860 – 86910
    Helixi873 – 8764
    Helixi879 – 8835
    Helixi887 – 89812
    Helixi903 – 91412
    Helixi924 – 93613
    Beta strandi940 – 9478
    Helixi948 – 96417
    Beta strandi965 – 9673
    Beta strandi973 – 9753
    Helixi981 – 9888
    Helixi996 – 10049

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1O7FX-ray2.50A1-481[»]
    2BYVX-ray2.70E1-1011[»]
    3CF6X-ray2.20E324-1011[»]
    4F7ZX-ray2.60A1-1011[»]
    ProteinModelPortaliQ9EQZ6.
    SMRiQ9EQZ6. Positions 10-1009.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9EQZ6.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini216 – 29176DEPPROSITE-ProRule annotationAdd
    BLAST
    Domaini496 – 634139N-terminal Ras-GEFPROSITE-ProRule annotationAdd
    BLAST
    Domaini772 – 1009238Ras-GEFPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The N-terminal nucleotide phosphate binding region cAMP 1 has a much lower affinity for cAMP as compared to cAMP 2.By similarity
    The DEP domain is involved in membrane localization independent from regulation by cAMP.By similarity

    Sequence similaritiesi

    Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 DEP domain.PROSITE-ProRule annotation
    Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
    Contains 1 Ras-GEF domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0664.
    GeneTreeiENSGT00750000117452.
    HOGENOMiHOG000230545.
    HOVERGENiHBG056985.
    InParanoidiQ9EQZ6.
    KOiK04351.
    OMAiTIYDWEL.
    OrthoDBiEOG7ZD1TF.
    TreeFamiTF313184.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    1.10.840.10. 1 hit.
    2.60.120.10. 2 hits.
    InterProiIPR002373. cAMP/cGMP_kin.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR000591. DEP_dom.
    IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR019804. Ras_G-nucl-exch_fac_CS.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    IPR014710. RmlC-like_jellyroll.
    IPR029071. Ubiquitin-rel_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 2 hits.
    PF00610. DEP. 1 hit.
    PF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    [Graphical view]
    PRINTSiPR00103. CAMPKINASE.
    SMARTiSM00100. cNMP. 2 hits.
    SM00049. DEP. 1 hit.
    SM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    [Graphical view]
    SUPFAMiSSF48366. SSF48366. 2 hits.
    SSF51206. SSF51206. 2 hits.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
    PS50186. DEP. 1 hit.
    PS00720. RASGEF. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative promoter usage and alternative splicing. Align

    Isoform 1 (identifier: Q9EQZ6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVAAHAAHSQ SSAEWIACLD KRPLERSSED VDIIFTRLKG VKAFEKFHPN     50
    LLRQICLCGY YENLEKGITL FRQGDIGTNW YAVLAGSLDV KVSETSSHQD 100
    AVTICTLGIG TAFGESILDN TPRHATIVTR ESSELLRIEQ EDFKALWEKY 150
    RQYMAGLLAP PYGVMETGSN NDRIPDKENT PLIEPHVPLR PAHTITKVPS 200
    EKILRAGKIL RIAILSRAPH MIRDRKYHLK TYRQCCVGTE LVDWMIQQTS 250
    CVHSRTQAVG MWQVLLEDGV LNHVDQERHF QDKYLFYRFL DDEREDAPLP 300
    TEEEKKECDE ELQDTMLLLS QMGPDAHMRM ILRKPPGQRT VDDLEIIYDE 350
    LLHIKALSHL STTVKRELAG VLIFESHAKG GTVLFNQGEE GTSWYIILKG 400
    SVNVVIYGKG VVCTLHEGDD FGKLALVNDA PRAASIVLRE DNCHFLRVDK 450
    EDFNRILRDV EANTVRLKEH DQDVLVLEKV PAGNRAANQG NSQPQQKYTV 500
    MSGTPEKILE HFLETIRLEP SLNEATDSVL NDFVMMHCVF MPNTQLCPAL 550
    VAHYHAQPSQ GTEQERMDYA LNNKRRVIRL VLQWAAMYGD LLQEDDVAMA 600
    FLEEFYVSVS DDARMMAAFK EQLPELEKIV KQISEDAKAP QKKHKVLLQQ 650
    FNTGDERAQK RQPIRGSDEV LFKVYCIDHT YTTIRVPVAA SVKEVISAVA 700
    DKLGSGEGLI IVKMNSGGEK VVLKSNDVSV FTTLTINGRL FACPREQFDS 750
    LTPLPEQEGP TTGTVGTFEL MSSKDLAYQM TTYDWELFNC VHELELIYHT 800
    FGRHNFKKTT ANLDLFLRRF NEIQFWVVTE VCLCSQLSKR VQLLKKFIKI 850
    AAHCKEYKNL NSFFAIVMGL SNVAVSRLAL TWEKLPSKFK KFYAEFESLM 900
    DPSRNHRAYR LTAAKLEPPL IPFMPLLIKD MTFTHEGNKT FIDNLVNFEK 950
    MRMIANTART VRYYRSQPFN PDAAQANKNH QDVRSYVRQL NVIDNQRTLS 1000
    QMSHRLEPRR P 1011

    Note: Produced by alternative promoter usage.

    Length:1,011
    Mass (Da):115,491
    Last modified:March 1, 2001 - v1
    Checksum:i449BC537475B03AA
    GO
    Isoform 2 (identifier: Q9EQZ6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-315: Missing.

    Note: Produced by alternative promoter usage.

    Show »
    Length:696
    Mass (Da):79,440
    Checksum:i4006240D4B85A747
    GO
    Isoform 3 (identifier: Q9EQZ6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         180-197: Missing.

    Note: Produced by alternative splicing of isoform 1. No experimental confirmation available.

    Show »
    Length:993
    Mass (Da):113,489
    Checksum:iF503405FD9A9C12F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti313 – 3131Q → E in BAB23633. (PubMed:16141072)Curated
    Sequence conflicti452 – 4521D → E in BAB23633. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 315315Missing in isoform 2. 2 PublicationsVSP_007614Add
    BLAST
    Alternative sequencei180 – 19718Missing in isoform 3. 1 PublicationVSP_007615Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF115480 mRNA. Translation: AAD09132.1.
    AB021132 mRNA. Translation: BAB18976.1.
    AB037668 mRNA. Translation: BAB72180.1.
    AK004874 mRNA. Translation: BAB23633.1.
    CCDSiCCDS16120.1. [Q9EQZ6-3]
    CCDS57176.1. [Q9EQZ6-1]
    RefSeqiNP_001191094.1. NM_001204165.1. [Q9EQZ6-1]
    NP_001191095.1. NM_001204166.1.
    NP_062662.1. NM_019688.2. [Q9EQZ6-3]
    UniGeneiMm.196153.

    Genome annotation databases

    EnsembliENSMUST00000090826; ENSMUSP00000088336; ENSMUSG00000049044. [Q9EQZ6-1]
    ENSMUST00000102698; ENSMUSP00000099759; ENSMUSG00000049044. [Q9EQZ6-3]
    GeneIDi56508.
    KEGGimmu:56508.
    UCSCiuc008kbn.2. mouse. [Q9EQZ6-1]

    Keywords - Coding sequence diversityi

    Alternative promoter usage, Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF115480 mRNA. Translation: AAD09132.1 .
    AB021132 mRNA. Translation: BAB18976.1 .
    AB037668 mRNA. Translation: BAB72180.1 .
    AK004874 mRNA. Translation: BAB23633.1 .
    CCDSi CCDS16120.1. [Q9EQZ6-3 ]
    CCDS57176.1. [Q9EQZ6-1 ]
    RefSeqi NP_001191094.1. NM_001204165.1. [Q9EQZ6-1 ]
    NP_001191095.1. NM_001204166.1.
    NP_062662.1. NM_019688.2. [Q9EQZ6-3 ]
    UniGenei Mm.196153.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1O7F X-ray 2.50 A 1-481 [» ]
    2BYV X-ray 2.70 E 1-1011 [» ]
    3CF6 X-ray 2.20 E 324-1011 [» ]
    4F7Z X-ray 2.60 A 1-1011 [» ]
    ProteinModelPortali Q9EQZ6.
    SMRi Q9EQZ6. Positions 10-1009.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 208026. 3 interactions.
    DIPi DIP-32333N.
    IntActi Q9EQZ6. 2 interactions.

    PTM databases

    PhosphoSitei Q9EQZ6.

    Proteomic databases

    MaxQBi Q9EQZ6.
    PaxDbi Q9EQZ6.
    PRIDEi Q9EQZ6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000090826 ; ENSMUSP00000088336 ; ENSMUSG00000049044 . [Q9EQZ6-1 ]
    ENSMUST00000102698 ; ENSMUSP00000099759 ; ENSMUSG00000049044 . [Q9EQZ6-3 ]
    GeneIDi 56508.
    KEGGi mmu:56508.
    UCSCi uc008kbn.2. mouse. [Q9EQZ6-1 ]

    Organism-specific databases

    CTDi 11069.
    MGIi MGI:1917723. Rapgef4.

    Phylogenomic databases

    eggNOGi COG0664.
    GeneTreei ENSGT00750000117452.
    HOGENOMi HOG000230545.
    HOVERGENi HBG056985.
    InParanoidi Q9EQZ6.
    KOi K04351.
    OMAi TIYDWEL.
    OrthoDBi EOG7ZD1TF.
    TreeFami TF313184.

    Miscellaneous databases

    EvolutionaryTracei Q9EQZ6.
    NextBioi 312814.
    PROi Q9EQZ6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9EQZ6.
    Bgeei Q9EQZ6.
    CleanExi MM_RAPGEF4.
    Genevestigatori Q9EQZ6.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    1.10.840.10. 1 hit.
    2.60.120.10. 2 hits.
    InterProi IPR002373. cAMP/cGMP_kin.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR000591. DEP_dom.
    IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR019804. Ras_G-nucl-exch_fac_CS.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    IPR014710. RmlC-like_jellyroll.
    IPR029071. Ubiquitin-rel_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 2 hits.
    PF00610. DEP. 1 hit.
    PF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00103. CAMPKINASE.
    SMARTi SM00100. cNMP. 2 hits.
    SM00049. DEP. 1 hit.
    SM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48366. SSF48366. 2 hits.
    SSF51206. SSF51206. 2 hits.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
    PS50186. DEP. 1 hit.
    PS00720. RASGEF. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A brain cAMP-dependent Rap1 guanine-nucleotide exchange factor."
      Gaudriault G.E., Takaya K., Vale W.W.
      Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH RIMS1 AND RIMS2.
    3. "Characterization of the gene EPAC2: structure, chromosomal localization, tissue expression, and identification of the liver-specific isoform."
      Ueno H., Shibasaki T., Iwanaga T., Takahashi K., Yokoyama Y., Liu L.M., Yokoi N., Ozaki N., Matsukura S., Yano H., Seino S.
      Genomics 78:91-98(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE PROMOTER USAGE.
      Tissue: Liver.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Liver.
    5. Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 1-463.
    6. "Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B."
      Rehmann H., Arias-Palomo E., Hadders M.A., Schwede F., Llorca O., Bos J.L.
      Nature 455:124-127(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 324-1011 IN COMPLEX WITH CAMP ANALOG AND RAP1B, SUBUNIT, MUTAGENESIS OF LEU-467; TYR-498 AND TYR-569.

    Entry informationi

    Entry nameiRPGF4_MOUSE
    AccessioniPrimary (citable) accession number: Q9EQZ6
    Secondary accession number(s): Q8VIP9, Q9CW52, Q9Z1P0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2003
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3