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Protein

TSC22 domain family protein 3

Gene

Tsc22d3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities. Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
TSC22 domain family protein 3
Alternative name(s):
Glucocorticoid-induced leucine zipper protein
Gene namesi
Name:Tsc22d3
Synonyms:Dsipi, Gilz
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi621654. Tsc22d3.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Localization depends on differentiation status of myoblasts. In undifferentiated myoblasts, localizes to the cytoplasm, but in differentiating myoblasts is localized to the nucleus (By similarity).By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002193731 – 134TSC22 domain family protein 3Add BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei102PhosphoserineCombined sources1
Modified residuei125PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9EQZ1.
PRIDEiQ9EQZ1.

PTM databases

iPTMnetiQ9EQZ1.
PhosphoSitePlusiQ9EQZ1.

Expressioni

Inductioni

By glucocorticoids in lymphoid cells and upon IL4, IL10, IL13 or glucocorticoid treatment in monocyte/macrophage cells. Transiently induced by IL2 deprivation in T-cells. Expression is up-regulated by synthetic glucocorticoid dexamethasone in differentiating myoblasts (By similarity).By similarity

Gene expression databases

BgeeiENSRNOG00000013786.
GenevisibleiQ9EQZ1. RN.

Interactioni

Subunit structurei

Can form homodimers, however it is likely to function as a monomer. Interacts with AP1 and NFKB1. Interacts with MYOD1. Interacts with HDAC1; this interaction affects HDAC1 activity on MYOG promoter and thus inhibits MYOD1 transcriptional activity (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051018.

Structurei

3D structure databases

ProteinModelPortaliQ9EQZ1.
SMRiQ9EQZ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 60AP1-bindingBy similarityAdd BLAST60
Regioni76 – 97Leucine-zipperAdd BLAST22

Domaini

The leucine-zipper is involved in homodimerization.By similarity

Sequence similaritiesi

Belongs to the TSC-22/Dip/Bun family.Curated

Phylogenomic databases

eggNOGiKOG4797. Eukaryota.
ENOG411251N. LUCA.
GeneTreeiENSGT00530000063062.
HOGENOMiHOG000015349.
HOVERGENiHBG075918.
InParanoidiQ9EQZ1.
OMAiSTEMFAK.
OrthoDBiEOG091G06PM.

Family and domain databases

InterProiView protein in InterPro
IPR000580. TSC-22_Dip_Bun.
PANTHERiPTHR12348. PTHR12348. 1 hit.
PfamiView protein in Pfam
PF01166. TSC22. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD007152. TSC-22_Dip_Bun. 1 hit.
PROSITEiView protein in PROSITE
PS01289. TSC22. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9EQZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTEMYQTPM EVAVYQLHNF SISFFSSLLG GDVVSVKLDN SASGASVVAL
60 70 80 90 100
DNKIEQAMDL VKNHLMYAVR EEVEVLKEQI RELVEKNSQL ERENTLLKTL
110 120 130
ASPEQLEKFQ SRLSPEEPAP EAPETPEAPG GSAV
Length:134
Mass (Da):14,836
Last modified:March 1, 2001 - v1
Checksum:iC3B6CC1266908342
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025431 mRNA. Translation: BAB18679.1.
BC061979 mRNA. Translation: AAH61979.1.
RefSeqiNP_112635.1. NM_031345.1.
UniGeneiRn.21970.

Genome annotation databases

EnsembliENSRNOT00000085118; ENSRNOP00000072713; ENSRNOG00000056135.
GeneIDi83514.
KEGGirno:83514.
UCSCiRGD:621654. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025431 mRNA. Translation: BAB18679.1.
BC061979 mRNA. Translation: AAH61979.1.
RefSeqiNP_112635.1. NM_031345.1.
UniGeneiRn.21970.

3D structure databases

ProteinModelPortaliQ9EQZ1.
SMRiQ9EQZ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051018.

PTM databases

iPTMnetiQ9EQZ1.
PhosphoSitePlusiQ9EQZ1.

Proteomic databases

PaxDbiQ9EQZ1.
PRIDEiQ9EQZ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000085118; ENSRNOP00000072713; ENSRNOG00000056135.
GeneIDi83514.
KEGGirno:83514.
UCSCiRGD:621654. rat.

Organism-specific databases

CTDi1831.
RGDi621654. Tsc22d3.

Phylogenomic databases

eggNOGiKOG4797. Eukaryota.
ENOG411251N. LUCA.
GeneTreeiENSGT00530000063062.
HOGENOMiHOG000015349.
HOVERGENiHBG075918.
InParanoidiQ9EQZ1.
OMAiSTEMFAK.
OrthoDBiEOG091G06PM.

Miscellaneous databases

PROiPR:Q9EQZ1.

Gene expression databases

BgeeiENSRNOG00000013786.
GenevisibleiQ9EQZ1. RN.

Family and domain databases

InterProiView protein in InterPro
IPR000580. TSC-22_Dip_Bun.
PANTHERiPTHR12348. PTHR12348. 1 hit.
PfamiView protein in Pfam
PF01166. TSC22. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD007152. TSC-22_Dip_Bun. 1 hit.
PROSITEiView protein in PROSITE
PS01289. TSC22. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiT22D3_RAT
AccessioniPrimary (citable) accession number: Q9EQZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: May 10, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.