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Q9EQY6

- PIGM_RAT

UniProt

Q9EQY6 - PIGM_RAT

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Protein
GPI mannosyltransferase 1
Gene
Pigm
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly By similarity.

Pathwayi

GO - Molecular functioni

  1. mannosyltransferase activity Source: RGD

GO - Biological processi

  1. GPI anchor biosynthetic process Source: RGD
  2. mannosylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00196.

Protein family/group databases

CAZyiGT50. Glycosyltransferase Family 50.

Names & Taxonomyi

Protein namesi
Recommended name:
GPI mannosyltransferase 1 (EC:2.4.1.-)
Alternative name(s):
GPI mannosyltransferase I
Short name:
GPI-MT-I
Phosphatidylinositol-glycan biosynthesis class M protein
Short name:
PIG-M
Gene namesi
Name:Pigm
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi71041. Pigm.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei18 – 3821Helical; Reviewed prediction
Add
BLAST
Topological domaini39 – 8951Lumenal Reviewed prediction
Add
BLAST
Transmembranei90 – 11021Helical; Reviewed prediction
Add
BLAST
Topological domaini111 – 16959Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei170 – 19021Helical; Reviewed prediction
Add
BLAST
Topological domaini191 – 22434Lumenal Reviewed prediction
Add
BLAST
Transmembranei225 – 24521Helical; Reviewed prediction
Add
BLAST
Topological domaini246 – 28742Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei288 – 30821Helical; Reviewed prediction
Add
BLAST
Topological domaini309 – 32921Lumenal Reviewed prediction
Add
BLAST
Transmembranei330 – 35021Helical; Reviewed prediction
Add
BLAST
Topological domaini351 – 3577Cytoplasmic Reviewed prediction
Transmembranei358 – 37821Helical; Reviewed prediction
Add
BLAST
Topological domaini379 – 3846Lumenal Reviewed prediction
Transmembranei385 – 40521Helical; Reviewed prediction
Add
BLAST
Topological domaini406 – 42318Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423GPI mannosyltransferase 1
PRO_0000246217Add
BLAST

Proteomic databases

PRIDEiQ9EQY6.

Expressioni

Gene expression databases

GenevestigatoriQ9EQY6.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010551.

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGM family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG268708.
GeneTreeiENSGT00390000017728.
HOGENOMiHOG000186884.
HOVERGENiHBG082137.
InParanoidiQ9EQY6.
KOiK05284.
OMAiEFLEHTY.
OrthoDBiEOG7SBNQM.
PhylomeDBiQ9EQY6.
TreeFamiTF314752.

Family and domain databases

InterProiIPR007704. Mannosyltransferase_DXD.
[Graphical view]
PANTHERiPTHR12886. PTHR12886. 1 hit.
PfamiPF05007. Mannosyl_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EQY6-1 [UniParc]FASTAAdd to Basket

« Hide

MSYTKHWGEW FLNLRVPPAG VFGVAFLARV ALVFYGVFQD RTLLVRYTDI    50
DYHVFTDAAR FVTEGRSPYL RATYRYTPLL SWLLTPNVYL SELFGKFLFI 100
SCDLLTAFLL YRLLLLKGLG RRQACGYCVF WLLNPLPMAV SSRGNADSIV 150
ASLVLTTLYL IEKRLIACAA VFYGFAVHMK MYPVTYILPI ALHLRPERDS 200
DEGLRLARYS FQARLYDFLK RLCSWAVLLF VAIAGLTFLA LSFGFYYKYG 250
WEFLEHTYLY HLTRRDIRHN FSPYFYMLYL TAESKWSFTL GIAAFLPQFI 300
LLSAASFAYY RDLVFCCFLH TSIFVTFNKV CTSQYFLWYL CLLPLVMPLV 350
RMPWKRAVVL LMLWFIGQAL WLAPAYVLEF QGKNTFLFIW LAGLFFLLIN 400
CSILIQIISH YKEDRLTERI KYD 423
Length:423
Mass (Da):49,594
Last modified:March 1, 2001 - v1
Checksum:i7FC172B5DF98992D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028126 mRNA. Translation: BAB18566.1.
RefSeqiNP_077058.1. NM_024144.1.
UniGeneiRn.163231.

Genome annotation databases

EnsembliENSRNOT00000010551; ENSRNOP00000010551; ENSRNOG00000007735.
GeneIDi79112.
KEGGirno:79112.
UCSCiRGD:71041. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028126 mRNA. Translation: BAB18566.1 .
RefSeqi NP_077058.1. NM_024144.1.
UniGenei Rn.163231.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000010551.

Protein family/group databases

CAZyi GT50. Glycosyltransferase Family 50.

Proteomic databases

PRIDEi Q9EQY6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000010551 ; ENSRNOP00000010551 ; ENSRNOG00000007735 .
GeneIDi 79112.
KEGGi rno:79112.
UCSCi RGD:71041. rat.

Organism-specific databases

CTDi 93183.
RGDi 71041. Pigm.

Phylogenomic databases

eggNOGi NOG268708.
GeneTreei ENSGT00390000017728.
HOGENOMi HOG000186884.
HOVERGENi HBG082137.
InParanoidi Q9EQY6.
KOi K05284.
OMAi EFLEHTY.
OrthoDBi EOG7SBNQM.
PhylomeDBi Q9EQY6.
TreeFami TF314752.

Enzyme and pathway databases

UniPathwayi UPA00196 .

Miscellaneous databases

NextBioi 614510.
PROi Q9EQY6.

Gene expression databases

Genevestigatori Q9EQY6.

Family and domain databases

InterProi IPR007704. Mannosyltransferase_DXD.
[Graphical view ]
PANTHERi PTHR12886. PTHR12886. 1 hit.
Pfami PF05007. Mannosyl_trans. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER."
    Maeda Y., Watanabe R., Harris C.L., Hong Y., Ohishi K., Kinoshita K., Kinoshita T.
    EMBO J. 20:250-261(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPIGM_RAT
AccessioniPrimary (citable) accession number: Q9EQY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 1, 2001
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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