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Q9EQY6

- PIGM_RAT

UniProt

Q9EQY6 - PIGM_RAT

Protein

GPI mannosyltransferase 1

Gene

Pigm

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly By similarity.By similarity

    Pathwayi

    GO - Molecular functioni

    1. mannosyltransferase activity Source: RGD

    GO - Biological processi

    1. GPI anchor biosynthetic process Source: RGD
    2. mannosylation Source: GOC

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    GPI-anchor biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00196.

    Protein family/group databases

    CAZyiGT50. Glycosyltransferase Family 50.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GPI mannosyltransferase 1 (EC:2.4.1.-)
    Alternative name(s):
    GPI mannosyltransferase I
    Short name:
    GPI-MT-I
    Phosphatidylinositol-glycan biosynthesis class M protein
    Short name:
    PIG-M
    Gene namesi
    Name:Pigm
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 13

    Organism-specific databases

    RGDi71041. Pigm.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 423423GPI mannosyltransferase 1PRO_0000246217Add
    BLAST

    Proteomic databases

    PRIDEiQ9EQY6.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9EQY6.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000010551.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1717CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini39 – 8951LumenalSequence AnalysisAdd
    BLAST
    Topological domaini111 – 16959CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini191 – 22434LumenalSequence AnalysisAdd
    BLAST
    Topological domaini246 – 28742CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini309 – 32921LumenalSequence AnalysisAdd
    BLAST
    Topological domaini351 – 3577CytoplasmicSequence Analysis
    Topological domaini379 – 3846LumenalSequence Analysis
    Topological domaini406 – 42318CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei18 – 3821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei90 – 11021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei170 – 19021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei225 – 24521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei288 – 30821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei330 – 35021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei358 – 37821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei385 – 40521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PIGM family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG268708.
    GeneTreeiENSGT00390000017728.
    HOGENOMiHOG000186884.
    HOVERGENiHBG082137.
    InParanoidiQ9EQY6.
    KOiK05284.
    OMAiEFLEHTY.
    OrthoDBiEOG7SBNQM.
    PhylomeDBiQ9EQY6.
    TreeFamiTF314752.

    Family and domain databases

    InterProiIPR007704. Mannosyltransferase_DXD.
    [Graphical view]
    PANTHERiPTHR12886. PTHR12886. 1 hit.
    PfamiPF05007. Mannosyl_trans. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9EQY6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYTKHWGEW FLNLRVPPAG VFGVAFLARV ALVFYGVFQD RTLLVRYTDI    50
    DYHVFTDAAR FVTEGRSPYL RATYRYTPLL SWLLTPNVYL SELFGKFLFI 100
    SCDLLTAFLL YRLLLLKGLG RRQACGYCVF WLLNPLPMAV SSRGNADSIV 150
    ASLVLTTLYL IEKRLIACAA VFYGFAVHMK MYPVTYILPI ALHLRPERDS 200
    DEGLRLARYS FQARLYDFLK RLCSWAVLLF VAIAGLTFLA LSFGFYYKYG 250
    WEFLEHTYLY HLTRRDIRHN FSPYFYMLYL TAESKWSFTL GIAAFLPQFI 300
    LLSAASFAYY RDLVFCCFLH TSIFVTFNKV CTSQYFLWYL CLLPLVMPLV 350
    RMPWKRAVVL LMLWFIGQAL WLAPAYVLEF QGKNTFLFIW LAGLFFLLIN 400
    CSILIQIISH YKEDRLTERI KYD 423
    Length:423
    Mass (Da):49,594
    Last modified:March 1, 2001 - v1
    Checksum:i7FC172B5DF98992D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028126 mRNA. Translation: BAB18566.1.
    RefSeqiNP_077058.1. NM_024144.1.
    UniGeneiRn.163231.

    Genome annotation databases

    EnsembliENSRNOT00000010551; ENSRNOP00000010551; ENSRNOG00000007735.
    GeneIDi79112.
    KEGGirno:79112.
    UCSCiRGD:71041. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028126 mRNA. Translation: BAB18566.1 .
    RefSeqi NP_077058.1. NM_024144.1.
    UniGenei Rn.163231.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000010551.

    Protein family/group databases

    CAZyi GT50. Glycosyltransferase Family 50.

    Proteomic databases

    PRIDEi Q9EQY6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000010551 ; ENSRNOP00000010551 ; ENSRNOG00000007735 .
    GeneIDi 79112.
    KEGGi rno:79112.
    UCSCi RGD:71041. rat.

    Organism-specific databases

    CTDi 93183.
    RGDi 71041. Pigm.

    Phylogenomic databases

    eggNOGi NOG268708.
    GeneTreei ENSGT00390000017728.
    HOGENOMi HOG000186884.
    HOVERGENi HBG082137.
    InParanoidi Q9EQY6.
    KOi K05284.
    OMAi EFLEHTY.
    OrthoDBi EOG7SBNQM.
    PhylomeDBi Q9EQY6.
    TreeFami TF314752.

    Enzyme and pathway databases

    UniPathwayi UPA00196 .

    Miscellaneous databases

    NextBioi 614510.
    PROi Q9EQY6.

    Gene expression databases

    Genevestigatori Q9EQY6.

    Family and domain databases

    InterProi IPR007704. Mannosyltransferase_DXD.
    [Graphical view ]
    PANTHERi PTHR12886. PTHR12886. 1 hit.
    Pfami PF05007. Mannosyl_trans. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER."
      Maeda Y., Watanabe R., Harris C.L., Hong Y., Ohishi K., Kinoshita K., Kinoshita T.
      EMBO J. 20:250-261(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiPIGM_RAT
    AccessioniPrimary (citable) accession number: Q9EQY6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3