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Q9EQX6

- PDGFC_RAT

UniProt

Q9EQX6 - PDGFC_RAT

Protein

Platelet-derived growth factor C

Gene

Pdgfc

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei225 – 2262CleavageBy similarity
    Sitei231 – 2322CleavageBy similarity
    Sitei234 – 2352CleavageBy similarity

    GO - Biological processi

    1. activation of transmembrane receptor protein tyrosine kinase activity Source: Ensembl
    2. cellular response to amino acid stimulus Source: Ensembl
    3. organ morphogenesis Source: Ensembl
    4. platelet-derived growth factor receptor signaling pathway Source: Ensembl
    5. positive regulation of cell division Source: UniProtKB-KW
    6. positive regulation of DNA replication Source: Ensembl
    7. positive regulation of fibroblast proliferation Source: Ensembl
    8. regulation of peptidyl-tyrosine phosphorylation Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein, Growth factor, Mitogen

    Enzyme and pathway databases

    ReactomeiREACT_212371. Signaling by PDGF.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Platelet-derived growth factor C
    Short name:
    PDGF-C
    Alternative name(s):
    Fallotein
    Spinal cord-derived growth factor
    Short name:
    rScdfg
    VEGF-E
    Cleaved into the following 2 chains:
    Platelet-derived growth factor C, receptor-binding form
    Short name:
    PDGFC receptor-binding form
    Gene namesi
    Name:Pdgfc
    Synonyms:Scdgf
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 2

    Organism-specific databases

    RGDi68410. Pdgfc.

    Subcellular locationi

    Cytoplasm By similarity. Secreted By similarity. Nucleus By similarity. Cytoplasmic granule By similarity
    Note: Sumoylated form is predominant in the nucleus. Stored in alpha granules in platelets. Membrane associated when bound to receptors.By similarity

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. cytoplasm Source: UniProtKB-SubCell
    3. extracellular space Source: Ensembl
    4. membrane Source: InterPro
    5. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 345Platelet-derived growth factor C, receptor-binding formPRO_0000343876
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 345323Platelet-derived growth factor C, latent formPRO_0000343875Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi25 – 251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi104 ↔ 124PROSITE-ProRule annotation
    Disulfide bondi250 ↔ 294PROSITE-ProRule annotation
    Disulfide bondi274 – 274Interchain (with C-286)PROSITE-ProRule annotation
    Disulfide bondi280 ↔ 335PROSITE-ProRule annotation
    Disulfide bondi286 – 286Interchain (with C-274)PROSITE-ProRule annotation
    Disulfide bondi287 ↔ 337PROSITE-ProRule annotation

    Post-translational modificationi

    Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after basic residues in the hinge region (region connecting the CUB and growth factor domains) gives rise to the receptor-binding form. Cleaved by PLAT and PLG By similarity.By similarity
    Sumoylated with SUMO1.By similarity
    N-glycosylated.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiQ9EQX6.

    Expressioni

    Tissue specificityi

    Highly expressed in the kidney and adrenal gland. In the kidney, it is expressed in arteriolar smooth muscle cells and in epithelial cells of individual segments (at protein level).2 Publications

    Developmental stagei

    Expressed in the floor plate of the spinal cord at E11 and also in the ventricular zone at E16, but not in adult. In the brain, expression is more significant at E16 than at adult, with high expression in the cortex, pontine area and choroid plexus. Detected in the otocyst at E16.3 Publications

    Inductioni

    Up-regulated in mesangial, visceral epithelial, and interstitial cells after predominant injury to these cells. Expression levels increase in hepatic cells undergoing in vitro transdifferentiation, which represents a model for hepatic fibrogenesis. Expression induced by indoxyl sulfate. Expression induced by angiotensin-2 via EGR1 in smooth muscle cells in neonatal but not in adult rats.3 Publications

    Gene expression databases

    GenevestigatoriQ9EQX6.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked. Interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts (via CUB domain) with PLAT (via kringle domain) By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9EQX6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 163118CUBPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PDGF/VEGF growth factor family.Curated
    Contains 1 CUB domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG74970.
    GeneTreeiENSGT00390000005171.
    HOGENOMiHOG000261610.
    HOVERGENiHBG057324.
    InParanoidiQ9EQX6.
    KOiK05450.
    OMAiDCVCRGN.
    OrthoDBiEOG7VB2FN.
    PhylomeDBiQ9EQX6.
    TreeFamiTF332130.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    2.60.120.290. 1 hit.
    InterProiIPR000859. CUB_dom.
    IPR029034. Cystine-knot_cytokine.
    IPR000072. PDGF/VEGF_dom.
    [Graphical view]
    PfamiPF00431. CUB. 1 hit.
    PF00341. PDGF. 1 hit.
    [Graphical view]
    SMARTiSM00042. CUB. 1 hit.
    SM00141. PDGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF49854. SSF49854. 1 hit.
    SSF57501. SSF57501. 1 hit.
    PROSITEiPS01180. CUB. 1 hit.
    PS50278. PDGF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9EQX6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLLGLLLLT SALAGQRTGT RAESNLSSKL QLSSDKEQNG VQDPRHERVV    50
    TISGNGSIHS PKFPHTYPRN TVLVWRLVAV DENVRIQLTF DERFGLEDPE 100
    DDLCKYDFVE VEEPSDGSVL GRWCGSGTVP GKQTSKGNHI RIRFVSDEYF 150
    PSEPGFCIHY SIIMPQVTET TSPSVLPPSA LSLDLLNNAV TAFSTVEELI 200
    RFLEPDRWQI DLDSLYKPTW PLLGKAFLYG KKSKAVNLNL LKEEVKLYSC 250
    TPRNFSVSIR EELKRTDTIF WPGCLLVKRC GGNCACCLHN CNECQCVPRK 300
    VTKKYHEVLQ LRPKIGVKGL HKSLTDVALE HHEECDCVCR GNTEG 345
    Length:345
    Mass (Da):38,734
    Last modified:March 1, 2001 - v1
    Checksum:iF296DA6E9B765D10
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB033830 mRNA. Translation: BAB19969.1.
    AF508348 mRNA. Translation: AAM47265.1.
    RefSeqiNP_112607.1. NM_031317.1.
    UniGeneiRn.211987.

    Genome annotation databases

    EnsembliENSRNOT00000015081; ENSRNOP00000015081; ENSRNOG00000010695.
    GeneIDi79429.
    KEGGirno:79429.
    UCSCiRGD:68410. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB033830 mRNA. Translation: BAB19969.1 .
    AF508348 mRNA. Translation: AAM47265.1 .
    RefSeqi NP_112607.1. NM_031317.1.
    UniGenei Rn.211987.

    3D structure databases

    ProteinModelPortali Q9EQX6.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9EQX6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000015081 ; ENSRNOP00000015081 ; ENSRNOG00000010695 .
    GeneIDi 79429.
    KEGGi rno:79429.
    UCSCi RGD:68410. rat.

    Organism-specific databases

    CTDi 56034.
    RGDi 68410. Pdgfc.

    Phylogenomic databases

    eggNOGi NOG74970.
    GeneTreei ENSGT00390000005171.
    HOGENOMi HOG000261610.
    HOVERGENi HBG057324.
    InParanoidi Q9EQX6.
    KOi K05450.
    OMAi DCVCRGN.
    OrthoDBi EOG7VB2FN.
    PhylomeDBi Q9EQX6.
    TreeFami TF332130.

    Enzyme and pathway databases

    Reactomei REACT_212371. Signaling by PDGF.

    Miscellaneous databases

    NextBioi 614787.
    PROi Q9EQX6.

    Gene expression databases

    Genevestigatori Q9EQX6.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    2.60.120.290. 1 hit.
    InterProi IPR000859. CUB_dom.
    IPR029034. Cystine-knot_cytokine.
    IPR000072. PDGF/VEGF_dom.
    [Graphical view ]
    Pfami PF00431. CUB. 1 hit.
    PF00341. PDGF. 1 hit.
    [Graphical view ]
    SMARTi SM00042. CUB. 1 hit.
    SM00141. PDGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49854. SSF49854. 1 hit.
    SSF57501. SSF57501. 1 hit.
    PROSITEi PS01180. CUB. 1 hit.
    PS50278. PDGF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of SCDGF-B, a novel growth factor homologous to SCDGF/PDGF-C/fallotein."
      Hamada T., Ui-Tei K., Imaki J., Miyata Y.
      Biochem. Biophys. Res. Commun. 280:733-737(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Kidney.
    2. "Platelet derived growth factor C (PDGF-C) expression in wound healing."
      Brown S.A., Coberly D.M., Rohrich R.R., Chao J.J.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 42-299.
      Strain: Sprague-Dawley.
      Tissue: Skin.
    3. "Expression of a novel PDGF isoform, PDGF-C, in normal and diseased rat kidney."
      Eitner F., Ostendorf T., Van Roeyen C., Kitahara M., Li X., Aase K., Grone H.J., Eriksson U., Floege J.
      J. Am. Soc. Nephrol. 13:910-917(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INDUCTION.
    4. "The expression of SCDGF/PDGF-C/fallotein and SCDGF-B/PDGF-D in the rat central nervous system."
      Hamada T., Ui-Tei K., Imaki J., Takahashi F., Onodera H., Mishima T., Miyata Y.
      Mech. Dev. 112:161-164(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    5. "Expression of platelet-derived growth factor in the developing cochlea of rats."
      Lee Y.W., Ozeki M., Juhn S.K., Lin J.
      Acta Oto-Laryngol. 124:558-562(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.
    6. "Expression patterns of PDGF-A, -B, -C and -D and the PDGF-receptors alpha and beta in activated rat hepatic stellate cells (HSC)."
      Breitkopf K., Roeyen C., Sawitza I., Wickert L., Floege J., Gressner A.M.
      Cytokine 31:349-357(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY FIBROGENESIS.
    7. "Indoxyl sulfate stimulates proliferation of rat vascular smooth muscle cells."
      Yamamoto H., Tsuruoka S., Ioka T., Ando H., Ito C., Akimoto T., Fujimura A., Asano Y., Kusano E.
      Kidney Int. 69:1780-1785(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY INDOXYL SULFATE.
    8. "Angiotensin II induction of PDGF-C expression is mediated by AT1 receptor-dependent Egr-1 transactivation."
      Sanchez-Guerrero E., Midgley V.C., Khachigian L.M.
      Nucleic Acids Res. 36:1941-1951(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiPDGFC_RAT
    AccessioniPrimary (citable) accession number: Q9EQX6
    Secondary accession number(s): Q8K429
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3