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Protein

Allograft inflammatory factor 1-like

Gene

Aif1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Actin-binding protein that promotes actin bundling. May neither bind calcium nor depend on calcium for function (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi60 – 71121PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Actin-binding, Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Allograft inflammatory factor 1-like
Alternative name(s):
Ionized calcium-binding adapter molecule 2
Gene namesi
Name:Aif1l
Synonyms:Iba2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1919598. Aif1l.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 150149Allograft inflammatory factor 1-likePRO_0000073871Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei2 – 21PhosphoserineBy similarity
Modified residuei13 – 131N6-acetyllysineBy similarity
Modified residuei134 – 1341PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9EQX4.
MaxQBiQ9EQX4.
PaxDbiQ9EQX4.
PeptideAtlasiQ9EQX4.
PRIDEiQ9EQX4.

PTM databases

iPTMnetiQ9EQX4.
PhosphoSiteiQ9EQX4.

Expressioni

Gene expression databases

BgeeiQ9EQX4.
ExpressionAtlasiQ9EQX4. baseline and differential.
GenevisibleiQ9EQX4. MM.

Interactioni

Subunit structurei

Homodimer (Potential). Monomer (By similarity).By similarityCurated

GO - Molecular functioni

Protein-protein interaction databases

BioGridi224458. 6 interactions.
IntActiQ9EQX4. 6 interactions.
STRINGi10090.ENSMUSP00000001920.

Structurei

3D structure databases

ProteinModelPortaliQ9EQX4.
SMRiQ9EQX4. Positions 9-150.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 8236EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini83 – 11735EF-hand 2; degeneratePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410INJ9. Eukaryota.
ENOG4111MIW. LUCA.
GeneTreeiENSGT00390000013846.
HOGENOMiHOG000231928.
HOVERGENiHBG004002.
InParanoidiQ9EQX4.
KOiK18617.
OMAiLCDPKFS.
OrthoDBiEOG73FQPC.
PhylomeDBiQ9EQX4.
TreeFamiTF320736.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR028453. Aif1-like.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
PANTHERiPTHR10356:SF5. PTHR10356:SF5. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EQX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVALSNRFQ GGKAFGLLKA RQEKRLEEIN REFLCDQKYS DEENLPEKLA
60 70 80 90 100
AFKEKYMEFD LNNEGEIDLM SLKRMMEKLG VPKTHLEMKK MISEVTGGVS
110 120 130 140 150
DTISYRDFVN MMLGKRSAVL KLVMMFEGKA NESSPKPAGP PPERDIASLP
Length:150
Mass (Da):17,024
Last modified:March 1, 2001 - v1
Checksum:iC707C3059FCA7A00
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti111 – 1111M → K in BAC26211 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035322 mRNA. Translation: BAB20749.1.
AB094629 Genomic DNA. Translation: BAC55012.1.
AK028955 mRNA. Translation: BAC26211.1.
AK045539 mRNA. Translation: BAC32410.1.
BC024599 mRNA. Translation: AAH24599.1.
CCDSiCCDS15904.1.
RefSeqiNP_660126.1. NM_145144.1.
UniGeneiMm.24838.

Genome annotation databases

EnsembliENSMUST00000001920; ENSMUSP00000001920; ENSMUSG00000001864.
GeneIDi108897.
KEGGimmu:108897.
UCSCiuc008jeg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035322 mRNA. Translation: BAB20749.1.
AB094629 Genomic DNA. Translation: BAC55012.1.
AK028955 mRNA. Translation: BAC26211.1.
AK045539 mRNA. Translation: BAC32410.1.
BC024599 mRNA. Translation: AAH24599.1.
CCDSiCCDS15904.1.
RefSeqiNP_660126.1. NM_145144.1.
UniGeneiMm.24838.

3D structure databases

ProteinModelPortaliQ9EQX4.
SMRiQ9EQX4. Positions 9-150.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi224458. 6 interactions.
IntActiQ9EQX4. 6 interactions.
STRINGi10090.ENSMUSP00000001920.

PTM databases

iPTMnetiQ9EQX4.
PhosphoSiteiQ9EQX4.

Proteomic databases

EPDiQ9EQX4.
MaxQBiQ9EQX4.
PaxDbiQ9EQX4.
PeptideAtlasiQ9EQX4.
PRIDEiQ9EQX4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001920; ENSMUSP00000001920; ENSMUSG00000001864.
GeneIDi108897.
KEGGimmu:108897.
UCSCiuc008jeg.1. mouse.

Organism-specific databases

CTDi83543.
MGIiMGI:1919598. Aif1l.

Phylogenomic databases

eggNOGiENOG410INJ9. Eukaryota.
ENOG4111MIW. LUCA.
GeneTreeiENSGT00390000013846.
HOGENOMiHOG000231928.
HOVERGENiHBG004002.
InParanoidiQ9EQX4.
KOiK18617.
OMAiLCDPKFS.
OrthoDBiEOG73FQPC.
PhylomeDBiQ9EQX4.
TreeFamiTF320736.

Miscellaneous databases

PROiQ9EQX4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9EQX4.
ExpressionAtlasiQ9EQX4. baseline and differential.
GenevisibleiQ9EQX4. MM.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR028453. Aif1-like.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
PANTHERiPTHR10356:SF5. PTHR10356:SF5. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of mouse iba2 cDNA encoding a novel EF-hand calcium-binding protein."
    Imai Y., Kohsaka S.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Brain.
  2. "Complete sequence of mouse iba2 gene."
    Imai Y., Kohsaka S.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Corpora quadrigemina and Skin.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney.

Entry informationi

Entry nameiAIF1L_MOUSE
AccessioniPrimary (citable) accession number: Q9EQX4
Secondary accession number(s): Q8C150
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.