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Protein

Kinesin-like protein KIF13A

Gene

Kif13a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis (By similarity). Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex.By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi102 – 1098ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • microtubule motor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Cell cycle, Cell division, Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF13A
Gene namesi
Name:Kif13a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1098264. Kif13a.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • endosome membrane Source: UniProtKB
  • kinesin complex Source: GO_Central
  • microtubule Source: UniProtKB-KW
  • midbody Source: UniProtKB
  • trans-Golgi network membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endosome, Golgi apparatus, Membrane, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17491749Kinesin-like protein KIF13APRO_0000125447Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei636 – 6361PhosphoserineBy similarity
Modified residuei1274 – 12741PhosphoserineBy similarity
Modified residuei1441 – 14411PhosphoserineBy similarity
Modified residuei1477 – 14771PhosphoserineCombined sources
Modified residuei1481 – 14811PhosphoserineCombined sources
Modified residuei1524 – 15241PhosphoserineBy similarity
Modified residuei1600 – 16001PhosphoserineCombined sources
Modified residuei1650 – 16501PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9EQW7.
MaxQBiQ9EQW7.
PaxDbiQ9EQW7.
PeptideAtlasiQ9EQW7.
PRIDEiQ9EQW7.

PTM databases

iPTMnetiQ9EQW7.
PhosphoSiteiQ9EQW7.

Expressioni

Developmental stagei

At E9.5, expressed essentially in the central nervous system. Widely expressed at E10.5. At E11.5, expressed in the telencephaon, otic vesicles, limb buds, nasal processes and urogenital bud.1 Publication

Gene expression databases

CleanExiMM_KIF13A.

Interactioni

Subunit structurei

Interacts with AP1G1 and AP1G2. Interacts with ZFYVE26 (By similarity). Interacts with AP2B1.By similarity1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055304.

Structurei

Secondary structure

1
1749
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi390 – 43142Combined sources
Beta strandi433 – 4364Combined sources
Beta strandi439 – 4424Combined sources
Beta strandi448 – 4514Combined sources
Beta strandi458 – 4603Combined sources
Beta strandi462 – 4654Combined sources
Beta strandi468 – 4758Combined sources
Beta strandi478 – 4814Combined sources
Beta strandi492 – 4965Combined sources
Beta strandi502 – 5065Combined sources
Beta strandi512 – 5143Combined sources
Beta strandi530 – 5334Combined sources
Turni534 – 5363Combined sources
Beta strandi537 – 5426Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5DJOX-ray1.74A/B390-555[»]
ProteinModelPortaliQ9EQW7.
SMRiQ9EQW7. Positions 5-350, 447-544.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 352348Kinesin motorPROSITE-ProRule annotationAdd
BLAST
Domaini469 – 51951FHAAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili359 – 43173Sequence analysisAdd
BLAST
Coiled coili552 – 775224Sequence analysisAdd
BLAST
Coiled coili1086 – 112641Sequence analysisAdd
BLAST
Coiled coili1475 – 149925Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Contains 1 FHA domain.Curated
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0245. Eukaryota.
COG5059. LUCA.
HOGENOMiHOG000230729.
HOVERGENiHBG052244.
InParanoidiQ9EQW7.
PhylomeDBiQ9EQW7.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
3.40.850.10. 1 hit.
InterProiIPR000253. FHA_dom.
IPR032923. KIF13A.
IPR022164. Kinesin-like.
IPR027640. Kinesin-like_fam.
IPR022140. Kinesin-like_KIF1-typ.
IPR032405. Kinesin_assoc.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PTHR24115:SF458. PTHR24115:SF458. 2 hits.
PfamiPF12473. DUF3694. 1 hit.
PF12423. KIF1B. 1 hit.
PF00225. Kinesin. 1 hit.
PF16183. Kinesin_assoc. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EQW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDTKVKVAV RVRPMNRREL ELNTKCVVEM EGNQTVLHPP PSNTKQGERK
60 70 80 90 100
PPKVFAFDYC FWSMDESNTT KYAGQEVVFK CLGEGILEKA FQGYNACIFA
110 120 130 140 150
YGQTGSGKSF SMMGHAEQLG LIPRLCCALF QRIALEQNES QTFKVEVSYM
160 170 180 190 200
EIYNEKVRDL LDPKGSRQSL KVREHKVLGP YVDGLSQLAV TSFEDIESLM
210 220 230 240 250
SEGNKSRTVA ATNMNEESSR SHAVFNIIIT QTLYDLQSGN SGEKVSKVSL
260 270 280 290 300
VDLAGSERVS KTGAAGERLK EGSNINKSLT TLGLVISSLA DQAAGKGKNK
310 320 330 340 350
FVPYRDSVLT WLLKDNLGGN SQTSMIATIS PAADNYEETL STLRYADRAK
360 370 380 390 400
RIVNHAVVNE DPNAKVIREL REEVEKLREQ LSKAEAMKPP ELKEKLEESE
410 420 430 440 450
KLIKELTVTW EEKLRKTEAI AQERQRQLES MGISLETSGI KVGDDKCYLV
460 470 480 490 500
NLNADPALNE LLVYYLKDHT RVGADTSQDI QLFGIGIQPE HCEIDIAADG
510 520 530 540 550
DITLTPKENA RSCVNGTLVC NTTQLWHGDR ILWGNNHFFR INLPKRKRRD
560 570 580 590 600
WLKDFERETS SAEHDLDAAS EASSEPDYNY EFAQMEVIMK TLNSNDPVQN
610 620 630 640 650
VVQVLEKQYL EEKRTALEEQ RLMYERELEQ LRQQLSPERQ PPSSASDRLA
660 670 680 690 700
YSSQTAQQKV TQWAEERDEL FRQSLAKLRE QLVKANTLVR EANFLAEEMS
710 720 730 740 750
KLTDYQVTLQ IPAANLSANR KRGAIVSEPA IQARRKGKGT QVWTIEKLEN
760 770 780 790 800
KLIDMRDLYQ EWKENVPEAK RLYGKRGDPF YEAQENHNLI GVANVFLECL
810 820 830 840 850
FCDVKLQYAV PIISQQGEVA GRLHVEVTRI TGTIPERMAE DDSSENSSES
860 870 880 890 900
GSLEVVDSSG EVIHRVKKLT CRVIIKEATG LPISLSNFVF CQYTFWDQCE
910 920 930 940 950
STVAAPVVDP DVPSPQSKDA QYTVTFSHCK DYVVTVTEEF LEFISDGALA
960 970 980 990 1000
IEVWGHRCAG NGSPIWEVDS LHAKTRTLHD RWNEVTRRIE VWISILELNE
1010 1020 1030 1040 1050
LGDYAAVELH QAKDVNTGGV FQLRQGHSRR VQVTVKPVQH SGTLPLMVEA
1060 1070 1080 1090 1100
ILSVSIGCVT ARSTKLQRGL DSYQEEDLNC VRERWSDALI KRREYLDEQI
1110 1120 1130 1140 1150
KKVSNKKEKT EDDMEREARL VEQWVGLTEE RNAVLVPAPG SGIPGAPADW
1160 1170 1180 1190 1200
VPPPGMETHI PVLFLDLNAD DLSANEQLVG PHASGVNSIL PKEHGSQFFY
1210 1220 1230 1240 1250
LPIIKHSDDE VSATASWDSS VHDSLHLNRV TPQNERIYLI VKTTVQLSHP
1260 1270 1280 1290 1300
AAMELVLRKR IAANIYNKQS FTQSLKRRIS LINICYSCGV TYEIVSNIPK
1310 1320 1330 1340 1350
ATEEIEDRET LALLAARSEN EGTLDGETYI EKYTRGVLQV ENILSLERLR
1360 1370 1380 1390 1400
QAVTVKEALS TKARHIRRSL STPNVHNVSS SRPDLSGFDE DDKGWPENQL
1410 1420 1430 1440 1450
DVSDYSSSYQ DVACYGTLPR DSPRRSKEGC PSENPHALTV SPFKAFSPQP
1460 1470 1480 1490 1500
PKFFKPLMPV KEEHKKRLAL EARPLLSQED SEEEENELEA LSRKLMLTQP
1510 1520 1530 1540 1550
YVPVEFADFS VYNASLENRE WSSSKADLTD SRALEKAVSR SPTTSSLTSG
1560 1570 1580 1590 1600
YFSHSASNAT LSDMAVPSSD SSDQLAVSTK EVECAEPPGP SLAPDVRRAS
1610 1620 1630 1640 1650
NQELTEVGRG SGKDETIAVP LEENSALPKG TPSPQSIPEE SSRMPCRTAS
1660 1670 1680 1690 1700
CSELDVGPSK DGHQAREFCP GEVTIEHTTN ILEDHSFTEF MGVSDGKDFD
1710 1720 1730 1740
GLADCSVGEP SRRRALTNET DHKGIPERPP DADRLHPKIE NDQEATATR
Length:1,749
Mass (Da):195,813
Last modified:March 1, 2001 - v1
Checksum:iDAE9E026127DDBF2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti100 – 1001A → T in BAA22389 (PubMed:9275178).Curated
Sequence conflicti157 – 1571V → A in BAA22389 (PubMed:9275178).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037923 mRNA. Translation: BAB16346.1.
AB001429 mRNA. Translation: BAA22389.1.
CCDSiCCDS36652.1.
UniGeneiMm.342703.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037923 mRNA. Translation: BAB16346.1.
AB001429 mRNA. Translation: BAA22389.1.
CCDSiCCDS36652.1.
UniGeneiMm.342703.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5DJOX-ray1.74A/B390-555[»]
ProteinModelPortaliQ9EQW7.
SMRiQ9EQW7. Positions 5-350, 447-544.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055304.

PTM databases

iPTMnetiQ9EQW7.
PhosphoSiteiQ9EQW7.

Proteomic databases

EPDiQ9EQW7.
MaxQBiQ9EQW7.
PaxDbiQ9EQW7.
PeptideAtlasiQ9EQW7.
PRIDEiQ9EQW7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1098264. Kif13a.

Phylogenomic databases

eggNOGiKOG0245. Eukaryota.
COG5059. LUCA.
HOGENOMiHOG000230729.
HOVERGENiHBG052244.
InParanoidiQ9EQW7.
PhylomeDBiQ9EQW7.

Miscellaneous databases

ChiTaRSiKif13a. mouse.
PROiQ9EQW7.
SOURCEiSearch...

Gene expression databases

CleanExiMM_KIF13A.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
3.40.850.10. 1 hit.
InterProiIPR000253. FHA_dom.
IPR032923. KIF13A.
IPR022164. Kinesin-like.
IPR027640. Kinesin-like_fam.
IPR022140. Kinesin-like_KIF1-typ.
IPR032405. Kinesin_assoc.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PTHR24115:SF458. PTHR24115:SF458. 2 hits.
PfamiPF12473. DUF3694. 1 hit.
PF12423. KIF1B. 1 hit.
PF00225. Kinesin. 1 hit.
PF16183. Kinesin_assoc. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex."
    Nakagawa T., Setou M., Seog D.H., Ogasawara K., Dohmae N., Takio K., Hirokawa N.
    Cell 103:569-581(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH AP2B1.
    Strain: ICR.
    Tissue: Brain.
  2. "Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome."
    Nakagawa T., Tanaka Y., Matsuoka E., Kondo S., Okada Y., Noda Y., Kanai Y., Hirokawa N.
    Proc. Natl. Acad. Sci. U.S.A. 94:9654-9659(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 98-257.
    Strain: ICR.
  3. "Identification of the human KIF13A gene homologous to Drosophila kinesin-73 and candidate for schizophrenia."
    Jamain S., Quach H., Fellous M., Bourgeron T.
    Genomics 74:36-44(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1477; SER-1481 AND SER-1600, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Heart, Kidney, Lung, Pancreas and Spleen.

Entry informationi

Entry nameiKI13A_MOUSE
AccessioniPrimary (citable) accession number: Q9EQW7
Secondary accession number(s): O35062
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.