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Protein

Oligodendrocyte transcription factor 2

Gene

Olig2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development.2 Publications

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA binding transcription factor activity Source: MGI
  • HMG box domain binding Source: UniProtKB
  • protein homodimerization activity Source: MGI
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: MGI

GO - Biological processi

  • myelination Source: MGI
  • negative regulation of neuron differentiation Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • nervous system development Source: MGI
  • neuron fate commitment Source: MGI
  • oligodendrocyte differentiation Source: MGI
  • positive regulation of oligodendrocyte differentiation Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • spinal cord motor neuron differentiation Source: MGI
  • spinal cord oligodendrocyte cell differentiation Source: MGI
  • spinal cord oligodendrocyte cell fate specification Source: MGI
  • thalamus development Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Oligodendrocyte transcription factor 2
Short name:
Oligo2
Gene namesi
Name:Olig2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1355331 Olig2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001274151 – 323Oligodendrocyte transcription factor 2Add BLAST323

Proteomic databases

PaxDbiQ9EQW6
PRIDEiQ9EQW6

PTM databases

iPTMnetiQ9EQW6
PhosphoSitePlusiQ9EQW6

Expressioni

Tissue specificityi

Expressed specifically in the brain.1 Publication

Developmental stagei

Expressed in the ventral spinal cord as early as 9.5 dpc. Expression becomes progressively restricted to a narrow zone within the ventral neuroepithelium of the spinal cord. In the 14.5 dpc spinal cord, expressed in the oligodendrocyte progenitors of the ventral ventricular zone, but not dorsal root ganglia Schwann cells. Also expressed scattered in the mantle zone, likely corresponding to oligodendrocyte progenitors migrating out from their site of origin. In the brain, from 10.5 through 14.5 dpc, expressed in numerous cells in the ventricular and subventricular zones of the lateral and medial ganglionic eminences, suggesting that expression might not be limited to the oligodendrocytic lineage. By 15.5 dpc, dispersed throughout the gray matter, with little or no residual expression in the ventricular zone. In the postnatal brain, present preferentially in the white matter, such as corpus callosum and cerebellar medulla. Expressed in the 13.5 and 14.5 dpc retina and in the olfactory epithelium from 11.5 dpc onward.2 Publications

Inductioni

By SHH. Also induced by NKX6-1 in the developing spinal cord, but not in the rostral hindbrain.2 Publications

Gene expression databases

BgeeiENSMUSG00000039830
CleanExiMM_OLIG2
ExpressionAtlasiQ9EQW6 baseline and differential
GenevisibleiQ9EQW6 MM

Interactioni

Subunit structurei

Interacts with NKX2-2.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • HMG box domain binding Source: UniProtKB
  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

BioGridi206152, 8 interactors
IntActiQ9EQW6, 4 interactors
STRINGi10090.ENSMUSP00000036797

Structurei

3D structure databases

ProteinModelPortaliQ9EQW6
SMRiQ9EQW6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 162bHLHPROSITE-ProRule annotationAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi77 – 88Poly-SerAdd BLAST12
Compositional biasi206 – 212Poly-Ala7
Compositional biasi225 – 237Poly-AlaAdd BLAST13
Compositional biasi266 – 270Poly-Ala5
Compositional biasi273 – 284Poly-GlyAdd BLAST12

Domaini

The bHLH is essential for interaction with NKX2-2.

Phylogenomic databases

eggNOGiKOG3898 Eukaryota
ENOG4111U26 LUCA
GeneTreeiENSGT00530000063239
HOGENOMiHOG000015765
HOVERGENiHBG053370
InParanoidiQ9EQW6
KOiK09085
OMAiSFQHWGG
OrthoDBiEOG091G129L
PhylomeDBiQ9EQW6
TreeFamiTF322733

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR032658 Olig2
PANTHERiPTHR19290:SF32 PTHR19290:SF32, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Q9EQW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSDASLVSS RPSSPEPDDL FLPARSKGGS SSGFTGGTVS SSTPSDCPPE
60 70 80 90 100
LSSELRGAMG ASGAHPGDKL GGGGFKSSSS STSSSTSSAA TSSTKKDKKQ
110 120 130 140 150
MTEPELQQLR LKINSRERKR MHDLNIAMDG LREVMPYAHG PSVRKLSKIA
160 170 180 190 200
TLLLARNYIL MLTNSLEEMK RLVSEIYGGH HAGFHPSACG GLAHSAPLPT
210 220 230 240 250
ATAHPAAAAH AAHHPAVHHP ILPPAAAAAA AAAAAAAVSS ASLPGSGLSS
260 270 280 290 300
VGSIRPPHGL LKSPSAAAAA PLGGGGGGSG GSGGFQHWGG MPCPCSMCQV
310 320
PPPHHHVSAM GAGTLPRLTS DAK
Length:323
Mass (Da):32,407
Last modified:March 1, 2001 - v1
Checksum:i598AE76CB512D716
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198L → I in AAF61722 (PubMed:10719889).Curated1
Sequence conflicti205P → PTRHGAP (PubMed:10719889).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038697 mRNA Translation: BAB18907.1
AF232929 Genomic DNA Translation: AAF61722.1
BC051967 mRNA Translation: AAH51967.1
CCDSiCCDS28323.1
RefSeqiNP_058663.2, NM_016967.2
UniGeneiMm.37289

Genome annotation databases

EnsembliENSMUST00000035608; ENSMUSP00000036797; ENSMUSG00000039830
GeneIDi50913
KEGGimmu:50913
UCSCiuc007zxe.1 mouse

Similar proteinsi

Entry informationi

Entry nameiOLIG2_MOUSE
AccessioniPrimary (citable) accession number: Q9EQW6
Secondary accession number(s): Q9JKN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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