SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9EQU3

- TLR9_MOUSE

UniProt

Q9EQU3 - TLR9_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Toll-like receptor 9
Gene
Tlr9
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Plays a role in defense against systemic mouse cytomegalovirus infection. Controls lymphocyte response to Helicobacter infection.2 Publications

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. siRNA binding Source: UniProtKB
  3. transmembrane signaling receptor activity Source: InterPro
  4. unmethylated CpG binding Source: Ensembl

GO - Biological processi

  1. MyD88-dependent toll-like receptor signaling pathway Source: InterPro
  2. cellular response to lipopolysaccharide Source: Ensembl
  3. cellular response to metal ion Source: Ensembl
  4. defense response to bacterium Source: Ensembl
  5. defense response to virus Source: MGI
  6. immune response Source: MGI
  7. inflammatory response Source: UniProtKB-KW
  8. innate immune response Source: BHF-UCL
  9. maintenance of gastrointestinal epithelium Source: BHF-UCL
  10. male gonad development Source: Ensembl
  11. microglial cell activation involved in immune response Source: Ensembl
  12. negative regulation of interleukin-6 production Source: BHF-UCL
  13. pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response Source: Ensembl
  14. positive regulation of autophagy Source: Ensembl
  15. positive regulation of inflammatory response Source: InterPro
  16. positive regulation of interferon-alpha biosynthetic process Source: UniProtKB
  17. positive regulation of interferon-beta biosynthetic process Source: UniProtKB
  18. positive regulation of interferon-beta production Source: BHF-UCL
  19. positive regulation of interferon-gamma biosynthetic process Source: UniProtKB
  20. positive regulation of interleukin-10 production Source: BHF-UCL
  21. positive regulation of interleukin-12 production Source: BHF-UCL
  22. positive regulation of interleukin-18 production Source: BHF-UCL
  23. positive regulation of interleukin-6 production Source: BHF-UCL
  24. positive regulation of nitric-oxide synthase biosynthetic process Source: BHF-UCL
  25. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  26. positive regulation of tumor necrosis factor production Source: BHF-UCL
  27. regulation of cytokine secretion Source: InterPro
  28. regulation of inflammatory response Source: BHF-UCL
  29. response to molecule of bacterial origin Source: BHF-UCL
  30. response to virus Source: MGI
  31. toll-like receptor 9 signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiREACT_198527. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
REACT_198976. Trafficking and processing of endosomal TLR.

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 9
Alternative name(s):
CD_antigen: CD289
Gene namesi
Name:Tlr9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1932389. Tlr9.

Subcellular locationi

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome. Lysosome. Cytoplasmic vesiclephagosome
Note: Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 818793Extracellular Reviewed prediction
Add
BLAST
Transmembranei819 – 83921Helical; Reviewed prediction
Add
BLAST
Topological domaini840 – 1032193Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. early phagosome Source: UniProtKB
  2. endoplasmic reticulum Source: UniProtKB
  3. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  4. endosome Source: UniProtKB
  5. integral component of membrane Source: UniProtKB-KW
  6. lysosome Source: UniProtKB
  7. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Lysosome, Membrane

Pathology & Biotechi

Disruption phenotypei

Reduced proliferation of lymphocytes, reduced interferon-gamma production by splenocytes and reduced neutrophil numbers following Helicobacter infection.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi499 – 4991L → P: Highly susceptible to mouse cytomegalovirus infection. Shows low level of cytokine induction and natural killer activation on viral infection. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Chaini26 – 10321007Toll-like receptor 9
PRO_0000034738Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi64 – 641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi129 – 1291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi147 – 1471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi200 – 2001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi210 – 2101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi242 – 2421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi300 – 3001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi309 – 3091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi332 – 3321N-linked (GlcNAc...) Reviewed prediction
Glycosylationi340 – 3401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi495 – 4951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi514 – 5141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi568 – 5681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi670 – 6701N-linked (GlcNAc...) Reviewed prediction
Glycosylationi695 – 6951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi700 – 7001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi732 – 7321N-linked (GlcNAc...) Reviewed prediction
Glycosylationi752 – 7521N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9EQU3.
PRIDEiQ9EQU3.

PTM databases

PhosphoSiteiQ9EQU3.

Expressioni

Tissue specificityi

Expressed in the basolateral region of gastric epithelial cells with high levels detected in antrum and body mucosa (at protein level). Detected in spleen and stomach at higher levels in C57BL/6 mice than BALB/C.1 Publication

Inductioni

Following Helicobacter infection, down-regulated in C57BL/6 mice and up-regulated in BALB/C mice.1 Publication

Gene expression databases

BgeeiQ9EQU3.
CleanExiMM_TLR9.
GenevestigatoriQ9EQU3.

Interactioni

Subunit structurei

Interacts with MYD88 via their respective TIR domains By similarity. Interacts with BTK By similarity. Interacts (via transmembrane domain) with UNC93B1. Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum.4 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082207.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4QDHX-ray2.40A/B480-753[»]
ProteinModelPortaliQ9EQU3.
SMRiQ9EQU3. Positions 34-1013.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati62 – 8524LRR 1
Add
BLAST
Repeati87 – 11024LRR 2
Add
BLAST
Repeati122 – 14726LRR 3
Add
BLAST
Repeati150 – 16617LRR 4
Add
BLAST
Repeati167 – 19024LRR 5
Add
BLAST
Repeati198 – 22124LRR 6
Add
BLAST
Repeati223 – 24220LRR 7
Add
BLAST
Repeati243 – 26826LRR 8
Add
BLAST
Repeati283 – 30624LRR 9
Add
BLAST
Repeati308 – 33225LRR 10
Add
BLAST
Repeati333 – 35624LRR 11
Add
BLAST
Repeati363 – 38624LRR 12
Add
BLAST
Repeati390 – 41324LRR 13
Add
BLAST
Repeati415 – 44026LRR 14
Add
BLAST
Repeati471 – 49525LRR 15
Add
BLAST
Repeati497 – 52024LRR 16
Add
BLAST
Repeati521 – 54424LRR 17
Add
BLAST
Repeati546 – 57328LRR 18
Add
BLAST
Repeati575 – 59925LRR 19
Add
BLAST
Repeati601 – 62323LRR 20
Add
BLAST
Repeati628 – 65124LRR 21
Add
BLAST
Repeati653 – 67624LRR 22
Add
BLAST
Repeati677 – 70024LRR 23
Add
BLAST
Repeati702 – 72423LRR 24
Add
BLAST
Repeati725 – 74824LRR 25
Add
BLAST
Repeati750 – 77324LRR 26
Add
BLAST
Domaini868 – 1016149TIR
Add
BLAST

Sequence similaritiesi

Contains 1 TIR domain.

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00750000117479.
HOGENOMiHOG000230468.
HOVERGENiHBG018601.
InParanoidiQ4L0K3.
KOiK10161.
OMAiLYLHFFQ.
OrthoDBiEOG7C8GGD.
TreeFamiTF325595.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
InterProiIPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027181. TLR9.
[Graphical view]
PANTHERiPTHR24373:SF37. PTHR24373:SF37. 1 hit.
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 5 hits.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 16 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EQU3-1 [UniParc]FASTAAdd to Basket

« Hide

MVLRRRTLHP LSLLVQAAVL AETLALGTLP AFLPCELKPH GLVDCNWLFL     50
KSVPRFSAAA SCSNITRLSL ISNRIHHLHN SDFVHLSNLR QLNLKWNCPP 100
TGLSPLHFSC HMTIEPRTFL AMRTLEELNL SYNGITTVPR LPSSLVNLSL 150
SHTNILVLDA NSLAGLYSLR VLFMDGNCYY KNPCTGAVKV TPGALLGLSN 200
LTHLSLKYNN LTKVPRQLPP SLEYLLVSYN LIVKLGPEDL ANLTSLRVLD 250
VGGNCRRCDH APNPCIECGQ KSLHLHPETF HHLSHLEGLV LKDSSLHTLN 300
SSWFQGLVNL SVLDLSENFL YESITHTNAF QNLTRLRKLN LSFNYRKKVS 350
FARLHLASSF KNLVSLQELN MNGIFFRLLN KYTLRWLADL PKLHTLHLQM 400
NFINQAQLSI FGTFRALRFV DLSDNRISGP STLSEATPEE ADDAEQEELL 450
SADPHPAPLS TPASKNFMDR CKNFKFTMDL SRNNLVTIKP EMFVNLSRLQ 500
CLSLSHNSIA QAVNGSQFLP LTNLQVLDLS HNKLDLYHWK SFSELPQLQA 550
LDLSYNSQPF SMKGIGHNFS FVTHLSMLQS LSLAHNDIHT RVSSHLNSNS 600
VRFLDFSGNG MGRMWDEGGL YLHFFQGLSG LLKLDLSQNN LHILRPQNLD 650
NLPKSLKLLS LRDNYLSFFN WTSLSFLPNL EVLDLAGNQL KALTNGTLPN 700
GTLLQKLDVS SNSIVSVVPA FFALAVELKE VNLSHNILKT VDRSWFGPIV 750
MNLTVLDVRS NPLHCACGAA FVDLLLEVQT KVPGLANGVK CGSPGQLQGR 800
SIFAQDLRLC LDEVLSWDCF GLSLLAVAVG MVVPILHHLC GWDVWYCFHL 850
CLAWLPLLAR SRRSAQTLPY DAFVVFDKAQ SAVADWVYNE LRVRLEERRG 900
RRALRLCLED RDWLPGQTLF ENLWASIYGS RKTLFVLAHT DRVSGLLRTS 950
FLLAQQRLLE DRKDVVVLVI LRPDAHRSRY VRLRQRLCRQ SVLFWPQQPN 1000
GQGGFWAQLS TALTRDNRHF YNQNFCRGPT AE 1032
Length:1,032
Mass (Da):116,412
Last modified:December 14, 2011 - v3
Checksum:iC13A7888588CE297
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti325 – 3251T → N in BAB19260. 1 Publication
Sequence conflicti325 – 3251T → N in AAK29625. 1 Publication
Sequence conflicti325 – 3251T → N in AAK28488. 1 Publication
Sequence conflicti325 – 3251T → N in AAU04980. 1 Publication
Sequence conflicti378 – 3781L → S in BAB19260. 1 Publication
Sequence conflicti378 – 3781L → S in AAK29625. 1 Publication
Sequence conflicti378 – 3781L → S in AAK28488. 1 Publication
Sequence conflicti378 – 3781L → S in AAU04980. 1 Publication
Sequence conflicti554 – 5541S → G in AAK28488. 1 Publication
Sequence conflicti562 – 5621M → I in AAK28488. 1 Publication
Sequence conflicti573 – 5731T → A in AAK29625. 1 Publication
Sequence conflicti573 – 5731T → A in AAK28488. 1 Publication
Sequence conflicti573 – 5731T → A in AAU04980. 1 Publication
Sequence conflicti579 – 5791Q → H in AAK29625. 1 Publication
Sequence conflicti579 – 5791Q → H in AAK28488. 1 Publication
Sequence conflicti579 – 5791Q → H in AAU04980. 1 Publication
Sequence conflicti867 – 8671T → A in AAK29625. 1 Publication
Sequence conflicti867 – 8671T → A in AAK28488. 1 Publication
Sequence conflicti867 – 8671T → A in AAU04980. 1 Publication
Sequence conflicti897 – 8971E → G in AAK28488. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB045181 mRNA. Translation: BAB19260.1.
AF348140 mRNA. Translation: AAK29625.1.
AF314224 mRNA. Translation: AAK28488.1.
AC164430 Genomic DNA. No translation available.
AY649790 Genomic DNA. Translation: AAU04980.1.
AY649791 Genomic DNA. Translation: AAU04981.1.
CCDSiCCDS40755.1.
RefSeqiNP_112455.2. NM_031178.2.
UniGeneiMm.44889.

Genome annotation databases

EnsembliENSMUST00000062241; ENSMUSP00000082207; ENSMUSG00000045322.
GeneIDi81897.
KEGGimmu:81897.
UCSCiuc009rjh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB045181 mRNA. Translation: BAB19260.1 .
AF348140 mRNA. Translation: AAK29625.1 .
AF314224 mRNA. Translation: AAK28488.1 .
AC164430 Genomic DNA. No translation available.
AY649790 Genomic DNA. Translation: AAU04980.1 .
AY649791 Genomic DNA. Translation: AAU04981.1 .
CCDSi CCDS40755.1.
RefSeqi NP_112455.2. NM_031178.2.
UniGenei Mm.44889.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4QDH X-ray 2.40 A/B 480-753 [» ]
ProteinModelPortali Q9EQU3.
SMRi Q9EQU3. Positions 34-1013.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000082207.

Chemistry

ChEMBLi CHEMBL6128.

PTM databases

PhosphoSitei Q9EQU3.

Proteomic databases

PaxDbi Q9EQU3.
PRIDEi Q9EQU3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000062241 ; ENSMUSP00000082207 ; ENSMUSG00000045322 .
GeneIDi 81897.
KEGGi mmu:81897.
UCSCi uc009rjh.1. mouse.

Organism-specific databases

CTDi 54106.
MGIi MGI:1932389. Tlr9.

Phylogenomic databases

eggNOGi COG4886.
GeneTreei ENSGT00750000117479.
HOGENOMi HOG000230468.
HOVERGENi HBG018601.
InParanoidi Q4L0K3.
KOi K10161.
OMAi LYLHFFQ.
OrthoDBi EOG7C8GGD.
TreeFami TF325595.

Enzyme and pathway databases

Reactomei REACT_198527. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
REACT_198976. Trafficking and processing of endosomal TLR.

Miscellaneous databases

NextBioi 350461.
PROi Q9EQU3.
SOURCEi Search...

Gene expression databases

Bgeei Q9EQU3.
CleanExi MM_TLR9.
Genevestigatori Q9EQU3.

Family and domain databases

Gene3Di 3.40.50.10140. 1 hit.
InterProi IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027181. TLR9.
[Graphical view ]
PANTHERi PTHR24373:SF37. PTHR24373:SF37. 1 hit.
Pfami PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 5 hits.
PF01582. TIR. 1 hit.
[Graphical view ]
SMARTi SM00369. LRR_TYP. 1 hit.
[Graphical view ]
SUPFAMi SSF52200. SSF52200. 1 hit.
PROSITEi PS51450. LRR. 16 hits.
PS50104. TIR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition."
    Bauer S.M., Kirschning C.J., Hacker H., Redecke V., Hausmann S., Akira S., Wagner H., Lipford G.B.
    Proc. Natl. Acad. Sci. U.S.A. 98:9237-9242(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Macrophage.
  3. "Toll-like receptor 9 mediates CpG-DNA signaling."
    Chuang T.-H., Lee J., Kline L., Mathison J.C., Ulevitch R.J.
    J. Leukoc. Biol. 71:538-544(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "TLR9 polymorphisms determine murine lymphocyte responses to Helicobacter: results from a genome-wide scan."
    Anderson A.E., Worku M.L., Khamri W., Bamford K.B., Walker M.M., Thursz M.R.
    Eur. J. Immunol. 37:1548-1561(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-964, FUNCTION, TISSUE SPECIFICITY, INDUCTION, DISRUPTION PHENOTYPE.
    Strain: BALB/c and C57BL/6.
  6. "Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection."
    Tabeta K., Georgel P., Janssen E., Du X., Hoebe K., Crozat K., Mudd S., Shamel L., Sovath S., Goode J., Alexopoulou L., Flavell R.A., Beutler B.
    Proc. Natl. Acad. Sci. U.S.A. 101:3516-3521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN CYTOMEGALOVIRUS INFECTION, MUTAGENESIS OF LEU-499.
  7. "The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling."
    Brinkmann M.M., Spooner E., Hoebe K., Beutler B., Ploegh H.L., Kim Y.M.
    J. Cell Biol. 177:265-275(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH UNC93B1.
  8. "A single base mutation in the PRAT4A gene reveals differential interaction of PRAT4A with Toll-like receptors."
    Kiyokawa T., Akashi-Takamura S., Shibata T., Matsumoto F., Nishitani C., Kuroki Y., Seto Y., Miyake K.
    Int. Immunol. 20:1407-1415(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CNPY3.
  9. "UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes."
    Kim Y.M., Brinkmann M.M., Paquet M.E., Ploegh H.L.
    Nature 452:234-238(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  10. "Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone."
    Liu B., Yang Y., Qiu Z., Staron M., Hong F., Li Y., Wu S., Li Y., Hao B., Bona R., Han D., Li Z.
    Nat. Commun. 1:79-79(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CNPY3 AND HSP90B1.
  11. Erratum
    Liu B., Yang Y., Qiu Z., Staron M., Hong F., Li Y., Wu S., Li Y., Hao B., Bona R., Han D., Li Z.
    Nat. Commun. 3:653-653(2012)
  12. "CMRF-35-like molecule 3 preferentially promotes TLR9-triggered proinflammatory cytokine production in macrophages by enhancing TNF receptor-associated factor 6 ubiquitination."
    Wu Y., Zhu X., Li N., Chen T., Yang M., Yao M., Liu X., Jin B., Wang X., Cao X.
    J. Immunol. 187:4881-4889(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CD300LH.

Entry informationi

Entry nameiTLR9_MOUSE
AccessioniPrimary (citable) accession number: Q9EQU3
Secondary accession number(s): F8VPN5
, Q4L0K3, Q4L0K4, Q99MF2, Q99MQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: December 14, 2011
Last modified: September 3, 2014
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi