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Protein

Synaptotagmin-13

Gene

Syt13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transport vesicle docking to the plasma membrane.

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-13
Alternative name(s):
Synaptotagmin XIII
Short name:
SytXIII
Gene namesi
Name:Syt13
Synonyms:Kiaa1427
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1933945. Syt13.

Subcellular locationi

  • Cytoplasmic vesicle membrane 1 Publication; Single-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6VesicularSequence analysis6
Transmembranei7 – 29HelicalSequence analysisAdd BLAST23
Topological domaini30 – 426CytoplasmicSequence analysisAdd BLAST397

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839761 – 426Synaptotagmin-13Add BLAST426

Proteomic databases

PaxDbiQ9EQT6.
PeptideAtlasiQ9EQT6.
PRIDEiQ9EQT6.

PTM databases

iPTMnetiQ9EQT6.
PhosphoSitePlusiQ9EQT6.
SwissPalmiQ9EQT6.

Expressioni

Tissue specificityi

Expressed in brain, heart, spleen, lung and testis.1 Publication

Developmental stagei

Expressed in embryo at 7 dpc onwards.1 Publication

Gene expression databases

BgeeiENSMUSG00000027220.
CleanExiMM_SYT13.
GenevisibleiQ9EQT6. MM.

Interactioni

Subunit structurei

Interacts with NRXN1.1 Publication

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ9EQT6.
SMRiQ9EQT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini175 – 259C2 1PROSITE-ProRule annotationAdd BLAST85
Domaini289 – 394C2 2PROSITE-ProRule annotationAdd BLAST106

Domaini

The first C2 domain/C2A does not mediate Ca2+-dependent phospholipid binding.
The second C2 domain/C2B domain binds phospholipids regardless of whether calcium is present.

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IT3H. Eukaryota.
ENOG4110ZXG. LUCA.
GeneTreeiENSGT00830000128339.
HOGENOMiHOG000231448.
HOVERGENiHBG098553.
InParanoidiQ9EQT6.
KOiK19913.
OMAiEMIMFEL.
OrthoDBiEOG091G0DPW.
PhylomeDBiQ9EQT6.
TreeFamiTF315600.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiView protein in InterPro
IPR000008. C2_dom.
IPR028692. SYT13.
PANTHERiPTHR10024:SF339. PTHR10024:SF339. 1 hit.
PfamiView protein in Pfam
PF00168. C2. 2 hits.
SMARTiView protein in SMART
SM00239. C2. 1 hit.
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiView protein in PROSITE
PS50004. C2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9EQT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSVPVIAL GATLGTATSI LALCGVTCLC RHMHPKKGLL PRDREPDPEK
60 70 80 90 100
ARPGVLQAAQ QFNIKKSTEP VQPRPLLKFP DIYGPRPAVT APEVINYADY
110 120 130 140 150
TLETTEESAA PASPQAQSDS RLKRQVTEEL SIRPQNGVVE DVCVMETWNP
160 170 180 190 200
EKAASWNQAP KLHFRLDYDQ KKAELFVTSL EAVTSDHEGG CDCYIQGSVA
210 220 230 240 250
VKTGSVEAQT ALKKRQLHTT WEEGLALPLG EEELPTATLT LTLRTCDRFS
260 270 280 290 300
RHSVIGELRL GLDGASVPLG AAQWGELKTT AKEPSAGAGE VLLSISYLPA
310 320 330 340 350
ANRLLVVLIK AKNLHSNQSK ELLGKDVSVK VTLKHQAQKL KKKQTKRAKH
360 370 380 390 400
KINPVWNEMI MFELPDDLLR ASSVELEVLG QGEEGPSCEL GHCSLGLHAS
410 420
GSERSHWEEM LKNPRRQIAM WHQLHL
Length:426
Mass (Da):46,870
Last modified:March 1, 2001 - v1
Checksum:i8B67FAF369861CBE
GO

Sequence cautioni

The sequence BAC98167 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52R → G in BAC31748 (PubMed:16141072).Curated1
Sequence conflicti103E → G in BAC98167 (PubMed:14621295).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB048947 mRNA. Translation: BAB19628.1.
AK044038 mRNA. Translation: BAC31748.1.
AK049840 mRNA. Translation: BAC33948.1.
AK082425 mRNA. Translation: BAC38491.1.
AK129357 mRNA. Translation: BAC98167.1. Different initiation.
BC030907 mRNA. Translation: AAH30907.1.
CCDSiCCDS16451.1.
RefSeqiNP_109650.1. NM_030725.4.
UniGeneiMm.33490.

Genome annotation databases

EnsembliENSMUST00000028648; ENSMUSP00000028648; ENSMUSG00000027220.
GeneIDi80976.
KEGGimmu:80976.
UCSCiuc008lfn.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSYT13_MOUSE
AccessioniPrimary (citable) accession number: Q9EQT6
Secondary accession number(s): Q6ZPR2, Q8BRK6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2001
Last modified: July 5, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families