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Q9EQT6 (SYT13_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Synaptotagmin-13
Alternative name(s):
Synaptotagmin XIII
Short name=SytXIII
Gene names
Name:Syt13
Synonyms:Kiaa1427
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length426 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in transport vesicle docking to the plasma membrane.

Subunit structure

Interacts with NRXN1. Ref.1

Subcellular location

Cytoplasmic vesicle membrane; Single-pass membrane protein Ref.1.

Tissue specificity

Expressed in brain, heart, spleen, lung and testis. Ref.1

Developmental stage

Expressed in embryo at 7 dpc onwards. Ref.1

Domain

The first C2 domain/C2A does not mediate Ca2+-dependent phospholipid binding.

The second C2 domain/C2B domain binds phospholipids regardless of whether calcium is present.

Sequence similarities

Belongs to the synaptotagmin family.

Contains 2 C2 domains.

Sequence caution

The sequence BAC98167.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 426426Synaptotagmin-13
PRO_0000183976

Regions

Topological domain1 – 66Vesicular Potential
Transmembrane7 – 2923Helical; Potential
Topological domain30 – 426397Cytoplasmic Potential
Domain175 – 25985C2 1
Domain289 – 394106C2 2

Experimental info

Sequence conflict521R → G in BAC31748. Ref.2
Sequence conflict1031E → G in BAC98167. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9EQT6 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 8B67FAF369861CBE

FASTA42646,870
        10         20         30         40         50         60 
MVLSVPVIAL GATLGTATSI LALCGVTCLC RHMHPKKGLL PRDREPDPEK ARPGVLQAAQ 

        70         80         90        100        110        120 
QFNIKKSTEP VQPRPLLKFP DIYGPRPAVT APEVINYADY TLETTEESAA PASPQAQSDS 

       130        140        150        160        170        180 
RLKRQVTEEL SIRPQNGVVE DVCVMETWNP EKAASWNQAP KLHFRLDYDQ KKAELFVTSL 

       190        200        210        220        230        240 
EAVTSDHEGG CDCYIQGSVA VKTGSVEAQT ALKKRQLHTT WEEGLALPLG EEELPTATLT 

       250        260        270        280        290        300 
LTLRTCDRFS RHSVIGELRL GLDGASVPLG AAQWGELKTT AKEPSAGAGE VLLSISYLPA 

       310        320        330        340        350        360 
ANRLLVVLIK AKNLHSNQSK ELLGKDVSVK VTLKHQAQKL KKKQTKRAKH KINPVWNEMI 

       370        380        390        400        410        420 
MFELPDDLLR ASSVELEVLG QGEEGPSCEL GHCSLGLHAS GSERSHWEEM LKNPRRQIAM 


WHQLHL 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of KIAA1427 protein as an atypical synaptotagmin (Syt XIII)."
Fukuda M., Mikoshiba K.
Biochem. J. 354:249-257(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH NRXN1, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
Strain: BALB/c.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Brain cortex, Cerebellum and Hippocampus.
[3]"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB048947 mRNA. Translation: BAB19628.1.
AK044038 mRNA. Translation: BAC31748.1.
AK049840 mRNA. Translation: BAC33948.1.
AK082425 mRNA. Translation: BAC38491.1.
AK129357 mRNA. Translation: BAC98167.1. Different initiation.
BC030907 mRNA. Translation: AAH30907.1.
RefSeqNP_109650.1. NM_030725.4.
UniGeneMm.33490.

3D structure databases

ProteinModelPortalQ9EQT6.
SMRQ9EQT6. Positions 156-426.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9EQT6.

Proteomic databases

PaxDbQ9EQT6.
PRIDEQ9EQT6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000028648; ENSMUSP00000028648; ENSMUSG00000027220.
GeneID80976.
KEGGmmu:80976.
UCSCuc008lfn.1. mouse.

Organism-specific databases

CTD57586.
MGIMGI:1933945. Syt13.
RougeSearch...

Phylogenomic databases

eggNOGNOG277582.
GeneTreeENSGT00750000117732.
HOGENOMHOG000231448.
HOVERGENHBG098553.
InParanoidQ9EQT6.
OMADHDGGCD.
OrthoDBEOG71P2B0.
PhylomeDBQ9EQT6.
TreeFamTF315600.

Gene expression databases

BgeeQ9EQT6.
CleanExMM_SYT13.
GenevestigatorQ9EQT6.

Family and domain databases

Gene3D2.60.40.150. 2 hits.
InterProIPR000008. C2_dom.
IPR028692. SYT13.
[Graphical view]
PANTHERPTHR10024:SF157. PTHR10024:SF157. 1 hit.
PfamPF00168. C2. 2 hits.
[Graphical view]
SMARTSM00239. C2. 1 hit.
[Graphical view]
SUPFAMSSF49562. SSF49562. 2 hits.
PROSITEPS50004. C2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSYT13. mouse.
NextBio350302.
PROQ9EQT6.
SOURCESearch...

Entry information

Entry nameSYT13_MOUSE
AccessionPrimary (citable) accession number: Q9EQT6
Secondary accession number(s): Q6ZPR2, Q8BRK6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot