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Protein

Synaptotagmin-13

Gene

Syt13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transport vesicle docking to the plasma membrane.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-13
Alternative name(s):
Synaptotagmin XIII
Short name:
SytXIII
Gene namesi
Name:Syt13
Synonyms:Kiaa1427
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1933945. Syt13.

Subcellular locationi

  • Cytoplasmic vesicle membrane 1 Publication; Single-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66VesicularSequence Analysis
Transmembranei7 – 2923HelicalSequence AnalysisAdd
BLAST
Topological domaini30 – 426397CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Synaptotagmin-13PRO_0000183976Add
BLAST

Proteomic databases

PaxDbiQ9EQT6.
PRIDEiQ9EQT6.

PTM databases

PhosphoSiteiQ9EQT6.

Expressioni

Tissue specificityi

Expressed in brain, heart, spleen, lung and testis.1 Publication

Developmental stagei

Expressed in embryo at 7 dpc onwards.1 Publication

Gene expression databases

BgeeiQ9EQT6.
CleanExiMM_SYT13.
GenevisibleiQ9EQT6. MM.

Interactioni

Subunit structurei

Interacts with NRXN1.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028648.

Structurei

3D structure databases

ProteinModelPortaliQ9EQT6.
SMRiQ9EQT6. Positions 156-426.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini175 – 25985C2 1PROSITE-ProRule annotationAdd
BLAST
Domaini289 – 394106C2 2PROSITE-ProRule annotationAdd
BLAST

Domaini

The first C2 domain/C2A does not mediate Ca2+-dependent phospholipid binding.
The second C2 domain/C2B domain binds phospholipids regardless of whether calcium is present.

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated
Contains 2 C2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG277582.
GeneTreeiENSGT00790000123049.
HOGENOMiHOG000231448.
HOVERGENiHBG098553.
InParanoidiQ9EQT6.
OMAiLKHQARK.
OrthoDBiEOG71P2B0.
PhylomeDBiQ9EQT6.
TreeFamiTF315600.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR028692. SYT13.
[Graphical view]
PANTHERiPTHR10024:SF211. PTHR10024:SF211. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EQT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSVPVIAL GATLGTATSI LALCGVTCLC RHMHPKKGLL PRDREPDPEK
60 70 80 90 100
ARPGVLQAAQ QFNIKKSTEP VQPRPLLKFP DIYGPRPAVT APEVINYADY
110 120 130 140 150
TLETTEESAA PASPQAQSDS RLKRQVTEEL SIRPQNGVVE DVCVMETWNP
160 170 180 190 200
EKAASWNQAP KLHFRLDYDQ KKAELFVTSL EAVTSDHEGG CDCYIQGSVA
210 220 230 240 250
VKTGSVEAQT ALKKRQLHTT WEEGLALPLG EEELPTATLT LTLRTCDRFS
260 270 280 290 300
RHSVIGELRL GLDGASVPLG AAQWGELKTT AKEPSAGAGE VLLSISYLPA
310 320 330 340 350
ANRLLVVLIK AKNLHSNQSK ELLGKDVSVK VTLKHQAQKL KKKQTKRAKH
360 370 380 390 400
KINPVWNEMI MFELPDDLLR ASSVELEVLG QGEEGPSCEL GHCSLGLHAS
410 420
GSERSHWEEM LKNPRRQIAM WHQLHL
Length:426
Mass (Da):46,870
Last modified:March 1, 2001 - v1
Checksum:i8B67FAF369861CBE
GO

Sequence cautioni

The sequence BAC98167.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti52 – 521R → G in BAC31748 (PubMed:16141072).Curated
Sequence conflicti103 – 1031E → G in BAC98167 (PubMed:14621295).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB048947 mRNA. Translation: BAB19628.1.
AK044038 mRNA. Translation: BAC31748.1.
AK049840 mRNA. Translation: BAC33948.1.
AK082425 mRNA. Translation: BAC38491.1.
AK129357 mRNA. Translation: BAC98167.1. Different initiation.
BC030907 mRNA. Translation: AAH30907.1.
CCDSiCCDS16451.1.
RefSeqiNP_109650.1. NM_030725.4.
UniGeneiMm.33490.

Genome annotation databases

EnsembliENSMUST00000028648; ENSMUSP00000028648; ENSMUSG00000027220.
GeneIDi80976.
KEGGimmu:80976.
UCSCiuc008lfn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB048947 mRNA. Translation: BAB19628.1.
AK044038 mRNA. Translation: BAC31748.1.
AK049840 mRNA. Translation: BAC33948.1.
AK082425 mRNA. Translation: BAC38491.1.
AK129357 mRNA. Translation: BAC98167.1. Different initiation.
BC030907 mRNA. Translation: AAH30907.1.
CCDSiCCDS16451.1.
RefSeqiNP_109650.1. NM_030725.4.
UniGeneiMm.33490.

3D structure databases

ProteinModelPortaliQ9EQT6.
SMRiQ9EQT6. Positions 156-426.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028648.

PTM databases

PhosphoSiteiQ9EQT6.

Proteomic databases

PaxDbiQ9EQT6.
PRIDEiQ9EQT6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028648; ENSMUSP00000028648; ENSMUSG00000027220.
GeneIDi80976.
KEGGimmu:80976.
UCSCiuc008lfn.1. mouse.

Organism-specific databases

CTDi57586.
MGIiMGI:1933945. Syt13.
RougeiSearch...

Phylogenomic databases

eggNOGiNOG277582.
GeneTreeiENSGT00790000123049.
HOGENOMiHOG000231448.
HOVERGENiHBG098553.
InParanoidiQ9EQT6.
OMAiLKHQARK.
OrthoDBiEOG71P2B0.
PhylomeDBiQ9EQT6.
TreeFamiTF315600.

Miscellaneous databases

ChiTaRSiSyt13. mouse.
NextBioi350302.
PROiQ9EQT6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9EQT6.
CleanExiMM_SYT13.
GenevisibleiQ9EQT6. MM.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR028692. SYT13.
[Graphical view]
PANTHERiPTHR10024:SF211. PTHR10024:SF211. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of KIAA1427 protein as an atypical synaptotagmin (Syt XIII)."
    Fukuda M., Mikoshiba K.
    Biochem. J. 354:249-257(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH NRXN1, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
    Strain: BALB/c.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain cortex, Cerebellum and Hippocampus.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Eye.

Entry informationi

Entry nameiSYT13_MOUSE
AccessioniPrimary (citable) accession number: Q9EQT6
Secondary accession number(s): Q6ZPR2, Q8BRK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2001
Last modified: July 22, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.