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Q9EQT6

- SYT13_MOUSE

UniProt

Q9EQT6 - SYT13_MOUSE

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Protein

Synaptotagmin-13

Gene
Syt13, Kiaa1427
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in transport vesicle docking to the plasma membrane.

GO - Biological processi

  1. vesicle-mediated transport Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-13
Alternative name(s):
Synaptotagmin XIII
Short name:
SytXIII
Gene namesi
Name:Syt13
Synonyms:Kiaa1427
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1933945. Syt13.

Subcellular locationi

Cytoplasmic vesicle membrane; Single-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66Vesicular Reviewed prediction
Transmembranei7 – 2923Helical; Reviewed predictionAdd
BLAST
Topological domaini30 – 426397Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  2. integral component of plasma membrane Source: MGI
  3. transport vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Synaptotagmin-13PRO_0000183976Add
BLAST

Proteomic databases

PaxDbiQ9EQT6.
PRIDEiQ9EQT6.

PTM databases

PhosphoSiteiQ9EQT6.

Expressioni

Tissue specificityi

Expressed in brain, heart, spleen, lung and testis.1 Publication

Developmental stagei

Expressed in embryo at 7 dpc onwards.1 Publication

Gene expression databases

BgeeiQ9EQT6.
CleanExiMM_SYT13.
GenevestigatoriQ9EQT6.

Interactioni

Subunit structurei

Interacts with NRXN1.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9EQT6.
SMRiQ9EQT6. Positions 156-426.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini175 – 25985C2 1Add
BLAST
Domaini289 – 394106C2 2Add
BLAST

Domaini

The first C2 domain/C2A does not mediate Ca2+-dependent phospholipid binding.
The second C2 domain/C2B domain binds phospholipids regardless of whether calcium is present.

Sequence similaritiesi

Belongs to the synaptotagmin family.
Contains 2 C2 domains.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG277582.
GeneTreeiENSGT00750000117732.
HOGENOMiHOG000231448.
HOVERGENiHBG098553.
InParanoidiQ9EQT6.
OMAiDHDGGCD.
OrthoDBiEOG71P2B0.
PhylomeDBiQ9EQT6.
TreeFamiTF315600.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR028692. SYT13.
[Graphical view]
PANTHERiPTHR10024:SF211. PTHR10024:SF211. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EQT6-1 [UniParc]FASTAAdd to Basket

« Hide

MVLSVPVIAL GATLGTATSI LALCGVTCLC RHMHPKKGLL PRDREPDPEK    50
ARPGVLQAAQ QFNIKKSTEP VQPRPLLKFP DIYGPRPAVT APEVINYADY 100
TLETTEESAA PASPQAQSDS RLKRQVTEEL SIRPQNGVVE DVCVMETWNP 150
EKAASWNQAP KLHFRLDYDQ KKAELFVTSL EAVTSDHEGG CDCYIQGSVA 200
VKTGSVEAQT ALKKRQLHTT WEEGLALPLG EEELPTATLT LTLRTCDRFS 250
RHSVIGELRL GLDGASVPLG AAQWGELKTT AKEPSAGAGE VLLSISYLPA 300
ANRLLVVLIK AKNLHSNQSK ELLGKDVSVK VTLKHQAQKL KKKQTKRAKH 350
KINPVWNEMI MFELPDDLLR ASSVELEVLG QGEEGPSCEL GHCSLGLHAS 400
GSERSHWEEM LKNPRRQIAM WHQLHL 426
Length:426
Mass (Da):46,870
Last modified:March 1, 2001 - v1
Checksum:i8B67FAF369861CBE
GO

Sequence cautioni

The sequence BAC98167.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti52 – 521R → G in BAC31748. 1 Publication
Sequence conflicti103 – 1031E → G in BAC98167. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB048947 mRNA. Translation: BAB19628.1.
AK044038 mRNA. Translation: BAC31748.1.
AK049840 mRNA. Translation: BAC33948.1.
AK082425 mRNA. Translation: BAC38491.1.
AK129357 mRNA. Translation: BAC98167.1. Different initiation.
BC030907 mRNA. Translation: AAH30907.1.
CCDSiCCDS16451.1.
RefSeqiNP_109650.1. NM_030725.4.
UniGeneiMm.33490.

Genome annotation databases

EnsembliENSMUST00000028648; ENSMUSP00000028648; ENSMUSG00000027220.
GeneIDi80976.
KEGGimmu:80976.
UCSCiuc008lfn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB048947 mRNA. Translation: BAB19628.1 .
AK044038 mRNA. Translation: BAC31748.1 .
AK049840 mRNA. Translation: BAC33948.1 .
AK082425 mRNA. Translation: BAC38491.1 .
AK129357 mRNA. Translation: BAC98167.1 . Different initiation.
BC030907 mRNA. Translation: AAH30907.1 .
CCDSi CCDS16451.1.
RefSeqi NP_109650.1. NM_030725.4.
UniGenei Mm.33490.

3D structure databases

ProteinModelPortali Q9EQT6.
SMRi Q9EQT6. Positions 156-426.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9EQT6.

Proteomic databases

PaxDbi Q9EQT6.
PRIDEi Q9EQT6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028648 ; ENSMUSP00000028648 ; ENSMUSG00000027220 .
GeneIDi 80976.
KEGGi mmu:80976.
UCSCi uc008lfn.1. mouse.

Organism-specific databases

CTDi 57586.
MGIi MGI:1933945. Syt13.
Rougei Search...

Phylogenomic databases

eggNOGi NOG277582.
GeneTreei ENSGT00750000117732.
HOGENOMi HOG000231448.
HOVERGENi HBG098553.
InParanoidi Q9EQT6.
OMAi DHDGGCD.
OrthoDBi EOG71P2B0.
PhylomeDBi Q9EQT6.
TreeFami TF315600.

Miscellaneous databases

ChiTaRSi SYT13. mouse.
NextBioi 350302.
PROi Q9EQT6.
SOURCEi Search...

Gene expression databases

Bgeei Q9EQT6.
CleanExi MM_SYT13.
Genevestigatori Q9EQT6.

Family and domain databases

Gene3Di 2.60.40.150. 2 hits.
InterProi IPR000008. C2_dom.
IPR028692. SYT13.
[Graphical view ]
PANTHERi PTHR10024:SF211. PTHR10024:SF211. 1 hit.
Pfami PF00168. C2. 2 hits.
[Graphical view ]
SMARTi SM00239. C2. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 2 hits.
PROSITEi PS50004. C2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of KIAA1427 protein as an atypical synaptotagmin (Syt XIII)."
    Fukuda M., Mikoshiba K.
    Biochem. J. 354:249-257(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH NRXN1, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
    Strain: BALB/c.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain cortex, Cerebellum and Hippocampus.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Eye.

Entry informationi

Entry nameiSYT13_MOUSE
AccessioniPrimary (citable) accession number: Q9EQT6
Secondary accession number(s): Q6ZPR2, Q8BRK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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