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Q9EQT6

- SYT13_MOUSE

UniProt

Q9EQT6 - SYT13_MOUSE

Protein

Synaptotagmin-13

Gene

Syt13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    May be involved in transport vesicle docking to the plasma membrane.

    GO - Biological processi

    1. vesicle-mediated transport Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synaptotagmin-13
    Alternative name(s):
    Synaptotagmin XIII
    Short name:
    SytXIII
    Gene namesi
    Name:Syt13
    Synonyms:Kiaa1427
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1933945. Syt13.

    Subcellular locationi

    Cytoplasmic vesicle membrane 1 Publication; Single-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
    2. integral component of plasma membrane Source: MGI
    3. transport vesicle Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 426426Synaptotagmin-13PRO_0000183976Add
    BLAST

    Proteomic databases

    PaxDbiQ9EQT6.
    PRIDEiQ9EQT6.

    PTM databases

    PhosphoSiteiQ9EQT6.

    Expressioni

    Tissue specificityi

    Expressed in brain, heart, spleen, lung and testis.1 Publication

    Developmental stagei

    Expressed in embryo at 7 dpc onwards.1 Publication

    Gene expression databases

    BgeeiQ9EQT6.
    CleanExiMM_SYT13.
    GenevestigatoriQ9EQT6.

    Interactioni

    Subunit structurei

    Interacts with NRXN1.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ9EQT6.
    SMRiQ9EQT6. Positions 156-426.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 66VesicularSequence Analysis
    Topological domaini30 – 426397CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2923HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini175 – 25985C2 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini289 – 394106C2 2PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The first C2 domain/C2A does not mediate Ca2+-dependent phospholipid binding.
    The second C2 domain/C2B domain binds phospholipids regardless of whether calcium is present.

    Sequence similaritiesi

    Belongs to the synaptotagmin family.Curated
    Contains 2 C2 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG277582.
    GeneTreeiENSGT00750000117732.
    HOGENOMiHOG000231448.
    HOVERGENiHBG098553.
    InParanoidiQ9EQT6.
    OMAiDHDGGCD.
    OrthoDBiEOG71P2B0.
    PhylomeDBiQ9EQT6.
    TreeFamiTF315600.

    Family and domain databases

    Gene3Di2.60.40.150. 2 hits.
    InterProiIPR000008. C2_dom.
    IPR028692. SYT13.
    [Graphical view]
    PANTHERiPTHR10024:SF211. PTHR10024:SF211. 1 hit.
    PfamiPF00168. C2. 2 hits.
    [Graphical view]
    SMARTiSM00239. C2. 1 hit.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 2 hits.
    PROSITEiPS50004. C2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9EQT6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLSVPVIAL GATLGTATSI LALCGVTCLC RHMHPKKGLL PRDREPDPEK    50
    ARPGVLQAAQ QFNIKKSTEP VQPRPLLKFP DIYGPRPAVT APEVINYADY 100
    TLETTEESAA PASPQAQSDS RLKRQVTEEL SIRPQNGVVE DVCVMETWNP 150
    EKAASWNQAP KLHFRLDYDQ KKAELFVTSL EAVTSDHEGG CDCYIQGSVA 200
    VKTGSVEAQT ALKKRQLHTT WEEGLALPLG EEELPTATLT LTLRTCDRFS 250
    RHSVIGELRL GLDGASVPLG AAQWGELKTT AKEPSAGAGE VLLSISYLPA 300
    ANRLLVVLIK AKNLHSNQSK ELLGKDVSVK VTLKHQAQKL KKKQTKRAKH 350
    KINPVWNEMI MFELPDDLLR ASSVELEVLG QGEEGPSCEL GHCSLGLHAS 400
    GSERSHWEEM LKNPRRQIAM WHQLHL 426
    Length:426
    Mass (Da):46,870
    Last modified:March 1, 2001 - v1
    Checksum:i8B67FAF369861CBE
    GO

    Sequence cautioni

    The sequence BAC98167.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti52 – 521R → G in BAC31748. (PubMed:16141072)Curated
    Sequence conflicti103 – 1031E → G in BAC98167. (PubMed:14621295)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB048947 mRNA. Translation: BAB19628.1.
    AK044038 mRNA. Translation: BAC31748.1.
    AK049840 mRNA. Translation: BAC33948.1.
    AK082425 mRNA. Translation: BAC38491.1.
    AK129357 mRNA. Translation: BAC98167.1. Different initiation.
    BC030907 mRNA. Translation: AAH30907.1.
    CCDSiCCDS16451.1.
    RefSeqiNP_109650.1. NM_030725.4.
    UniGeneiMm.33490.

    Genome annotation databases

    EnsembliENSMUST00000028648; ENSMUSP00000028648; ENSMUSG00000027220.
    GeneIDi80976.
    KEGGimmu:80976.
    UCSCiuc008lfn.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB048947 mRNA. Translation: BAB19628.1 .
    AK044038 mRNA. Translation: BAC31748.1 .
    AK049840 mRNA. Translation: BAC33948.1 .
    AK082425 mRNA. Translation: BAC38491.1 .
    AK129357 mRNA. Translation: BAC98167.1 . Different initiation.
    BC030907 mRNA. Translation: AAH30907.1 .
    CCDSi CCDS16451.1.
    RefSeqi NP_109650.1. NM_030725.4.
    UniGenei Mm.33490.

    3D structure databases

    ProteinModelPortali Q9EQT6.
    SMRi Q9EQT6. Positions 156-426.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9EQT6.

    Proteomic databases

    PaxDbi Q9EQT6.
    PRIDEi Q9EQT6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028648 ; ENSMUSP00000028648 ; ENSMUSG00000027220 .
    GeneIDi 80976.
    KEGGi mmu:80976.
    UCSCi uc008lfn.1. mouse.

    Organism-specific databases

    CTDi 57586.
    MGIi MGI:1933945. Syt13.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG277582.
    GeneTreei ENSGT00750000117732.
    HOGENOMi HOG000231448.
    HOVERGENi HBG098553.
    InParanoidi Q9EQT6.
    OMAi DHDGGCD.
    OrthoDBi EOG71P2B0.
    PhylomeDBi Q9EQT6.
    TreeFami TF315600.

    Miscellaneous databases

    ChiTaRSi SYT13. mouse.
    NextBioi 350302.
    PROi Q9EQT6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9EQT6.
    CleanExi MM_SYT13.
    Genevestigatori Q9EQT6.

    Family and domain databases

    Gene3Di 2.60.40.150. 2 hits.
    InterProi IPR000008. C2_dom.
    IPR028692. SYT13.
    [Graphical view ]
    PANTHERi PTHR10024:SF211. PTHR10024:SF211. 1 hit.
    Pfami PF00168. C2. 2 hits.
    [Graphical view ]
    SMARTi SM00239. C2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 2 hits.
    PROSITEi PS50004. C2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of KIAA1427 protein as an atypical synaptotagmin (Syt XIII)."
      Fukuda M., Mikoshiba K.
      Biochem. J. 354:249-257(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH NRXN1, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
      Strain: BALB/c.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Brain cortex, Cerebellum and Hippocampus.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Eye.

    Entry informationi

    Entry nameiSYT13_MOUSE
    AccessioniPrimary (citable) accession number: Q9EQT6
    Secondary accession number(s): Q6ZPR2, Q8BRK6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3