Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tubulointerstitial nephritis antigen-like

Gene

Tinagl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

MEROPSiC01.975.

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulointerstitial nephritis antigen-like
Alternative name(s):
Glucocorticoid-inducible protein 5
Gene namesi
Name:Tinagl1
Synonyms:Gis5, Lcn7, Tinagl
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70956. Tinagl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 467446Tubulointerstitial nephritis antigen-likePRO_0000026484Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 72AlternatePROSITE-ProRule annotation
Disulfide bondi70 ↔ 84AlternatePROSITE-ProRule annotation
Disulfide bondi70 ↔ 72PROSITE-ProRule annotation
Disulfide bondi76 ↔ 83PROSITE-ProRule annotation
Glycosylationi77 – 771N-linked (GlcNAc...)Sequence analysis
Disulfide bondi84 ↔ 91PROSITE-ProRule annotation
Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9EQT5.
PRIDEiQ9EQT5.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018464.

Structurei

3D structure databases

ProteinModelPortaliQ9EQT5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 9648SMBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation
Contains 1 SMB (somatomedin-B) domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1544. Eukaryota.
ENOG410YN9K. LUCA.
HOGENOMiHOG000241342.
HOVERGENiHBG053961.
InParanoidiQ9EQT5.
PhylomeDBiQ9EQT5.

Family and domain databases

InterProiIPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR001212. Somatomedin_B_dom.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00524. SMB_1. 1 hit.
PS50958. SMB_2. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EQT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWGCPLGLLL LLLAGQAALE ARRSRWRREL APGLHLRGIR DAGGRYCQEQ
60 70 80 90 100
DMCCRGRADE CALPYLGATC YCDLFCNRTV SDCCPDFWDF CLGIPPPFPP
110 120 130 140 150
VQGCMHAGRI YPIFGTYWEN CNRCTCHEKG QWECDQEPCL VDPAMIKAIN
160 170 180 190 200
RGNYGWQAGN HSAFWGMTLD EGIRYRLGTI RPSSSVMNMN EIYTVLGQGE
210 220 230 240 250
VLPTAFEASE KWPNLIHEPL DQGNCAGSWA FSTAAVASDR VSIHSLGHMT
260 270 280 290 300
PILSPQNLLS CDTHHQKGCR GGRLDGAWWF LRRRGVVSDN CYPFSGREQN
310 320 330 340 350
DEASPTPRCM MHSRAMGRGK RQATSRCPNS QVDSNDIYQV TPVYRLASDE
360 370 380 390 400
KEIMKELMEN GPVQALMEVH EDFFLYQRGI YSHTPVSQGR PEQYRRHGTH
410 420 430 440 450
SVKITGWGEE TLPDGRTIKY WTAANSWGPW WGERGHFRIV RGINECDIET
460
FVLGVWGRVG MEDMGHH
Length:467
Mass (Da):52,821
Last modified:March 1, 2001 - v1
Checksum:iFB844FAEE7B1EC8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB050717 mRNA. Translation: BAB18637.1.
RefSeqiNP_446034.1. NM_053582.2.
UniGeneiRn.1256.

Genome annotation databases

GeneIDi94174.
KEGGirno:94174.
UCSCiRGD:70956. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB050717 mRNA. Translation: BAB18637.1.
RefSeqiNP_446034.1. NM_053582.2.
UniGeneiRn.1256.

3D structure databases

ProteinModelPortaliQ9EQT5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018464.

Protein family/group databases

MEROPSiC01.975.

Proteomic databases

PaxDbiQ9EQT5.
PRIDEiQ9EQT5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi94174.
KEGGirno:94174.
UCSCiRGD:70956. rat.

Organism-specific databases

CTDi64129.
RGDi70956. Tinagl1.

Phylogenomic databases

eggNOGiKOG1544. Eukaryota.
ENOG410YN9K. LUCA.
HOGENOMiHOG000241342.
HOVERGENiHBG053961.
InParanoidiQ9EQT5.
PhylomeDBiQ9EQT5.

Miscellaneous databases

PROiQ9EQT5.

Family and domain databases

InterProiIPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR001212. Somatomedin_B_dom.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00524. SMB_1. 1 hit.
PS50958. SMB_2. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of a novel glucocorticoid-inducible cDNA partially homologous to tubulointerstitial nephritis antigen."
    Yoshida H., Takaishi K., Harada M., Nagasaka T., Tsurufuji S., Taniguchi M.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTINAL_RAT
AccessioniPrimary (citable) accession number: Q9EQT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.