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Protein

Lathosterol oxidase

Gene

Sc5d

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol.1 Publication

Catalytic activityi

A Delta7-sterol + 2 ferrocytochrome b5 + O2 + 2 H+ = a Delta(5,7)-sterol + 2 ferricytochrome b5 + 2 H2O.2 Publications

Cofactori

Fe cationBy similarity

GO - Molecular functioni

  • C-5 sterol desaturase activity Source: RGD
  • iron ion binding Source: InterPro
  • lathosterol oxidase activity Source: RGD

GO - Biological processi

  • cholesterol biosynthetic process via lathosterol Source: RGD
  • fatty acid metabolic process Source: RGD

Keywordsi

Molecular functionOxidoreductase
Biological processLipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism
LigandIron

Enzyme and pathway databases

ReactomeiR-RNO-6807047 Cholesterol biosynthesis via desmosterol
R-RNO-6807062 Cholesterol biosynthesis via lathosterol

Names & Taxonomyi

Protein namesi
Recommended name:
Lathosterol oxidase (EC:1.14.19.20)
Alternative name(s):
C-5 sterol desaturase
Delta(7)-sterol 5-desaturase
Delta(7)-sterol C5(6)-desaturase
Lathosterol 5-desaturase
Sterol-C5-desaturaseImported
Gene namesi
Name:Sc5dImported
Synonyms:C5dImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi620775 Sc5d

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004345581 – 299Lathosterol oxidaseAdd BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei253PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9EQS5

Expressioni

Gene expression databases

BgeeiENSRNOG00000008305
GenevisibleiQ9EQS5 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011284

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi138 – 143Histidine box-16
Motifi151 – 155Histidine box-25
Motifi228 – 233Histidine box-36

Domaini

The histidine box domains may contain the active site and/or be involved in metal ion binding.

Sequence similaritiesi

Belongs to the sterol desaturase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0872 Eukaryota
COG3000 LUCA
GeneTreeiENSGT00550000075101
HOGENOMiHOG000200579
HOVERGENiHBG012628
KOiK00227
OMAiFINGSAH
OrthoDBiEOG091G0C85
PhylomeDBiQ9EQS5
TreeFamiTF300797

Family and domain databases

InterProiView protein in InterPro
IPR006694 Fatty_acid_hydroxylase
PfamiView protein in Pfam
PF04116 FA_hydroxylase, 1 hit

Sequencei

Sequence statusi: Complete.

Q9EQS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLVLSAADY YFFTPYVYPA TWPEDNIIRQ TVSLLVVTNL GAYILYFFCA
60 70 80 90 100
TLSYYFVYDH SLMKHPQFLK NQVSREIMFT VKSLPWISIP TVSLFLLELR
110 120 130 140 150
GYSKLYDDIG DFPNGWIHLI MSVISFLFFT DMLIYWIHRG LHHRLLYKHI
160 170 180 190 200
HKPHHIWKIP TPFASHAFHP VDGFLQSLPY HIYPFVFPLH KVVYLGLYVL
210 220 230 240 250
VNVWTISIHD GDFRVPQIFR PFINGSAHHT DHHMLFDYNY GQYFTLWDRI
260 270 280 290
GGSFKHPSSF EGKGPHSYVK NMTEKESNSL AENGCKSKKL CNGEFTKNE
Length:299
Mass (Da):35,147
Last modified:March 1, 2001 - v1
Checksum:iAE2D03FF486A46A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052846 mRNA Translation: BAB19798.1
AC133265 Genomic DNA No translation available.
CH473975 Genomic DNA Translation: EDL95251.1
BC081704 mRNA Translation: AAH81704.1
RefSeqiNP_446094.1, NM_053642.2
XP_017450895.1, XM_017595406.1
UniGeneiRn.17462
Rn.18741

Genome annotation databases

EnsembliENSRNOT00000011284; ENSRNOP00000011284; ENSRNOG00000008305
GeneIDi114100
KEGGirno:114100
UCSCiRGD:620775 rat

Similar proteinsi

Entry informationi

Entry nameiSC5D_RAT
AccessioniPrimary (citable) accession number: Q9EQS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2015
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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