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Protein

C-Myc-binding protein

Gene

Mycbp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
C-Myc-binding protein
Alternative name(s):
Associate of Myc 1
Short name:
AMY-1
Gene namesi
Name:Mycbp
Synonyms:Amy1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1891750. Mycbp.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002209811 – 103C-Myc-binding proteinAdd BLAST103

Proteomic databases

EPDiQ9EQS3.
MaxQBiQ9EQS3.
PaxDbiQ9EQS3.
PeptideAtlasiQ9EQS3.
PRIDEiQ9EQS3.

PTM databases

iPTMnetiQ9EQS3.
PhosphoSitePlusiQ9EQS3.

Expressioni

Inductioni

MYCBP expression is synergistically activated by SP1 and GATA-1.1 Publication

Gene expression databases

BgeeiENSMUSG00000028647.
CleanExiMM_AMY1.
MM_MYCBP.
ExpressionAtlasiQ9EQS3. baseline and differential.
GenevisibleiQ9EQS3. MM.

Interactioni

Subunit structurei

Binds via its C-terminal region to the N-terminal region of MYC. Associates with AKAP1/S-AKAP84. Interacts with MYCBPAP (By similarity).By similarity

Protein-protein interaction databases

BioGridi207892. 1 interactor.
CORUMiQ9EQS3.
IntActiQ9EQS3. 1 interactor.
STRINGi10090.ENSMUSP00000030400.

Structurei

3D structure databases

ProteinModelPortaliQ9EQS3.
SMRiQ9EQS3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AMY1 family.Curated

Phylogenomic databases

eggNOGiENOG410J2G0. Eukaryota.
ENOG41126S1. LUCA.
GeneTreeiENSGT00390000017974.
HOGENOMiHOG000260967.
HOVERGENiHBG052546.
InParanoidiQ9EQS3.
OMAiQYEPLQE.
TreeFamiTF329224.

Family and domain databases

InterProiView protein in InterPro
IPR026060. AMY1.
PANTHERiPTHR13168. PTHR13168. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9EQS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHYKAADSK REQFRRYLEK SGVLDTLTKV LVALYEEPEK PTSALDFLKH
60 70 80 90 100
HLGAATPENP EIELLRLELA EMKEKYEATV EENKKLKAKL VQYEPPQEEK

RAE
Length:103
Mass (Da):11,970
Last modified:September 18, 2013 - v5
Checksum:i7B9D901788F912D0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11R → H in BAB20018 (PubMed:12620400).Curated1
Sequence conflicti65L → V in BAA31257 (PubMed:12620400).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015858 mRNA. Translation: BAA31257.1.
AB052913 Genomic DNA. Translation: BAB20018.1.
AK077633 mRNA. Translation: BAC36916.1.
AK077762 mRNA. Translation: BAC36997.1.
AK037661 mRNA. Translation: BAE20517.1.
AK145773 mRNA. Translation: BAE26643.1.
AL606962 Genomic DNA. No translation available.
CH466552 Genomic DNA. Translation: EDL30369.1.
BC028344 mRNA. Translation: AAH28344.1.
BC048478 mRNA. Translation: AAH48478.1.
CCDSiCCDS18621.1.
RefSeqiNP_062634.2. NM_019660.3.
UniGeneiMm.446553.

Genome annotation databases

EnsembliENSMUST00000030400; ENSMUSP00000030400; ENSMUSG00000028647.
GeneIDi56309.
KEGGimmu:56309.
UCSCiuc008uql.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiMYCBP_MOUSE
AccessioniPrimary (citable) accession number: Q9EQS3
Secondary accession number(s): O88308, Q8R048
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: September 18, 2013
Last modified: September 27, 2017
This is version 102 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families