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Protein

C-Myc-binding protein

Gene

Mycbp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
C-Myc-binding protein
Alternative name(s):
Associate of Myc 1
Short name:
AMY-1
Gene namesi
Name:Mycbp
Synonyms:Amy1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1891750. Mycbp.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Translocates into the nucleus in the S phase of the cell cycle.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 103102C-Myc-binding proteinPRO_0000220981Add
BLAST

Proteomic databases

EPDiQ9EQS3.
MaxQBiQ9EQS3.
PaxDbiQ9EQS3.
PRIDEiQ9EQS3.

PTM databases

iPTMnetiQ9EQS3.
PhosphoSiteiQ9EQS3.

Expressioni

Inductioni

MYCBP expression is synergistically activated by SP1 and GATA-1.1 Publication

Gene expression databases

CleanExiMM_AMY1.
MM_MYCBP.
ExpressionAtlasiQ9EQS3. baseline and differential.
GenevisibleiQ9EQS3. MM.

Interactioni

Subunit structurei

Binds via its C-terminal region to the N-terminal region of MYC. Associates with AKAP1/S-AKAP84. Interacts with MYCBPAP (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9EQS3. 1 interaction.
STRINGi10090.ENSMUSP00000030400.

Structurei

3D structure databases

ProteinModelPortaliQ9EQS3.
SMRiQ9EQS3. Positions 43-94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AMY1 family.Curated

Phylogenomic databases

eggNOGiENOG410J2G0. Eukaryota.
ENOG41126S1. LUCA.
GeneTreeiENSGT00390000017974.
HOGENOMiHOG000260967.
HOVERGENiHBG052546.
InParanoidiQ9EQS3.
OMAiQYEPLQE.
OrthoDBiEOG7Q8CNC.
TreeFamiTF329224.

Family and domain databases

InterProiIPR026060. AMY1.
[Graphical view]
PANTHERiPTHR13168. PTHR13168. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EQS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHYKAADSK REQFRRYLEK SGVLDTLTKV LVALYEEPEK PTSALDFLKH
60 70 80 90 100
HLGAATPENP EIELLRLELA EMKEKYEATV EENKKLKAKL VQYEPPQEEK

RAE
Length:103
Mass (Da):11,970
Last modified:September 18, 2013 - v5
Checksum:i7B9D901788F912D0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111R → H in BAB20018 (PubMed:12620400).Curated
Sequence conflicti65 – 651L → V in BAA31257 (PubMed:12620400).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015858 mRNA. Translation: BAA31257.1.
AB052913 Genomic DNA. Translation: BAB20018.1.
AK077633 mRNA. Translation: BAC36916.1.
AK077762 mRNA. Translation: BAC36997.1.
AK037661 mRNA. Translation: BAE20517.1.
AK145773 mRNA. Translation: BAE26643.1.
AL606962 Genomic DNA. No translation available.
CH466552 Genomic DNA. Translation: EDL30369.1.
BC028344 mRNA. Translation: AAH28344.1.
BC048478 mRNA. Translation: AAH48478.1.
CCDSiCCDS18621.1.
RefSeqiNP_062634.2. NM_019660.3.
UniGeneiMm.446553.

Genome annotation databases

EnsembliENSMUST00000030400; ENSMUSP00000030400; ENSMUSG00000028647.
GeneIDi56309.
KEGGimmu:56309.
UCSCiuc008uql.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015858 mRNA. Translation: BAA31257.1.
AB052913 Genomic DNA. Translation: BAB20018.1.
AK077633 mRNA. Translation: BAC36916.1.
AK077762 mRNA. Translation: BAC36997.1.
AK037661 mRNA. Translation: BAE20517.1.
AK145773 mRNA. Translation: BAE26643.1.
AL606962 Genomic DNA. No translation available.
CH466552 Genomic DNA. Translation: EDL30369.1.
BC028344 mRNA. Translation: AAH28344.1.
BC048478 mRNA. Translation: AAH48478.1.
CCDSiCCDS18621.1.
RefSeqiNP_062634.2. NM_019660.3.
UniGeneiMm.446553.

3D structure databases

ProteinModelPortaliQ9EQS3.
SMRiQ9EQS3. Positions 43-94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9EQS3. 1 interaction.
STRINGi10090.ENSMUSP00000030400.

PTM databases

iPTMnetiQ9EQS3.
PhosphoSiteiQ9EQS3.

Proteomic databases

EPDiQ9EQS3.
MaxQBiQ9EQS3.
PaxDbiQ9EQS3.
PRIDEiQ9EQS3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030400; ENSMUSP00000030400; ENSMUSG00000028647.
GeneIDi56309.
KEGGimmu:56309.
UCSCiuc008uql.1. mouse.

Organism-specific databases

CTDi26292.
MGIiMGI:1891750. Mycbp.

Phylogenomic databases

eggNOGiENOG410J2G0. Eukaryota.
ENOG41126S1. LUCA.
GeneTreeiENSGT00390000017974.
HOGENOMiHOG000260967.
HOVERGENiHBG052546.
InParanoidiQ9EQS3.
OMAiQYEPLQE.
OrthoDBiEOG7Q8CNC.
TreeFamiTF329224.

Miscellaneous databases

PROiQ9EQS3.
SOURCEiSearch...

Gene expression databases

CleanExiMM_AMY1.
MM_MYCBP.
ExpressionAtlasiQ9EQS3. baseline and differential.
GenevisibleiQ9EQS3. MM.

Family and domain databases

InterProiIPR026060. AMY1.
[Graphical view]
PANTHERiPTHR13168. PTHR13168. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the mouse AMY-1 gene and identification of the synergistic activation of the AMY-1 promoter by GATA-1 and Sp1."
    Furusawa M., Taira T., Iguchi-Ariga S.M.M., Ariga H.
    Genomics 81:221-233(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], INDUCTION.
    Strain: 129/SvEvTacfBr.
    Tissue: Spleen and Thymus.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor and Testis.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Kidney, Pancreas and Testis.

Entry informationi

Entry nameiMYCBP_MOUSE
AccessioniPrimary (citable) accession number: Q9EQS3
Secondary accession number(s): O88308, Q8R048
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: September 18, 2013
Last modified: June 8, 2016
This is version 94 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.