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Protein

C-Myc-binding protein

Gene

Mycbp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
C-Myc-binding protein
Alternative name(s):
Associate of Myc 1
Short name:
AMY-1
Gene namesi
Name:Mycbp
Synonyms:Amy1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1891750. Mycbp.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Translocates into the nucleus in the S phase of the cell cycle.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 103102C-Myc-binding proteinPRO_0000220981Add
BLAST

Proteomic databases

EPDiQ9EQS3.
MaxQBiQ9EQS3.
PaxDbiQ9EQS3.
PeptideAtlasiQ9EQS3.
PRIDEiQ9EQS3.

PTM databases

iPTMnetiQ9EQS3.
PhosphoSiteiQ9EQS3.

Expressioni

Inductioni

MYCBP expression is synergistically activated by SP1 and GATA-1.1 Publication

Gene expression databases

BgeeiENSMUSG00000028647.
CleanExiMM_AMY1.
MM_MYCBP.
ExpressionAtlasiQ9EQS3. baseline and differential.
GenevisibleiQ9EQS3. MM.

Interactioni

Subunit structurei

Binds via its C-terminal region to the N-terminal region of MYC. Associates with AKAP1/S-AKAP84. Interacts with MYCBPAP (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9EQS3. 1 interaction.
STRINGi10090.ENSMUSP00000030400.

Structurei

3D structure databases

ProteinModelPortaliQ9EQS3.
SMRiQ9EQS3. Positions 43-94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AMY1 family.Curated

Phylogenomic databases

eggNOGiENOG410J2G0. Eukaryota.
ENOG41126S1. LUCA.
GeneTreeiENSGT00390000017974.
HOGENOMiHOG000260967.
HOVERGENiHBG052546.
InParanoidiQ9EQS3.
OMAiQYEPLQE.
TreeFamiTF329224.

Family and domain databases

InterProiIPR026060. AMY1.
[Graphical view]
PANTHERiPTHR13168. PTHR13168. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EQS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHYKAADSK REQFRRYLEK SGVLDTLTKV LVALYEEPEK PTSALDFLKH
60 70 80 90 100
HLGAATPENP EIELLRLELA EMKEKYEATV EENKKLKAKL VQYEPPQEEK

RAE
Length:103
Mass (Da):11,970
Last modified:September 18, 2013 - v5
Checksum:i7B9D901788F912D0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111R → H in BAB20018 (PubMed:12620400).Curated
Sequence conflicti65 – 651L → V in BAA31257 (PubMed:12620400).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015858 mRNA. Translation: BAA31257.1.
AB052913 Genomic DNA. Translation: BAB20018.1.
AK077633 mRNA. Translation: BAC36916.1.
AK077762 mRNA. Translation: BAC36997.1.
AK037661 mRNA. Translation: BAE20517.1.
AK145773 mRNA. Translation: BAE26643.1.
AL606962 Genomic DNA. No translation available.
CH466552 Genomic DNA. Translation: EDL30369.1.
BC028344 mRNA. Translation: AAH28344.1.
BC048478 mRNA. Translation: AAH48478.1.
CCDSiCCDS18621.1.
RefSeqiNP_062634.2. NM_019660.3.
UniGeneiMm.446553.

Genome annotation databases

EnsembliENSMUST00000030400; ENSMUSP00000030400; ENSMUSG00000028647.
GeneIDi56309.
KEGGimmu:56309.
UCSCiuc008uql.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015858 mRNA. Translation: BAA31257.1.
AB052913 Genomic DNA. Translation: BAB20018.1.
AK077633 mRNA. Translation: BAC36916.1.
AK077762 mRNA. Translation: BAC36997.1.
AK037661 mRNA. Translation: BAE20517.1.
AK145773 mRNA. Translation: BAE26643.1.
AL606962 Genomic DNA. No translation available.
CH466552 Genomic DNA. Translation: EDL30369.1.
BC028344 mRNA. Translation: AAH28344.1.
BC048478 mRNA. Translation: AAH48478.1.
CCDSiCCDS18621.1.
RefSeqiNP_062634.2. NM_019660.3.
UniGeneiMm.446553.

3D structure databases

ProteinModelPortaliQ9EQS3.
SMRiQ9EQS3. Positions 43-94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9EQS3. 1 interaction.
STRINGi10090.ENSMUSP00000030400.

PTM databases

iPTMnetiQ9EQS3.
PhosphoSiteiQ9EQS3.

Proteomic databases

EPDiQ9EQS3.
MaxQBiQ9EQS3.
PaxDbiQ9EQS3.
PeptideAtlasiQ9EQS3.
PRIDEiQ9EQS3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030400; ENSMUSP00000030400; ENSMUSG00000028647.
GeneIDi56309.
KEGGimmu:56309.
UCSCiuc008uql.1. mouse.

Organism-specific databases

CTDi26292.
MGIiMGI:1891750. Mycbp.

Phylogenomic databases

eggNOGiENOG410J2G0. Eukaryota.
ENOG41126S1. LUCA.
GeneTreeiENSGT00390000017974.
HOGENOMiHOG000260967.
HOVERGENiHBG052546.
InParanoidiQ9EQS3.
OMAiQYEPLQE.
TreeFamiTF329224.

Miscellaneous databases

PROiQ9EQS3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028647.
CleanExiMM_AMY1.
MM_MYCBP.
ExpressionAtlasiQ9EQS3. baseline and differential.
GenevisibleiQ9EQS3. MM.

Family and domain databases

InterProiIPR026060. AMY1.
[Graphical view]
PANTHERiPTHR13168. PTHR13168. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMYCBP_MOUSE
AccessioniPrimary (citable) accession number: Q9EQS3
Secondary accession number(s): O88308, Q8R048
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: September 18, 2013
Last modified: September 7, 2016
This is version 96 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.