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Protein

Transaldolase

Gene

Taldo1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.By similarity

Catalytic activityi

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Transaldolase (Taldo1)
  3. no protein annotated in this organism
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei142Schiff-base intermediate with substrateBy similarity1

GO - Molecular functioni

  • carbohydrate binding Source: RGD
  • monosaccharide binding Source: RGD
  • sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity Source: RGD

GO - Biological processi

  • carbohydrate metabolic process Source: InterPro
  • fructose 6-phosphate metabolic process Source: RGD
  • glyceraldehyde-3-phosphate metabolic process Source: RGD
  • pentose-phosphate shunt Source: RGD
  • pentose-phosphate shunt, non-oxidative branch Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Pentose shunt

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

ReactomeiR-RNO-163754. Insulin effects increased synthesis of Xylulose-5-Phosphate.
R-RNO-71336. Pentose phosphate pathway (hexose monophosphate shunt).
UniPathwayiUPA00115; UER00414.

Names & Taxonomyi

Protein namesi
Recommended name:
Transaldolase (EC:2.2.1.2)
Gene namesi
Name:Taldo1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi620674. Taldo1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: RGD
  • extracellular exosome Source: Ensembl
  • intracellular membrane-bounded organelle Source: RGD
  • nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735671 – 337TransaldolaseAdd BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei115N6-acetyllysineBy similarity1
Modified residuei219N6-acetyllysineBy similarity1
Modified residuei237PhosphoserineCombined sources1
Modified residuei256PhosphoserineBy similarity1
Modified residuei269N6-acetyllysineBy similarity1
Modified residuei286N6-acetyllysineBy similarity1
Modified residuei321N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9EQS0.
PRIDEiQ9EQS0.

2D gel databases

World-2DPAGE0004:Q9EQS0.

PTM databases

iPTMnetiQ9EQS0.
PhosphoSitePlusiQ9EQS0.

Expressioni

Gene expression databases

BgeeiENSRNOG00000018367.
GenevisibleiQ9EQS0. RN.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi249806. 1 interactor.
IntActiQ9EQS0. 1 interactor.
STRINGi10116.ENSRNOP00000024863.

Structurei

3D structure databases

ProteinModelPortaliQ9EQS0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transaldolase family. Type 1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG2772. Eukaryota.
COG0176. LUCA.
GeneTreeiENSGT00390000017361.
HOGENOMiHOG000281234.
HOVERGENiHBG054014.
InParanoidiQ9EQS0.
KOiK00616.
OMAiFRNIDEI.
OrthoDBiEOG091G0FTU.
PhylomeDBiQ9EQS0.
TreeFamiTF300757.

Family and domain databases

CDDicd00957. Transaldolase_TalAB. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00492. Transaldolase_1. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001585. TAL/FSA.
IPR004730. Transaldolase_1.
IPR018225. Transaldolase_AS.
[Graphical view]
PANTHERiPTHR10683. PTHR10683. 1 hit.
PfamiPF00923. TAL_FSA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00874. talAB. 1 hit.
PROSITEiPS01054. TRANSALDOLASE_1. 1 hit.
PS00958. TRANSALDOLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EQS0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSPVKRQR MESALDQLKQ FTTVVADTGD FNAIDEYKPQ DATTNPSLIL
60 70 80 90 100
AAAQMPAYQE LVEEAIAYGK KLGGPQEEQI KNAIDKLFVL FGAEILKKIP
110 120 130 140 150
GRVSTEVDAR LSFDKDAMVA RARRIIELYK EAGISKDRIL IKLSSTWEGI
160 170 180 190 200
QAGKELEEQH GIHCNMTLLF SFAQAVACAE AGVTLISPFV GRILDWHVAN
210 220 230 240 250
TDKKSYEPQE DPGVKSVTKI YNYYKKFGYK TIVMGASFRN TGEIKALAGC
260 270 280 290 300
DFLTISPKLL GELLKDSSKL APTLSVKAAQ TSDLEKIHLD EKAFRWLHNE
310 320 330
DQMAVEKLSD GIRKFAADAI KLERMLTERM FSAENGK
Length:337
Mass (Da):37,460
Last modified:April 4, 2006 - v2
Checksum:iF01F64276053B45D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100P → L in AAG43169 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069306 mRNA. Translation: AAG43169.1.
BC059126 mRNA. Translation: AAH59126.1.
RefSeqiNP_113999.2. NM_031811.3.
UniGeneiRn.3136.

Genome annotation databases

EnsembliENSRNOT00000024863; ENSRNOP00000024863; ENSRNOG00000018367.
GeneIDi83688.
KEGGirno:83688.
UCSCiRGD:620674. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069306 mRNA. Translation: AAG43169.1.
BC059126 mRNA. Translation: AAH59126.1.
RefSeqiNP_113999.2. NM_031811.3.
UniGeneiRn.3136.

3D structure databases

ProteinModelPortaliQ9EQS0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249806. 1 interactor.
IntActiQ9EQS0. 1 interactor.
STRINGi10116.ENSRNOP00000024863.

PTM databases

iPTMnetiQ9EQS0.
PhosphoSitePlusiQ9EQS0.

2D gel databases

World-2DPAGE0004:Q9EQS0.

Proteomic databases

PaxDbiQ9EQS0.
PRIDEiQ9EQS0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024863; ENSRNOP00000024863; ENSRNOG00000018367.
GeneIDi83688.
KEGGirno:83688.
UCSCiRGD:620674. rat.

Organism-specific databases

CTDi6888.
RGDi620674. Taldo1.

Phylogenomic databases

eggNOGiKOG2772. Eukaryota.
COG0176. LUCA.
GeneTreeiENSGT00390000017361.
HOGENOMiHOG000281234.
HOVERGENiHBG054014.
InParanoidiQ9EQS0.
KOiK00616.
OMAiFRNIDEI.
OrthoDBiEOG091G0FTU.
PhylomeDBiQ9EQS0.
TreeFamiTF300757.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00414.
ReactomeiR-RNO-163754. Insulin effects increased synthesis of Xylulose-5-Phosphate.
R-RNO-71336. Pentose phosphate pathway (hexose monophosphate shunt).

Miscellaneous databases

PROiQ9EQS0.

Gene expression databases

BgeeiENSRNOG00000018367.
GenevisibleiQ9EQS0. RN.

Family and domain databases

CDDicd00957. Transaldolase_TalAB. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00492. Transaldolase_1. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001585. TAL/FSA.
IPR004730. Transaldolase_1.
IPR018225. Transaldolase_AS.
[Graphical view]
PANTHERiPTHR10683. PTHR10683. 1 hit.
PfamiPF00923. TAL_FSA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00874. talAB. 1 hit.
PROSITEiPS01054. TRANSALDOLASE_1. 1 hit.
PS00958. TRANSALDOLASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTALDO_RAT
AccessioniPrimary (citable) accession number: Q9EQS0
Secondary accession number(s): Q6PCV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: April 4, 2006
Last modified: November 30, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.