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Protein

Transaldolase

Gene

Taldo1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.By similarity

Catalytic activityi

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Transaldolase (Taldo1)
  3. no protein annotated in this organism
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei142Schiff-base intermediate with substrateBy similarity1

GO - Molecular functioni

  • carbohydrate binding Source: RGD
  • monosaccharide binding Source: RGD
  • sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity Source: RGD

GO - Biological processi

  • carbohydrate metabolic process Source: InterPro
  • fructose 6-phosphate metabolic process Source: RGD
  • glyceraldehyde-3-phosphate metabolic process Source: RGD
  • pentose-phosphate shunt Source: RGD
  • pentose-phosphate shunt, non-oxidative branch Source: RGD

Keywordsi

Molecular functionTransferase
Biological processPentose shunt
LigandSchiff base

Enzyme and pathway databases

ReactomeiR-RNO-163754 Insulin effects increased synthesis of Xylulose-5-Phosphate
R-RNO-71336 Pentose phosphate pathway (hexose monophosphate shunt)
UniPathwayiUPA00115; UER00414

Names & Taxonomyi

Protein namesi
Recommended name:
Transaldolase (EC:2.2.1.2)
Gene namesi
Name:Taldo1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi620674 Taldo1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735671 – 337TransaldolaseAdd BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei115N6-acetyllysineBy similarity1
Modified residuei219N6-acetyllysineBy similarity1
Modified residuei237PhosphoserineCombined sources1
Modified residuei256PhosphoserineBy similarity1
Modified residuei269N6-acetyllysineBy similarity1
Modified residuei286N6-acetyllysineBy similarity1
Modified residuei321N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9EQS0
PRIDEiQ9EQS0

2D gel databases

World-2DPAGEi0004:Q9EQS0

PTM databases

iPTMnetiQ9EQS0
PhosphoSitePlusiQ9EQS0

Expressioni

Gene expression databases

BgeeiENSRNOG00000018367
GenevisibleiQ9EQS0 RN

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi249806, 1 interactor
IntActiQ9EQS0, 1 interactor
STRINGi10116.ENSRNOP00000024863

Structurei

3D structure databases

ProteinModelPortaliQ9EQS0
SMRiQ9EQS0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transaldolase family. Type 1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG2772 Eukaryota
COG0176 LUCA
GeneTreeiENSGT00390000017361
HOGENOMiHOG000281234
HOVERGENiHBG054014
InParanoidiQ9EQS0
KOiK00616
OMAiMAFDKLH
OrthoDBiEOG091G0FTU
PhylomeDBiQ9EQS0
TreeFamiTF300757

Family and domain databases

CDDicd00957 Transaldolase_TalAB, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00492 Transaldolase_1, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001585 TAL/FSA
IPR004730 Transaldolase_1
IPR018225 Transaldolase_AS
PANTHERiPTHR10683 PTHR10683, 1 hit
PTHR10683:SF20 PTHR10683:SF20, 1 hit
PfamiView protein in Pfam
PF00923 TAL_FSA, 1 hit
TIGRFAMsiTIGR00874 talAB, 1 hit
PROSITEiView protein in PROSITE
PS01054 TRANSALDOLASE_1, 1 hit
PS00958 TRANSALDOLASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9EQS0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSPVKRQR MESALDQLKQ FTTVVADTGD FNAIDEYKPQ DATTNPSLIL
60 70 80 90 100
AAAQMPAYQE LVEEAIAYGK KLGGPQEEQI KNAIDKLFVL FGAEILKKIP
110 120 130 140 150
GRVSTEVDAR LSFDKDAMVA RARRIIELYK EAGISKDRIL IKLSSTWEGI
160 170 180 190 200
QAGKELEEQH GIHCNMTLLF SFAQAVACAE AGVTLISPFV GRILDWHVAN
210 220 230 240 250
TDKKSYEPQE DPGVKSVTKI YNYYKKFGYK TIVMGASFRN TGEIKALAGC
260 270 280 290 300
DFLTISPKLL GELLKDSSKL APTLSVKAAQ TSDLEKIHLD EKAFRWLHNE
310 320 330
DQMAVEKLSD GIRKFAADAI KLERMLTERM FSAENGK
Length:337
Mass (Da):37,460
Last modified:April 4, 2006 - v2
Checksum:iF01F64276053B45D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100P → L in AAG43169 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069306 mRNA Translation: AAG43169.1
BC059126 mRNA Translation: AAH59126.1
RefSeqiNP_113999.2, NM_031811.3
UniGeneiRn.3136

Genome annotation databases

EnsembliENSRNOT00000024863; ENSRNOP00000024863; ENSRNOG00000018367
GeneIDi83688
KEGGirno:83688
UCSCiRGD:620674 rat

Similar proteinsi

Entry informationi

Entry nameiTALDO_RAT
AccessioniPrimary (citable) accession number: Q9EQS0
Secondary accession number(s): Q6PCV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: April 4, 2006
Last modified: May 23, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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