ID   FANCG_MOUSE             Reviewed;         623 AA.
AC   Q9EQR6; A2AG34;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   27-MAR-2024, entry version 155.
DE   RecName: Full=Fanconi anemia group G protein homolog;
DE            Short=Protein FACG;
GN   Name=Fancg;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11093276; DOI=10.1038/sj.ejhg.5200552;
RA   Demuth I., Wlodarski M., Tipping A.J., Morgan N.V., de Winter J.P.,
RA   Thiel M., Grasl S., Schindler D., D'Andrea A.D., Altay C., Kayserili H.,
RA   Zatterale A., Kunze J., Ebell W., Mathew C.G., Joenje H., Sperling K.,
RA   Digweed M.;
RT   "Spectrum of mutations in the Fanconi anaemia group G gene, FANCG/XRCC9.";
RL   Eur. J. Hum. Genet. 8:861-868(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC   STRAIN=FVB/NJ;
RX   PubMed=11918676; DOI=10.1046/j.1365-2443.2002.00518.x;
RA   van de Vrugt H.J., Koomen M., Berns M.A., de Vries Y., Rooimans M.A.,
RA   van der Weel L., Blom E., de Groot J., Schepers R.J., Stone S.,
RA   Hoatlin M.E., Cheng N.C., Joenje H., Arwert F.;
RT   "Characterization, expression and complex formation of the murine Fanconi
RT   anaemia gene product Fancg.";
RL   Genes Cells 7:333-342(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- FUNCTION: DNA repair protein that may operate in a postreplication
CC       repair or a cell cycle checkpoint function. May be implicated in
CC       interstrand DNA cross-link repair and in the maintenance of normal
CC       chromosome stability. Candidate tumor suppressor gene (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Belongs to the multisubunit FA complex composed of FANCA,
CC       FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. In complex
CC       with FANCF, FANCA and FANCL, but not with FANCC, nor FANCE, interacts
CC       with HES1; this interaction may be essential for the stability and
CC       nuclear localization of FA core complex proteins. The complex with
CC       FANCC and FANCG may also include EIF2AK2 and HSP70. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11918676}.
CC   -!- TISSUE SPECIFICITY: Highest expression levels in spleen, thymus and
CC       testis. {ECO:0000269|PubMed:11918676}.
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DR   EMBL; AF112439; AAG43198.1; -; mRNA.
DR   EMBL; AY049715; AAL12165.1; -; mRNA.
DR   EMBL; AL672276; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS18087.1; -.
DR   RefSeq; NP_001156705.1; NM_001163233.1.
DR   RefSeq; NP_444311.1; NM_053081.2.
DR   RefSeq; XP_006538190.1; XM_006538127.2.
DR   RefSeq; XP_006538191.1; XM_006538128.2.
DR   AlphaFoldDB; Q9EQR6; -.
DR   SMR; Q9EQR6; -.
DR   BioGRID; 208603; 1.
DR   STRING; 10090.ENSMUSP00000030165; -.
DR   iPTMnet; Q9EQR6; -.
DR   PhosphoSitePlus; Q9EQR6; -.
DR   EPD; Q9EQR6; -.
DR   MaxQB; Q9EQR6; -.
DR   PaxDb; 10090-ENSMUSP00000030165; -.
DR   ProteomicsDB; 277040; -.
DR   Pumba; Q9EQR6; -.
DR   Antibodypedia; 25694; 489 antibodies from 37 providers.
DR   DNASU; 60534; -.
DR   Ensembl; ENSMUST00000030165.5; ENSMUSP00000030165.5; ENSMUSG00000028453.11.
DR   GeneID; 60534; -.
DR   KEGG; mmu:60534; -.
DR   UCSC; uc008sos.2; mouse.
DR   AGR; MGI:1926471; -.
DR   CTD; 2189; -.
DR   MGI; MGI:1926471; Fancg.
DR   VEuPathDB; HostDB:ENSMUSG00000028453; -.
DR   eggNOG; ENOG502QVUI; Eukaryota.
DR   GeneTree; ENSGT00390000007195; -.
DR   HOGENOM; CLU_018870_0_0_1; -.
DR   InParanoid; Q9EQR6; -.
DR   OMA; CCLAWRA; -.
DR   OrthoDB; 5304064at2759; -.
DR   PhylomeDB; Q9EQR6; -.
DR   TreeFam; TF330722; -.
DR   Reactome; R-MMU-6783310; Fanconi Anemia Pathway.
DR   Reactome; R-MMU-9833482; PKR-mediated signaling.
DR   BioGRID-ORCS; 60534; 36 hits in 114 CRISPR screens.
DR   ChiTaRS; Fancg; mouse.
DR   PRO; PR:Q9EQR6; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; Q9EQR6; Protein.
DR   Bgee; ENSMUSG00000028453; Expressed in spermatocyte and 178 other cell types or tissues.
DR   GO; GO:0000785; C:chromatin; ISO:MGI.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0043240; C:Fanconi anaemia nuclear complex; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; ISO:MGI.
DR   GO; GO:0005730; C:nucleolus; ISO:MGI.
DR   GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR   GO; GO:0006974; P:DNA damage response; IMP:MGI.
DR   GO; GO:0036297; P:interstrand cross-link repair; IEA:InterPro.
DR   GO; GO:0007005; P:mitochondrion organization; ISO:MGI.
DR   GO; GO:0001541; P:ovarian follicle development; IMP:MGI.
DR   GO; GO:0006513; P:protein monoubiquitination; ISO:MGI.
DR   GO; GO:0009314; P:response to radiation; IMP:MGI.
DR   GO; GO:0007286; P:spermatid development; IMP:MGI.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR039684; FANCG.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR15254:SF2; FANCONI ANEMIA GROUP G PROTEIN; 1.
DR   PANTHER; PTHR15254; FANCONI ANEMIA GROUP G PROTEIN FAMILY MEMBER; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS50293; TPR_REGION; 1.
DR   Genevisible; Q9EQR6; MM.
PE   2: Evidence at transcript level;
KW   DNA damage; DNA repair; Nucleus; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..623
FT                   /note="Fanconi anemia group G protein homolog"
FT                   /id="PRO_0000106293"
FT   REPEAT          251..284
FT                   /note="TPR 1"
FT   REPEAT          349..382
FT                   /note="TPR 2"
FT   REPEAT          458..491
FT                   /note="TPR 3"
FT   REPEAT          517..550
FT                   /note="TPR 4"
SQ   SEQUENCE   623 AA;  68506 MW;  061586EF186F74AF CRC64;
     MSSQVIPALP KTFSSSLDLW REKNDQLVRQ AKQLTRDSRP SLRRQQSAQD TLEGLRELLL
     TLQGLPAAVP ALPLELTVLC NCIILRASLV QAFTEDLTQD LQRGLERVLE AQHHLEPKSQ
     QGLKELWHSV LSASSLPPEL LPALHCLASL QAVFWMSTDH LEDLTLLLQT LNGSQTQSSE
     DLLLLLKSWS PPAEESPAPL ILQDAESLRD VLLTAFACRQ GFQELITGSL PHAQSNLHEA
     ASGLCPPSVL VQVYTALGAC LRKMGNPQRA LLYLTEALKV GTTCALPLLE ASRVYRQLGD
     RAAELESLEL LVEALSATHS SETFKSLIEV ELLLPQPDPA SPLHCGTQSQ AKHLLASRCL
     QTGRAEDAAE HYLDLLAMLL GGSETRFSPP TSSLGPCIPE LCLEAAAALI QAGRALDALT
     VCEELLNRTS SLLPKMSSLW ENARKRAKEL PCCPVWVSAT HLLQGQAWSQ LKAQKEALSE
     FSQCLELLFR TLPEDKEQGS DCEQKCRSDV ALKQLRVAAL ISRGLEWVAS GQDTKALSDF
     LLSVQICPGN RDGSFYLLQT LKRLDRKNEA SAFWREAHSQ LPLEDAAGSL PLYLETCLSW
     IHPPNREAFL EEFGTSVLES CVL
//