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Q9EQR6

- FANCG_MOUSE

UniProt

Q9EQR6 - FANCG_MOUSE

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Protein

Fanconi anemia group G protein homolog

Gene

Fancg

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene (By similarity).By similarity

GO - Biological processi

  1. cellular response to DNA damage stimulus Source: MGI
  2. DNA repair Source: UniProtKB-KW
  3. mitochondrion organization Source: Ensembl
  4. ovarian follicle development Source: MGI
  5. response to radiation Source: MGI
  6. spermatid development Source: MGI
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Fanconi anemia group G protein homolog
Short name:
Protein FACG
Gene namesi
Name:Fancg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1926471. Fancg.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. Fanconi anaemia nuclear complex Source: UniProtKB
  2. mitochondrion Source: Ensembl
  3. nucleolus Source: Ensembl
  4. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 623623Fanconi anemia group G protein homologPRO_0000106293Add
BLAST

Proteomic databases

MaxQBiQ9EQR6.
PRIDEiQ9EQR6.

PTM databases

PhosphoSiteiQ9EQR6.

Expressioni

Tissue specificityi

Highest expression levels in spleen, thymus and testis.1 Publication

Gene expression databases

BgeeiQ9EQR6.
CleanExiMM_FANCG.
ExpressionAtlasiQ9EQR6. baseline and differential.
GenevestigatoriQ9EQR6.

Interactioni

Subunit structurei

Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. In complex with FANCF, FANCA and FANCL, but not with FANCC, nor FANCE, interacts with HES1; this interaction may be essential for the stability and nuclear localization of FA core complex proteins. The complex with FANCC and FANCG may also include EIF2AK2 and HSP70.By similarity

Protein-protein interaction databases

BioGridi208603. 1 interaction.
STRINGi10090.ENSMUSP00000030165.

Structurei

3D structure databases

ProteinModelPortaliQ9EQR6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati251 – 28434TPR 1Add
BLAST
Repeati349 – 38234TPR 2Add
BLAST
Repeati458 – 49134TPR 3Add
BLAST
Repeati517 – 55034TPR 4Add
BLAST

Sequence similaritiesi

Contains 4 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiNOG40254.
GeneTreeiENSGT00390000007195.
HOGENOMiHOG000231403.
HOVERGENiHBG051551.
InParanoidiQ9EQR6.
KOiK10894.
OMAiDTKALQD.
OrthoDBiEOG7S21Z5.
PhylomeDBiQ9EQR6.
TreeFamiTF330722.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
[Graphical view]
PROSITEiPS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EQR6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSQVIPALP KTFSSSLDLW REKNDQLVRQ AKQLTRDSRP SLRRQQSAQD
60 70 80 90 100
TLEGLRELLL TLQGLPAAVP ALPLELTVLC NCIILRASLV QAFTEDLTQD
110 120 130 140 150
LQRGLERVLE AQHHLEPKSQ QGLKELWHSV LSASSLPPEL LPALHCLASL
160 170 180 190 200
QAVFWMSTDH LEDLTLLLQT LNGSQTQSSE DLLLLLKSWS PPAEESPAPL
210 220 230 240 250
ILQDAESLRD VLLTAFACRQ GFQELITGSL PHAQSNLHEA ASGLCPPSVL
260 270 280 290 300
VQVYTALGAC LRKMGNPQRA LLYLTEALKV GTTCALPLLE ASRVYRQLGD
310 320 330 340 350
RAAELESLEL LVEALSATHS SETFKSLIEV ELLLPQPDPA SPLHCGTQSQ
360 370 380 390 400
AKHLLASRCL QTGRAEDAAE HYLDLLAMLL GGSETRFSPP TSSLGPCIPE
410 420 430 440 450
LCLEAAAALI QAGRALDALT VCEELLNRTS SLLPKMSSLW ENARKRAKEL
460 470 480 490 500
PCCPVWVSAT HLLQGQAWSQ LKAQKEALSE FSQCLELLFR TLPEDKEQGS
510 520 530 540 550
DCEQKCRSDV ALKQLRVAAL ISRGLEWVAS GQDTKALSDF LLSVQICPGN
560 570 580 590 600
RDGSFYLLQT LKRLDRKNEA SAFWREAHSQ LPLEDAAGSL PLYLETCLSW
610 620
IHPPNREAFL EEFGTSVLES CVL
Length:623
Mass (Da):68,506
Last modified:March 1, 2001 - v1
Checksum:i061586EF186F74AF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF112439 mRNA. Translation: AAG43198.1.
AY049715 mRNA. Translation: AAL12165.1.
AL672276 Genomic DNA. Translation: CAM14317.1.
CCDSiCCDS18087.1.
RefSeqiNP_001156705.1. NM_001163233.1.
NP_444311.1. NM_053081.2.
XP_006538190.1. XM_006538127.1.
XP_006538191.1. XM_006538128.1.
UniGeneiMm.23122.

Genome annotation databases

EnsembliENSMUST00000030165; ENSMUSP00000030165; ENSMUSG00000028453.
GeneIDi60534.
KEGGimmu:60534.
UCSCiuc008sos.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF112439 mRNA. Translation: AAG43198.1 .
AY049715 mRNA. Translation: AAL12165.1 .
AL672276 Genomic DNA. Translation: CAM14317.1 .
CCDSi CCDS18087.1.
RefSeqi NP_001156705.1. NM_001163233.1.
NP_444311.1. NM_053081.2.
XP_006538190.1. XM_006538127.1.
XP_006538191.1. XM_006538128.1.
UniGenei Mm.23122.

3D structure databases

ProteinModelPortali Q9EQR6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 208603. 1 interaction.
STRINGi 10090.ENSMUSP00000030165.

PTM databases

PhosphoSitei Q9EQR6.

Proteomic databases

MaxQBi Q9EQR6.
PRIDEi Q9EQR6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030165 ; ENSMUSP00000030165 ; ENSMUSG00000028453 .
GeneIDi 60534.
KEGGi mmu:60534.
UCSCi uc008sos.2. mouse.

Organism-specific databases

CTDi 2189.
MGIi MGI:1926471. Fancg.

Phylogenomic databases

eggNOGi NOG40254.
GeneTreei ENSGT00390000007195.
HOGENOMi HOG000231403.
HOVERGENi HBG051551.
InParanoidi Q9EQR6.
KOi K10894.
OMAi DTKALQD.
OrthoDBi EOG7S21Z5.
PhylomeDBi Q9EQR6.
TreeFami TF330722.

Miscellaneous databases

NextBioi 314973.
PROi Q9EQR6.
SOURCEi Search...

Gene expression databases

Bgeei Q9EQR6.
CleanExi MM_FANCG.
ExpressionAtlasi Q9EQR6. baseline and differential.
Genevestigatori Q9EQR6.

Family and domain databases

Gene3Di 1.25.40.10. 1 hit.
InterProi IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
[Graphical view ]
Pfami PF00515. TPR_1. 1 hit.
[Graphical view ]
PROSITEi PS50293. TPR_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterization, expression and complex formation of the murine Fanconi anaemia gene product Fancg."
    van de Vrugt H.J., Koomen M., Berns M.A., de Vries Y., Rooimans M.A., van der Weel L., Blom E., de Groot J., Schepers R.J., Stone S., Hoatlin M.E., Cheng N.C., Joenje H., Arwert F.
    Genes Cells 7:333-342(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: FVB.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiFANCG_MOUSE
AccessioniPrimary (citable) accession number: Q9EQR6
Secondary accession number(s): A2AG34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3