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Q9EQR6

- FANCG_MOUSE

UniProt

Q9EQR6 - FANCG_MOUSE

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Protein
Fanconi anemia group G protein homolog
Gene
Fancg
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene By similarity.

GO - Biological processi

  1. DNA repair Source: UniProtKB-KW
  2. cellular response to DNA damage stimulus Source: MGI
  3. mitochondrion organization Source: Ensembl
  4. ovarian follicle development Source: MGI
  5. response to radiation Source: MGI
  6. spermatid development Source: MGI
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Fanconi anemia group G protein homolog
Short name:
Protein FACG
Gene namesi
Name:Fancg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1926471. Fancg.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. Fanconi anaemia nuclear complex Source: UniProtKB
  2. mitochondrion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 623623Fanconi anemia group G protein homolog
PRO_0000106293Add
BLAST

Proteomic databases

PRIDEiQ9EQR6.

PTM databases

PhosphoSiteiQ9EQR6.

Expressioni

Tissue specificityi

Highest expression levels in spleen, thymus and testis.1 Publication

Gene expression databases

BgeeiQ9EQR6.
CleanExiMM_FANCG.
GenevestigatoriQ9EQR6.

Interactioni

Subunit structurei

Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM By similarity. In complex with FANCF, FANCA and FANCL, but not with FANCC, nor FANCE, interacts with HES1; this interaction may be essential for the stability and nuclear localization of FA core complex proteins By similarity. The complex with FANCC and FANCG may also include EIF2AK2 and HSP70 By similarity.

Protein-protein interaction databases

BioGridi208603. 1 interaction.
STRINGi10090.ENSMUSP00000030165.

Structurei

3D structure databases

ProteinModelPortaliQ9EQR6.
SMRiQ9EQR6. Positions 253-283, 520-546, 553-590.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati251 – 28434TPR 1
Add
BLAST
Repeati349 – 38234TPR 2
Add
BLAST
Repeati458 – 49134TPR 3
Add
BLAST
Repeati517 – 55034TPR 4
Add
BLAST

Sequence similaritiesi

Contains 4 TPR repeats.

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiNOG40254.
GeneTreeiENSGT00390000007195.
HOGENOMiHOG000231403.
HOVERGENiHBG051551.
InParanoidiA2AG34.
KOiK10894.
OMAiDTKALQD.
OrthoDBiEOG7S21Z5.
PhylomeDBiQ9EQR6.
TreeFamiTF330722.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
[Graphical view]
PROSITEiPS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EQR6-1 [UniParc]FASTAAdd to Basket

« Hide

MSSQVIPALP KTFSSSLDLW REKNDQLVRQ AKQLTRDSRP SLRRQQSAQD    50
TLEGLRELLL TLQGLPAAVP ALPLELTVLC NCIILRASLV QAFTEDLTQD 100
LQRGLERVLE AQHHLEPKSQ QGLKELWHSV LSASSLPPEL LPALHCLASL 150
QAVFWMSTDH LEDLTLLLQT LNGSQTQSSE DLLLLLKSWS PPAEESPAPL 200
ILQDAESLRD VLLTAFACRQ GFQELITGSL PHAQSNLHEA ASGLCPPSVL 250
VQVYTALGAC LRKMGNPQRA LLYLTEALKV GTTCALPLLE ASRVYRQLGD 300
RAAELESLEL LVEALSATHS SETFKSLIEV ELLLPQPDPA SPLHCGTQSQ 350
AKHLLASRCL QTGRAEDAAE HYLDLLAMLL GGSETRFSPP TSSLGPCIPE 400
LCLEAAAALI QAGRALDALT VCEELLNRTS SLLPKMSSLW ENARKRAKEL 450
PCCPVWVSAT HLLQGQAWSQ LKAQKEALSE FSQCLELLFR TLPEDKEQGS 500
DCEQKCRSDV ALKQLRVAAL ISRGLEWVAS GQDTKALSDF LLSVQICPGN 550
RDGSFYLLQT LKRLDRKNEA SAFWREAHSQ LPLEDAAGSL PLYLETCLSW 600
IHPPNREAFL EEFGTSVLES CVL 623
Length:623
Mass (Da):68,506
Last modified:March 1, 2001 - v1
Checksum:i061586EF186F74AF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF112439 mRNA. Translation: AAG43198.1.
AY049715 mRNA. Translation: AAL12165.1.
AL672276 Genomic DNA. Translation: CAM14317.1.
CCDSiCCDS18087.1.
RefSeqiNP_001156705.1. NM_001163233.1.
NP_444311.1. NM_053081.2.
XP_006538190.1. XM_006538127.1.
XP_006538191.1. XM_006538128.1.
UniGeneiMm.23122.

Genome annotation databases

EnsembliENSMUST00000030165; ENSMUSP00000030165; ENSMUSG00000028453.
GeneIDi60534.
KEGGimmu:60534.
UCSCiuc008sos.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF112439 mRNA. Translation: AAG43198.1 .
AY049715 mRNA. Translation: AAL12165.1 .
AL672276 Genomic DNA. Translation: CAM14317.1 .
CCDSi CCDS18087.1.
RefSeqi NP_001156705.1. NM_001163233.1.
NP_444311.1. NM_053081.2.
XP_006538190.1. XM_006538127.1.
XP_006538191.1. XM_006538128.1.
UniGenei Mm.23122.

3D structure databases

ProteinModelPortali Q9EQR6.
SMRi Q9EQR6. Positions 253-283, 520-546, 553-590.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 208603. 1 interaction.
STRINGi 10090.ENSMUSP00000030165.

PTM databases

PhosphoSitei Q9EQR6.

Proteomic databases

PRIDEi Q9EQR6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030165 ; ENSMUSP00000030165 ; ENSMUSG00000028453 .
GeneIDi 60534.
KEGGi mmu:60534.
UCSCi uc008sos.2. mouse.

Organism-specific databases

CTDi 2189.
MGIi MGI:1926471. Fancg.

Phylogenomic databases

eggNOGi NOG40254.
GeneTreei ENSGT00390000007195.
HOGENOMi HOG000231403.
HOVERGENi HBG051551.
InParanoidi A2AG34.
KOi K10894.
OMAi DTKALQD.
OrthoDBi EOG7S21Z5.
PhylomeDBi Q9EQR6.
TreeFami TF330722.

Miscellaneous databases

NextBioi 314973.
PROi Q9EQR6.
SOURCEi Search...

Gene expression databases

Bgeei Q9EQR6.
CleanExi MM_FANCG.
Genevestigatori Q9EQR6.

Family and domain databases

Gene3Di 1.25.40.10. 1 hit.
InterProi IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
[Graphical view ]
Pfami PF00515. TPR_1. 1 hit.
[Graphical view ]
PROSITEi PS50293. TPR_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterization, expression and complex formation of the murine Fanconi anaemia gene product Fancg."
    van de Vrugt H.J., Koomen M., Berns M.A., de Vries Y., Rooimans M.A., van der Weel L., Blom E., de Groot J., Schepers R.J., Stone S., Hoatlin M.E., Cheng N.C., Joenje H., Arwert F.
    Genes Cells 7:333-342(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: FVB.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiFANCG_MOUSE
AccessioniPrimary (citable) accession number: Q9EQR6
Secondary accession number(s): A2AG34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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