Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fanconi anemia group G protein homolog

Gene

Fancg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene (By similarity).By similarity

GO - Biological processi

  • cellular response to DNA damage stimulus Source: MGI
  • DNA repair Source: UniProtKB-KW
  • mitochondrion organization Source: MGI
  • ovarian follicle development Source: MGI
  • response to radiation Source: MGI
  • spermatid development Source: MGI
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

ReactomeiREACT_290303. Fanconi Anemia pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Fanconi anemia group G protein homolog
Short name:
Protein FACG
Gene namesi
Name:Fancg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1926471. Fancg.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 623623Fanconi anemia group G protein homologPRO_0000106293Add
BLAST

Proteomic databases

MaxQBiQ9EQR6.
PRIDEiQ9EQR6.

PTM databases

PhosphoSiteiQ9EQR6.

Expressioni

Tissue specificityi

Highest expression levels in spleen, thymus and testis.1 Publication

Gene expression databases

BgeeiQ9EQR6.
CleanExiMM_FANCG.
ExpressionAtlasiQ9EQR6. baseline and differential.
GenevisibleiQ9EQR6. MM.

Interactioni

Subunit structurei

Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. In complex with FANCF, FANCA and FANCL, but not with FANCC, nor FANCE, interacts with HES1; this interaction may be essential for the stability and nuclear localization of FA core complex proteins. The complex with FANCC and FANCG may also include EIF2AK2 and HSP70.By similarity

Protein-protein interaction databases

BioGridi208603. 1 interaction.
STRINGi10090.ENSMUSP00000030165.

Structurei

3D structure databases

ProteinModelPortaliQ9EQR6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati251 – 28434TPR 1Add
BLAST
Repeati349 – 38234TPR 2Add
BLAST
Repeati458 – 49134TPR 3Add
BLAST
Repeati517 – 55034TPR 4Add
BLAST

Sequence similaritiesi

Contains 4 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiNOG40254.
GeneTreeiENSGT00390000007195.
HOGENOMiHOG000231403.
HOVERGENiHBG051551.
InParanoidiQ9EQR6.
KOiK10894.
OMAiSRGLEWV.
OrthoDBiEOG7S21Z5.
PhylomeDBiQ9EQR6.
TreeFamiTF330722.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
[Graphical view]
PROSITEiPS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EQR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSQVIPALP KTFSSSLDLW REKNDQLVRQ AKQLTRDSRP SLRRQQSAQD
60 70 80 90 100
TLEGLRELLL TLQGLPAAVP ALPLELTVLC NCIILRASLV QAFTEDLTQD
110 120 130 140 150
LQRGLERVLE AQHHLEPKSQ QGLKELWHSV LSASSLPPEL LPALHCLASL
160 170 180 190 200
QAVFWMSTDH LEDLTLLLQT LNGSQTQSSE DLLLLLKSWS PPAEESPAPL
210 220 230 240 250
ILQDAESLRD VLLTAFACRQ GFQELITGSL PHAQSNLHEA ASGLCPPSVL
260 270 280 290 300
VQVYTALGAC LRKMGNPQRA LLYLTEALKV GTTCALPLLE ASRVYRQLGD
310 320 330 340 350
RAAELESLEL LVEALSATHS SETFKSLIEV ELLLPQPDPA SPLHCGTQSQ
360 370 380 390 400
AKHLLASRCL QTGRAEDAAE HYLDLLAMLL GGSETRFSPP TSSLGPCIPE
410 420 430 440 450
LCLEAAAALI QAGRALDALT VCEELLNRTS SLLPKMSSLW ENARKRAKEL
460 470 480 490 500
PCCPVWVSAT HLLQGQAWSQ LKAQKEALSE FSQCLELLFR TLPEDKEQGS
510 520 530 540 550
DCEQKCRSDV ALKQLRVAAL ISRGLEWVAS GQDTKALSDF LLSVQICPGN
560 570 580 590 600
RDGSFYLLQT LKRLDRKNEA SAFWREAHSQ LPLEDAAGSL PLYLETCLSW
610 620
IHPPNREAFL EEFGTSVLES CVL
Length:623
Mass (Da):68,506
Last modified:March 1, 2001 - v1
Checksum:i061586EF186F74AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112439 mRNA. Translation: AAG43198.1.
AY049715 mRNA. Translation: AAL12165.1.
AL672276 Genomic DNA. Translation: CAM14317.1.
CCDSiCCDS18087.1.
RefSeqiNP_001156705.1. NM_001163233.1.
NP_444311.1. NM_053081.2.
XP_006538190.1. XM_006538127.2.
XP_006538191.1. XM_006538128.2.
UniGeneiMm.23122.

Genome annotation databases

EnsembliENSMUST00000030165; ENSMUSP00000030165; ENSMUSG00000028453.
GeneIDi60534.
KEGGimmu:60534.
UCSCiuc008sos.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112439 mRNA. Translation: AAG43198.1.
AY049715 mRNA. Translation: AAL12165.1.
AL672276 Genomic DNA. Translation: CAM14317.1.
CCDSiCCDS18087.1.
RefSeqiNP_001156705.1. NM_001163233.1.
NP_444311.1. NM_053081.2.
XP_006538190.1. XM_006538127.2.
XP_006538191.1. XM_006538128.2.
UniGeneiMm.23122.

3D structure databases

ProteinModelPortaliQ9EQR6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208603. 1 interaction.
STRINGi10090.ENSMUSP00000030165.

PTM databases

PhosphoSiteiQ9EQR6.

Proteomic databases

MaxQBiQ9EQR6.
PRIDEiQ9EQR6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030165; ENSMUSP00000030165; ENSMUSG00000028453.
GeneIDi60534.
KEGGimmu:60534.
UCSCiuc008sos.2. mouse.

Organism-specific databases

CTDi2189.
MGIiMGI:1926471. Fancg.

Phylogenomic databases

eggNOGiNOG40254.
GeneTreeiENSGT00390000007195.
HOGENOMiHOG000231403.
HOVERGENiHBG051551.
InParanoidiQ9EQR6.
KOiK10894.
OMAiSRGLEWV.
OrthoDBiEOG7S21Z5.
PhylomeDBiQ9EQR6.
TreeFamiTF330722.

Enzyme and pathway databases

ReactomeiREACT_290303. Fanconi Anemia pathway.

Miscellaneous databases

NextBioi314973.
PROiQ9EQR6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9EQR6.
CleanExiMM_FANCG.
ExpressionAtlasiQ9EQR6. baseline and differential.
GenevisibleiQ9EQR6. MM.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
[Graphical view]
PROSITEiPS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterization, expression and complex formation of the murine Fanconi anaemia gene product Fancg."
    van de Vrugt H.J., Koomen M., Berns M.A., de Vries Y., Rooimans M.A., van der Weel L., Blom E., de Groot J., Schepers R.J., Stone S., Hoatlin M.E., Cheng N.C., Joenje H., Arwert F.
    Genes Cells 7:333-342(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: FVB.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiFANCG_MOUSE
AccessioniPrimary (citable) accession number: Q9EQR6
Secondary accession number(s): A2AG34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2001
Last modified: July 22, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.