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Q9EQR6 (FANCG_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Fanconi anemia group G protein homolog

Short name=Protein FACG
Gene names
Name:Fancg
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length623 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene By similarity.

Subunit structure

Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM By similarity. In complex with FANCF, FANCA and FANCL, but not with FANCC, nor FANCE, interacts with HES1; this interaction may be essential for the stability and nuclear localization of FA core complex proteins By similarity. The complex with FANCC and FANCG may also include EIF2AK2 and HSP70 By similarity.

Subcellular location

Nucleus Ref.2.

Tissue specificity

Highest expression levels in spleen, thymus and testis. Ref.2

Sequence similarities

Contains 4 TPR repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 623623Fanconi anemia group G protein homolog
PRO_0000106293

Regions

Repeat251 – 28434TPR 1
Repeat349 – 38234TPR 2
Repeat458 – 49134TPR 3
Repeat517 – 55034TPR 4

Sequences

Sequence LengthMass (Da)Tools
Q9EQR6 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 061586EF186F74AF

FASTA62368,506
        10         20         30         40         50         60 
MSSQVIPALP KTFSSSLDLW REKNDQLVRQ AKQLTRDSRP SLRRQQSAQD TLEGLRELLL 

        70         80         90        100        110        120 
TLQGLPAAVP ALPLELTVLC NCIILRASLV QAFTEDLTQD LQRGLERVLE AQHHLEPKSQ 

       130        140        150        160        170        180 
QGLKELWHSV LSASSLPPEL LPALHCLASL QAVFWMSTDH LEDLTLLLQT LNGSQTQSSE 

       190        200        210        220        230        240 
DLLLLLKSWS PPAEESPAPL ILQDAESLRD VLLTAFACRQ GFQELITGSL PHAQSNLHEA 

       250        260        270        280        290        300 
ASGLCPPSVL VQVYTALGAC LRKMGNPQRA LLYLTEALKV GTTCALPLLE ASRVYRQLGD 

       310        320        330        340        350        360 
RAAELESLEL LVEALSATHS SETFKSLIEV ELLLPQPDPA SPLHCGTQSQ AKHLLASRCL 

       370        380        390        400        410        420 
QTGRAEDAAE HYLDLLAMLL GGSETRFSPP TSSLGPCIPE LCLEAAAALI QAGRALDALT 

       430        440        450        460        470        480 
VCEELLNRTS SLLPKMSSLW ENARKRAKEL PCCPVWVSAT HLLQGQAWSQ LKAQKEALSE 

       490        500        510        520        530        540 
FSQCLELLFR TLPEDKEQGS DCEQKCRSDV ALKQLRVAAL ISRGLEWVAS GQDTKALSDF 

       550        560        570        580        590        600 
LLSVQICPGN RDGSFYLLQT LKRLDRKNEA SAFWREAHSQ LPLEDAAGSL PLYLETCLSW 

       610        620 
IHPPNREAFL EEFGTSVLES CVL 

« Hide

References

« Hide 'large scale' references
[1]"Spectrum of mutations in the Fanconi anaemia group G gene, FANCG/XRCC9."
Demuth I., Wlodarski M., Tipping A.J., Morgan N.V., de Winter J.P., Thiel M., Grasl S., Schindler D., D'Andrea A.D., Altay C., Kayserili H., Zatterale A., Kunze J., Ebell W., Mathew C.G., Joenje H., Sperling K., Digweed M.
Eur. J. Hum. Genet. 8:861-868(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Characterization, expression and complex formation of the murine Fanconi anaemia gene product Fancg."
van de Vrugt H.J., Koomen M., Berns M.A., de Vries Y., Rooimans M.A., van der Weel L., Blom E., de Groot J., Schepers R.J., Stone S., Hoatlin M.E., Cheng N.C., Joenje H., Arwert F.
Genes Cells 7:333-342(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Strain: FVB.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF112439 mRNA. Translation: AAG43198.1.
AY049715 mRNA. Translation: AAL12165.1.
AL672276 Genomic DNA. Translation: CAM14317.1.
RefSeqNP_001156705.1. NM_001163233.1.
NP_444311.1. NM_053081.2.
XP_006538190.1. XM_006538127.1.
XP_006538191.1. XM_006538128.1.
UniGeneMm.23122.

3D structure databases

ProteinModelPortalQ9EQR6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid208603. 1 interaction.
STRING10090.ENSMUSP00000030165.

PTM databases

PhosphoSiteQ9EQR6.

Proteomic databases

PRIDEQ9EQR6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000030165; ENSMUSP00000030165; ENSMUSG00000028453.
GeneID60534.
KEGGmmu:60534.
UCSCuc008sos.2. mouse.

Organism-specific databases

CTD2189.
MGIMGI:1926471. Fancg.

Phylogenomic databases

eggNOGNOG40254.
GeneTreeENSGT00390000007195.
HOGENOMHOG000231403.
HOVERGENHBG051551.
InParanoidA2AG34.
KOK10894.
OMADTKALQD.
OrthoDBEOG7S21Z5.
PhylomeDBQ9EQR6.
TreeFamTF330722.

Gene expression databases

BgeeQ9EQR6.
CleanExMM_FANCG.
GenevestigatorQ9EQR6.

Family and domain databases

Gene3D1.25.40.10. 1 hit.
InterProIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
[Graphical view]
PfamPF00515. TPR_1. 1 hit.
[Graphical view]
PROSITEPS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio314973.
PROQ9EQR6.
SOURCESearch...

Entry information

Entry nameFANCG_MOUSE
AccessionPrimary (citable) accession number: Q9EQR6
Secondary accession number(s): A2AG34
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot