Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9EQR6

- FANCG_MOUSE

UniProt

Q9EQR6 - FANCG_MOUSE

Protein

Fanconi anemia group G protein homolog

Gene

Fancg

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene By similarity.By similarity

    GO - Biological processi

    1. cellular response to DNA damage stimulus Source: MGI
    2. DNA repair Source: UniProtKB-KW
    3. mitochondrion organization Source: Ensembl
    4. ovarian follicle development Source: MGI
    5. response to radiation Source: MGI
    6. spermatid development Source: MGI

    Keywords - Biological processi

    DNA damage, DNA repair

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fanconi anemia group G protein homolog
    Short name:
    Protein FACG
    Gene namesi
    Name:Fancg
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1926471. Fancg.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. Fanconi anaemia nuclear complex Source: UniProtKB
    2. mitochondrion Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 623623Fanconi anemia group G protein homologPRO_0000106293Add
    BLAST

    Proteomic databases

    PRIDEiQ9EQR6.

    PTM databases

    PhosphoSiteiQ9EQR6.

    Expressioni

    Tissue specificityi

    Highest expression levels in spleen, thymus and testis.1 Publication

    Gene expression databases

    BgeeiQ9EQR6.
    CleanExiMM_FANCG.
    GenevestigatoriQ9EQR6.

    Interactioni

    Subunit structurei

    Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. In complex with FANCF, FANCA and FANCL, but not with FANCC, nor FANCE, interacts with HES1; this interaction may be essential for the stability and nuclear localization of FA core complex proteins. The complex with FANCC and FANCG may also include EIF2AK2 and HSP70.By similarity

    Protein-protein interaction databases

    BioGridi208603. 1 interaction.
    STRINGi10090.ENSMUSP00000030165.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9EQR6.
    SMRiQ9EQR6. Positions 253-283, 520-546, 553-590.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati251 – 28434TPR 1Add
    BLAST
    Repeati349 – 38234TPR 2Add
    BLAST
    Repeati458 – 49134TPR 3Add
    BLAST
    Repeati517 – 55034TPR 4Add
    BLAST

    Sequence similaritiesi

    Contains 4 TPR repeats.Curated

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiNOG40254.
    GeneTreeiENSGT00390000007195.
    HOGENOMiHOG000231403.
    HOVERGENiHBG051551.
    InParanoidiA2AG34.
    KOiK10894.
    OMAiDTKALQD.
    OrthoDBiEOG7S21Z5.
    PhylomeDBiQ9EQR6.
    TreeFamiTF330722.

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    InterProiIPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    [Graphical view]
    PfamiPF00515. TPR_1. 1 hit.
    [Graphical view]
    PROSITEiPS50293. TPR_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9EQR6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSQVIPALP KTFSSSLDLW REKNDQLVRQ AKQLTRDSRP SLRRQQSAQD    50
    TLEGLRELLL TLQGLPAAVP ALPLELTVLC NCIILRASLV QAFTEDLTQD 100
    LQRGLERVLE AQHHLEPKSQ QGLKELWHSV LSASSLPPEL LPALHCLASL 150
    QAVFWMSTDH LEDLTLLLQT LNGSQTQSSE DLLLLLKSWS PPAEESPAPL 200
    ILQDAESLRD VLLTAFACRQ GFQELITGSL PHAQSNLHEA ASGLCPPSVL 250
    VQVYTALGAC LRKMGNPQRA LLYLTEALKV GTTCALPLLE ASRVYRQLGD 300
    RAAELESLEL LVEALSATHS SETFKSLIEV ELLLPQPDPA SPLHCGTQSQ 350
    AKHLLASRCL QTGRAEDAAE HYLDLLAMLL GGSETRFSPP TSSLGPCIPE 400
    LCLEAAAALI QAGRALDALT VCEELLNRTS SLLPKMSSLW ENARKRAKEL 450
    PCCPVWVSAT HLLQGQAWSQ LKAQKEALSE FSQCLELLFR TLPEDKEQGS 500
    DCEQKCRSDV ALKQLRVAAL ISRGLEWVAS GQDTKALSDF LLSVQICPGN 550
    RDGSFYLLQT LKRLDRKNEA SAFWREAHSQ LPLEDAAGSL PLYLETCLSW 600
    IHPPNREAFL EEFGTSVLES CVL 623
    Length:623
    Mass (Da):68,506
    Last modified:March 1, 2001 - v1
    Checksum:i061586EF186F74AF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF112439 mRNA. Translation: AAG43198.1.
    AY049715 mRNA. Translation: AAL12165.1.
    AL672276 Genomic DNA. Translation: CAM14317.1.
    CCDSiCCDS18087.1.
    RefSeqiNP_001156705.1. NM_001163233.1.
    NP_444311.1. NM_053081.2.
    XP_006538190.1. XM_006538127.1.
    XP_006538191.1. XM_006538128.1.
    UniGeneiMm.23122.

    Genome annotation databases

    EnsembliENSMUST00000030165; ENSMUSP00000030165; ENSMUSG00000028453.
    GeneIDi60534.
    KEGGimmu:60534.
    UCSCiuc008sos.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF112439 mRNA. Translation: AAG43198.1 .
    AY049715 mRNA. Translation: AAL12165.1 .
    AL672276 Genomic DNA. Translation: CAM14317.1 .
    CCDSi CCDS18087.1.
    RefSeqi NP_001156705.1. NM_001163233.1.
    NP_444311.1. NM_053081.2.
    XP_006538190.1. XM_006538127.1.
    XP_006538191.1. XM_006538128.1.
    UniGenei Mm.23122.

    3D structure databases

    ProteinModelPortali Q9EQR6.
    SMRi Q9EQR6. Positions 253-283, 520-546, 553-590.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 208603. 1 interaction.
    STRINGi 10090.ENSMUSP00000030165.

    PTM databases

    PhosphoSitei Q9EQR6.

    Proteomic databases

    PRIDEi Q9EQR6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030165 ; ENSMUSP00000030165 ; ENSMUSG00000028453 .
    GeneIDi 60534.
    KEGGi mmu:60534.
    UCSCi uc008sos.2. mouse.

    Organism-specific databases

    CTDi 2189.
    MGIi MGI:1926471. Fancg.

    Phylogenomic databases

    eggNOGi NOG40254.
    GeneTreei ENSGT00390000007195.
    HOGENOMi HOG000231403.
    HOVERGENi HBG051551.
    InParanoidi A2AG34.
    KOi K10894.
    OMAi DTKALQD.
    OrthoDBi EOG7S21Z5.
    PhylomeDBi Q9EQR6.
    TreeFami TF330722.

    Miscellaneous databases

    NextBioi 314973.
    PROi Q9EQR6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9EQR6.
    CleanExi MM_FANCG.
    Genevestigatori Q9EQR6.

    Family and domain databases

    Gene3Di 1.25.40.10. 1 hit.
    InterProi IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    [Graphical view ]
    Pfami PF00515. TPR_1. 1 hit.
    [Graphical view ]
    PROSITEi PS50293. TPR_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Characterization, expression and complex formation of the murine Fanconi anaemia gene product Fancg."
      van de Vrugt H.J., Koomen M., Berns M.A., de Vries Y., Rooimans M.A., van der Weel L., Blom E., de Groot J., Schepers R.J., Stone S., Hoatlin M.E., Cheng N.C., Joenje H., Arwert F.
      Genes Cells 7:333-342(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Strain: FVB.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiFANCG_MOUSE
    AccessioniPrimary (citable) accession number: Q9EQR6
    Secondary accession number(s): A2AG34
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3