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Protein

Alkyldihydroxyacetonephosphate synthase, peroxisomal

Gene

Agps

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.By similarity

Catalytic activityi

1-acyl-glycerone 3-phosphate + a long-chain alcohol = an alkyl-glycerone 3-phosphate + a long-chain acid anion.

Cofactori

FADBy similarity

Pathwayi: ether lipid biosynthesis

This protein is involved in the pathway ether lipid biosynthesis, which is part of Glycerolipid metabolism.
View all proteins of this organism that are known to be involved in the pathway ether lipid biosynthesis and in Glycerolipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei405 – 4051Important for enzyme activityBy similarity
Binding sitei501 – 5011SubstrateBy similarity
Active sitei564 – 5641Proton donor/acceptorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi220 – 2267FADBy similarity
Nucleotide bindingi289 – 2957FADBy similarity
Nucleotide bindingi302 – 3054FADBy similarity
Nucleotide bindingi354 – 3607FADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00781.

Names & Taxonomyi

Protein namesi
Recommended name:
Alkyldihydroxyacetonephosphate synthase, peroxisomal (EC:2.5.1.26)
Short name:
Alkyl-DHAP synthase
Alternative name(s):
Alkylglycerone-phosphate synthase
Gene namesi
Name:Agps
Synonyms:Ads
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620364. Agps.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: RGD
  • peroxisome Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4444PeroxisomeBy similarityAdd
BLAST
Chaini45 – 644600Alkyldihydroxyacetonephosphate synthase, peroxisomalPRO_0000231677Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei51 – 511PhosphoserineBy similarity
Modified residuei56 – 561PhosphoserineBy similarity
Modified residuei88 – 881N6-acetyllysineBy similarity
Modified residuei333 – 3331N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9EQR2.
PRIDEiQ9EQR2.

PTM databases

iPTMnetiQ9EQR2.
PhosphoSiteiQ9EQR2.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002111.

Structurei

3D structure databases

ProteinModelPortaliQ9EQR2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini188 – 370183FAD-binding PCMH-typePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni601 – 6033Important for enzyme activityBy similarity

Sequence similaritiesi

Contains 1 FAD-binding PCMH-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1233. Eukaryota.
COG0277. LUCA.
HOVERGENiHBG004179.
InParanoidiQ9EQR2.
KOiK00803.
PhylomeDBiQ9EQR2.

Family and domain databases

Gene3Di3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
InterProiIPR025650. Alkyl-DHAP_Synthase.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR016164. FAD-linked_Oxase-like_C.
IPR004113. FAD-linked_oxidase_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
PANTHERiPTHR11748:SF3. PTHR11748:SF3. 1 hit.
PfamiPF02913. FAD-oxidase_C. 1 hit.
PF01565. FAD_binding_4. 1 hit.
[Graphical view]
SUPFAMiSSF55103. SSF55103. 2 hits.
SSF56176. SSF56176. 1 hit.
PROSITEiPS51387. FAD_PCMH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EQR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAAGEAGA SERDPDAVRA RRRLRVLSGH LLGRPQEAPS TNECKARRAA
60 70 80 90 100
SAAGASPAAS PAAPESGTIP KKRQELMKWN GWGYNDSKFL LNKKGQVELT
110 120 130 140 150
GKRYPLSGLA LPTLKDWIQN TLGVNLEHKT TSKPSINPSE APPSIVNEDF
160 170 180 190 200
LQELKEAHIS YSQDADDRVF RAHGHCLHEI FLLREGMFER IPDIVVWPTC
210 220 230 240 250
HDDVVKIVNL ACKYNLCIIP IGGGTSVSYG LMCPADETRT IISLDTSQMN
260 270 280 290 300
RILWVDENNL TAHVEAGITG QDLERQLKES GYCTGHEPDS LEFSIVGGWI
310 320 330 340 350
STRASGMKKN VYGNIEDLVV HMKMVTPRGV IEKSSQGPRM STGPDIHHFI
360 370 380 390 400
MGSEGTLGVI TEATIKIRPT PEYQKYGSVA FPNFEQGVAC LREIAKQRCA
410 420 430 440 450
PASIRLMDNQ QFQFGHALKP QVSSIFTSFL DGFKKFYITK FKGFDPNQIS
460 470 480 490 500
VATLLFEGDR EKVLQHEKQV YDIAAKFGGL AAGEDNGQRG YLLTYVIAYM
510 520 530 540 550
RDLGLEYYVV GESFETSAPW DRVIDLCRNV KERIRRECKE RGVQFAPLST
560 570 580 590 600
CRVTQTYDAG ACIYFYFAFN YRGISDPLTV FEQTEAAARD EILANGGSLS
610 620 630 640
HHHGVGKLRK QWLKESISDV GFGMLKSVKD YVDPSNIFGN RNLL
Length:644
Mass (Da):71,587
Last modified:March 1, 2001 - v1
Checksum:iCF88FFEF0BE20C75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121052 mRNA. Translation: AAG43235.1.
RefSeqiNP_445802.2. NM_053350.2.
UniGeneiRn.40603.

Genome annotation databases

GeneIDi84114.
KEGGirno:84114.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121052 mRNA. Translation: AAG43235.1.
RefSeqiNP_445802.2. NM_053350.2.
UniGeneiRn.40603.

3D structure databases

ProteinModelPortaliQ9EQR2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002111.

PTM databases

iPTMnetiQ9EQR2.
PhosphoSiteiQ9EQR2.

Proteomic databases

PaxDbiQ9EQR2.
PRIDEiQ9EQR2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi84114.
KEGGirno:84114.

Organism-specific databases

CTDi8540.
RGDi620364. Agps.

Phylogenomic databases

eggNOGiKOG1233. Eukaryota.
COG0277. LUCA.
HOVERGENiHBG004179.
InParanoidiQ9EQR2.
KOiK00803.
PhylomeDBiQ9EQR2.

Enzyme and pathway databases

UniPathwayiUPA00781.

Miscellaneous databases

PROiQ9EQR2.

Family and domain databases

Gene3Di3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
InterProiIPR025650. Alkyl-DHAP_Synthase.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR016164. FAD-linked_Oxase-like_C.
IPR004113. FAD-linked_oxidase_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
PANTHERiPTHR11748:SF3. PTHR11748:SF3. 1 hit.
PfamiPF02913. FAD-oxidase_C. 1 hit.
PF01565. FAD_binding_4. 1 hit.
[Graphical view]
SUPFAMiSSF55103. SSF55103. 2 hits.
SSF56176. SSF56176. 1 hit.
PROSITEiPS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADAS_RAT
AccessioniPrimary (citable) accession number: Q9EQR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.