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Protein

Alkyldihydroxyacetonephosphate synthase, peroxisomal

Gene

Agps

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.By similarity

Catalytic activityi

1-acyl-glycerone 3-phosphate + a long-chain alcohol = an alkyl-glycerone 3-phosphate + a long-chain acid anion.

Cofactori

FADBy similarity

Pathwayi: ether lipid biosynthesis

This protein is involved in the pathway ether lipid biosynthesis, which is part of Glycerolipid metabolism.
View all proteins of this organism that are known to be involved in the pathway ether lipid biosynthesis and in Glycerolipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei405Important for enzyme activityBy similarity1
Binding sitei501SubstrateBy similarity1
Active sitei564Proton donor/acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi220 – 226FADBy similarity7
Nucleotide bindingi289 – 295FADBy similarity7
Nucleotide bindingi302 – 305FADBy similarity4
Nucleotide bindingi354 – 360FADBy similarity7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism
LigandFAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00781

Names & Taxonomyi

Protein namesi
Recommended name:
Alkyldihydroxyacetonephosphate synthase, peroxisomal (EC:2.5.1.26)
Short name:
Alkyl-DHAP synthase
Alternative name(s):
Alkylglycerone-phosphate synthase
Gene namesi
Name:Agps
Synonyms:Ads
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620364 Agps

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 44PeroxisomeBy similarityAdd BLAST44
ChainiPRO_000023167745 – 644Alkyldihydroxyacetonephosphate synthase, peroxisomalAdd BLAST600

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei51PhosphoserineBy similarity1
Modified residuei56PhosphoserineBy similarity1
Modified residuei88N6-acetyllysineBy similarity1
Modified residuei333N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9EQR2
PRIDEiQ9EQR2

PTM databases

iPTMnetiQ9EQR2
PhosphoSitePlusiQ9EQR2

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002111

Structurei

3D structure databases

ProteinModelPortaliQ9EQR2
SMRiQ9EQR2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini188 – 370FAD-binding PCMH-typePROSITE-ProRule annotationAdd BLAST183

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni601 – 603Important for enzyme activityBy similarity3

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1233 Eukaryota
COG0277 LUCA
HOVERGENiHBG004179
InParanoidiQ9EQR2
KOiK00803
PhylomeDBiQ9EQR2

Family and domain databases

Gene3Di1.10.45.10, 1 hit
3.30.43.10, 2 hits
InterProiView protein in InterPro
IPR025650 Alkyl-DHAP_Synthase
IPR016166 FAD-bd_2
IPR036318 FAD-bd_2-like_sf
IPR016167 FAD-bd_2_sub1
IPR016164 FAD-linked_Oxase-like_C
IPR004113 FAD-linked_oxidase_C
IPR006094 Oxid_FAD_bind_N
IPR016171 Vanillyl_alc_oxidase_C-sub2
PANTHERiPTHR11748:SF3 PTHR11748:SF3, 1 hit
PfamiView protein in Pfam
PF02913 FAD-oxidase_C, 1 hit
PF01565 FAD_binding_4, 1 hit
SUPFAMiSSF55103 SSF55103, 2 hits
SSF56176 SSF56176, 1 hit
PROSITEiView protein in PROSITE
PS51387 FAD_PCMH, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EQR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAAGEAGA SERDPDAVRA RRRLRVLSGH LLGRPQEAPS TNECKARRAA
60 70 80 90 100
SAAGASPAAS PAAPESGTIP KKRQELMKWN GWGYNDSKFL LNKKGQVELT
110 120 130 140 150
GKRYPLSGLA LPTLKDWIQN TLGVNLEHKT TSKPSINPSE APPSIVNEDF
160 170 180 190 200
LQELKEAHIS YSQDADDRVF RAHGHCLHEI FLLREGMFER IPDIVVWPTC
210 220 230 240 250
HDDVVKIVNL ACKYNLCIIP IGGGTSVSYG LMCPADETRT IISLDTSQMN
260 270 280 290 300
RILWVDENNL TAHVEAGITG QDLERQLKES GYCTGHEPDS LEFSIVGGWI
310 320 330 340 350
STRASGMKKN VYGNIEDLVV HMKMVTPRGV IEKSSQGPRM STGPDIHHFI
360 370 380 390 400
MGSEGTLGVI TEATIKIRPT PEYQKYGSVA FPNFEQGVAC LREIAKQRCA
410 420 430 440 450
PASIRLMDNQ QFQFGHALKP QVSSIFTSFL DGFKKFYITK FKGFDPNQIS
460 470 480 490 500
VATLLFEGDR EKVLQHEKQV YDIAAKFGGL AAGEDNGQRG YLLTYVIAYM
510 520 530 540 550
RDLGLEYYVV GESFETSAPW DRVIDLCRNV KERIRRECKE RGVQFAPLST
560 570 580 590 600
CRVTQTYDAG ACIYFYFAFN YRGISDPLTV FEQTEAAARD EILANGGSLS
610 620 630 640
HHHGVGKLRK QWLKESISDV GFGMLKSVKD YVDPSNIFGN RNLL
Length:644
Mass (Da):71,587
Last modified:March 1, 2001 - v1
Checksum:iCF88FFEF0BE20C75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121052 mRNA Translation: AAG43235.1
RefSeqiNP_445802.2, NM_053350.2
UniGeneiRn.40603

Genome annotation databases

GeneIDi84114
KEGGirno:84114

Similar proteinsi

Entry informationi

Entry nameiADAS_RAT
AccessioniPrimary (citable) accession number: Q9EQR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health