Reviewed, UniProtKB/Swiss-Prot Q9EQR2 (ADAS_RAT)

Names and origin

Protein names

Recommended name:
    Alkyldihydroxyacetonephosphate synthase, peroxisomal
      Short name=Alkyl-DHAP synthase
    EC=2.5.1.26
Alternative name(s):
    Alkylglycerone-phosphate synthase

Gene names

Name:	Agps
Synonyms:	Ads

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	644 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	1-acyl-glycerone 3-phosphate + a long-chain alcohol = an alkyl-glycerone 3-phosphate + a long-chain acid anion.
Cofactor	FAD By similarity.
Pathway	Glycerolipid metabolism; ether lipid biosynthesis.
Subcellular location	Peroxisome By similarity.
Sequence similarities	Belongs to the FAD-binding oxidoreductase/transferase type 4 family. Contains 1 FAD-binding PCMH-type domain.

Ontologies

Keywords
Biological process	Lipid synthesis
Cellular component	Peroxisome
Domain	Transit peptide
Ligand	FAD Flavoprotein
Molecular function	Transferase
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Biological process	lipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW response to chemical stimulus Inferred from expression pattern. Source: RGD
Cellular component	mitochondrion Inferred from direct assay. Source: RGD peroxisome Inferred from direct assay. Source: HGNC
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro alkylglycerone-phosphate synthase activity Inferred from direct assay. Source: RGD oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 44	44	Peroxisome By similarity
	Chain	45 – 644	600	Alkyldihydroxyacetonephosphate synthase, peroxisomal		PRO_0000231677
Regions
	Domain	188 – 370	183	FAD-binding PCMH-type
Sites
	Active site	564	1	By similarity
Amino acid modifications
	Modified residue	51	1	Phosphoserine By similarity
	Modified residue	56	1	Phosphoserine By similarity
	Modified residue	88	1	N6-acetyllysine By similarity
	Modified residue	155	1	N6-acetyllysine By similarity
	Modified residue	333	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9EQR2-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: CF88FFEF0BE20C75	FASTA	644	71,587
	10 20 30 40 50 60 MAEAAGEAGA SERDPDAVRA RRRLRVLSGH LLGRPQEAPS TNECKARRAA SAAGASPAAS 70 80 90 100 110 120 PAAPESGTIP KKRQELMKWN GWGYNDSKFL LNKKGQVELT GKRYPLSGLA LPTLKDWIQN 130 140 150 160 170 180 TLGVNLEHKT TSKPSINPSE APPSIVNEDF LQELKEAHIS YSQDADDRVF RAHGHCLHEI 190 200 210 220 230 240 FLLREGMFER IPDIVVWPTC HDDVVKIVNL ACKYNLCIIP IGGGTSVSYG LMCPADETRT 250 260 270 280 290 300 IISLDTSQMN RILWVDENNL TAHVEAGITG QDLERQLKES GYCTGHEPDS LEFSIVGGWI 310 320 330 340 350 360 STRASGMKKN VYGNIEDLVV HMKMVTPRGV IEKSSQGPRM STGPDIHHFI MGSEGTLGVI 370 380 390 400 410 420 TEATIKIRPT PEYQKYGSVA FPNFEQGVAC LREIAKQRCA PASIRLMDNQ QFQFGHALKP 430 440 450 460 470 480 QVSSIFTSFL DGFKKFYITK FKGFDPNQIS VATLLFEGDR EKVLQHEKQV YDIAAKFGGL 490 500 510 520 530 540 AAGEDNGQRG YLLTYVIAYM RDLGLEYYVV GESFETSAPW DRVIDLCRNV KERIRRECKE 550 560 570 580 590 600 RGVQFAPLST CRVTQTYDAG ACIYFYFAFN YRGISDPLTV FEQTEAAARD EILANGGSLS 610 620 630 640 HHHGVGKLRK QWLKESISDV GFGMLKSVKD YVDPSNIFGN RNLL

References

[1]	"Cloning of rat alkyl-dihydroxyacetonephosphate synthase." Gondcaille C., Bugaut M. Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF121052 mRNA. Translation: AAG43235.1.
IPI	IPI00190345.
RefSeq	NP_445802.1.
UniGene	Rn.211989 Rn.40603
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9EQR2.
PTM databases
PhosphoSite	Q9EQR2.
Proteomic databases
PRIDE	Q9EQR2.
Genome annotation databases
Ensembl	ENSRNOT00000002111; ENSRNOP00000002111; ENSRNOG00000001547; Rattus norvegicus. [Genome view]
GeneID	84114.
KEGG	rno:84114.
Organism-specific databases
CTD	84114.
RGD	620364. Agps.
Phylogenomic databases
HOVERGEN	Q9EQR2.
Enzyme and pathway databases
BRENDA	2.5.1.26. 248.
Gene expression databases
Genevestigator	Q9EQR2.
Family and domain databases
InterPro	IPR016166. FAD-bd_2. IPR016167. FAD-bd_2_sub1. IPR016168. FAD-linked_Oxase_FAD-bd_sub2. IPR004113. FAD-linked_oxidase_C. IPR006094. Oxid_FAD_bind_N. [Graphical view]
Gene3D	G3DSA:3.30.43.10. FAD-binding_2_sub1. 1 hit. G3DSA:3.30.465.20. FAD-linked_oxidase_FAD-bd_sub2. 1 hit.
Pfam	PF02913. FAD-oxidase_C. 1 hit. PF01565. FAD_binding_4. 1 hit. [Graphical view]
PROSITE	PS51387. FAD_PCMH. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	616637.

Entry information

Entry name

ADAS_RAT

Accession

Primary (citable) accession number: Q9EQR2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	March 1, 2001
Last modified:	October 13, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)