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Q9EQQ8

- CNRG_CAVPO

UniProt

Q9EQQ8 - CNRG_CAVPO

Protein

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Gene

PDE6G

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones By similarity.By similarity

    Catalytic activityi

    Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

    GO - Molecular functioni

    1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB-EC
    2. cGMP binding Source: InterPro

    GO - Biological processi

    1. activation of MAPK activity Source: Ensembl
    2. positive regulation of epidermal growth factor receptor signaling pathway Source: Ensembl
    3. positive regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
    4. response to stimulus Source: UniProtKB-KW
    5. visual perception Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Sensory transduction, Vision

    Keywords - Ligandi

    cGMP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC:3.1.4.35)
    Short name:
    GMP-PDE gamma
    Gene namesi
    Name:PDE6G
    OrganismiCavia porcellus (Guinea pig)
    Taxonomic identifieri10141 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
    ProteomesiUP000005447: Unplaced

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 8787Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaPRO_0000166115Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Interactioni

    Subunit structurei

    Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.By similarity

    Protein-protein interaction databases

    STRINGi10141.ENSCPOP00000018118.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9EQQ8.
    SMRiQ9EQQ8. Positions 1-87.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi24 – 4522Arg/Lys-rich (basic)Add
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG44345.
    GeneTreeiENSGT00390000013260.
    HOGENOMiHOG000261673.
    HOVERGENiHBG000447.
    InParanoidiQ9EQQ8.
    OMAiTRVMGGP.
    OrthoDBiEOG7SN8FW.
    TreeFamiTF333297.

    Family and domain databases

    Gene3Di4.10.1120.10. 1 hit.
    InterProiIPR006952. PDE6_gamma.
    [Graphical view]
    PANTHERiPTHR12122. PTHR12122. 1 hit.
    PfamiPF04868. PDE6_gamma. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000969. 35-cGMP_Pdiase_g. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9EQQ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNLELPKAEI RSATRVVGGP VTPRKGPPKF KQRQTRQFKS KPPKKGVQGF   50
    GDDIPGMEGL GTDITVICPW EAFNHLELHE LAQYGII 87
    Length:87
    Mass (Da):9,653
    Last modified:March 1, 2001 - v1
    Checksum:i21BF681796854C5D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF132929 mRNA. Translation: AAG43274.1.
    RefSeqiNP_001166467.1. NM_001172996.1.
    XP_005001441.1. XM_005001384.1.

    Genome annotation databases

    EnsembliENSCPOT00000025817; ENSCPOP00000018118; ENSCPOG00000022389.
    GeneIDi100135595.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF132929 mRNA. Translation: AAG43274.1 .
    RefSeqi NP_001166467.1. NM_001172996.1.
    XP_005001441.1. XM_005001384.1.

    3D structure databases

    ProteinModelPortali Q9EQQ8.
    SMRi Q9EQQ8. Positions 1-87.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10141.ENSCPOP00000018118.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCPOT00000025817 ; ENSCPOP00000018118 ; ENSCPOG00000022389 .
    GeneIDi 100135595.

    Organism-specific databases

    CTDi 5148.

    Phylogenomic databases

    eggNOGi NOG44345.
    GeneTreei ENSGT00390000013260.
    HOGENOMi HOG000261673.
    HOVERGENi HBG000447.
    InParanoidi Q9EQQ8.
    OMAi TRVMGGP.
    OrthoDBi EOG7SN8FW.
    TreeFami TF333297.

    Family and domain databases

    Gene3Di 4.10.1120.10. 1 hit.
    InterProi IPR006952. PDE6_gamma.
    [Graphical view ]
    PANTHERi PTHR12122. PTHR12122. 1 hit.
    Pfami PF04868. PDE6_gamma. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000969. 35-cGMP_Pdiase_g. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of an airway smooth muscle cyclic-GMP phosphodiesterase 6 gamma-subunit."
      Tate R.J., Pyne N.J.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Airway smooth muscle.

    Entry informationi

    Entry nameiCNRG_CAVPO
    AccessioniPrimary (citable) accession number: Q9EQQ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3