Reviewed, UniProtKB/Swiss-Prot Q9EQQ8 (CNRG_CAVPO)

Names and origin

Protein names

Recommended name:
    Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
      Short name=GMP-PDE gamma
    EC=3.1.4.17

Gene names

Name:

PDE6G

Organism

Cavia porcellus (Guinea pig)

Taxonomic identifier

10141 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricognathi › Caviidae › Cavia

Protein attributes

Sequence length	87 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones By similarity.
Catalytic activity	Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.
Subunit structure	Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain By similarity.
Sequence similarities	Belongs to the rod/cone cGMP-PDE gamma subunit family.

Ontologies

Keywords
Biological process	Sensory transduction Vision
Ligand	cGMP
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW visual perception Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3',5'-cyclic-nucleotide phosphodiesterase activity Inferred from electronic annotation. Source: EC cGMP binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 87	87	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma		PRO_0000166115
Regions
	Compositional bias	24 – 45	22	Arg/Lys-rich (basic)

Sequences

	Sequence		Length	Mass (Da)
	Q9EQQ8-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 21BF681796854C5D	FASTA	87	9,653
	10 20 30 40 50 60 MNLELPKAEI RSATRVVGGP VTPRKGPPKF KQRQTRQFKS KPPKKGVQGF GDDIPGMEGL 70 80 GTDITVICPW EAFNHLELHE LAQYGII

References

[1]	"Molecular cloning and characterization of an airway smooth muscle cyclic-GMP phosphodiesterase 6 gamma-subunit." Tate R.J., Pyne N.J. Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Airway smooth muscle.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF132929 mRNA. Translation: AAG43274.1.
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSCPOT00000025817; ENSCPOP00000018118; ENSCPOG00000022389; Cavia porcellus. [Genome view]
Phylogenomic databases
HOVERGEN	Q9EQQ8.
OMA	EFRSATR.
Enzyme and pathway databases
BRENDA	3.1.4.17. 44.
Family and domain databases
InterPro	IPR006952. PDE6_gamma. [Graphical view]
PANTHER	PTHR12122. PDE6_gamma. 1 hit.
Pfam	PF04868. PDE6_gamma. 1 hit. [Graphical view]
PIRSF	PIRSF000969. 35-cGMP_Pdiase_g. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CNRG_CAVPO

Accession

Primary (citable) accession number: Q9EQQ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	March 1, 2001
Last modified:	November 3, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)