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Protein

Probable G-protein coupled receptor 45

Gene

Gpr45

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor. May play a role in brain function.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 45
Alternative name(s):
PSP24-1
PSP24-alpha
Gene namesi
Name:Gpr45
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2135882. Gpr45.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838ExtracellularSequence analysisAdd
BLAST
Transmembranei39 – 5921Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini60 – 7516CytoplasmicSequence analysisAdd
BLAST
Transmembranei76 – 9621Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini97 – 10913ExtracellularSequence analysisAdd
BLAST
Transmembranei110 – 13021Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini131 – 14919CytoplasmicSequence analysisAdd
BLAST
Transmembranei150 – 17021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini171 – 19828ExtracellularSequence analysisAdd
BLAST
Transmembranei199 – 21921Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini220 – 26950CytoplasmicSequence analysisAdd
BLAST
Transmembranei270 – 29021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini291 – 30616ExtracellularSequence analysisAdd
BLAST
Transmembranei307 – 32721Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini328 – 37346CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: MGI
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 373373Probable G-protein coupled receptor 45PRO_0000069575Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9EQQ4.
PRIDEiQ9EQQ4.

PTM databases

PhosphoSiteiQ9EQQ4.

Expressioni

Tissue specificityi

Brain specific.

Gene expression databases

BgeeiQ9EQQ4.
CleanExiMM_GPR45.
ExpressionAtlasiQ9EQQ4. baseline and differential.
GenevisibleiQ9EQQ4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110409.

Structurei

3D structure databases

ProteinModelPortaliQ9EQQ4.
SMRiQ9EQQ4. Positions 29-340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000008078.
HOGENOMiHOG000039990.
HOVERGENiHBG051812.
InParanoidiQ9EQQ4.
KOiK08409.
OMAiVCIIVYQ.
OrthoDBiEOG71K62X.
PhylomeDBiQ9EQQ4.
TreeFamiTF338633.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EQQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACNSTPMGT YEHLLLNVSN TLDPGDTPLS APLRISLAIM MLLMIVVGFL
60 70 80 90 100
GNTVVCIIVY QRPAMRSAIN LLLATLAFSD IMLSLCCMPF TAITLITVRW
110 120 130 140 150
HFGDHFCRLS ATLYWFFVLE GVAILLIISV DRFLIIVQRQ DKLNPRRAKM
160 170 180 190 200
IIAASWVLSF CISAPSFTGW TFMEVPARAP QCVLGYTEFP AERAYVVTLV
210 220 230 240 250
VAVFFAPFGV MLCSYLCILN TVRKNAVRVH NQSDSLDLRQ LTGAGLRRLR
260 270 280 290 300
RQQQQASLDL SFKTKAFTTI LILFVGFSLC WLPHSVYSLL SAFSRRFYYS
310 320 330 340 350
ASFYTTSTCV LWLSYLKSVF NPIVYCWRIK KFREACIELL PHTFQILPKV
360 370
PERIQRKIQP STIYVCNENQ SAV
Length:373
Mass (Da):42,358
Last modified:March 1, 2001 - v1
Checksum:i693BE5DE9673FB2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139642 Genomic DNA. Translation: AAG42572.1.
CCDSiCCDS14919.1.
RefSeqiNP_444337.3. NM_053107.4.
XP_006496409.1. XM_006496346.2.
XP_006496410.1. XM_006496347.2.
XP_006496411.1. XM_006496348.1.
XP_006496412.1. XM_006496349.2.
UniGeneiMm.444976.

Genome annotation databases

EnsembliENSMUST00000114761; ENSMUSP00000110409; ENSMUSG00000041907.
ENSMUST00000179766; ENSMUSP00000135986; ENSMUSG00000041907.
GeneIDi93690.
KEGGimmu:93690.
UCSCiuc007avd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139642 Genomic DNA. Translation: AAG42572.1.
CCDSiCCDS14919.1.
RefSeqiNP_444337.3. NM_053107.4.
XP_006496409.1. XM_006496346.2.
XP_006496410.1. XM_006496347.2.
XP_006496411.1. XM_006496348.1.
XP_006496412.1. XM_006496349.2.
UniGeneiMm.444976.

3D structure databases

ProteinModelPortaliQ9EQQ4.
SMRiQ9EQQ4. Positions 29-340.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110409.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9EQQ4.

Proteomic databases

PaxDbiQ9EQQ4.
PRIDEiQ9EQQ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114761; ENSMUSP00000110409; ENSMUSG00000041907.
ENSMUST00000179766; ENSMUSP00000135986; ENSMUSG00000041907.
GeneIDi93690.
KEGGimmu:93690.
UCSCiuc007avd.2. mouse.

Organism-specific databases

CTDi11250.
MGIiMGI:2135882. Gpr45.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000008078.
HOGENOMiHOG000039990.
HOVERGENiHBG051812.
InParanoidiQ9EQQ4.
KOiK08409.
OMAiVCIIVYQ.
OrthoDBiEOG71K62X.
PhylomeDBiQ9EQQ4.
TreeFamiTF338633.

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.

Miscellaneous databases

NextBioi351433.
PROiQ9EQQ4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9EQQ4.
CleanExiMM_GPR45.
ExpressionAtlasiQ9EQQ4. baseline and differential.
GenevisibleiQ9EQQ4. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45."
    Kawasawa Y., Kume K., Nakade S., Haga H., Izumi T., Shimizu T.
    Biochem. Biophys. Res. Commun. 276:952-956(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiGPR45_MOUSE
AccessioniPrimary (citable) accession number: Q9EQQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 1, 2001
Last modified: May 11, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.