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Protein

Probable G-protein coupled receptor 63

Gene

Gpr63

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor. May play a role in brain function.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 63
Alternative name(s):
PSP24-2
PSP24-beta
Gene namesi
Name:Gpr63
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2135884. Gpr63.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8787ExtracellularSequence analysisAdd
BLAST
Transmembranei88 – 11225Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini113 – 12311CytoplasmicSequence analysisAdd
BLAST
Transmembranei124 – 14825Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini149 – 16517ExtracellularSequence analysisAdd
BLAST
Transmembranei166 – 19025Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini191 – 20212CytoplasmicSequence analysisAdd
BLAST
Transmembranei203 – 22220Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini223 – 24725ExtracellularSequence analysisAdd
BLAST
Transmembranei248 – 27225Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini273 – 32149CytoplasmicSequence analysisAdd
BLAST
Transmembranei322 – 34524Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini346 – 35712ExtracellularSequence analysisAdd
BLAST
Transmembranei358 – 37922Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini380 – 42546CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: MGI
  • plasma membrane Source: UniProtKB-SubCell
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Probable G-protein coupled receptor 63PRO_0000069582Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi22 – 221N-linked (GlcNAc...)Sequence analysis
Glycosylationi34 – 341N-linked (GlcNAc...)Sequence analysis
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9EQQ3.
PRIDEiQ9EQQ3.

Expressioni

Tissue specificityi

Brain specific.

Gene expression databases

BgeeiQ9EQQ3.
CleanExiMM_GPR63.
GenevisibleiQ9EQQ3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039312.

Structurei

3D structure databases

ProteinModelPortaliQ9EQQ3.
SMRiQ9EQQ3. Positions 83-376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000008078.
HOGENOMiHOG000039990.
HOVERGENiHBG051812.
InParanoidiQ9EQQ3.
KOiK04321.
OMAiIYYWRIK.
OrthoDBiEOG71K62X.
TreeFamiTF332301.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EQQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVSGVLTAP AVLTAPHSGT SNTTFVVFEN SHVNITAPLP FQHPSAGPLL
60 70 80 90 100
RYSLETMTSP GFSSLAVNST AVTPAPAVFK SLNLAVQIIL SAIMIFILFV
110 120 130 140 150
SFLGNLVVCL MVYQKAAMRS AINILLASLA FADMLLAVLN MPFALVTILT
160 170 180 190 200
TRWIFGKFFC RLSAMFFWLF VIEGVAILLI ISIDRFLIIV QRQDKLNPYR
210 220 230 240 250
AKVLIAVSWA TAFSVAFPLA VGNPDLQIPS RAPQCVFGYT TNSGYQAYVI
260 270 280 290 300
LISLISFFIP FLVILYSFMG ILNTLRHNAL RIHSYPEGIC LSQASKLGLM
310 320 330 340 350
SLQRPFQMSI DMGFKTRAFT TILILFAVFI VCWAPFTTYS LVATFSKHFY
360 370 380 390 400
YQHNFFEIST WLLWLCYLKS ALNPLIYYWR IKKFHDACLD MMPKSFKFLP
410 420
RLPGHTRRRI RPSAVYVCGE HRTVL
Length:425
Mass (Da):47,788
Last modified:July 27, 2011 - v2
Checksum:iE9E99B8E51DDED36
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti407 – 4071R → S in AAG42573 (PubMed:11027574).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139643 Genomic DNA. Translation: AAG42573.1.
AK036257 mRNA. Translation: BAC29364.1.
AL772199 Genomic DNA. Translation: CAM27170.1.
CH466538 Genomic DNA. Translation: EDL05529.1.
CCDSiCCDS18008.1.
RefSeqiNP_109658.2. NM_030733.3.
XP_006538445.1. XM_006538382.2.
XP_006538446.1. XM_006538383.2.
XP_006538447.1. XM_006538384.2.
UniGeneiMm.160412.

Genome annotation databases

EnsembliENSMUST00000038920; ENSMUSP00000039312; ENSMUSG00000040372.
GeneIDi81006.
KEGGimmu:81006.
UCSCiuc008see.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139643 Genomic DNA. Translation: AAG42573.1.
AK036257 mRNA. Translation: BAC29364.1.
AL772199 Genomic DNA. Translation: CAM27170.1.
CH466538 Genomic DNA. Translation: EDL05529.1.
CCDSiCCDS18008.1.
RefSeqiNP_109658.2. NM_030733.3.
XP_006538445.1. XM_006538382.2.
XP_006538446.1. XM_006538383.2.
XP_006538447.1. XM_006538384.2.
UniGeneiMm.160412.

3D structure databases

ProteinModelPortaliQ9EQQ3.
SMRiQ9EQQ3. Positions 83-376.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039312.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ9EQQ3.
PRIDEiQ9EQQ3.

Protocols and materials databases

DNASUi81006.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038920; ENSMUSP00000039312; ENSMUSG00000040372.
GeneIDi81006.
KEGGimmu:81006.
UCSCiuc008see.1. mouse.

Organism-specific databases

CTDi81491.
MGIiMGI:2135884. Gpr63.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000008078.
HOGENOMiHOG000039990.
HOVERGENiHBG051812.
InParanoidiQ9EQQ3.
KOiK04321.
OMAiIYYWRIK.
OrthoDBiEOG71K62X.
TreeFamiTF332301.

Miscellaneous databases

NextBioi350346.
PROiQ9EQQ3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9EQQ3.
CleanExiMM_GPR63.
GenevisibleiQ9EQQ3. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45."
    Kawasawa Y., Kume K., Nakade S., Haga H., Izumi T., Shimizu T.
    Biochem. Biophys. Res. Commun. 276:952-956(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiGPR63_MOUSE
AccessioniPrimary (citable) accession number: Q9EQQ3
Secondary accession number(s): Q8BZ93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: July 27, 2011
Last modified: May 11, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.