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Protein

Protein YIPF5

Gene

Yipf5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in transport between endoplasmic reticulum and Golgi.By similarity

GO - Biological processi

  • protein transport Source: UniProtKB-KW
  • regulation of ER to Golgi vesicle-mediated transport Source: MGI
  • vesicle-mediated transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein YIPF5
Alternative name(s):
YIP1 family member 5
YPT-interacting protein 1 A
Gene namesi
Name:Yipf5
Synonyms:Yip1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1914430. Yipf5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 124124CytoplasmicSequence analysisAdd
BLAST
Transmembranei125 – 14521HelicalSequence analysisAdd
BLAST
Topological domaini146 – 1461LumenalSequence analysis
Transmembranei147 – 16721HelicalSequence analysisAdd
BLAST
Topological domaini168 – 1736CytoplasmicSequence analysis
Transmembranei174 – 19421HelicalSequence analysisAdd
BLAST
Topological domaini195 – 1962LumenalSequence analysis
Transmembranei197 – 21721HelicalSequence analysisAdd
BLAST
Topological domaini218 – 23619CytoplasmicSequence analysisAdd
BLAST
Transmembranei237 – 25721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum exit site Source: MGI
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • ER to Golgi transport vesicle Source: MGI
  • Golgi cisterna membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • nuclear outer membrane-endoplasmic reticulum membrane network Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257Protein YIPF5PRO_0000234330Add
BLAST

Proteomic databases

EPDiQ9EQQ2.
MaxQBiQ9EQQ2.
PaxDbiQ9EQQ2.
PRIDEiQ9EQQ2.

PTM databases

PhosphoSiteiQ9EQQ2.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiQ9EQQ2.
CleanExiMM_YIPF5.
GenevisibleiQ9EQQ2. MM.

Interactioni

Subunit structurei

Interacts with the COPII coat components Sec23 (SEC23A and/or SEC23B) and Sec24 (SEC24A and/or SEC24B). Interacts with YIF1A. May interact with RAB1A (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025364.

Structurei

3D structure databases

ProteinModelPortaliQ9EQQ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni75 – 10632Interaction with Sec23By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the YIP1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3103. Eukaryota.
COG5080. LUCA.
GeneTreeiENSGT00510000046817.
HOGENOMiHOG000037706.
HOVERGENiHBG055241.
InParanoidiQ9EQQ2.
OMAiFDNLNTD.
OrthoDBiEOG7CRTQW.
PhylomeDBiQ9EQQ2.
TreeFamiTF313100.

Family and domain databases

InterProiIPR006977. Yip1.
[Graphical view]
PfamiPF04893. Yip1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EQQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGFDNLNSG FYQTSYSIDE QSQQSYDYGG SGGPYSKQYA GCDYSQQGRF
60 70 80 90 100
VPPDMMQPQQ TYTGQIYQPT QAYPPTTPQP FYGDSFEEEP PLLEELGINF
110 120 130 140 150
DHIWQKTLTV LHPLRAADGS IMNETDLAGP VVFCLAFGAT LLLAGKIQFG
160 170 180 190 200
YVYGISAIGC LGMFCLLNLM SMTGVSFGCV ASVLGYCLLP MILLSSFAVV
210 220 230 240 250
FSLQGMVGIL LTATIIGWCS FSASKIFISA LAMDGQQLLV AYPCALLYGV

FALISVF
Length:257
Mass (Da):27,873
Last modified:March 1, 2001 - v1
Checksum:i792206E7E4B39190
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140226 mRNA. Translation: AAG48522.1.
AK010089 mRNA. Translation: BAB26694.1.
AK151425 mRNA. Translation: BAE30389.1.
AK151461 mRNA. Translation: BAE30419.1.
AK152440 mRNA. Translation: BAE31221.1.
AK153123 mRNA. Translation: BAE31738.1.
AK160004 mRNA. Translation: BAE35552.1.
AK167526 mRNA. Translation: BAE39596.1.
BC003317 mRNA. Translation: AAH03317.1.
BC055301 mRNA. Translation: AAH55301.1.
CCDSiCCDS29207.1.
RefSeqiNP_075800.1. NM_023311.3.
UniGeneiMm.270382.

Genome annotation databases

EnsembliENSMUST00000025364; ENSMUSP00000025364; ENSMUSG00000024487.
GeneIDi67180.
KEGGimmu:67180.
UCSCiuc008etd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140226 mRNA. Translation: AAG48522.1.
AK010089 mRNA. Translation: BAB26694.1.
AK151425 mRNA. Translation: BAE30389.1.
AK151461 mRNA. Translation: BAE30419.1.
AK152440 mRNA. Translation: BAE31221.1.
AK153123 mRNA. Translation: BAE31738.1.
AK160004 mRNA. Translation: BAE35552.1.
AK167526 mRNA. Translation: BAE39596.1.
BC003317 mRNA. Translation: AAH03317.1.
BC055301 mRNA. Translation: AAH55301.1.
CCDSiCCDS29207.1.
RefSeqiNP_075800.1. NM_023311.3.
UniGeneiMm.270382.

3D structure databases

ProteinModelPortaliQ9EQQ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025364.

PTM databases

PhosphoSiteiQ9EQQ2.

Proteomic databases

EPDiQ9EQQ2.
MaxQBiQ9EQQ2.
PaxDbiQ9EQQ2.
PRIDEiQ9EQQ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025364; ENSMUSP00000025364; ENSMUSG00000024487.
GeneIDi67180.
KEGGimmu:67180.
UCSCiuc008etd.1. mouse.

Organism-specific databases

CTDi81555.
MGIiMGI:1914430. Yipf5.

Phylogenomic databases

eggNOGiKOG3103. Eukaryota.
COG5080. LUCA.
GeneTreeiENSGT00510000046817.
HOGENOMiHOG000037706.
HOVERGENiHBG055241.
InParanoidiQ9EQQ2.
OMAiFDNLNTD.
OrthoDBiEOG7CRTQW.
PhylomeDBiQ9EQQ2.
TreeFamiTF313100.

Miscellaneous databases

NextBioi323812.
PROiQ9EQQ2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9EQQ2.
CleanExiMM_YIPF5.
GenevisibleiQ9EQQ2. MM.

Family and domain databases

InterProiIPR006977. Yip1.
[Graphical view]
PfamiPF04893. Yip1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A membrane protein enriched in endoplasmic reticulum exit sites interacts with COPII."
    Tang B.L., Ong Y.S., Huang B., Wei S., Wong E.T., Qi R., Horstmann H., Hong W.
    J. Biol. Chem. 276:40008-40017(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow, Placenta and Tongue.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: 129.
    Tissue: Eye and Mammary tumor.
  4. "Cdc2 kinase-dependent disassembly of endoplasmic reticulum (ER) exit sites inhibits ER-to-Golgi vesicular transport during mitosis."
    Kano F., Tanaka A.R., Yamauchi S., Kondo H., Murata M.
    Mol. Biol. Cell 15:4289-4298(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Pancreas.

Entry informationi

Entry nameiYIPF5_MOUSE
AccessioniPrimary (citable) accession number: Q9EQQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: March 1, 2001
Last modified: March 16, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.