ID   ARRC_MOUSE              Reviewed;         381 AA.
AC   Q9EQP6;
DT   05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   24-JAN-2024, entry version 133.
DE   RecName: Full=Arrestin-C;
DE   AltName: Full=Cone arrestin;
DE            Short=cArr;
DE   AltName: Full=Retinal cone arrestin-3;
GN   Name=Arr3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Retina;
RX   PubMed=12135752; DOI=10.1016/s0014-5793(02)03014-4;
RA   Zhu X., Ma B., Babu S., Murage J., Knox B.E., Craft C.M.;
RT   "Mouse cone arrestin gene characterization: promoter targets expression to
RT   cone photoreceptors.";
RL   FEBS Lett. 524:116-122(2002).
RN   [2]
RP   PROTEIN SEQUENCE OF 310-319, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=OF1; TISSUE=Hippocampus;
RA   Lubec G., Sunyer B., Chen W.-Q.;
RL   Submitted (JAN-2009) to UniProtKB.
RN   [3]
RP   SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX   PubMed=28151698; DOI=10.1369/0022155416689675;
RA   Zalis M.C., Johansson S., Englund-Johansson U.;
RT   "Immunocytochemical Profiling of Cultured Mouse Primary Retinal Cells.";
RL   J. Histochem. Cytochem. 65:223-239(2017).
CC   -!- FUNCTION: May play a role in an as yet undefined retina-specific signal
CC       transduction. Could bind to photoactivated-phosphorylated red/green
CC       opsins.
CC   -!- SUBUNIT: Homodimer; disulfide-linked in response to retinal
CC       illumination (By similarity). Interacts with CXCR4; the interaction is
CC       dependent on the C-terminal phosphorylation of CXCR4 and modulates the
CC       calcium ion mobilization activity of CXCR4 (By similarity). Interacts
CC       with GPR84 (By similarity). {ECO:0000250|UniProtKB:P36575,
CC       ECO:0000250|UniProtKB:Q9N0H5}.
CC   -!- SUBCELLULAR LOCATION: Photoreceptor inner segment
CC       {ECO:0000269|PubMed:28151698}. Cell projection, cilium, photoreceptor
CC       outer segment {ECO:0000269|PubMed:28151698}.
CC   -!- TISSUE SPECIFICITY: Inner and outer segments, and the inner plexiform
CC       regions of the retina.
CC   -!- DEVELOPMENTAL STAGE: At postnatal day 11 (P11) expressed in the soma
CC       and photoreceptor processes of the retinal inner segment, outer
CC       segment, outer plexiform layer, and inner plexiform layer. Expression
CC       in the inner plexiform layer is lost at P22.
CC       {ECO:0000269|PubMed:28151698}.
CC   -!- SIMILARITY: Belongs to the arrestin family. {ECO:0000305}.
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DR   EMBL; AF156979; AAG38954.1; -; mRNA.
DR   CCDS; CCDS41075.1; -.
DR   RefSeq; NP_573468.1; NM_133205.3.
DR   AlphaFoldDB; Q9EQP6; -.
DR   SMR; Q9EQP6; -.
DR   BioGRID; 228402; 4.
DR   STRING; 10090.ENSMUSP00000109398; -.
DR   iPTMnet; Q9EQP6; -.
DR   PhosphoSitePlus; Q9EQP6; -.
DR   MaxQB; Q9EQP6; -.
DR   PaxDb; 10090-ENSMUSP00000109398; -.
DR   PeptideAtlas; Q9EQP6; -.
DR   ProteomicsDB; 277235; -.
DR   Antibodypedia; 27367; 261 antibodies from 33 providers.
DR   DNASU; 170735; -.
DR   Ensembl; ENSMUST00000113769.8; ENSMUSP00000109398.2; ENSMUSG00000060890.12.
DR   GeneID; 170735; -.
DR   KEGG; mmu:170735; -.
DR   UCSC; uc009twd.2; mouse.
DR   AGR; MGI:2159617; -.
DR   CTD; 407; -.
DR   MGI; MGI:2159617; Arr3.
DR   VEuPathDB; HostDB:ENSMUSG00000060890; -.
DR   eggNOG; KOG3865; Eukaryota.
DR   GeneTree; ENSGT00950000182887; -.
DR   HOGENOM; CLU_033484_0_0_1; -.
DR   InParanoid; Q9EQP6; -.
DR   OMA; FHGEDIP; -.
DR   OrthoDB; 3059077at2759; -.
DR   PhylomeDB; Q9EQP6; -.
DR   TreeFam; TF314260; -.
DR   BioGRID-ORCS; 170735; 0 hits in 77 CRISPR screens.
DR   PRO; PR:Q9EQP6; -.
DR   Proteomes; UP000000589; Chromosome X.
DR   RNAct; Q9EQP6; Protein.
DR   Bgee; ENSMUSG00000060890; Expressed in retinal neural layer and 21 other cell types or tissues.
DR   ExpressionAtlas; Q9EQP6; baseline and differential.
DR   GO; GO:0001917; C:photoreceptor inner segment; ISO:MGI.
DR   GO; GO:0001750; C:photoreceptor outer segment; IDA:MGI.
DR   GO; GO:0045202; C:synapse; IDA:MGI.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central.
DR   GO; GO:0002046; F:opsin binding; IDA:MGI.
DR   GO; GO:0051219; F:phosphoprotein binding; IDA:MGI.
DR   GO; GO:0019904; F:protein domain specific binding; ISO:MGI.
DR   GO; GO:0006897; P:endocytosis; IDA:MGI.
DR   GO; GO:0002031; P:G protein-coupled receptor internalization; IBA:GO_Central.
DR   GO; GO:0001932; P:regulation of protein phosphorylation; IDA:MGI.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   GO; GO:0007601; P:visual perception; IBA:GO_Central.
DR   Gene3D; 2.60.40.640; -; 1.
DR   Gene3D; 2.60.40.840; -; 1.
DR   InterPro; IPR000698; Arrestin.
DR   InterPro; IPR014752; Arrestin-like_C.
DR   InterPro; IPR011021; Arrestin-like_N.
DR   InterPro; IPR011022; Arrestin_C-like.
DR   InterPro; IPR017864; Arrestin_CS.
DR   InterPro; IPR014753; Arrestin_N.
DR   InterPro; IPR014756; Ig_E-set.
DR   PANTHER; PTHR11792; ARRESTIN; 1.
DR   PANTHER; PTHR11792:SF19; ARRESTIN-C; 1.
DR   Pfam; PF02752; Arrestin_C; 1.
DR   Pfam; PF00339; Arrestin_N; 1.
DR   PRINTS; PR00309; ARRESTIN.
DR   SMART; SM01017; Arrestin_C; 1.
DR   SUPFAM; SSF81296; E set domains; 2.
DR   PROSITE; PS00295; ARRESTINS; 1.
DR   Genevisible; Q9EQP6; MM.
PE   1: Evidence at protein level;
KW   Cell projection; Direct protein sequencing; Disulfide bond;
KW   Reference proteome; Sensory transduction; Vision.
FT   CHAIN           1..381
FT                   /note="Arrestin-C"
FT                   /id="PRO_0000205204"
SQ   SEQUENCE   381 AA;  41921 MW;  3BEAC282EC438920 CRC64;
     MSTVFKKTSS NGKFSIYLGK RDFVDDVDTV EPIDGVVLVD PEYLEGRKLF VRLTCAFRYG
     RDDLDVIGLT FRKDLYVQTK QVAPAEPTSI QGPLTALQER LLHKLGVNAY PFTLQMVANL
     PCSVTLQPGP EDSGKPCGVD FEVKSFCAEN LEEKIPKSDS VQLVVRKVQF SALEPGPGPS
     AQTIRSFFLS SQPLQLQAWM DREVHYHGEA ISVHVSINNY TNKVIRRIKI AVVQTTDVVL
     YSLDKYTKTV FVQEFTETVA ANSSFSQTFA VTPLLAANCQ KQGLALDGKL KHEDTNLASS
     TILRPGMNKE LLGILVSYKV RVNLVVSYGG ILGGLPASDV GVELPVILIH PKPSPGERAV
     ATSSEDIVIE EFMQHNSQTQ S
//