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Protein

Arrestin-C

Gene

Arr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins.

GO - Molecular functioni

  1. opsin binding Source: MGI
  2. phosphoprotein binding Source: MGI

GO - Biological processi

  1. endocytosis Source: MGI
  2. regulation of protein phosphorylation Source: MGI
  3. signal transduction Source: InterPro
  4. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Sensory transduction, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Arrestin-C
Alternative name(s):
Cone arrestin
Short name:
cArr
Retinal cone arrestin-3
Gene namesi
Name:Arr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2159617. Arr3.

Subcellular locationi

GO - Cellular componenti

  1. photoreceptor inner segment Source: MGI
  2. photoreceptor outer segment Source: MGI
  3. synapse Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 381381Arrestin-CPRO_0000205204Add
BLAST

Proteomic databases

MaxQBiQ9EQP6.
PaxDbiQ9EQP6.
PRIDEiQ9EQP6.

Expressioni

Tissue specificityi

Inner and outer segments, and the inner plexiform regions of the retina.

Gene expression databases

BgeeiQ9EQP6.
CleanExiMM_ARR3.
ExpressionAtlasiQ9EQP6. baseline and differential.
GenevestigatoriQ9EQP6.

Interactioni

Subunit structurei

Interacts with CXCR4; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates the calcium ion mobilization activity of CXCR4.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9EQP6.
SMRiQ9EQP6. Positions 2-375.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arrestin family.Curated

Phylogenomic databases

eggNOGiNOG302111.
GeneTreeiENSGT00390000013152.
HOGENOMiHOG000231319.
HOVERGENiHBG002399.
InParanoidiQ9EQP6.
KOiK13801.
OMAiVKSFCAE.
OrthoDBiEOG79W954.
PhylomeDBiQ9EQP6.
TreeFamiTF314260.

Family and domain databases

Gene3Di2.60.40.640. 1 hit.
2.60.40.840. 1 hit.
InterProiIPR000698. Arrestin.
IPR011021. Arrestin-like_N.
IPR014752. Arrestin_C.
IPR011022. Arrestin_C-like.
IPR017864. Arrestin_CS.
IPR014753. Arrestin_N.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR11792. PTHR11792. 1 hit.
PfamiPF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view]
PRINTSiPR00309. ARRESTIN.
SMARTiSM01017. Arrestin_C. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 2 hits.
PROSITEiPS00295. ARRESTINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EQP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTVFKKTSS NGKFSIYLGK RDFVDDVDTV EPIDGVVLVD PEYLEGRKLF
60 70 80 90 100
VRLTCAFRYG RDDLDVIGLT FRKDLYVQTK QVAPAEPTSI QGPLTALQER
110 120 130 140 150
LLHKLGVNAY PFTLQMVANL PCSVTLQPGP EDSGKPCGVD FEVKSFCAEN
160 170 180 190 200
LEEKIPKSDS VQLVVRKVQF SALEPGPGPS AQTIRSFFLS SQPLQLQAWM
210 220 230 240 250
DREVHYHGEA ISVHVSINNY TNKVIRRIKI AVVQTTDVVL YSLDKYTKTV
260 270 280 290 300
FVQEFTETVA ANSSFSQTFA VTPLLAANCQ KQGLALDGKL KHEDTNLASS
310 320 330 340 350
TILRPGMNKE LLGILVSYKV RVNLVVSYGG ILGGLPASDV GVELPVILIH
360 370 380
PKPSPGERAV ATSSEDIVIE EFMQHNSQTQ S
Length:381
Mass (Da):41,921
Last modified:February 28, 2001 - v1
Checksum:i3BEAC282EC438920
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156979 mRNA. Translation: AAG38954.1.
CCDSiCCDS41075.1.
RefSeqiNP_573468.1. NM_133205.3.
UniGeneiMm.95518.

Genome annotation databases

EnsembliENSMUST00000113769; ENSMUSP00000109398; ENSMUSG00000060890.
GeneIDi170735.
KEGGimmu:170735.
UCSCiuc009twd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156979 mRNA. Translation: AAG38954.1.
CCDSiCCDS41075.1.
RefSeqiNP_573468.1. NM_133205.3.
UniGeneiMm.95518.

3D structure databases

ProteinModelPortaliQ9EQP6.
SMRiQ9EQP6. Positions 2-375.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiQ9EQP6.
PaxDbiQ9EQP6.
PRIDEiQ9EQP6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113769; ENSMUSP00000109398; ENSMUSG00000060890.
GeneIDi170735.
KEGGimmu:170735.
UCSCiuc009twd.2. mouse.

Organism-specific databases

CTDi407.
MGIiMGI:2159617. Arr3.

Phylogenomic databases

eggNOGiNOG302111.
GeneTreeiENSGT00390000013152.
HOGENOMiHOG000231319.
HOVERGENiHBG002399.
InParanoidiQ9EQP6.
KOiK13801.
OMAiVKSFCAE.
OrthoDBiEOG79W954.
PhylomeDBiQ9EQP6.
TreeFamiTF314260.

Miscellaneous databases

NextBioi370278.
PROiQ9EQP6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9EQP6.
CleanExiMM_ARR3.
ExpressionAtlasiQ9EQP6. baseline and differential.
GenevestigatoriQ9EQP6.

Family and domain databases

Gene3Di2.60.40.640. 1 hit.
2.60.40.840. 1 hit.
InterProiIPR000698. Arrestin.
IPR011021. Arrestin-like_N.
IPR014752. Arrestin_C.
IPR011022. Arrestin_C-like.
IPR017864. Arrestin_CS.
IPR014753. Arrestin_N.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR11792. PTHR11792. 1 hit.
PfamiPF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view]
PRINTSiPR00309. ARRESTIN.
SMARTiSM01017. Arrestin_C. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 2 hits.
PROSITEiPS00295. ARRESTINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Mouse cone arrestin gene characterization: promoter targets expression to cone photoreceptors."
    Zhu X., Ma B., Babu S., Murage J., Knox B.E., Craft C.M.
    FEBS Lett. 524:116-122(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.
  2. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 310-319, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.

Entry informationi

Entry nameiARRC_MOUSE
AccessioniPrimary (citable) accession number: Q9EQP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 4, 2002
Last sequence update: February 28, 2001
Last modified: January 6, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.