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Q9EQP6 (ARRC_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Arrestin-C
Alternative name(s):
Cone arrestin
Short name=cArr
Retinal cone arrestin-3
Gene names
Name:Arr3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins.

Subunit structure

Interacts with CXCR4; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates the calcium ion mobilization activity of CXCR4 By similarity.

Tissue specificity

Inner and outer segments, and the inner plexiform regions of the retina.

Sequence similarities

Belongs to the arrestin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 381381Arrestin-C
PRO_0000205204

Sequences

Sequence LengthMass (Da)Tools
Q9EQP6 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 3BEAC282EC438920

FASTA38141,921
        10         20         30         40         50         60 
MSTVFKKTSS NGKFSIYLGK RDFVDDVDTV EPIDGVVLVD PEYLEGRKLF VRLTCAFRYG 

        70         80         90        100        110        120 
RDDLDVIGLT FRKDLYVQTK QVAPAEPTSI QGPLTALQER LLHKLGVNAY PFTLQMVANL 

       130        140        150        160        170        180 
PCSVTLQPGP EDSGKPCGVD FEVKSFCAEN LEEKIPKSDS VQLVVRKVQF SALEPGPGPS 

       190        200        210        220        230        240 
AQTIRSFFLS SQPLQLQAWM DREVHYHGEA ISVHVSINNY TNKVIRRIKI AVVQTTDVVL 

       250        260        270        280        290        300 
YSLDKYTKTV FVQEFTETVA ANSSFSQTFA VTPLLAANCQ KQGLALDGKL KHEDTNLASS 

       310        320        330        340        350        360 
TILRPGMNKE LLGILVSYKV RVNLVVSYGG ILGGLPASDV GVELPVILIH PKPSPGERAV 

       370        380 
ATSSEDIVIE EFMQHNSQTQ S

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References

[1]"Mouse cone arrestin gene characterization: promoter targets expression to cone photoreceptors."
Zhu X., Ma B., Babu S., Murage J., Knox B.E., Craft C.M.
FEBS Lett. 524:116-122(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Retina.
[2]Lubec G., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 310-319, MASS SPECTROMETRY.
Strain: OF1.
Tissue: Hippocampus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF156979 mRNA. Translation: AAG38954.1.
IPIIPI00111388.
RefSeqNP_573468.1. NM_133205.3.
UniGeneMm.95518.

3D structure databases

ProteinModelPortalQ9EQP6.
SMRQ9EQP6. Positions 2-375.
ModBaseSearch...

Proteomic databases

PaxDbQ9EQP6.
PRIDEQ9EQP6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000113769; ENSMUSP00000109398; ENSMUSG00000060890.
GeneID170735.
KEGGmmu:170735.

Organism-specific databases

CTD407.
MGIMGI:2159617. Arr3.

Phylogenomic databases

eggNOGNOG302111.
GeneTreeENSGT00390000013152.
HOGENOMHOG000231319.
HOVERGENHBG002399.
InParanoidQ9EQP6.
KOK13801.
OrthoDBEOG4MCX0K.

Gene expression databases

ArrayExpressQ9EQP6.
BgeeQ9EQP6.
CleanExMM_ARR3.
GenevestigatorQ9EQP6.
GermOnlineENSMUSG00000060890. Mus musculus.

Family and domain databases

Gene3D2.60.40.640. 1 hit.
2.60.40.840. 1 hit.
InterProIPR000698. Arrestin.
IPR011021. Arrestin-like_N.
IPR014752. Arrestin_C.
IPR011022. Arrestin_C-like.
IPR017864. Arrestin_CS.
IPR014753. Arrestin_N.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERPTHR11792. PTHR11792. 1 hit.
PfamPF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view]
PRINTSPR00309. ARRESTIN.
SMARTSM01017. Arrestin_C. 1 hit.
[Graphical view]
SUPFAMSSF81296. Ig_E-set. 2 hits.
PROSITEPS00295. ARRESTINS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio370278.
SOURCESearch...

Entry information

Entry nameARRC_MOUSE
AccessionPrimary (citable) accession number: Q9EQP6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: March 1, 2001
Last modified: April 3, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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