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Q9EQP6

- ARRC_MOUSE

UniProt

Q9EQP6 - ARRC_MOUSE

Protein

Arrestin-C

Gene

Arr3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins.

    GO - Molecular functioni

    1. opsin binding Source: MGI
    2. phosphoprotein binding Source: MGI

    GO - Biological processi

    1. endocytosis Source: MGI
    2. regulation of protein phosphorylation Source: MGI
    3. signal transduction Source: InterPro
    4. visual perception Source: UniProtKB-KW

    Keywords - Biological processi

    Sensory transduction, Vision

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arrestin-C
    Alternative name(s):
    Cone arrestin
    Short name:
    cArr
    Retinal cone arrestin-3
    Gene namesi
    Name:Arr3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:2159617. Arr3.

    Subcellular locationi

    GO - Cellular componenti

    1. photoreceptor inner segment Source: MGI
    2. photoreceptor outer segment Source: MGI
    3. synapse Source: MGI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 381381Arrestin-CPRO_0000205204Add
    BLAST

    Proteomic databases

    MaxQBiQ9EQP6.
    PaxDbiQ9EQP6.
    PRIDEiQ9EQP6.

    Expressioni

    Tissue specificityi

    Inner and outer segments, and the inner plexiform regions of the retina.

    Gene expression databases

    BgeeiQ9EQP6.
    CleanExiMM_ARR3.
    GenevestigatoriQ9EQP6.

    Interactioni

    Subunit structurei

    Interacts with CXCR4; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates the calcium ion mobilization activity of CXCR4.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9EQP6.
    SMRiQ9EQP6. Positions 2-375.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the arrestin family.Curated

    Phylogenomic databases

    eggNOGiNOG302111.
    GeneTreeiENSGT00390000013152.
    HOGENOMiHOG000231319.
    HOVERGENiHBG002399.
    InParanoidiQ9EQP6.
    KOiK13801.
    OMAiKGRKMFV.
    OrthoDBiEOG79W954.
    PhylomeDBiQ9EQP6.
    TreeFamiTF314260.

    Family and domain databases

    Gene3Di2.60.40.640. 1 hit.
    2.60.40.840. 1 hit.
    InterProiIPR000698. Arrestin.
    IPR011021. Arrestin-like_N.
    IPR014752. Arrestin_C.
    IPR011022. Arrestin_C-like.
    IPR017864. Arrestin_CS.
    IPR014753. Arrestin_N.
    IPR014756. Ig_E-set.
    [Graphical view]
    PANTHERiPTHR11792. PTHR11792. 1 hit.
    PfamiPF02752. Arrestin_C. 1 hit.
    PF00339. Arrestin_N. 1 hit.
    [Graphical view]
    PRINTSiPR00309. ARRESTIN.
    SMARTiSM01017. Arrestin_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF81296. SSF81296. 2 hits.
    PROSITEiPS00295. ARRESTINS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9EQP6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTVFKKTSS NGKFSIYLGK RDFVDDVDTV EPIDGVVLVD PEYLEGRKLF    50
    VRLTCAFRYG RDDLDVIGLT FRKDLYVQTK QVAPAEPTSI QGPLTALQER 100
    LLHKLGVNAY PFTLQMVANL PCSVTLQPGP EDSGKPCGVD FEVKSFCAEN 150
    LEEKIPKSDS VQLVVRKVQF SALEPGPGPS AQTIRSFFLS SQPLQLQAWM 200
    DREVHYHGEA ISVHVSINNY TNKVIRRIKI AVVQTTDVVL YSLDKYTKTV 250
    FVQEFTETVA ANSSFSQTFA VTPLLAANCQ KQGLALDGKL KHEDTNLASS 300
    TILRPGMNKE LLGILVSYKV RVNLVVSYGG ILGGLPASDV GVELPVILIH 350
    PKPSPGERAV ATSSEDIVIE EFMQHNSQTQ S 381
    Length:381
    Mass (Da):41,921
    Last modified:March 1, 2001 - v1
    Checksum:i3BEAC282EC438920
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF156979 mRNA. Translation: AAG38954.1.
    CCDSiCCDS41075.1.
    RefSeqiNP_573468.1. NM_133205.3.
    UniGeneiMm.95518.

    Genome annotation databases

    EnsembliENSMUST00000113769; ENSMUSP00000109398; ENSMUSG00000060890.
    GeneIDi170735.
    KEGGimmu:170735.
    UCSCiuc009twd.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF156979 mRNA. Translation: AAG38954.1 .
    CCDSi CCDS41075.1.
    RefSeqi NP_573468.1. NM_133205.3.
    UniGenei Mm.95518.

    3D structure databases

    ProteinModelPortali Q9EQP6.
    SMRi Q9EQP6. Positions 2-375.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    MaxQBi Q9EQP6.
    PaxDbi Q9EQP6.
    PRIDEi Q9EQP6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000113769 ; ENSMUSP00000109398 ; ENSMUSG00000060890 .
    GeneIDi 170735.
    KEGGi mmu:170735.
    UCSCi uc009twd.2. mouse.

    Organism-specific databases

    CTDi 407.
    MGIi MGI:2159617. Arr3.

    Phylogenomic databases

    eggNOGi NOG302111.
    GeneTreei ENSGT00390000013152.
    HOGENOMi HOG000231319.
    HOVERGENi HBG002399.
    InParanoidi Q9EQP6.
    KOi K13801.
    OMAi KGRKMFV.
    OrthoDBi EOG79W954.
    PhylomeDBi Q9EQP6.
    TreeFami TF314260.

    Miscellaneous databases

    NextBioi 370278.
    PROi Q9EQP6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9EQP6.
    CleanExi MM_ARR3.
    Genevestigatori Q9EQP6.

    Family and domain databases

    Gene3Di 2.60.40.640. 1 hit.
    2.60.40.840. 1 hit.
    InterProi IPR000698. Arrestin.
    IPR011021. Arrestin-like_N.
    IPR014752. Arrestin_C.
    IPR011022. Arrestin_C-like.
    IPR017864. Arrestin_CS.
    IPR014753. Arrestin_N.
    IPR014756. Ig_E-set.
    [Graphical view ]
    PANTHERi PTHR11792. PTHR11792. 1 hit.
    Pfami PF02752. Arrestin_C. 1 hit.
    PF00339. Arrestin_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00309. ARRESTIN.
    SMARTi SM01017. Arrestin_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81296. SSF81296. 2 hits.
    PROSITEi PS00295. ARRESTINS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse cone arrestin gene characterization: promoter targets expression to cone photoreceptors."
      Zhu X., Ma B., Babu S., Murage J., Knox B.E., Craft C.M.
      FEBS Lett. 524:116-122(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Retina.
    2. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 310-319, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.

    Entry informationi

    Entry nameiARRC_MOUSE
    AccessioniPrimary (citable) accession number: Q9EQP6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 5, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3