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Q9EQP6

- ARRC_MOUSE

UniProt

Q9EQP6 - ARRC_MOUSE

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Protein
Arrestin-C
Gene
Arr3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins.

GO - Molecular functioni

  1. opsin binding Source: MGI
  2. phosphoprotein binding Source: MGI

GO - Biological processi

  1. endocytosis Source: MGI
  2. regulation of protein phosphorylation Source: MGI
  3. signal transduction Source: InterPro
  4. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Sensory transduction, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Arrestin-C
Alternative name(s):
Cone arrestin
Short name:
cArr
Retinal cone arrestin-3
Gene namesi
Name:Arr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:2159617. Arr3.

Subcellular locationi

GO - Cellular componenti

  1. photoreceptor inner segment Source: MGI
  2. photoreceptor outer segment Source: MGI
  3. synapse Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 381381Arrestin-C
PRO_0000205204Add
BLAST

Proteomic databases

MaxQBiQ9EQP6.
PaxDbiQ9EQP6.
PRIDEiQ9EQP6.

Expressioni

Tissue specificityi

Inner and outer segments, and the inner plexiform regions of the retina.

Gene expression databases

BgeeiQ9EQP6.
CleanExiMM_ARR3.
GenevestigatoriQ9EQP6.

Interactioni

Subunit structurei

Interacts with CXCR4; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates the calcium ion mobilization activity of CXCR4 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9EQP6.
SMRiQ9EQP6. Positions 2-375.

Family & Domainsi

Sequence similaritiesi

Belongs to the arrestin family.

Phylogenomic databases

eggNOGiNOG302111.
GeneTreeiENSGT00390000013152.
HOGENOMiHOG000231319.
HOVERGENiHBG002399.
InParanoidiQ9EQP6.
KOiK13801.
OMAiKGRKMFV.
OrthoDBiEOG79W954.
PhylomeDBiQ9EQP6.
TreeFamiTF314260.

Family and domain databases

Gene3Di2.60.40.640. 1 hit.
2.60.40.840. 1 hit.
InterProiIPR000698. Arrestin.
IPR011021. Arrestin-like_N.
IPR014752. Arrestin_C.
IPR011022. Arrestin_C-like.
IPR017864. Arrestin_CS.
IPR014753. Arrestin_N.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR11792. PTHR11792. 1 hit.
PfamiPF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view]
PRINTSiPR00309. ARRESTIN.
SMARTiSM01017. Arrestin_C. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 2 hits.
PROSITEiPS00295. ARRESTINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EQP6-1 [UniParc]FASTAAdd to Basket

« Hide

MSTVFKKTSS NGKFSIYLGK RDFVDDVDTV EPIDGVVLVD PEYLEGRKLF    50
VRLTCAFRYG RDDLDVIGLT FRKDLYVQTK QVAPAEPTSI QGPLTALQER 100
LLHKLGVNAY PFTLQMVANL PCSVTLQPGP EDSGKPCGVD FEVKSFCAEN 150
LEEKIPKSDS VQLVVRKVQF SALEPGPGPS AQTIRSFFLS SQPLQLQAWM 200
DREVHYHGEA ISVHVSINNY TNKVIRRIKI AVVQTTDVVL YSLDKYTKTV 250
FVQEFTETVA ANSSFSQTFA VTPLLAANCQ KQGLALDGKL KHEDTNLASS 300
TILRPGMNKE LLGILVSYKV RVNLVVSYGG ILGGLPASDV GVELPVILIH 350
PKPSPGERAV ATSSEDIVIE EFMQHNSQTQ S 381
Length:381
Mass (Da):41,921
Last modified:March 1, 2001 - v1
Checksum:i3BEAC282EC438920
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF156979 mRNA. Translation: AAG38954.1.
CCDSiCCDS41075.1.
RefSeqiNP_573468.1. NM_133205.3.
UniGeneiMm.95518.

Genome annotation databases

EnsembliENSMUST00000113769; ENSMUSP00000109398; ENSMUSG00000060890.
GeneIDi170735.
KEGGimmu:170735.
UCSCiuc009twd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF156979 mRNA. Translation: AAG38954.1 .
CCDSi CCDS41075.1.
RefSeqi NP_573468.1. NM_133205.3.
UniGenei Mm.95518.

3D structure databases

ProteinModelPortali Q9EQP6.
SMRi Q9EQP6. Positions 2-375.
ModBasei Search...
MobiDBi Search...

Proteomic databases

MaxQBi Q9EQP6.
PaxDbi Q9EQP6.
PRIDEi Q9EQP6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000113769 ; ENSMUSP00000109398 ; ENSMUSG00000060890 .
GeneIDi 170735.
KEGGi mmu:170735.
UCSCi uc009twd.2. mouse.

Organism-specific databases

CTDi 407.
MGIi MGI:2159617. Arr3.

Phylogenomic databases

eggNOGi NOG302111.
GeneTreei ENSGT00390000013152.
HOGENOMi HOG000231319.
HOVERGENi HBG002399.
InParanoidi Q9EQP6.
KOi K13801.
OMAi KGRKMFV.
OrthoDBi EOG79W954.
PhylomeDBi Q9EQP6.
TreeFami TF314260.

Miscellaneous databases

NextBioi 370278.
PROi Q9EQP6.
SOURCEi Search...

Gene expression databases

Bgeei Q9EQP6.
CleanExi MM_ARR3.
Genevestigatori Q9EQP6.

Family and domain databases

Gene3Di 2.60.40.640. 1 hit.
2.60.40.840. 1 hit.
InterProi IPR000698. Arrestin.
IPR011021. Arrestin-like_N.
IPR014752. Arrestin_C.
IPR011022. Arrestin_C-like.
IPR017864. Arrestin_CS.
IPR014753. Arrestin_N.
IPR014756. Ig_E-set.
[Graphical view ]
PANTHERi PTHR11792. PTHR11792. 1 hit.
Pfami PF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view ]
PRINTSi PR00309. ARRESTIN.
SMARTi SM01017. Arrestin_C. 1 hit.
[Graphical view ]
SUPFAMi SSF81296. SSF81296. 2 hits.
PROSITEi PS00295. ARRESTINS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mouse cone arrestin gene characterization: promoter targets expression to cone photoreceptors."
    Zhu X., Ma B., Babu S., Murage J., Knox B.E., Craft C.M.
    FEBS Lett. 524:116-122(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.
  2. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 310-319, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.

Entry informationi

Entry nameiARRC_MOUSE
AccessioniPrimary (citable) accession number: Q9EQP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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