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Q9EQP5

- PRELP_RAT

UniProt

Q9EQP5 - PRELP_RAT

Protein

Prolargin

Gene

Prelp

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    May anchor basement membranes to the underlying connective tissue.By similarity

    GO - Molecular functioni

    1. extracellular matrix structural constituent Source: InterPro
    2. heparin binding Source: RGD

    GO - Biological processi

    1. cell aging Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_196475. Keratan sulfate biosynthesis.
    REACT_198617. Keratan sulfate degradation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prolargin
    Alternative name(s):
    Proline-arginine-rich end leucine-rich repeat protein
    Gene namesi
    Name:Prelp
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 13

    Organism-specific databases

    RGDi620226. Prelp.

    Subcellular locationi

    GO - Cellular componenti

    1. proteinaceous extracellular matrix Source: RGD

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 377356ProlarginPRO_0000032746Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi284 – 2841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi315 – 3151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi322 – 3221N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi327 ↔ 368By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9EQP5.
    PRIDEiQ9EQP5.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9EQP5.

    Interactioni

    Subunit structurei

    Binds the basement membrane heparan sulfate proteoglycan perlecan and triple helical collagens type I and type II.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000004241.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9EQP5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati90 – 10920LRR 1Add
    BLAST
    Repeati110 – 13324LRR 2Add
    BLAST
    Repeati134 – 15724LRR 3Add
    BLAST
    Repeati158 – 17821LRR 4Add
    BLAST
    Repeati179 – 20224LRR 5Add
    BLAST
    Repeati203 – 22826LRR 6Add
    BLAST
    Repeati229 – 24921LRR 7Add
    BLAST
    Repeati250 – 27324LRR 8Add
    BLAST
    Repeati274 – 29825LRR 9Add
    BLAST
    Repeati299 – 31820LRR 10Add
    BLAST
    Repeati319 – 35739LRR 11Add
    BLAST
    Repeati358 – 37720LRR 12Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi68 – 8417Cys-richAdd
    BLAST
    Compositional biasi192 – 1976Poly-Leu

    Domaini

    The basic N-terminal Arg/Pro-rich region binds heparin and heparan sulfate. Binds collagens type I and type II through its leucine-rich repeat domain By similarity.By similarity

    Sequence similaritiesi

    Contains 12 LRR (leucine-rich) repeats.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG4886.
    GeneTreeiENSGT00600000084286.
    HOGENOMiHOG000234447.
    HOVERGENiHBG108061.
    InParanoidiQ9EQP5.
    KOiK08125.
    OMAiDTFQGLK.
    OrthoDBiEOG741Z2B.
    PhylomeDBiQ9EQP5.
    TreeFamiTF334562.

    Family and domain databases

    InterProiIPR001611. Leu-rich_rpt.
    IPR000372. LRR-contain_N.
    IPR027216. Prolargin.
    [Graphical view]
    PANTHERiPTHR24371:SF15. PTHR24371:SF15. 1 hit.
    PfamiPF00560. LRR_1. 3 hits.
    PF13855. LRR_8. 2 hits.
    PF01462. LRRNT. 1 hit.
    [Graphical view]
    SMARTiSM00013. LRRNT. 1 hit.
    [Graphical view]
    PROSITEiPS51450. LRR. 10 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9EQP5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRASFFWFLP LLLILASVAQ GQPRPKPGIR RKPKPRPTPS FPQPHEPAEP    50
    TDLPPPLPPG PPSVFPDCPR ECYCPPDFPS ALYCDSRNLR KVPIIPPRIH 100
    YLYLQNNFIT ELPVESFKNA TGLRWINLDN NRIRKVDQRV LEKLPGLAFL 150
    YMDKNQLEEV PSALPRNLEQ LRLSQNLISR IPPGVFSKLE NLLLLDLQHN 200
    RLSDGVFKAD TFQGLKNLMQ LNLAHNILRR MPPKVPPAIH QLYLDSNKIE 250
    TIPSGYFKDF PNLAFIRMNY NKLSDRGLPK NSFNISNLLV LHLSHNKISN 300
    VPAISNKLEH LYLNNNSIEK INGTQICPSN LVAFHDFSSD LENVPHLRYL 350
    RLDGNFLKPP IPLDLMMCFR LLQSVVI 377
    Length:377
    Mass (Da):43,179
    Last modified:March 1, 2001 - v1
    Checksum:i79CBE62534753C46
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF163569 mRNA. Translation: AAG23724.1.
    BC072487 mRNA. Translation: AAH72487.1.
    RefSeqiNP_445837.1. NM_053385.1.
    XP_006249953.1. XM_006249891.1.
    UniGeneiRn.112602.

    Genome annotation databases

    EnsembliENSRNOT00000004241; ENSRNOP00000004241; ENSRNOG00000003120.
    GeneIDi84400.
    KEGGirno:84400.
    UCSCiRGD:620226. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF163569 mRNA. Translation: AAG23724.1 .
    BC072487 mRNA. Translation: AAH72487.1 .
    RefSeqi NP_445837.1. NM_053385.1.
    XP_006249953.1. XM_006249891.1.
    UniGenei Rn.112602.

    3D structure databases

    ProteinModelPortali Q9EQP5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000004241.

    Proteomic databases

    PaxDbi Q9EQP5.
    PRIDEi Q9EQP5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000004241 ; ENSRNOP00000004241 ; ENSRNOG00000003120 .
    GeneIDi 84400.
    KEGGi rno:84400.
    UCSCi RGD:620226. rat.

    Organism-specific databases

    CTDi 5549.
    RGDi 620226. Prelp.

    Phylogenomic databases

    eggNOGi COG4886.
    GeneTreei ENSGT00600000084286.
    HOGENOMi HOG000234447.
    HOVERGENi HBG108061.
    InParanoidi Q9EQP5.
    KOi K08125.
    OMAi DTFQGLK.
    OrthoDBi EOG741Z2B.
    PhylomeDBi Q9EQP5.
    TreeFami TF334562.

    Enzyme and pathway databases

    Reactomei REACT_196475. Keratan sulfate biosynthesis.
    REACT_198617. Keratan sulfate degradation.

    Miscellaneous databases

    NextBioi 616827.
    PROi Q9EQP5.

    Gene expression databases

    Genevestigatori Q9EQP5.

    Family and domain databases

    InterProi IPR001611. Leu-rich_rpt.
    IPR000372. LRR-contain_N.
    IPR027216. Prolargin.
    [Graphical view ]
    PANTHERi PTHR24371:SF15. PTHR24371:SF15. 1 hit.
    Pfami PF00560. LRR_1. 3 hits.
    PF13855. LRR_8. 2 hits.
    PF01462. LRRNT. 1 hit.
    [Graphical view ]
    SMARTi SM00013. LRRNT. 1 hit.
    [Graphical view ]
    PROSITEi PS51450. LRR. 10 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The amino-terminal part of PRELP binds to heparin and heparan sulfate."
      Bengtsson E., Aspberg A., Heinegaard D., Sommarin Y., Spillmann D.
      J. Biol. Chem. 275:40695-40702(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Chondrosarcoma.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.

    Entry informationi

    Entry nameiPRELP_RAT
    AccessioniPrimary (citable) accession number: Q9EQP5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3