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Protein

Prolargin

Gene

Prelp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May anchor basement membranes to the underlying connective tissue.By similarity

GO - Molecular functioni

  • extracellular matrix structural constituent Source: InterPro
  • heparin binding Source: RGD

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-2022854 Keratan sulfate biosynthesis
R-RNO-2022857 Keratan sulfate degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Prolargin
Alternative name(s):
Proline-arginine-rich end leucine-rich repeat protein
Gene namesi
Name:Prelp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi620226 Prelp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000003274622 – 377ProlarginAdd BLAST356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi284N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi315N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi322N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi327 ↔ 368By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9EQP5
PRIDEiQ9EQP5

PTM databases

iPTMnetiQ9EQP5
PhosphoSitePlusiQ9EQP5

Expressioni

Gene expression databases

BgeeiENSRNOG00000003120
GenevisibleiQ9EQP5 RN

Interactioni

Subunit structurei

Binds the basement membrane heparan sulfate proteoglycan perlecan and triple helical collagens type I and type II.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004241

Structurei

3D structure databases

ProteinModelPortaliQ9EQP5
SMRiQ9EQP5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati90 – 109LRR 1Add BLAST20
Repeati110 – 133LRR 2Add BLAST24
Repeati134 – 157LRR 3Add BLAST24
Repeati158 – 178LRR 4Add BLAST21
Repeati179 – 202LRR 5Add BLAST24
Repeati203 – 228LRR 6Add BLAST26
Repeati229 – 249LRR 7Add BLAST21
Repeati250 – 273LRR 8Add BLAST24
Repeati274 – 298LRR 9Add BLAST25
Repeati299 – 318LRR 10Add BLAST20
Repeati319 – 357LRR 11Add BLAST39
Repeati358 – 377LRR 12Add BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi68 – 84Cys-richAdd BLAST17
Compositional biasi192 – 197Poly-Leu6

Domaini

The basic N-terminal Arg/Pro-rich region binds heparin and heparan sulfate. Binds collagens type I and type II through its leucine-rich repeat domain (By similarity).By similarity

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118969
HOGENOMiHOG000234447
HOVERGENiHBG108061
InParanoidiQ9EQP5
KOiK08125
OMAiYFKGFPN
PhylomeDBiQ9EQP5
TreeFamiTF334562

Family and domain databases

Gene3Di3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR027216 Prolargin
PANTHERiPTHR24373:SF152 PTHR24373:SF152, 1 hit
PfamiView protein in Pfam
PF00560 LRR_1, 1 hit
PF13855 LRR_8, 2 hits
PF01462 LRRNT, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 8 hits
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 10 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EQP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRASFFWFLP LLLILASVAQ GQPRPKPGIR RKPKPRPTPS FPQPHEPAEP
60 70 80 90 100
TDLPPPLPPG PPSVFPDCPR ECYCPPDFPS ALYCDSRNLR KVPIIPPRIH
110 120 130 140 150
YLYLQNNFIT ELPVESFKNA TGLRWINLDN NRIRKVDQRV LEKLPGLAFL
160 170 180 190 200
YMDKNQLEEV PSALPRNLEQ LRLSQNLISR IPPGVFSKLE NLLLLDLQHN
210 220 230 240 250
RLSDGVFKAD TFQGLKNLMQ LNLAHNILRR MPPKVPPAIH QLYLDSNKIE
260 270 280 290 300
TIPSGYFKDF PNLAFIRMNY NKLSDRGLPK NSFNISNLLV LHLSHNKISN
310 320 330 340 350
VPAISNKLEH LYLNNNSIEK INGTQICPSN LVAFHDFSSD LENVPHLRYL
360 370
RLDGNFLKPP IPLDLMMCFR LLQSVVI
Length:377
Mass (Da):43,179
Last modified:March 1, 2001 - v1
Checksum:i79CBE62534753C46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF163569 mRNA Translation: AAG23724.1
BC072487 mRNA Translation: AAH72487.1
RefSeqiNP_445837.1, NM_053385.1
XP_006249953.1, XM_006249891.3
XP_008767794.1, XM_008769572.1
UniGeneiRn.112602

Genome annotation databases

EnsembliENSRNOT00000004241; ENSRNOP00000004241; ENSRNOG00000003120
ENSRNOT00000076610; ENSRNOP00000068464; ENSRNOG00000003120
ENSRNOT00000079116; ENSRNOP00000075732; ENSRNOG00000003120
GeneIDi84400
KEGGirno:84400
UCSCiRGD:620226 rat

Similar proteinsi

Entry informationi

Entry nameiPRELP_RAT
AccessioniPrimary (citable) accession number: Q9EQP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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