ID   NKX24_MOUSE             Reviewed;         354 AA.
AC   Q9EQM3; A2ATK2; Q9EQM4;
DT   27-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   27-JAN-2003, sequence version 2.
DT   16-NOV-2011, entry version 77.
DE   RecName: Full=Homeobox protein Nkx-2.4;
DE   AltName: Full=Homeobox protein NK-2 homolog D;
GN   Name=Nkx2-4; Synonyms=Nkx2d;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   STRAIN=129/Sv, and C57BL/6;
RX   MEDLINE=20279852; PubMed=10818213; DOI=10.1007/s003350010089;
RA   Wang C.-C., Brodnicki T., Copeland N.G., Jenkins N.A., Harvey R.P.;
RT   "Conserved linkage of NK-2 homeobox gene pairs Nkx2-2/2-4 and Nkx2-
RT   1/2-9 in mammals.";
RL   Mamm. Genome 11:466-468(2000).
RN   [2]
RP   PARTIAL NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6;
RX   MEDLINE=92153416; PubMed=1346742; DOI=10.1016/0896-6273(92)90291-K;
RA   Price M., Lazzaro D., Pohl T., Mattei M.-G., Ruether U., Olivo J.-C.,
RA   Duboule D., di Lauro R.;
RT   "Regional expression of the homeobox gene Nkx-2.2 in the developing
RT   mammalian forebrain.";
RL   Neuron 8:241-255(1992).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- FUNCTION: Probable transcription factor.
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC   -!- TISSUE SPECIFICITY: In the embryo it is detected in the posterior
CC       hypotalamus and later in the head. In the adult it is detected
CC       only in testis.
CC   -!- DEVELOPMENTAL STAGE: Expressed in a restricted region of the
CC       posterior hypothalamus from E10. Detected in the head region from
CC       E12.5 to E14.5. Expression is down-regulated by E15.5.
CC   -!- SIMILARITY: Belongs to the NK-2 homeobox family.
CC   -!- SIMILARITY: Contains 1 homeobox DNA-binding domain.
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DR   EMBL; AF202038; AAG35618.1; -; Genomic_DNA.
DR   EMBL; AF202039; AAG35619.1; -; mRNA.
DR   EMBL; AL928876; CAM18290.1; -; Genomic_DNA.
DR   IPI; IPI00111298; -.
DR   RefSeq; NP_075993.1; NM_023504.1.
DR   UniGene; Mm.315498; -.
DR   ProteinModelPortal; Q9EQM3; -.
DR   SMR; Q9EQM3; 188-254.
DR   STRING; Q9EQM3; -.
DR   PRIDE; Q9EQM3; -.
DR   Ensembl; ENSMUST00000067020; ENSMUSP00000066690; ENSMUSG00000054160.
DR   GeneID; 228731; -.
DR   KEGG; mmu:228731; -.
DR   UCSC; uc008mss.1; mouse.
DR   CTD; 644524; -.
DR   MGI; MGI:97349; Nkx2-4.
DR   GeneTree; ENSGT00590000082895; -.
DR   HOGENOM; HBG715804; -.
DR   HOVERGEN; HBG006689; -.
DR   InParanoid; Q9EQM3; -.
DR   OMA; MDGAPPG; -.
DR   PhylomeDB; Q9EQM3; -.
DR   NextBio; 379096; -.
DR   ArrayExpress; Q9EQM3; -.
DR   Bgee; Q9EQM3; -.
DR   Genevestigator; Q9EQM3; -.
DR   GermOnline; ENSMUSG00000054160; Mus musculus.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
DR   InterPro; IPR001356; Homeobox.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR020479; Homeobox_eu.
DR   InterPro; IPR009057; Homeodomain-like.
DR   InterPro; IPR012287; Homeodomain-rel.
DR   Gene3D; G3DSA:1.10.10.60; Homeodomain-rel; 1.
DR   KO; K09344; -.
DR   Pfam; PF00046; Homeobox; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain_like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Developmental protein; DNA-binding; Homeobox;
KW   Nucleus; Reference proteome.
FT   CHAIN         1    354       Homeobox protein Nkx-2.4.
FT                                /FTId=PRO_0000048936.
FT   DNA_BIND    188    247       Homeobox.
FT   COMPBIAS     76     91       Poly-Ala.
FT   COMPBIAS    132    136       Poly-Ala.
FT   COMPBIAS    263    272       Poly-Pro.
SQ   SEQUENCE   354 AA;  36225 MW;  A7A0F450DB15616C CRC64;
     MSLSPKHTTP FSVSDILSPI EETYKKFGGV MDGAPPGLGA PLGAAAYRAP PSGPSSQAAA
     VAAGMQPPHA MAGHNAAAAA AAAAAAAAAA ATYHMPPGVS QFPHSAMGSY CNGGLGNMGE
     LPAYTDGMRG GAAAAATGWY GANTDPRYSS ISRFMGPSAG VNVAGMGSLT GIADAAKSLA
     PLHAAAPRRK RRVLFSQAQV YELERRFKQQ KYLSAPEREH LASMIHLTPT QVKIWFQNHR
     YKMKRQAKDK AAQQLQQEGG LGPPPPPPPP SPRRVAVPVL VKDGKPCQNG AGTPTPGQGG
     QQPQAPTPAP ELEELSPSPP ALHGPGGGLA ALDAATGDYG GGVLGANLLY GRTW
//