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Unreviewed, UniProtKB/TrEMBL Q9EQL0 (Q9EQL0_RAT)

Last modified January 19, 2010. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

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Names and origin

Protein namesRecommended name:
    Cellular tumor antigen p53 RuleBase RU003304V0
Gene names
Name: Tp53 RGD 3889
OrganismRattus norvegicus (Rat) EMBL AAG35765.1
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length271 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression By similarity. RuleBase RU003304V0

Subunit structure

Binds DNA as a homotetramer By similarity. RuleBase RU003304V0

Subcellular location

Cytoplasm. Nucleus By similarity RuleBase RU003304V0.

Sequence similarities

Belongs to the p53 family.

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Ontologies

Keywords
   Biological processApoptosis RuleBase RU003304V0
Cell cycle RuleBase RU003304V0
Transcription
Transcription regulation RuleBase RU003304V0 Spearmint SPM012346
   Cellular componentNucleus RuleBase RU003401V0 Spearmint SPM012346
   LigandDNA-binding RuleBase RU003304V0
Metal-binding RuleBase RU003304V0
Zinc RuleBase RU003304V0
   Molecular functionActivator RuleBase RU003304V0
   PTMPhosphoprotein RuleBase RU003304V0
Gene Ontology (GO)
   Biological processaging

Inferred from expression pattern. Source: RGD

apoptosis

Inferred from electronic annotation. Source: UniProtKB-KW

cell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

negative regulation of cell growth

Traceable author statement. Source: RGD

negative regulation of smooth muscle cell proliferation

Inferred from mutant phenotype. Source: RGD

positive regulation of apoptosis

Inferred from mutant phenotype. Source: RGD

positive regulation of cell cycle

Inferred from mutant phenotype. Source: RGD

positive regulation of leukocyte migration

Inferred from mutant phenotype. Source: RGD

regulation of intracellular pH

Inferred from mutant phenotype. Source: RGD

regulation of transcription from RNA polymerase II promoter

Traceable author statement. Source: RGD

response to UV

Inferred from expression pattern. Source: RGD

response to X-ray

Inferred from expression pattern. Source: RGD

response to amino acid stimulus

Inferred from expression pattern. Source: RGD

response to caffeine

Inferred from expression pattern. Source: RGD

response to cytokine stimulus

Inferred from expression pattern. Source: RGD

response to drug

Inferred from expression pattern. Source: RGD

response to hyperoxia

Inferred from expression pattern. Source: RGD

response to metal ion

Inferred from expression pattern. Source: RGD

response to oxidative stress

Inferred from expression pattern. Source: RGD

response to retinoic acid

Inferred from expression pattern. Source: RGD

response to vitamin B3

Inferred from expression pattern. Source: RGD

transcription

Inferred from electronic annotation. Source: UniProtKB-KW

wound healing

Inferred from expression pattern. Source: RGD

   Cellular componentchromatin

Inferred from direct assay. Source: RGD

cytosol

Inferred from direct assay. Source: RGD

mitochondrion

Inferred from direct assay. Source: RGD

transcription factor complex

Inferred from direct assay. Source: RGD

   Molecular functionRNA polymerase II transcription factor activity

Traceable author statement. Source: RGD

sequence-specific DNA binding

Inferred from direct assay. Source: RGD

transcription factor activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequences

Sequence LengthMass (Da)Tools
Q9EQL0-1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 1C8687B74B9317D2

FASTA27129,713
        10         20         30         40         50         60 
MEDSQSDMSI ELPLSQETFS CLWKLLPPDD ILPTTATGSP NSMEDLFLPQ DVAELLEGPE 

        70         80         90        100        110        120 
EALQVSAPAA QEPGTEAPAP VAPASATPWP LSSSVPSQKT YQGNYGFHLG FLQSGTAKSV 

       130        140        150        160        170        180 
MCTYSISLNK LFCQLAKTCP VQLWVTSTPP PGTRVRAMAI YKKSQHMTEV VRRCPHHERC 

       190        200        210        220        230        240 
SDGDGLAPPQ HLIRVEGNPY AEYLDDRQTF RHSVVVPYEP PEVGSDYTTI HYKYMCNSSC 

       250        260        270 
MGGMNRRPIL TIITLEDSRS VGVSASRCSE S

« Hide

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References

[1]"p35/HAS."
Dell'Acqua G., Mann M.J., Mu H., Griese D.P., Ehsan A., Dzau V.
Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Sprague-Dawley EMBL AAG35765.1.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF209191 mRNA. Translation: AAG35765.1.
IPIIPI00190116.
UniGeneRn.54443

3D structure databases

HSSPHSSP built from PDB template 1GZH based on UniProtKB Q9NP68.
SMRQ9EQL0. Positions 93-258.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9EQL0.

Genome annotation databases

EnsemblENSRNOT00000014890; ENSRNOP00000014890; ENSRNOG00000010756; Rattus norvegicus. [Genome view]
UCSCAF209191. rat.

Phylogenomic databases

HOVERGENQ9EQL0.

Gene expression databases

ArrayExpressQ9EQL0.
GenevestigatorQ9EQL0.

Family and domain databases

InterProIPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA_bd.
IPR011615. p53_DNA_bd.
IPR013872. p53_transactivation_domain.
IPR002117. p53_tumour_Ag.
IPR015551. Trp53.
[Graphical view]
Gene3DG3DSA:2.60.40.720. p53_RUNT_DNA_bd. 1 hit.
PANTHERPTHR11447. Trp53. 1 hit.
PfamPF00870. P53. 1 hit.
PF08563. P53_TAD. 1 hit.
[Graphical view]
PRINTSPR00386. P53SUPPRESSR.
PROSITEPS00348. P53. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameQ9EQL0_RAT
AccessionPrimary (citable) accession number: Q9EQL0
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: January 19, 2010
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information