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Q9EQK7

- ICMT_MOUSE

UniProt

Q9EQK7 - ICMT_MOUSE

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Protein

Protein-S-isoprenylcysteine O-methyltransferase

Gene
Icmt
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues By similarity.

Catalytic activityi

S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.

Cofactori

Divalent cations. Probably zinc By similarity.

GO - Molecular functioni

  1. cAMP response element binding protein binding Source: MGI
  2. protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity Source: MGI

GO - Biological processi

  1. C-terminal protein methylation Source: MGI
  2. in utero embryonic development Source: MGI
  3. liver development Source: MGI
  4. multicellular organism growth Source: MGI
  5. positive regulation of cell proliferation Source: MGI
  6. protein localization Source: MGI
  7. protein methylation Source: MGI
  8. regulation of Ras protein signal transduction Source: MGI
  9. regulation of RNA biosynthetic process Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

SABIO-RKQ9EQK7.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-S-isoprenylcysteine O-methyltransferase (EC:2.1.1.100)
Alternative name(s):
Isoprenylcysteine carboxylmethyltransferase
Prenylated protein carboxyl methyltransferase
Short name:
PPMT
Prenylcysteine carboxyl methyltransferase
Short name:
pcCMT
Gene namesi
Name:Icmt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1888594. Icmt.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei16 – 3217Helical; Reviewed predictionAdd
BLAST
Topological domaini33 – 408Lumenal Reviewed prediction
Transmembranei41 – 5818Helical; Reviewed predictionAdd
BLAST
Topological domaini59 – 6810Cytoplasmic Reviewed prediction
Transmembranei69 – 8618Helical; Reviewed predictionAdd
BLAST
Topological domaini87 – 915Lumenal Reviewed prediction
Transmembranei92 – 11120Helical; Reviewed predictionAdd
BLAST
Topological domaini112 – 13019Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei131 – 14818Helical; Reviewed predictionAdd
BLAST
Topological domaini149 – 1535Lumenal Reviewed prediction
Transmembranei154 – 17320Helical; Reviewed predictionAdd
BLAST
Topological domaini174 – 21138Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei212 – 22716Helical; Reviewed predictionAdd
BLAST
Topological domaini228 – 2281Lumenal Reviewed prediction
Transmembranei229 – 24315Helical; Reviewed predictionAdd
BLAST
Topological domaini244 – 28340Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283Protein-S-isoprenylcysteine O-methyltransferasePRO_0000209895Add
BLAST

Proteomic databases

PaxDbiQ9EQK7.
PRIDEiQ9EQK7.

PTM databases

PhosphoSiteiQ9EQK7.

Expressioni

Tissue specificityi

Highly enriched in adult cerebellum, with a low level expression in other brain regions.

Developmental stagei

During cerebellar development expression was low before postnatal day P6 and dramatically increased after P12.

Gene expression databases

CleanExiMM_ICMT.
GenevestigatoriQ9EQK7.

Structurei

3D structure databases

ProteinModelPortaliQ9EQK7.
SMRiQ9EQK7. Positions 181-274.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2020.
HOVERGENiHBG019034.
InParanoidiQ9EQK7.
KOiK00587.
PhylomeDBiQ9EQK7.

Family and domain databases

InterProiIPR007269. ICMT_MeTrfase.
IPR025770. PPMT_MeTrfase.
[Graphical view]
PfamiPF04140. ICMT. 1 hit.
[Graphical view]
PROSITEiPS51564. SAM_ICMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EQK7-1 [UniParc]FASTAAdd to Basket

« Hide

MAAARRGSAG SEARLSLATF LLGASVLALP LLTRAGLQGR TGLALYVAGL    50
NALLLLLYRP PRYQIAIRAC FLGFVFGCGV LLSFSQSSWN HFGWYVCSLS 100
LFHYSEYLVT AVNNPKSLSL DSFLLNHSLE YTVAALSSWI EFTLENIFWP 150
ELKQITWLSA TGLLMVVFGE CLRKAAMFTA GSNFNHVVQS EKSDTHTLVT 200
SGVYAWCRHP SYVGWFYWSI GTQVMLCNPI CGVVYALTVW RFFRDRTEEE 250
EISLIHFFGE EYLDYKKRVP TGLPFIKGVK VEL 283
Length:283
Mass (Da):31,790
Last modified:June 20, 2001 - v2
Checksum:iA6C17436EDC27F40
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241A → D in AA022288. 1 Publication
Sequence conflicti42 – 421G → A1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF209926 mRNA. Translation: AAG48552.1.
AA022288 mRNA. No translation available.
RefSeqiNP_598549.1. NM_133788.2.
UniGeneiMm.277464.

Genome annotation databases

GeneIDi57295.
KEGGimmu:57295.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF209926 mRNA. Translation: AAG48552.1 .
AA022288 mRNA. No translation available.
RefSeqi NP_598549.1. NM_133788.2.
UniGenei Mm.277464.

3D structure databases

ProteinModelPortali Q9EQK7.
SMRi Q9EQK7. Positions 181-274.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9EQK7.

Proteomic databases

PaxDbi Q9EQK7.
PRIDEi Q9EQK7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 57295.
KEGGi mmu:57295.

Organism-specific databases

CTDi 23463.
MGIi MGI:1888594. Icmt.

Phylogenomic databases

eggNOGi COG2020.
HOVERGENi HBG019034.
InParanoidi Q9EQK7.
KOi K00587.
PhylomeDBi Q9EQK7.

Enzyme and pathway databases

SABIO-RK Q9EQK7.

Miscellaneous databases

NextBioi 313651.
PROi Q9EQK7.
SOURCEi Search...

Gene expression databases

CleanExi MM_ICMT.
Genevestigatori Q9EQK7.

Family and domain databases

InterProi IPR007269. ICMT_MeTrfase.
IPR025770. PPMT_MeTrfase.
[Graphical view ]
Pfami PF04140. ICMT. 1 hit.
[Graphical view ]
PROSITEi PS51564. SAM_ICMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1."
    Lin X., Antalffy B., Kang D., Orr H.T., Zoghbi H.Y.
    Nat. Neurosci. 3:157-163(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 20-283.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-153.
    Strain: C57BL/6J.
    Tissue: Placenta.

Entry informationi

Entry nameiICMT_MOUSE
AccessioniPrimary (citable) accession number: Q9EQK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: June 11, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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