Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Major vault protein

Gene

Mvp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cell proliferation Source: UniProtKB
  • ERBB signaling pathway Source: MGI
  • negative regulation of protein autophosphorylation Source: MGI
  • negative regulation of protein tyrosine kinase activity Source: MGI
  • negative regulation of signaling Source: MGI
  • protein activation cascade Source: UniProtKB
  • regulation of signaling Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Major vault protein
Short name:
MVP
Gene namesi
Name:Mvp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1925638 Mvp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001589812 – 861Major vault proteinAdd BLAST860

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei421PhosphoserineBy similarity1
Cross-linki444Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki704Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Phosphorylated on Tyr residues after EGF stimulation.By similarity
Dephosphorylated by PTPN11.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9EQK5
MaxQBiQ9EQK5
PaxDbiQ9EQK5
PeptideAtlasiQ9EQK5
PRIDEiQ9EQK5

2D gel databases

REPRODUCTION-2DPAGEiQ9EQK5

PTM databases

iPTMnetiQ9EQK5
PhosphoSitePlusiQ9EQK5
SwissPalmiQ9EQK5

Expressioni

Gene expression databases

CleanExiMM_MVP

Interactioni

Subunit structurei

The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs). Interacts with PTEN and activated MAPK1. The phosphorylated protein interacts with the SH2 domains of PTPN11 and SRC. Interacts with APEX1 (By similarity). May interact with ZNF540 (By similarity). Interacts with TEP1.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9EQK5, 5 interactors
MINTiQ9EQK5
STRINGi10090.ENSMUSP00000127250

Structurei

Secondary structure

1861
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 10Combined sources4
Beta strandi14 – 20Combined sources7
Turni21 – 23Combined sources3
Beta strandi26 – 36Combined sources11
Beta strandi41 – 43Combined sources3
Beta strandi51 – 53Combined sources3
Beta strandi57 – 63Combined sources7
Beta strandi77 – 79Combined sources3
Beta strandi88 – 91Combined sources4
Beta strandi93 – 97Combined sources5
Beta strandi104 – 111Combined sources8
Beta strandi113 – 115Combined sources3
Beta strandi119 – 127Combined sources9
Beta strandi132 – 134Combined sources3
Beta strandi142 – 151Combined sources10
Beta strandi157 – 164Combined sources8
Beta strandi166 – 168Combined sources3
Beta strandi172 – 183Combined sources12
Beta strandi185 – 187Combined sources3
Beta strandi195 – 198Combined sources4
Beta strandi202 – 204Combined sources3
Beta strandi210 – 217Combined sources8
Beta strandi225 – 233Combined sources9
Beta strandi238 – 240Combined sources3
Beta strandi248 – 251Combined sources4
Turni253 – 255Combined sources3
Beta strandi257 – 259Combined sources3
Beta strandi265 – 272Combined sources8
Beta strandi274 – 276Combined sources3
Beta strandi280 – 286Combined sources7
Beta strandi290 – 292Combined sources3
Beta strandi299 – 308Combined sources10
Beta strandi315 – 322Combined sources8
Beta strandi324 – 326Combined sources3
Beta strandi331 – 336Combined sources6
Beta strandi356 – 359Combined sources4
Beta strandi361 – 365Combined sources5
Beta strandi369 – 377Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GF5X-ray2.50A/B1-383[»]
3GNFX-ray2.10B1-383[»]
3GNGX-ray3.00A1-383[»]
ProteinModelPortaliQ9EQK5
SMRiQ9EQK5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9EQK5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati2 – 56MVP 1Add BLAST55
Repeati57 – 111MVP 2Add BLAST55
Repeati112 – 164MVP 3Add BLAST53
Repeati165 – 217MVP 4Add BLAST53
Repeati218 – 272MVP 5Add BLAST55
Repeati273 – 323MVP 6Add BLAST51
Repeati324 – 379MVP 7Add BLAST56
Repeati380 – 457MVP 8Add BLAST78
Repeati458 – 520MVP 9Add BLAST63

Domaini

MVP 3 mediates interaction with PTEN.By similarity
MVP 4 mediates interaction with PARP4.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IF6T Eukaryota
ENOG410ZCU8 LUCA
HOVERGENiHBG003499
InParanoidiQ9EQK5

Family and domain databases

CDDicd08825 MVP_shoulder, 1 hit
InterProiView protein in InterPro
IPR021870 MVP_shoulder
IPR002499 Vault_N
PfamiView protein in Pfam
PF11978 MVP_shoulder, 1 hit
PF01505 Vault, 4 hits
PROSITEiView protein in PROSITE
PS51224 MVP, 8 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EQK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATEEAIIRI PPYHYIHVLD QNSNVSRVEV GPKTYIRQDN ERVLFAPVRM
60 70 80 90 100
VTVPPRHYCI VANPVSRDAQ SSVLFDVTGQ VRLRHADQEI RLAQDPFPLY
110 120 130 140 150
PGELLEKDIT PLQVVLPNTA LHLKALLDFE DKNGDKVMAG DEWLFEGPGT
160 170 180 190 200
YIPQKEVEVV EIIQATVIKQ NQALRLRARK ECFDRDGKER VTGEEWLVRS
210 220 230 240 250
VGAYLPAVFE EVLDLVDAVI LTEKTALHLR ARQNFKDLRG VAHRTGEEWL
260 270 280 290 300
VTVQDTEAHV PDVYEEVLGV VPITTLGPRH YCVILDPMGP DGKNQLGQKR
310 320 330 340 350
VVKGEKSFFL QPGERLERGI QDVYVLSEQQ GLLLKALQPL EEGEGEEKVA
360 370 380 390 400
HQAGDRWLIR GPLEYVPSAK VEVVEERQAI PLDQNEGIYV QDVKTGKVRA
410 420 430 440 450
VIGSTYMLTQ DEVLWEKELP SGVEELLNLG HDPLADRGQK GTAKVLQPSA
460 470 480 490 500
ARNKTRVVSY RVPHNAAVQV YDYRAKRARV VFGPELVSLD PEEQFTVLSL
510 520 530 540 550
SAGRPKRPHA RRALCLLLGP DFFTDVITIE TADHARLQLQ LAYNWHFELK
560 570 580 590 600
NRNDPEETAK LFSVPDFVGD ACKAIASRVR GAVASVTFDD FHKNSARIIR
610 620 630 640 650
MAVFGFEMSE DAGPDGALLP RARDRAVFPQ NGLVVSSVDV QSVEPVDQRT
660 670 680 690 700
RDALQRSVQL AIEITTNSQE AAAKHEAQRL EQEARGRLER QKILDQSEAE
710 720 730 740 750
KARKELLELE AMSMAVESTG NAKAEAESRA EAARIEGEGS VLQAKLKAQA
760 770 780 790 800
LAIETEAELE RVKKVREMEL IYSRAQLELE VSKAQQLADV EAKKFKEMTE
810 820 830 840 850
ALGPGTIRDL AVAGPEMQVK LLQSLGLKST LITDGSSPIN LFNTAFGLLG
860
LGSDGQPPVQ K
Length:861
Mass (Da):95,924
Last modified:July 27, 2011 - v4
Checksum:iB722F4FA747CA378
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti348K → R in AAG43520 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF210456 mRNA Translation: AAG43520.1
AY046318 Genomic DNA Translation: AAL02325.1
CH466531 Genomic DNA Translation: EDL17488.1
CH466531 Genomic DNA Translation: EDL17489.1
BC006709 mRNA Translation: AAH06709.1
RefSeqiXP_011240254.1, XM_011241952.2
UniGeneiMm.228797

Genome annotation databases

GeneIDi78388

Similar proteinsi

Entry informationi

Entry nameiMVP_MOUSE
AccessioniPrimary (citable) accession number: Q9EQK5
Secondary accession number(s): Q922X6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 110 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health