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Protein

39S ribosomal protein L46, mitochondrial

Gene

Mrpl46

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-5389840. Mitochondrial translation elongation.
R-MMU-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L46, mitochondrial
Short name:
L46mt
Short name:
MRP-L46
Gene namesi
Name:Mrpl46
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1914558. Mrpl46.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: MGI
  • mitochondrial large ribosomal subunit Source: GO_Central
  • mitochondrion Source: MGI
  • nucleoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 28339S ribosomal protein L46, mitochondrialPRO_0000030577
Transit peptidei1 – ?MitochondrionSequence analysis

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei217 – 2171N6-succinyllysineCombined sources
Modified residuei228 – 2281N6-acetyllysineBy similarity
Modified residuei246 – 2461N6-succinyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9EQI8.
MaxQBiQ9EQI8.
PaxDbiQ9EQI8.
PeptideAtlasiQ9EQI8.
PRIDEiQ9EQI8.

PTM databases

iPTMnetiQ9EQI8.
PhosphoSiteiQ9EQI8.

Expressioni

Gene expression databases

BgeeiQ9EQI8.
CleanExiMM_MRPL46.
GenevisibleiQ9EQI8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032841.

Structurei

3D structure databases

ProteinModelPortaliQ9EQI8.
SMRiQ9EQI8. Positions 41-276.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L46 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4548. Eukaryota.
ENOG4111HSF. LUCA.
GeneTreeiENSGT00390000015400.
HOGENOMiHOG000047532.
HOVERGENiHBG057426.
InParanoidiQ9EQI8.
KOiK17427.
OMAiFHKYKYP.
OrthoDBiEOG7GN2NC.
PhylomeDBiQ9EQI8.
TreeFamiTF324756.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR015797. NUDIX_hydrolase_dom-like.
IPR021757. Ribosomal_L46.
[Graphical view]
PfamiPF11788. MRP-L46. 1 hit.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EQI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPVGRTLL GLARGWRQLD RFWAGSSRGL SLEAASSSSR SPWRLSGALC
60 70 80 90 100
LQRPPLITKA LTPLQEEMAG LLQQIEVERS LYSDHELRAL DEAQRLAKKK
110 120 130 140 150
ADLYDEEQEQ GITLAQDLED MWEQAFLQFR PGARETEADK KNDRTSLHRK
160 170 180 190 200
LDRNLVLLVR EKLGDQDVWM LPQVEWQPGE TLRGTAERIL ATLSENNMEA
210 220 230 240 250
KFLGNAPCGH YKFKFPKAIQ TESDLGVKVF FFKALLLTGD FVQAGKKSRH
260 270 280
VWASKEELGD YLQPKYLAQV RRFLLDSDGL SCL
Length:283
Mass (Da):32,132
Last modified:March 1, 2001 - v1
Checksum:iBF715A364CCE53B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217090 mRNA. Translation: AAG44099.1.
BC061094 mRNA. Translation: AAH61094.1.
CCDSiCCDS21373.1.
RefSeqiNP_075820.1. NM_023331.2.
UniGeneiMm.193181.

Genome annotation databases

EnsembliENSMUST00000032841; ENSMUSP00000032841; ENSMUSG00000030612.
GeneIDi67308.
KEGGimmu:67308.
UCSCiuc009hxl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217090 mRNA. Translation: AAG44099.1.
BC061094 mRNA. Translation: AAH61094.1.
CCDSiCCDS21373.1.
RefSeqiNP_075820.1. NM_023331.2.
UniGeneiMm.193181.

3D structure databases

ProteinModelPortaliQ9EQI8.
SMRiQ9EQI8. Positions 41-276.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032841.

PTM databases

iPTMnetiQ9EQI8.
PhosphoSiteiQ9EQI8.

Proteomic databases

EPDiQ9EQI8.
MaxQBiQ9EQI8.
PaxDbiQ9EQI8.
PeptideAtlasiQ9EQI8.
PRIDEiQ9EQI8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032841; ENSMUSP00000032841; ENSMUSG00000030612.
GeneIDi67308.
KEGGimmu:67308.
UCSCiuc009hxl.1. mouse.

Organism-specific databases

CTDi26589.
MGIiMGI:1914558. Mrpl46.

Phylogenomic databases

eggNOGiKOG4548. Eukaryota.
ENOG4111HSF. LUCA.
GeneTreeiENSGT00390000015400.
HOGENOMiHOG000047532.
HOVERGENiHBG057426.
InParanoidiQ9EQI8.
KOiK17427.
OMAiFHKYKYP.
OrthoDBiEOG7GN2NC.
PhylomeDBiQ9EQI8.
TreeFamiTF324756.

Enzyme and pathway databases

ReactomeiR-MMU-5389840. Mitochondrial translation elongation.
R-MMU-5419276. Mitochondrial translation termination.

Miscellaneous databases

PROiQ9EQI8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9EQI8.
CleanExiMM_MRPL46.
GenevisibleiQ9EQI8. MM.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR015797. NUDIX_hydrolase_dom-like.
IPR021757. Ribosomal_L46.
[Graphical view]
PfamiPF11788. MRP-L46. 1 hit.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, mapping and expression analysis of C15orf4, a novel human gene with homology to the yeast mitochondrial ribosomal protein Ym130 gene."
    Carim-Todd L., Sumoy L., Andreu N., Estivill X., Escarceller M.
    DNA Seq. 12:91-96(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Spleen and Testis.
  4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-217 AND LYS-246, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiRM46_MOUSE
AccessioniPrimary (citable) accession number: Q9EQI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.