ID Q9EQI5_MOUSE Unreviewed; 113 AA. AC Q9EQI5; DT 01-MAR-2001, integrated into UniProtKB/TrEMBL. DT 01-MAR-2001, sequence version 1. DT 27-MAR-2024, entry version 186. DE SubName: Full=Chemokine subfamily B Cys-X-Cys {ECO:0000313|EMBL:BAB83941.1}; DE SubName: Full=Platelet basic protein {ECO:0000313|EMBL:AAI27044.1, ECO:0000313|EMBL:AAK30162.1, ECO:0000313|Ensembl:ENSMUSP00000031319.7}; DE SubName: Full=Thymus chemokine 1 {ECO:0000313|EMBL:AAG36786.1}; GN Name=Ppbp {ECO:0000313|EMBL:AAI27044.1, GN ECO:0000313|Ensembl:ENSMUSP00000031319.7, GN ECO:0000313|MGI:MGI:1888712}; GN Synonyms=Cxcl7 {ECO:0000313|MGI:MGI:1888712}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAG36786.1}; RN [1] {ECO:0000313|EMBL:BAB26811.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB26811.1}, and NOD RC {ECO:0000313|EMBL:BAE33955.1}; RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE33955.1}, and Inner ear RC {ECO:0000313|EMBL:BAE34343.1}; RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [2] {ECO:0000313|EMBL:AAG36786.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Thymus {ECO:0000313|EMBL:AAG36786.1}; RA Gong S.-Y., Chen W.-F., Qian X.-P., Xie L.-P., Guo J.-Z.; RT "Gene Cloning and Functional Analysis of Novel Chemokines Secreted by Mouse RT Thymic Stromal Cells."; RL Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:BAB26811.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB26811.1}, and NOD RC {ECO:0000313|EMBL:BAE33955.1}; RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE33955.1}, and Inner ear RC {ECO:0000313|EMBL:BAE34343.1}; RX PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare RT full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [4] {ECO:0000313|EMBL:BAB26811.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB26811.1}, and NOD RC {ECO:0000313|EMBL:BAE33955.1}; RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE33955.1}, and Inner ear RC {ECO:0000313|EMBL:BAE34343.1}; RX PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R., RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing RT pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [5] {ECO:0000313|EMBL:BAB83941.1} RP NUCLEOTIDE SEQUENCE. RA Todokoro K., Nagata Y., Oda M.; RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:AAK69476.1} RP NUCLEOTIDE SEQUENCE. RA Gong S., Fu W., Chen W.; RT "Gene Cloning and Functional Analysis of Novel Chemokines Secreted by Mouse RT Thymic Stromal Cells."; RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:BAB26811.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB26811.1}; RA Adachi J., Aizawa K., Akahira S., Akimura T., Arai A., Aono H., Arakawa T., RA Bono H., Carninci P., Fukuda S., Fukunishi Y., Furuno M., Hanagaki T., RA Hara A., Hayatsu N., Hiramoto K., Hiraoka T., Hori F., Imotani K., RA Ishii Y., Itoh M., Izawa M., Kasukawa T., Kato H., Kawai J., Kojima Y., RA Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., RA Nishi K., Nomura K., Numazaki R., Ohno M., Okazaki Y., Okido T., Owa C., RA Saito H., Saito R., Sakai C., Sakai K., Sano H., Sasaki D., Shibata K., RA Shibata Y., Shinagawa A., Shiraki T., Sogabe Y., Suzuki H., Tagami M., RA Tagawa A., Takahashi F., Tanaka T., Tejima Y., Toya T., Yamamura T., RA Yasunishi A., Yoshida K., Yoshino M., Muramatsu M., Hayashizaki Y.; RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:AAK30162.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=11468158; DOI=10.1182/blood.V98.3.610; RA Zhang C., Thornton M.A., Kowalska M.A., Sachis B.S., Feldman M., Poncz M., RA McKenzie S.E., Reilly M.P.; RT "Localization of distal regulatory domains in the megakaryocyte-specific RT platelet basic protein/platelet factor 4 gene locus."; RL Blood 98:610-617(2001). RN [9] {ECO:0000313|EMBL:BAB26811.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB26811.1}, and NOD RC {ECO:0000313|EMBL:BAE33955.1}; RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE33955.1}, and Inner ear RC {ECO:0000313|EMBL:BAE34343.1}; RX PubMed=11217851; DOI=10.1038/35055500; RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [10] {ECO:0000313|EMBL:BAB83941.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=11785982; DOI=10.1006/bbrc.2001.6279; RA Oda M., Haruta H., Nagao M., Nagata Y.; RT "Isolation and characterization of mouse homolog of the neutrophil RT activating peptide-2."; RL Biochem. Biophys. Res. Commun. 290:865-868(2002). RN [11] {ECO:0000313|EMBL:BAB26811.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB26811.1}, and NOD RC {ECO:0000313|EMBL:BAE33955.1}; RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE33955.1}, and Inner ear RC {ECO:0000313|EMBL:BAE34343.1}; RX PubMed=12466851; DOI=10.1038/nature01266; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [12] {ECO:0000313|EMBL:AAI27044.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=PCR rescued clones {ECO:0000313|EMBL:AAI27044.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M., RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [13] {ECO:0000313|EMBL:BAE33955.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE34343.1}, and NOD RC {ECO:0000313|EMBL:BAE33955.1}; RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE33955.1}, and Inner ear RC {ECO:0000313|EMBL:BAE34343.1}; RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., RA Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., RA Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K., RA Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., RA Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.; RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases. RN [14] {ECO:0000313|EMBL:BAB26811.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB26811.1}, and NOD RC {ECO:0000313|EMBL:BAE33955.1}; RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE33955.1}, and Inner ear RC {ECO:0000313|EMBL:BAE34343.1}; RG The FANTOM Consortium; RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [15] {ECO:0000313|EMBL:BAB26811.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB26811.1}, and NOD RC {ECO:0000313|EMBL:BAE33955.1}; RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE33955.1}, and Inner ear RC {ECO:0000313|EMBL:BAE34343.1}; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). RN [16] {ECO:0000313|Ensembl:ENSMUSP00000031319.7, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000031319.7, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [17] {ECO:0000313|Ensembl:ENSMUSP00000031319.7} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000031319.7}; RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}. CC -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family. CC {ECO:0000256|ARBA:ARBA00010665}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF219112; AAG36786.1; -; mRNA. DR EMBL; BC127043; AAI27044.1; -; mRNA. DR EMBL; BC127044; AAI27045.1; -; mRNA. DR EMBL; AF349465; AAK30162.1; -; Genomic_DNA. DR EMBL; AF278700; AAK69476.1; -; mRNA. DR EMBL; AK010273; BAB26811.1; -; mRNA. DR EMBL; AB042817; BAB83941.1; -; mRNA. DR EMBL; AK157077; BAE33955.1; -; mRNA. DR EMBL; AK157141; BAE33977.1; -; mRNA. DR EMBL; AK158061; BAE34343.1; -; mRNA. DR EMBL; AK171720; BAE42631.1; -; mRNA. DR PIR; JC7800; JC7800. DR RefSeq; NP_076274.1; NM_023785.3. DR STRING; 10090.ENSMUSP00000031319; -. DR PaxDb; 10090-ENSMUSP00000031319; -. DR ProteomicsDB; 339180; -. DR Antibodypedia; 1902; 725 antibodies from 36 providers. DR DNASU; 57349; -. DR Ensembl; ENSMUST00000031319.8; ENSMUSP00000031319.7; ENSMUSG00000029372.8. DR GeneID; 57349; -. DR KEGG; mmu:57349; -. DR UCSC; uc008ybh.1; mouse. DR AGR; MGI:1888712; -. DR CTD; 5473; -. DR MGI; MGI:1888712; Ppbp. DR VEuPathDB; HostDB:ENSMUSG00000029372; -. DR eggNOG; ENOG502S7MM; Eukaryota. DR GeneTree; ENSGT00940000162559; -. DR HOGENOM; CLU_143902_1_1_1; -. DR OMA; FVELYCM; -. DR OrthoDB; 4170999at2759; -. DR TreeFam; TF333433; -. DR Reactome; R-MMU-114608; Platelet degranulation. DR Reactome; R-MMU-380108; Chemokine receptors bind chemokines. DR Reactome; R-MMU-418594; G alpha (i) signalling events. DR Reactome; R-MMU-6798695; Neutrophil degranulation. DR BioGRID-ORCS; 57349; 0 hits in 80 CRISPR screens. DR Proteomes; UP000000589; Chromosome 5. DR Bgee; ENSMUSG00000029372; Expressed in femorotibial joint and 118 other cell types or tissues. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0031091; C:platelet alpha granule; ISO:MGI. DR GO; GO:0008009; F:chemokine activity; IDA:MGI. DR GO; GO:0045236; F:CXCR chemokine receptor binding; IBA:GO_Central. DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; ISO:MGI. DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central. DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central. DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central. DR GO; GO:0031640; P:killing of cells of another organism; ISO:MGI. DR GO; GO:0002523; P:leukocyte migration involved in inflammatory response; IMP:MGI. DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central. DR GO; GO:0071624; P:positive regulation of granulocyte chemotaxis; ISO:MGI. DR CDD; cd00273; Chemokine_CXC; 1. DR Gene3D; 2.40.50.40; -; 1. DR InterPro; IPR039809; Chemokine_b/g/d. DR InterPro; IPR001089; Chemokine_CXC. DR InterPro; IPR001811; Chemokine_IL8-like_dom. DR InterPro; IPR033899; CXC_Chemokine_domain. DR InterPro; IPR036048; Interleukin_8-like_sf. DR PANTHER; PTHR12015:SF198; PLATELET BASIC PROTEIN; 1. DR PANTHER; PTHR12015; SMALL INDUCIBLE CYTOKINE A; 1. DR Pfam; PF00048; IL8; 1. DR PRINTS; PR00436; INTERLEUKIN8. DR PRINTS; PR00437; SMALLCYTKCXC. DR SMART; SM00199; SCY; 1. DR SUPFAM; SSF54117; Interleukin 8-like chemokines; 1. PE 1: Evidence at protein level; KW Cytokine {ECO:0000256|ARBA:ARBA00022514}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Proteomics identification {ECO:0007829|MaxQB:Q9EQI5, KW ECO:0007829|PeptideAtlas:Q9EQI5}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..39 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 40..113 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5015099719" FT DOMAIN 49..109 FT /note="Chemokine interleukin-8-like" FT /evidence="ECO:0000259|SMART:SM00199" SQ SEQUENCE 113 AA; 12252 MW; 66F93D3F7D7862C8 CRC64; MGFRLRPTSS CTRACPLHNL QILLLLGLIL VALAPLTAGK SDGMDPYIEL RCRCTNTISG IPFNSISLVN VYRPGVHCAD VEVIATLKNG QKTCLDPNAP GVKRIVMKIL EGY //