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Q9EQI5

- Q9EQI5_MOUSE

UniProt

Q9EQI5 - Q9EQI5_MOUSE

Protein
Submitted name:

Chemokine (C-X-C motif) ligand 7, isoform CRA_b

Gene

Ppbp

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. chemokine activity Source: MGI

    GO - Biological processi

    1. leukocyte migration involved in inflammatory response Source: MGI
    2. neutrophil chemotaxis Source: InterPro
    3. neutrophil degranulation Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Chemokine (C-X-C motif) ligand 7, isoform CRA_bImported
    Submitted name:
    Chemokine subfamily B Cys-X-CysImported
    Submitted name:
    Platelet basic proteinImported
    Submitted name:
    Pro-platelet basic proteinImported
    Submitted name:
    Protein PpbpImported
    Submitted name:
    Thymus chemokine 1Imported
    Gene namesi
    Name:PpbpImported
    Synonyms:Cxcl7Imported
    ORF Names:mCG_1702Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1888712. Ppbp.

    Subcellular locationi

    Secreted SAAS annotation

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    SecretedSAAS annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ9EQI5.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000031319.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG39945.
    GeneTreeiENSGT00530000062901.
    HOGENOMiHOG000220915.
    HOVERGENiHBG107789.
    InParanoidiQ9EQI5.
    KOiK10029.
    OMAiNSARPFR.
    OrthoDBiEOG7NSB57.
    TreeFamiTF333433.

    Family and domain databases

    InterProiIPR001089. Chemokine_CXC.
    IPR001811. Chemokine_IL8-like_dom.
    IPR027223. PPBP.
    [Graphical view]
    PANTHERiPTHR10179. PTHR10179. 1 hit.
    PTHR10179:SF15. PTHR10179:SF15. 1 hit.
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    PRINTSiPR00437. SMALLCYTKCXC.
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9EQI5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGFRLRPTSS CTRACPLHNL QILLLLGLIL VALAPLTAGK SDGMDPYIEL    50
    RCRCTNTISG IPFNSISLVN VYRPGVHCAD VEVIATLKNG QKTCLDPNAP 100
    GVKRIVMKIL EGY 113
    Length:113
    Mass (Da):12,252
    Last modified:March 1, 2001 - v1
    Checksum:i66F93D3F7D7862C8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC105995 Genomic DNA. No translation available.
    AF219112 mRNA. Translation: AAG36786.1.
    BC127043 mRNA. Translation: AAI27044.1.
    BC127044 mRNA. Translation: AAI27045.1.
    AF349465 Genomic DNA. Translation: AAK30162.1.
    AF278700 mRNA. Translation: AAK69476.1.
    AK010273 mRNA. Translation: BAB26811.1.
    AB042817 mRNA. Translation: BAB83941.1.
    AK157077 mRNA. Translation: BAE33955.1.
    AK157141 mRNA. Translation: BAE33977.1.
    AK158061 mRNA. Translation: BAE34343.1.
    AK171720 mRNA. Translation: BAE42631.1.
    CH466617 Genomic DNA. Translation: EDL05308.1.
    PIRiJC7800.
    RefSeqiNP_076274.1. NM_023785.2.
    UniGeneiMm.293614.

    Genome annotation databases

    EnsembliENSMUST00000031319; ENSMUSP00000031319; ENSMUSG00000029372.
    GeneIDi57349.
    KEGGimmu:57349.
    UCSCiuc008ybh.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC105995 Genomic DNA. No translation available.
    AF219112 mRNA. Translation: AAG36786.1 .
    BC127043 mRNA. Translation: AAI27044.1 .
    BC127044 mRNA. Translation: AAI27045.1 .
    AF349465 Genomic DNA. Translation: AAK30162.1 .
    AF278700 mRNA. Translation: AAK69476.1 .
    AK010273 mRNA. Translation: BAB26811.1 .
    AB042817 mRNA. Translation: BAB83941.1 .
    AK157077 mRNA. Translation: BAE33955.1 .
    AK157141 mRNA. Translation: BAE33977.1 .
    AK158061 mRNA. Translation: BAE34343.1 .
    AK171720 mRNA. Translation: BAE42631.1 .
    CH466617 Genomic DNA. Translation: EDL05308.1 .
    PIRi JC7800.
    RefSeqi NP_076274.1. NM_023785.2.
    UniGenei Mm.293614.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000031319.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000031319 ; ENSMUSP00000031319 ; ENSMUSG00000029372 .
    GeneIDi 57349.
    KEGGi mmu:57349.
    UCSCi uc008ybh.1. mouse.

    Organism-specific databases

    CTDi 5473.
    MGIi MGI:1888712. Ppbp.

    Phylogenomic databases

    eggNOGi NOG39945.
    GeneTreei ENSGT00530000062901.
    HOGENOMi HOG000220915.
    HOVERGENi HBG107789.
    InParanoidi Q9EQI5.
    KOi K10029.
    OMAi NSARPFR.
    OrthoDBi EOG7NSB57.
    TreeFami TF333433.

    Miscellaneous databases

    NextBioi 313714.
    PROi Q9EQI5.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q9EQI5.

    Family and domain databases

    InterProi IPR001089. Chemokine_CXC.
    IPR001811. Chemokine_IL8-like_dom.
    IPR027223. PPBP.
    [Graphical view ]
    PANTHERi PTHR10179. PTHR10179. 1 hit.
    PTHR10179:SF15. PTHR10179:SF15. 1 hit.
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    PRINTSi PR00437. SMALLCYTKCXC.
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported and Inner earImported.
    2. "Gene Cloning and Functional Analysis of Novel Chemokines Secreted by Mouse Thymic Stromal Cells."
      Gong S.-Y., Chen W.-F., Qian X.-P., Xie L.-P., Guo J.-Z.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: ThymusImported.
    3. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported and Inner earImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported and Inner earImported.
    5. Todokoro K., Nagata Y., Oda M.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    6. "Gene Cloning and Functional Analysis of Novel Chemokines Secreted by Mouse Thymic Stromal Cells."
      Gong S., Fu W., Chen W.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    7. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    8. "Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus."
      Zhang C., Thornton M.A., Kowalska M.A., Sachis B.S., Feldman M., Poncz M., McKenzie S.E., Reilly M.P.
      Blood 98:610-617(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    9. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported and Inner earImported.
    10. "Isolation and characterization of mouse homolog of the neutrophil activating peptide-2."
      Oda M., Haruta H., Nagao M., Nagata Y.
      Biochem. Biophys. Res. Commun. 290:865-868(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    11. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported and Inner earImported.
    12. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    13. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PCR rescued clonesImported.
    14. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported and Inner earImported.
    15. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: Activated spleenImported.
    16. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported and Inner earImported.
    17. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported and Inner earImported.
    18. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    19. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    20. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ9EQI5_MOUSE
    AccessioniPrimary (citable) accession number: Q9EQI5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3