Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9EQH1

- GAB2_RAT

UniProt

Q9EQH1 - GAB2_RAT

Protein

GRB2-associated-binding protein 2

Gene

Gab2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 2 (01 Oct 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis By similarity.By similarity

    GO - Molecular functioni

    1. phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
    2. phosphatidylinositol-3,4-bisphosphate binding Source: UniProtKB
    3. protein domain specific binding Source: RGD
    4. transmembrane receptor protein tyrosine kinase adaptor activity Source: UniProtKB

    GO - Biological processi

    1. intracellular signal transduction Source: RGD
    2. osteoclast differentiation Source: UniProtKB
    3. phosphatidylinositol-mediated signaling Source: UniProtKB
    4. positive regulation of cell proliferation Source: UniProtKB
    5. positive regulation of mast cell degranulation Source: UniProtKB
    6. transmembrane receptor protein tyrosine kinase signaling pathway Source: GOC

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GRB2-associated-binding protein 2
    Alternative name(s):
    GRB2-associated binder 2
    Growth factor receptor bound protein 2-associated protein 2
    Gene namesi
    Name:Gab2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi621367. Gab2.

    Subcellular locationi

    Cytoplasm By similarity. Cell membrane By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. plasma membrane Source: UniProtKB
    3. protein complex Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 665665GRB2-associated-binding protein 2PRO_0000050287Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei135 – 1351PhosphoserineBy similarity
    Modified residuei142 – 1421PhosphoserineBy similarity
    Modified residuei143 – 1431PhosphoserineBy similarity
    Modified residuei149 – 1491PhosphoserineBy similarity
    Modified residuei150 – 1501PhosphoserineBy similarity
    Modified residuei160 – 1601PhosphoserineBy similarity
    Modified residuei165 – 1651PhosphoserineBy similarity
    Modified residuei211 – 2111PhosphoserineBy similarity
    Modified residuei220 – 2201PhosphoserineBy similarity
    Modified residuei261 – 2611PhosphoserineBy similarity
    Modified residuei262 – 2621PhosphothreonineBy similarity
    Modified residuei263 – 2631PhosphotyrosineBy similarity
    Modified residuei275 – 2751PhosphothreonineBy similarity
    Modified residuei278 – 2781PhosphoserineBy similarity
    Modified residuei284 – 2841PhosphothreonineBy similarity
    Modified residuei290 – 2901PhosphotyrosineBy similarity
    Modified residuei328 – 3281PhosphothreonineBy similarity
    Modified residuei382 – 3821PhosphothreonineBy similarity
    Modified residuei388 – 3881PhosphothreonineBy similarity
    Modified residuei402 – 4021PhosphoserineBy similarity
    Modified residuei441 – 4411PhosphotyrosineBy similarity
    Modified residuei532 – 5321PhosphoserineBy similarity
    Modified residuei612 – 6121PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated upon EGF stimulation. Phosphorylated on tyrosine residues by HCK upon IL6 signaling By similarity. Phosphorylated on tyrosine residue(s) by the thrombopoietin receptor (TPOR), stem cell factor receptor (SCFR), and T-cell and B-cell antigen receptors, gp130, IL-2R and IL-3R By similarity. Phosphorylated upon stimulation of TNFRSF11A/RANK by TNFSF11/RANKL By similarity.By similarity
    Dephosphorylated by PTPN11.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9EQH1.
    PRIDEiQ9EQH1.

    PTM databases

    PhosphoSiteiQ9EQH1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9EQH1.

    Interactioni

    Subunit structurei

    Interacts with HCK. Interacts with SHC1; may mediate interaction with receptors By similarity. Interacts with SYK By similarity. Interacts with PI-3 kinase By similarity. Interacts with GRB2 (via SH3 2 domain) By similarity. Interacts (phosphorylated) with PTPN11 By similarity. Interacts with TNFRSF11A (via cytoplasmic domain) By similarity. Interacts (phosphorylated) with 14-3-3 family proteins SFN, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ and YWHAZ; prevents interaction with GRB2 and attenuates GAB2 signaling By similarity.By similarity

    Protein-protein interaction databases

    BioGridi249977. 1 interaction.
    IntActiQ9EQH1. 1 interaction.
    MINTiMINT-7138417.
    STRINGi10116.ENSRNOP00000016361.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9EQH1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 119112PHPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi348 – 3558SH3-bindingBy similarity
    Motifi499 – 50810SH3-bindingBy similarity

    Domaini

    The SH3-binding motifs mediate interaction with SHC1 and GRB2.By similarity
    The PH domain mediates phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-bisphosphate binding.By similarity

    Sequence similaritiesi

    Belongs to the GAB family.Curated
    Contains 1 PH domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG83177.
    HOGENOMiHOG000236270.
    HOVERGENiHBG051685.
    InParanoidiQ9EQH1.
    KOiK08091.
    PhylomeDBiQ9EQH1.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view]
    PfamiPF00169. PH. 1 hit.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    [Graphical view]
    PROSITEiPS50003. PH_DOMAIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9EQH1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGGGGDDVV CTGWLRKSPP EKKLRRYAWK KRWFILRSGR MSGDPDVLEY    50
    YKNEHSKKPL RIINLNFCEQ VDAGLTFNKK ELQDSFVFDI KTSERTFYLV 100
    AETEADMNKW VQSICQICGF NQAEESTDSL RNLSSASHGP RSSPAEFSSS 150
    QHLLRERKSS APSHSSQPTL FTFEPPMTSH MQPALSTSAP QEYLYLHQCI 200
    SRRTENSRSA SFSQGTRQKS DTAVQKLAQS NGHCINGVSN QVHGFYSLPK 250
    PSRHNTEFKD STYDLPRSLA SHGHTKSSLT GSETDNEDVY TFKMPSNTLC 300
    REFGDLLVDN MDVPTTPLSA YQIPRTFTLD KNHNAMTVAT SGDSAIAPPP 350
    RPPKPSQAET PRWGSPQQKP PIGENSRSVA ATIPRRNTLP AMDNSRLHRA 400
    SSCETYEYPT RGSGESASWS AESPGKTAVG RSDSASSDEN YVPMNPGSST 450
    LLAMERAGDN SQSAYIPMGP GPHHFDPLGY PSTALPIHRG PSRGSEIQPP 500
    PVNRNLKPDR KAKPTPLDLR NNTVIDELPF KSPVTKSWSR INHTFNSSSS 550
    QYCRPISTQS ITSTDSGDSE ENYVPMQNPV SASPVPSGTN SPAPRKSTGS 600
    VDYLALDFQP GSPSPHRKPS TSSVTSDEKV DYVQVDKEKT QALQNTMQEW 650
    TDVRQSSEPS KGAKL 665
    Length:665
    Mass (Da):73,328
    Last modified:October 1, 2001 - v2
    Checksum:iBEB170B69406063E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF230367 mRNA. Translation: AAG44268.2.
    RefSeqiNP_445869.1. NM_053417.1.
    UniGeneiRn.211990.

    Genome annotation databases

    GeneIDi84477.
    KEGGirno:84477.
    UCSCiRGD:621367. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF230367 mRNA. Translation: AAG44268.2 .
    RefSeqi NP_445869.1. NM_053417.1.
    UniGenei Rn.211990.

    3D structure databases

    ProteinModelPortali Q9EQH1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 249977. 1 interaction.
    IntActi Q9EQH1. 1 interaction.
    MINTi MINT-7138417.
    STRINGi 10116.ENSRNOP00000016361.

    PTM databases

    PhosphoSitei Q9EQH1.

    Proteomic databases

    PaxDbi Q9EQH1.
    PRIDEi Q9EQH1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 84477.
    KEGGi rno:84477.
    UCSCi RGD:621367. rat.

    Organism-specific databases

    CTDi 9846.
    RGDi 621367. Gab2.

    Phylogenomic databases

    eggNOGi NOG83177.
    HOGENOMi HOG000236270.
    HOVERGENi HBG051685.
    InParanoidi Q9EQH1.
    KOi K08091.
    PhylomeDBi Q9EQH1.

    Miscellaneous databases

    NextBioi 616982.
    PROi Q9EQH1.

    Gene expression databases

    Genevestigatori Q9EQH1.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view ]
    Pfami PF00169. PH. 1 hit.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    [Graphical view ]
    PROSITEi PS50003. PH_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of Gab2 as the major molecule responsible for EGF-induced PI3-kinase activation and DNA synthesis in rat hepatocytes."
      Kong M., Mounier C., Wu J., Posner B.I.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiGAB2_RAT
    AccessioniPrimary (citable) accession number: Q9EQH1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 79 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3