SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9EQH1

- GAB2_RAT

UniProt

Q9EQH1 - GAB2_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
GRB2-associated-binding protein 2
Gene
Gab2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis By similarity.

GO - Molecular functioni

  1. phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
  2. phosphatidylinositol-3,4-bisphosphate binding Source: UniProtKB
  3. protein domain specific binding Source: RGD
  4. transmembrane receptor protein tyrosine kinase adaptor activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. intracellular signal transduction Source: RGD
  2. osteoclast differentiation Source: UniProtKB
  3. phosphatidylinositol-mediated signaling Source: UniProtKB
  4. positive regulation of cell proliferation Source: UniProtKB
  5. positive regulation of mast cell degranulation Source: UniProtKB
  6. transmembrane receptor protein tyrosine kinase signaling pathway Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
GRB2-associated-binding protein 2
Alternative name(s):
GRB2-associated binder 2
Growth factor receptor bound protein 2-associated protein 2
Gene namesi
Name:Gab2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621367. Gab2.

Subcellular locationi

Cytoplasm By similarity. Cell membrane By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. plasma membrane Source: UniProtKB
  3. protein complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 665665GRB2-associated-binding protein 2
PRO_0000050287Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei135 – 1351Phosphoserine By similarity
Modified residuei142 – 1421Phosphoserine By similarity
Modified residuei143 – 1431Phosphoserine By similarity
Modified residuei149 – 1491Phosphoserine By similarity
Modified residuei150 – 1501Phosphoserine By similarity
Modified residuei160 – 1601Phosphoserine By similarity
Modified residuei165 – 1651Phosphoserine By similarity
Modified residuei211 – 2111Phosphoserine By similarity
Modified residuei220 – 2201Phosphoserine By similarity
Modified residuei261 – 2611Phosphoserine By similarity
Modified residuei262 – 2621Phosphothreonine By similarity
Modified residuei263 – 2631Phosphotyrosine By similarity
Modified residuei275 – 2751Phosphothreonine By similarity
Modified residuei278 – 2781Phosphoserine By similarity
Modified residuei284 – 2841Phosphothreonine By similarity
Modified residuei290 – 2901Phosphotyrosine By similarity
Modified residuei328 – 3281Phosphothreonine By similarity
Modified residuei382 – 3821Phosphothreonine By similarity
Modified residuei388 – 3881Phosphothreonine By similarity
Modified residuei402 – 4021Phosphoserine By similarity
Modified residuei441 – 4411Phosphotyrosine By similarity
Modified residuei532 – 5321Phosphoserine By similarity
Modified residuei612 – 6121Phosphoserine By similarity

Post-translational modificationi

Phosphorylated upon EGF stimulation. Phosphorylated on tyrosine residues by HCK upon IL6 signaling By similarity. Phosphorylated on tyrosine residue(s) by the thrombopoietin receptor (TPOR), stem cell factor receptor (SCFR), and T-cell and B-cell antigen receptors, gp130, IL-2R and IL-3R By similarity. Phosphorylated upon stimulation of TNFRSF11A/RANK by TNFSF11/RANKL By similarity.
Dephosphorylated by PTPN11 By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9EQH1.
PRIDEiQ9EQH1.

PTM databases

PhosphoSiteiQ9EQH1.

Expressioni

Gene expression databases

GenevestigatoriQ9EQH1.

Interactioni

Subunit structurei

Interacts with HCK. Interacts with SHC1; may mediate interaction with receptors By similarity. Interacts with SYK By similarity. Interacts with PI-3 kinase By similarity. Interacts with GRB2 (via SH3 2 domain) By similarity. Interacts (phosphorylated) with PTPN11 By similarity. Interacts with TNFRSF11A (via cytoplasmic domain) By similarity. Interacts (phosphorylated) with 14-3-3 family proteins SFN, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ and YWHAZ; prevents interaction with GRB2 and attenuates GAB2 signaling By similarity.

Protein-protein interaction databases

BioGridi249977. 1 interaction.
IntActiQ9EQH1. 1 interaction.
MINTiMINT-7138417.
STRINGi10116.ENSRNOP00000016361.

Structurei

3D structure databases

ProteinModelPortaliQ9EQH1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 119112PH
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi348 – 3558SH3-binding By similarity
Motifi499 – 50810SH3-binding By similarity

Domaini

The SH3-binding motifs mediate interaction with SHC1 and GRB2 By similarity.
The PH domain mediates phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-bisphosphate binding By similarity.

Sequence similaritiesi

Belongs to the GAB family.
Contains 1 PH domain.

Phylogenomic databases

eggNOGiNOG83177.
HOGENOMiHOG000236270.
HOVERGENiHBG051685.
InParanoidiQ9EQH1.
KOiK08091.
PhylomeDBiQ9EQH1.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EQH1-1 [UniParc]FASTAAdd to Basket

« Hide

MSGGGGDDVV CTGWLRKSPP EKKLRRYAWK KRWFILRSGR MSGDPDVLEY    50
YKNEHSKKPL RIINLNFCEQ VDAGLTFNKK ELQDSFVFDI KTSERTFYLV 100
AETEADMNKW VQSICQICGF NQAEESTDSL RNLSSASHGP RSSPAEFSSS 150
QHLLRERKSS APSHSSQPTL FTFEPPMTSH MQPALSTSAP QEYLYLHQCI 200
SRRTENSRSA SFSQGTRQKS DTAVQKLAQS NGHCINGVSN QVHGFYSLPK 250
PSRHNTEFKD STYDLPRSLA SHGHTKSSLT GSETDNEDVY TFKMPSNTLC 300
REFGDLLVDN MDVPTTPLSA YQIPRTFTLD KNHNAMTVAT SGDSAIAPPP 350
RPPKPSQAET PRWGSPQQKP PIGENSRSVA ATIPRRNTLP AMDNSRLHRA 400
SSCETYEYPT RGSGESASWS AESPGKTAVG RSDSASSDEN YVPMNPGSST 450
LLAMERAGDN SQSAYIPMGP GPHHFDPLGY PSTALPIHRG PSRGSEIQPP 500
PVNRNLKPDR KAKPTPLDLR NNTVIDELPF KSPVTKSWSR INHTFNSSSS 550
QYCRPISTQS ITSTDSGDSE ENYVPMQNPV SASPVPSGTN SPAPRKSTGS 600
VDYLALDFQP GSPSPHRKPS TSSVTSDEKV DYVQVDKEKT QALQNTMQEW 650
TDVRQSSEPS KGAKL 665
Length:665
Mass (Da):73,328
Last modified:October 1, 2001 - v2
Checksum:iBEB170B69406063E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF230367 mRNA. Translation: AAG44268.2.
RefSeqiNP_445869.1. NM_053417.1.
UniGeneiRn.211990.

Genome annotation databases

GeneIDi84477.
KEGGirno:84477.
UCSCiRGD:621367. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF230367 mRNA. Translation: AAG44268.2 .
RefSeqi NP_445869.1. NM_053417.1.
UniGenei Rn.211990.

3D structure databases

ProteinModelPortali Q9EQH1.
ModBasei Search...

Protein-protein interaction databases

BioGridi 249977. 1 interaction.
IntActi Q9EQH1. 1 interaction.
MINTi MINT-7138417.
STRINGi 10116.ENSRNOP00000016361.

PTM databases

PhosphoSitei Q9EQH1.

Proteomic databases

PaxDbi Q9EQH1.
PRIDEi Q9EQH1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 84477.
KEGGi rno:84477.
UCSCi RGD:621367. rat.

Organism-specific databases

CTDi 9846.
RGDi 621367. Gab2.

Phylogenomic databases

eggNOGi NOG83177.
HOGENOMi HOG000236270.
HOVERGENi HBG051685.
InParanoidi Q9EQH1.
KOi K08091.
PhylomeDBi Q9EQH1.

Miscellaneous databases

NextBioi 616982.
PROi Q9EQH1.

Gene expression databases

Genevestigatori Q9EQH1.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view ]
Pfami PF00169. PH. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
[Graphical view ]
PROSITEi PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of Gab2 as the major molecule responsible for EGF-induced PI3-kinase activation and DNA synthesis in rat hepatocytes."
    Kong M., Mounier C., Wu J., Posner B.I.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiGAB2_RAT
AccessioniPrimary (citable) accession number: Q9EQH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2001
Last modified: September 3, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi