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Protein

Sciellin

Gene

Scel

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • embryo development Source: UniProtKB
  • epidermis development Source: UniProtKB
  • keratinocyte differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Sciellin
Gene namesi
Name:Scel
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1891228. Scel.

Subcellular locationi

  • Cytoplasm
  • Membrane

  • Note: May become cross-linked to membrane proteins by transglutaminase.

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: MGI
  • membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000759041 – 652SciellinAdd BLAST652

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei82N6-acetyllysineCombined sources1
Modified residuei264PhosphoserineCombined sources1
Modified residuei343PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9EQG3.
PaxDbiQ9EQG3.
PRIDEiQ9EQG3.

PTM databases

iPTMnetiQ9EQG3.
PhosphoSitePlusiQ9EQG3.

Expressioni

Tissue specificityi

Expressed in the upper layers of stratified epithelia, including, ependyma and choroid plexus of the brain ventricles.

Developmental stagei

Strong expression was seen in 17-17.5 day-old embryos. Expression was also detected in the amnion of 17.5 day-old embryo.

Gene expression databases

BgeeiENSMUSG00000022123.
CleanExiMM_SCEL.
ExpressionAtlasiQ9EQG3. baseline and differential.
GenevisibleiQ9EQG3. MM.

Interactioni

Protein-protein interaction databases

MINTiMINT-4998183.
STRINGi10090.ENSMUSP00000093233.

Structurei

3D structure databases

ProteinModelPortaliQ9EQG3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati207 – 2261Add BLAST20
Repeati227 – 2412Add BLAST15
Repeati242 – 2613Add BLAST20
Repeati262 – 2814Add BLAST20
Repeati282 – 3015Add BLAST20
Repeati302 – 3206Add BLAST19
Repeati321 – 3407Add BLAST20
Repeati341 – 3608Add BLAST20
Repeati361 – 3809Add BLAST20
Repeati381 – 39810Add BLAST18
Repeati399 – 41811Add BLAST20
Repeati419 – 43812Add BLAST20
Repeati439 – 45813Add BLAST20
Repeati459 – 47714Add BLAST19
Repeati478 – 49615Add BLAST19
Domaini583 – 649LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni207 – 49615 X approximate tandem repeatsAdd BLAST290

Sequence similaritiesi

Contains 1 LIM zinc-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiENOG410INGG. Eukaryota.
ENOG4111UEX. LUCA.
GeneTreeiENSGT00530000063872.
HOGENOMiHOG000294069.
HOVERGENiHBG023141.
InParanoidiQ9EQG3.
OMAiPKDGYQE.
OrthoDBiEOG091G09RH.
PhylomeDBiQ9EQG3.
TreeFamiTF335114.

Family and domain databases

Gene3Di2.10.110.10. 1 hit.
InterProiIPR001781. Znf_LIM.
[Graphical view]
SMARTiSM00132. LIM. 1 hit.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EQG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNFSSRKKS PTGNDLKSAR GAELRQQGFQ DVNKRRAFLQ DNSWIKKPPE
60 70 80 90 100
EEQDGNYGRV VLNRHNSHDA LDRKLIERDE PKATISRYRS EDMLDRTLSS
110 120 130 140 150
FRTPQSTKTP AVSSFNANTT ATASTPATTP VKKKRQSWFP PPPPGHNASP
160 170 180 190 200
STAASRRDPA LHPPLPPKPC SPIASPKPLG RTNRQIHAAT AGACGETERH
210 220 230 240 250
AERNIRTEDL DDIIRVAAAL QKTDKGEELD NLIRMNKSLN RNQGLDGLFR
260 270 280 290 300
ANLKAQQLDK RAQSLESLIY MNTQTDRDGK GNQAFGSLKK INQRADPDRR
310 320 330 340 350
SQDLRSVIRT HATAERIGRR KQDLDGLIKV NPDTNKNMKR GKSLDNLIKV
360 370 380 390 400
TPEVNRSNKG GPSLDNFTKG VPARSRANQR DQDLDSLIKV TPSANRSSQH
410 420 430 440 450
SLDELINTSP QTIKTTARHQ DLDKFIKVNP DVLTNNQRNH DVDSTIRGNP
460 470 480 490 500
TGTRCEQSEE LDNLIKVKPS ALRNTNGGQD LESLTEVNSH VAEKNGRIDG
510 520 530 540 550
QANGLTNSLF KESTRASVYS YEARNSLSSN SGNKNGGPKD TVVYTRTYVE
560 570 580 590 600
NSKSPKDGYQ ENISGKYIQT VYSTSDRSVI ERDMCTYCRK PLGVETKMIL
610 620 630 640 650
DELQICCHST CFKCEICKRP LENLQAGDSI WIYRQTIHCE PCYSKVMAKW

IQ
Length:652
Mass (Da):72,972
Last modified:January 10, 2006 - v2
Checksum:iA089C07DD710EF13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245700 mRNA. Translation: AAG40727.2.
AK020346 mRNA. Translation: BAB32078.1.
CCDSiCCDS37002.1.
RefSeqiNP_075024.2. NM_022886.2.
XP_006519418.1. XM_006519355.3.
UniGeneiMm.244003.

Genome annotation databases

EnsembliENSMUST00000095576; ENSMUSP00000093233; ENSMUSG00000022123.
GeneIDi64929.
KEGGimmu:64929.
UCSCiuc007uwr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245700 mRNA. Translation: AAG40727.2.
AK020346 mRNA. Translation: BAB32078.1.
CCDSiCCDS37002.1.
RefSeqiNP_075024.2. NM_022886.2.
XP_006519418.1. XM_006519355.3.
UniGeneiMm.244003.

3D structure databases

ProteinModelPortaliQ9EQG3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4998183.
STRINGi10090.ENSMUSP00000093233.

PTM databases

iPTMnetiQ9EQG3.
PhosphoSitePlusiQ9EQG3.

Proteomic databases

MaxQBiQ9EQG3.
PaxDbiQ9EQG3.
PRIDEiQ9EQG3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095576; ENSMUSP00000093233; ENSMUSG00000022123.
GeneIDi64929.
KEGGimmu:64929.
UCSCiuc007uwr.1. mouse.

Organism-specific databases

CTDi8796.
MGIiMGI:1891228. Scel.

Phylogenomic databases

eggNOGiENOG410INGG. Eukaryota.
ENOG4111UEX. LUCA.
GeneTreeiENSGT00530000063872.
HOGENOMiHOG000294069.
HOVERGENiHBG023141.
InParanoidiQ9EQG3.
OMAiPKDGYQE.
OrthoDBiEOG091G09RH.
PhylomeDBiQ9EQG3.
TreeFamiTF335114.

Miscellaneous databases

PROiQ9EQG3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022123.
CleanExiMM_SCEL.
ExpressionAtlasiQ9EQG3. baseline and differential.
GenevisibleiQ9EQG3. MM.

Family and domain databases

Gene3Di2.10.110.10. 1 hit.
InterProiIPR001781. Znf_LIM.
[Graphical view]
SMARTiSM00132. LIM. 1 hit.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCEL_MOUSE
AccessioniPrimary (citable) accession number: Q9EQG3
Secondary accession number(s): Q9CTT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 10, 2006
Last modified: November 2, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.