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Protein

Sciellin

Gene

Scel

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • embryo development Source: UniProtKB
  • epidermis development Source: UniProtKB
  • keratinocyte differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Sciellin
Gene namesi
Name:Scel
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1891228. Scel.

Subcellular locationi

  • Cytoplasm
  • Membrane

  • Note: May become cross-linked to membrane proteins by transglutaminase.

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: MGI
  • membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 652652SciellinPRO_0000075904Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei82 – 821N6-acetyllysineCombined sources
Modified residuei264 – 2641PhosphoserineCombined sources
Modified residuei343 – 3431PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9EQG3.
PaxDbiQ9EQG3.
PRIDEiQ9EQG3.

PTM databases

iPTMnetiQ9EQG3.
PhosphoSiteiQ9EQG3.

Expressioni

Tissue specificityi

Expressed in the upper layers of stratified epithelia, including, ependyma and choroid plexus of the brain ventricles.

Developmental stagei

Strong expression was seen in 17-17.5 day-old embryos. Expression was also detected in the amnion of 17.5 day-old embryo.

Gene expression databases

BgeeiQ9EQG3.
CleanExiMM_SCEL.
ExpressionAtlasiQ9EQG3. baseline and differential.
GenevisibleiQ9EQG3. MM.

Interactioni

Protein-protein interaction databases

MINTiMINT-4998183.
STRINGi10090.ENSMUSP00000093233.

Structurei

3D structure databases

ProteinModelPortaliQ9EQG3.
SMRiQ9EQG3. Positions 584-647.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati207 – 226201Add
BLAST
Repeati227 – 241152Add
BLAST
Repeati242 – 261203Add
BLAST
Repeati262 – 281204Add
BLAST
Repeati282 – 301205Add
BLAST
Repeati302 – 320196Add
BLAST
Repeati321 – 340207Add
BLAST
Repeati341 – 360208Add
BLAST
Repeati361 – 380209Add
BLAST
Repeati381 – 3981810Add
BLAST
Repeati399 – 4182011Add
BLAST
Repeati419 – 4382012Add
BLAST
Repeati439 – 4582013Add
BLAST
Repeati459 – 4771914Add
BLAST
Repeati478 – 4961915Add
BLAST
Domaini583 – 64967LIM zinc-bindingPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni207 – 49629015 X approximate tandem repeatsAdd
BLAST

Sequence similaritiesi

Contains 1 LIM zinc-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiENOG410INGG. Eukaryota.
ENOG4111UEX. LUCA.
GeneTreeiENSGT00530000063872.
HOGENOMiHOG000294069.
HOVERGENiHBG023141.
InParanoidiQ9EQG3.
OMAiPKDGYQE.
OrthoDBiEOG72C52Z.
PhylomeDBiQ9EQG3.
TreeFamiTF335114.

Family and domain databases

Gene3Di2.10.110.10. 1 hit.
InterProiIPR001781. Znf_LIM.
[Graphical view]
SMARTiSM00132. LIM. 1 hit.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EQG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNFSSRKKS PTGNDLKSAR GAELRQQGFQ DVNKRRAFLQ DNSWIKKPPE
60 70 80 90 100
EEQDGNYGRV VLNRHNSHDA LDRKLIERDE PKATISRYRS EDMLDRTLSS
110 120 130 140 150
FRTPQSTKTP AVSSFNANTT ATASTPATTP VKKKRQSWFP PPPPGHNASP
160 170 180 190 200
STAASRRDPA LHPPLPPKPC SPIASPKPLG RTNRQIHAAT AGACGETERH
210 220 230 240 250
AERNIRTEDL DDIIRVAAAL QKTDKGEELD NLIRMNKSLN RNQGLDGLFR
260 270 280 290 300
ANLKAQQLDK RAQSLESLIY MNTQTDRDGK GNQAFGSLKK INQRADPDRR
310 320 330 340 350
SQDLRSVIRT HATAERIGRR KQDLDGLIKV NPDTNKNMKR GKSLDNLIKV
360 370 380 390 400
TPEVNRSNKG GPSLDNFTKG VPARSRANQR DQDLDSLIKV TPSANRSSQH
410 420 430 440 450
SLDELINTSP QTIKTTARHQ DLDKFIKVNP DVLTNNQRNH DVDSTIRGNP
460 470 480 490 500
TGTRCEQSEE LDNLIKVKPS ALRNTNGGQD LESLTEVNSH VAEKNGRIDG
510 520 530 540 550
QANGLTNSLF KESTRASVYS YEARNSLSSN SGNKNGGPKD TVVYTRTYVE
560 570 580 590 600
NSKSPKDGYQ ENISGKYIQT VYSTSDRSVI ERDMCTYCRK PLGVETKMIL
610 620 630 640 650
DELQICCHST CFKCEICKRP LENLQAGDSI WIYRQTIHCE PCYSKVMAKW

IQ
Length:652
Mass (Da):72,972
Last modified:January 10, 2006 - v2
Checksum:iA089C07DD710EF13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245700 mRNA. Translation: AAG40727.2.
AK020346 mRNA. Translation: BAB32078.1.
CCDSiCCDS37002.1.
RefSeqiNP_075024.2. NM_022886.2.
XP_006519418.1. XM_006519355.2.
UniGeneiMm.244003.

Genome annotation databases

EnsembliENSMUST00000095576; ENSMUSP00000093233; ENSMUSG00000022123.
GeneIDi64929.
KEGGimmu:64929.
UCSCiuc007uwr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245700 mRNA. Translation: AAG40727.2.
AK020346 mRNA. Translation: BAB32078.1.
CCDSiCCDS37002.1.
RefSeqiNP_075024.2. NM_022886.2.
XP_006519418.1. XM_006519355.2.
UniGeneiMm.244003.

3D structure databases

ProteinModelPortaliQ9EQG3.
SMRiQ9EQG3. Positions 584-647.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4998183.
STRINGi10090.ENSMUSP00000093233.

PTM databases

iPTMnetiQ9EQG3.
PhosphoSiteiQ9EQG3.

Proteomic databases

MaxQBiQ9EQG3.
PaxDbiQ9EQG3.
PRIDEiQ9EQG3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095576; ENSMUSP00000093233; ENSMUSG00000022123.
GeneIDi64929.
KEGGimmu:64929.
UCSCiuc007uwr.1. mouse.

Organism-specific databases

CTDi8796.
MGIiMGI:1891228. Scel.

Phylogenomic databases

eggNOGiENOG410INGG. Eukaryota.
ENOG4111UEX. LUCA.
GeneTreeiENSGT00530000063872.
HOGENOMiHOG000294069.
HOVERGENiHBG023141.
InParanoidiQ9EQG3.
OMAiPKDGYQE.
OrthoDBiEOG72C52Z.
PhylomeDBiQ9EQG3.
TreeFamiTF335114.

Miscellaneous databases

NextBioi320223.
PROiQ9EQG3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9EQG3.
CleanExiMM_SCEL.
ExpressionAtlasiQ9EQG3. baseline and differential.
GenevisibleiQ9EQG3. MM.

Family and domain databases

Gene3Di2.10.110.10. 1 hit.
InterProiIPR001781. Znf_LIM.
[Graphical view]
SMARTiSM00132. LIM. 1 hit.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Gene characterization of sciellin (SCEL) and protein localization in vertebrate epithelia displaying barrier properties."
    Champliaud M.-F., Baden H.P., Koch M., Jin W., Burgeson R.E., Viel A.
    Genomics 70:264-268(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skin.
  2. Champliaud M.-F., Burgeson R.E., Baden H.P.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 157; 167-168; 343; 480-481; 508 AND 530-544.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-201.
    Strain: C57BL/6J.
    Tissue: Epididymis.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-264 AND SER-343, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney and Lung.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-82, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiSCEL_MOUSE
AccessioniPrimary (citable) accession number: Q9EQG3
Secondary accession number(s): Q9CTT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 10, 2006
Last modified: January 20, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.