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Protein

Dihydropyrimidinase-related protein 5

Gene

Dpysl5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May have a function in neuronal differentiation and/or axon growth.

GO - Molecular functioni

GO - Biological processi

  • axon guidance Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-399956. CRMPs in Sema3A signaling.

Protein family/group databases

MEROPSiM38.978.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropyrimidinase-related protein 5
Short name:
DRP-5
Alternative name(s):
Collapsin response mediator protein 5
Short name:
CRMP-5
Gene namesi
Name:Dpysl5
Synonyms:Crmp5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1929772. Dpysl5.

Subcellular locationi

  • Cytoplasm By similarity

  • Note: Translocates into the mitochondria upon interaction with SEPT4 isoform 4.1 Publication

GO - Cellular componenti

  • cytoplasm Source: MGI
  • dendrite Source: MGI
  • neuronal cell body Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001659251 – 564Dihydropyrimidinase-related protein 5Add BLAST564

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei509PhosphothreonineCombined sources1
Modified residuei514PhosphothreonineCombined sources1
Modified residuei532PhosphoserineCombined sources1
Modified residuei538PhosphoserineCombined sources1
Modified residuei559Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ9EQF6.
PaxDbiQ9EQF6.
PeptideAtlasiQ9EQF6.
PRIDEiQ9EQF6.

PTM databases

iPTMnetiQ9EQF6.
PhosphoSitePlusiQ9EQF6.
SwissPalmiQ9EQF6.

Expressioni

Tissue specificityi

Detected in brain.1 Publication

Developmental stagei

Detected in whole embryos after 11 days of development. Detected in embryonic head. Highly expressed in newborns and up to 7 days after birth. Expression is decreased after 14 days.1 Publication

Gene expression databases

BgeeiENSMUSG00000029168.
CleanExiMM_DPYSL5.
ExpressionAtlasiQ9EQF6. baseline and differential.
GenevisibleiQ9EQF6. MM.

Interactioni

Subunit structurei

Homotetramer, and heterotetramer with other DPYS-like proteins. Interacts with DPYSL2, DPYSL3 and DPYSL4. Interacts with SEPT4 isoform 4.2 Publications

Protein-protein interaction databases

BioGridi211143. 4 interactors.
IntActiQ9EQF6. 4 interactors.
MINTiMINT-4093583.
STRINGi10090.ENSMUSP00000085400.

Structurei

3D structure databases

ProteinModelPortaliQ9EQF6.
SMRiQ9EQF6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2584. Eukaryota.
COG0044. LUCA.
GeneTreeiENSGT00760000119241.
HOGENOMiHOG000219145.
HOVERGENiHBG000806.
InParanoidiQ9EQF6.
KOiK07529.
OMAiCRGLADP.
OrthoDBiEOG091G05F3.
PhylomeDBiQ9EQF6.
TreeFamiTF314706.

Family and domain databases

CDDicd01314. D-HYD. 1 hit.
Gene3Di2.30.40.10. 2 hits.
InterProiIPR006680. Amidohydro-rel.
IPR030626. DRP5.
IPR011778. Hydantoinase/dihydroPyrase.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PANTHERiPTHR11647:SF58. PTHR11647:SF58. 1 hit.
PfamiPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR02033. D-hydantoinase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9EQF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLANSASVRI LIKGGKVVND DCTHEADVYI ESGIIQQVGR ELMIPGGAKV
60 70 80 90 100
IDATGKLVIP GGIDTSTHFH QTFMNATCVD DFYHGTKAAL VGGTTMIIGH
110 120 130 140 150
VLPDKETSLV EAYEKCRALA DPKVCCDYAL HVGITWWAPK VKAEMETLVR
160 170 180 190 200
EKGVNSFQMF MTYKDLYMLR DSELYQVFHA CRDIGAIPRV HAENGELVAE
210 220 230 240 250
GAKEALDLGI TGPEGIEISH PEELEAEATH RVITIANRTH CPIYLVNVSS
260 270 280 290 300
ISAGDVIAAA KMQGKVVLAE TTNAHATLTG LHYYHQDWSH AAAYVTVPPL
310 320 330 340 350
RLDTNTSTYL MSLLANDTLN IVASDHRPFT TKQKAMGKED FTKIPHGVSG
360 370 380 390 400
VQDRMSVVWE RGVVGGKMDE NRFVAVTSSN AAKILNLYPR KGRIIPGADA
410 420 430 440 450
DVVVWDPEAT KTISASTQVQ GGDFNLYENM RCHGVPLVTI SRGRVVYENG
460 470 480 490 500
VFMCAEGTGK FCPLRSFPDI VYKKLVQREK TLKVRGVDRT PYLGDVAIVV
510 520 530 540 550
HPGKKEMGTP LADTPTRPVT RHGGMRDLHE SSFSLSGSQI DDHVPKRASA
560
RILAPPGGRS SGIW
Length:564
Mass (Da):61,516
Last modified:March 1, 2001 - v1
Checksum:iCA93790FC8F9CD98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF249295 mRNA. Translation: AAG37998.1.
BC065054 mRNA. Translation: AAH65054.1.
CCDSiCCDS39047.1.
RefSeqiNP_075534.1. NM_023047.2.
XP_006504108.1. XM_006504045.1.
UniGeneiMm.27732.

Genome annotation databases

EnsembliENSMUST00000088081; ENSMUSP00000085400; ENSMUSG00000029168.
ENSMUST00000114729; ENSMUSP00000110377; ENSMUSG00000029168.
GeneIDi65254.
KEGGimmu:65254.
UCSCiuc008wvw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF249295 mRNA. Translation: AAG37998.1.
BC065054 mRNA. Translation: AAH65054.1.
CCDSiCCDS39047.1.
RefSeqiNP_075534.1. NM_023047.2.
XP_006504108.1. XM_006504045.1.
UniGeneiMm.27732.

3D structure databases

ProteinModelPortaliQ9EQF6.
SMRiQ9EQF6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211143. 4 interactors.
IntActiQ9EQF6. 4 interactors.
MINTiMINT-4093583.
STRINGi10090.ENSMUSP00000085400.

Protein family/group databases

MEROPSiM38.978.

PTM databases

iPTMnetiQ9EQF6.
PhosphoSitePlusiQ9EQF6.
SwissPalmiQ9EQF6.

Proteomic databases

MaxQBiQ9EQF6.
PaxDbiQ9EQF6.
PeptideAtlasiQ9EQF6.
PRIDEiQ9EQF6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000088081; ENSMUSP00000085400; ENSMUSG00000029168.
ENSMUST00000114729; ENSMUSP00000110377; ENSMUSG00000029168.
GeneIDi65254.
KEGGimmu:65254.
UCSCiuc008wvw.1. mouse.

Organism-specific databases

CTDi56896.
MGIiMGI:1929772. Dpysl5.

Phylogenomic databases

eggNOGiKOG2584. Eukaryota.
COG0044. LUCA.
GeneTreeiENSGT00760000119241.
HOGENOMiHOG000219145.
HOVERGENiHBG000806.
InParanoidiQ9EQF6.
KOiK07529.
OMAiCRGLADP.
OrthoDBiEOG091G05F3.
PhylomeDBiQ9EQF6.
TreeFamiTF314706.

Enzyme and pathway databases

ReactomeiR-MMU-399956. CRMPs in Sema3A signaling.

Miscellaneous databases

ChiTaRSiDpysl5. mouse.
PROiQ9EQF6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029168.
CleanExiMM_DPYSL5.
ExpressionAtlasiQ9EQF6. baseline and differential.
GenevisibleiQ9EQF6. MM.

Family and domain databases

CDDicd01314. D-HYD. 1 hit.
Gene3Di2.30.40.10. 2 hits.
InterProiIPR006680. Amidohydro-rel.
IPR030626. DRP5.
IPR011778. Hydantoinase/dihydroPyrase.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PANTHERiPTHR11647:SF58. PTHR11647:SF58. 1 hit.
PfamiPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR02033. D-hydantoinase. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDPYL5_MOUSE
AccessioniPrimary (citable) accession number: Q9EQF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.