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Protein

Sentrin-specific protease 2

Gene

Senp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei477By similarity1
Active sitei494By similarity1
Active sitei547NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processmRNA transport, Protein transport, Translocation, Transport, Ubl conjugation pathway, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-RNO-3065679 SUMO is proteolytically processed

Protein family/group databases

MEROPSiC48.007

Names & Taxonomyi

Protein namesi
Recommended name:
Sentrin-specific protease 2 (EC:3.4.22.-)
Alternative name(s):
Axin-associating molecule
Short name:
Axam
Sentrin/SUMO-specific protease SENP2
Gene namesi
Name:Senp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi708378 Senp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Nuclear pore complex, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi547C → S: Abolishes protease activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001017201 – 588Sentrin-specific protease 2Add BLAST588

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32PhosphoserineBy similarity1
Modified residuei332PhosphoserineBy similarity1
Modified residuei343PhosphoserineBy similarity1

Post-translational modificationi

Polyubiquitinated; which leads to proteasomal degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9EQE1
PRIDEiQ9EQE1

PTM databases

iPTMnetiQ9EQE1
PhosphoSitePlusiQ9EQE1

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in brain, lung and testis.

Gene expression databases

BgeeiENSRNOG00000001773
ExpressionAtlasiQ9EQE1 baseline and differential
GenevisibleiQ9EQE1 RN

Interactioni

Subunit structurei

Binds to SUMO2 and SUMO3. Interacts with the C-terminal domain of NUP153 via its N-terminus. Interacts with MTA1 (By similarity). Binds to axin.By similarity

Protein-protein interaction databases

BioGridi249380, 2 interactors
STRINGi10116.ENSRNOP00000002425

Structurei

3D structure databases

ProteinModelPortaliQ9EQE1
SMRiQ9EQE1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni72 – 381Axin-bindingAdd BLAST310
Regioni394 – 558ProteaseAdd BLAST165

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi28 – 31Nuclear localization signalSequence analysis4
Motifi47 – 52Nuclear localization signalSequence analysis6
Motifi316 – 331Nuclear export signalBy similarityAdd BLAST16

Sequence similaritiesi

Belongs to the peptidase C48 family.Curated

Phylogenomic databases

eggNOGiKOG0778 Eukaryota
COG5160 LUCA
GeneTreeiENSGT00530000062941
HOGENOMiHOG000070234
HOVERGENiHBG054228
InParanoidiQ9EQE1
KOiK03345
OMAiRRGYQLE
OrthoDBiEOG091G092N
PhylomeDBiQ9EQE1
TreeFamiTF316289

Family and domain databases

InterProiView protein in InterPro
IPR003653 Peptidase_C48_C
PfamiView protein in Pfam
PF02902 Peptidase_C48, 1 hit
PROSITEiView protein in PROSITE
PS50600 ULP_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9EQE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRWLTKVLG TILRLCERPA PGARALLKRR RSSSSLFSTA VDTDEIPAKR
60 70 80 90 100
PRLDCFIHQV KNSLYNAASL FGFPFQLTTK PMVSSACNGT RNVAPSGEVF
110 120 130 140 150
SNSPSCELTT SGSCSSMLKL GNKSPNGISD YPKIRVTVAR DQPRRVLPSF
160 170 180 190 200
GFTLKSEGYN RRPSGRRHSK SNPESSLPWK PQEQGVTEMI SEEGGKGARR
210 220 230 240 250
PHCTVEEGVQ KDEREKYLKL LERLKEGAHG STFPPAVSHH SSQRTQMDTL
260 270 280 290 300
KTKGWMEEQN HGVRTTHLVP KQYRVVETRG PLCSVRSEKR YSKGKADTEK
310 320 330 340 350
VVGLRFEKDG TRGHQLEPDL SEEVSARLRL GSGSNGLLRR KISVLEAKEK
360 370 380 390 400
NFPSKEKDRR TEDLFELTED MEKEISNALG HGPPDEILSS AFKLRITRGD
410 420 430 440 450
IQTLKNYHWL NDEVINFYMN LLVERSKKQG YPALHALSTF FYPKLKSGGY
460 470 480 490 500
QAVKRWTKGV NLFDQELVLV PIHRKVHWSL VVMDLRKKCL KYLDSMGQKG
510 520 530 540 550
HRICEILLQY LQDESKTKRN TDLNLLEWTH YSMKPHEIPQ QLNGSDCGMF
560 570 580
TCKYADYISR DKPITFTQHQ MPLFRKKMVW EILHQQLL
Length:588
Mass (Da):67,252
Last modified:March 1, 2001 - v1
Checksum:iBEC186367D8284C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260129 mRNA Translation: AAG34653.1
RefSeqiNP_076479.1, NM_023989.1
UniGeneiRn.9367

Genome annotation databases

EnsembliENSRNOT00000002425; ENSRNOP00000002425; ENSRNOG00000001773
GeneIDi78973
KEGGirno:78973
UCSCiRGD:708378 rat

Similar proteinsi

Entry informationi

Entry nameiSENP2_RAT
AccessioniPrimary (citable) accession number: Q9EQE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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