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Q9EQD0

- FZD5_MOUSE

UniProt

Q9EQD0 - FZD5_MOUSE

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Protein

Frizzled-5

Gene
Fzd5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in yolk sac angiogenesis and in placental vascularization. Binds to Wnt2, Wnt10B, Wnt5A, but not to Wnt2B or Wnt4.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. PDZ domain binding Source: RefGenome
  3. protein binding Source: UniProtKB
  4. Wnt-activated receptor activity Source: RefGenome
  5. Wnt-protein binding Source: MGI

GO - Biological processi

  1. angiogenesis Source: MGI
  2. anterior/posterior axis specification, embryo Source: Ensembl
  3. apoptotic process involved in morphogenesis Source: MGI
  4. axonogenesis Source: RefGenome
  5. brain development Source: RefGenome
  6. branching involved in labyrinthine layer morphogenesis Source: MGI
  7. canonical Wnt signaling pathway Source: MGI
  8. cell maturation Source: MGI
  9. cellular response to molecule of bacterial origin Source: Ensembl
  10. chorionic trophoblast cell differentiation Source: MGI
  11. embryonic camera-type eye development Source: MGI
  12. gonad development Source: RefGenome
  13. labyrinthine layer blood vessel development Source: MGI
  14. negative regulation of cell proliferation Source: MGI
  15. positive regulation of interferon-gamma production Source: Ensembl
  16. positive regulation of JUN kinase activity Source: MGI
  17. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  18. post-embryonic camera-type eye development Source: MGI
  19. regulation of canonical Wnt signaling pathway Source: MGI
  20. regulation of chorionic trophoblast cell proliferation Source: MGI
  21. regulation of tight junction assembly Source: MGI
  22. regulation of transcription from RNA polymerase II promoter Source: RefGenome
  23. Spemann organizer formation Source: Ensembl
  24. syncytiotrophoblast cell differentiation involved in labyrinthine layer development Source: MGI
  25. T cell differentiation in thymus Source: MGI
  26. vasculature development Source: MGI
  27. Wnt signaling pathway Source: MGI
  28. Wnt signaling pathway involved in dorsal/ventral axis specification Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Angiogenesis, Differentiation, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_221970. Ca2+ pathway.
REACT_222715. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.

Protein family/group databases

MEROPSiI93.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-5
Short name:
Fz-5
Short name:
mFz5
Gene namesi
Name:Fzd5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:108571. Fzd5.

Subcellular locationi

Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein
Note: Localized at the plasma membrane and also found at the Golgi.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 238212Extracellular Reviewed predictionAdd
BLAST
Transmembranei239 – 25921Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini260 – 27011Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei271 – 29121Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini292 – 31524Extracellular Reviewed predictionAdd
BLAST
Transmembranei316 – 33621Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini337 – 35822Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei359 – 37921Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini380 – 40223Extracellular Reviewed predictionAdd
BLAST
Transmembranei403 – 42321Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini424 – 44926Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei450 – 47021Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini471 – 50030Extracellular Reviewed predictionAdd
BLAST
Transmembranei501 – 52121Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini522 – 58564Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell projection Source: RefGenome
  2. cell surface Source: Ensembl
  3. cytoplasm Source: RefGenome
  4. Golgi apparatus Source: BHF-UCL
  5. Golgi membrane Source: UniProtKB-SubCell
  6. integral component of membrane Source: UniProtKB-KW
  7. perinuclear region of cytoplasm Source: BHF-UCL
  8. plasma membrane Source: BHF-UCL
  9. tight junction Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed predictionAdd
BLAST
Chaini27 – 585559Frizzled-5PRO_0000243936Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 94 By similarity
Disulfide bondi41 ↔ 87 By similarity
Glycosylationi47 – 471N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi78 ↔ 116 By similarity
Disulfide bondi105 ↔ 147 By similarity
Disulfide bondi109 ↔ 133 By similarity
Glycosylationi151 – 1511N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Ubiquitinated by RNF43 and ZNRF3, leading to its degradation by the proteasome By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PRIDEiQ9EQD0.

PTM databases

PhosphoSiteiQ9EQD0.

Expressioni

Tissue specificityi

Expressed in eye, kidney, lung, chondrocytes, epithelial cells of the small intestine and gobelet cells of the colon.1 Publication

Developmental stagei

Expressed in the yolk sac, placenta, eye and lung bud at 9.5 dpc. At 10.5 dpc, also expressed in the placental blood vessel of embryonic origin.

Gene expression databases

CleanExiMM_FZD5.
GenevestigatoriQ9EQD0.

Interactioni

Subunit structurei

Interacts with GOPC.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
GopcQ8BH603EBI-7938232,EBI-296357

Protein-protein interaction databases

BioGridi199778. 1 interaction.
DIPiDIP-41260N.
IntActiQ9EQD0. 4 interactions.
MINTiMINT-1783095.
STRINGi10090.ENSMUSP00000067783.

Structurei

3D structure databases

ProteinModelPortaliQ9EQD0.
SMRiQ9EQD0. Positions 33-149, 197-536.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 150123FZAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi582 – 5843PDZ-binding By similarity

Domaini

The PDZ-binding motif mediates interaction with GOPC By similarity.
The FZ domain is involved in binding with Wnt ligands By similarity.

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG257258.
GeneTreeiENSGT00750000117488.
HOGENOMiHOG000233236.
HOVERGENiHBG006977.
InParanoidiQ9EQD0.
KOiK02375.
OMAiAATYHKQ.
OrthoDBiEOG7M3J01.
TreeFamiTF317907.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026547. FZD5.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF29. PTHR11309:SF29. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EQD0-1 [UniParc]FASTAAdd to Basket

« Hide

MARPDPSAPP SLLLLLLAQL VGRAAAASKA PVCQEITVPM CRGIGYNLTH    50
MPNQFNHDTQ DEAGLEVHQF WPLVEIHCSP DLRFFLCSMY TPICLPDYHK 100
PLPPCRSVCE RAKAGCSPLM RQYGFAWPER MSCDRLPVLG GDAEVLCMDY 150
NRSEATTASP KSFPAKPTLP GPPGAPSSGG ECPSGGPSVC TCREPFVPIL 200
KESHPLYNKV RTGQVPNCAV PCYQPSFSPD ERTFATFWIG LWSVLCFIST 250
STTVATFLID MERFRYPERP IIFLSACYLC VSLGFLVRLV VGHASVACSR 300
EHSHIHYETT GPALCTVVFL LVYFFGMASS IWWVILSLTW FLAAGMKWGN 350
EAIAGYAQYF HLAAWLIPSV KSITALALSS VDGDPVAGIC YVGNQNLNSL 400
RGFVLGPLVL YLLVGTLFLL AGFVSLFRIR SVIKQGGTKT DKLEKLMIRI 450
GIFTLLYTVP ASIVVACYLY EQHYRESWEA ALTCACPGPD AGQPRAKPEY 500
WVLMLKYFMC LVVGITSGVW IWSGKTLESW RRFTSRCCCS SRRGHKSGGA 550
MAAGDYAEAS AALTGRTGPP GPTAAYHKQV SLSHV 585
Length:585
Mass (Da):64,138
Last modified:October 3, 2012 - v3
Checksum:i5FC03620AF087733
GO

Sequence cautioni

The sequence AAG39355.1 differs from that shown. Reason: Frameshift at several positions.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41P → T in BAC26789. 1 Publication
Sequence conflicti123 – 1242YG → S in BAC53981. 1 Publication
Sequence conflicti402 – 4021G → S in AAG39355. 1 Publication
Sequence conflicti419 – 4191L → H in BAC53981. 1 Publication
Sequence conflicti444 – 4441E → G in BAC53981. 1 Publication
Sequence conflicti477 – 4771S → T in AAG39355. 1 Publication
Sequence conflicti481 – 4811A → P in AAG39355. 1 Publication
Sequence conflicti489 – 4891P → T in AAG39355. 1 Publication
Sequence conflicti521 – 5211I → F in BAC53981. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF272146 mRNA. Translation: AAG39355.1. Frameshift.
AB052910 mRNA. Translation: BAC53981.1.
AK030111 mRNA. Translation: BAC26789.1.
AC101915 Genomic DNA. No translation available.
CH466548 Genomic DNA. Translation: EDL00208.1.
CH466548 Genomic DNA. Translation: EDL00209.1.
AF005203 mRNA. Translation: AAC01953.1.
CCDSiCCDS15008.1.
RefSeqiNP_001036124.1. NM_001042659.1.
NP_073558.2. NM_022721.3.
UniGeneiMm.150813.
Mm.470210.

Genome annotation databases

EnsembliENSMUST00000063982; ENSMUSP00000067783; ENSMUSG00000045005.
ENSMUST00000116133; ENSMUSP00000111828; ENSMUSG00000045005.
GeneIDi14367.
KEGGimmu:14367.
UCSCiuc007bgy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF272146 mRNA. Translation: AAG39355.1 . Frameshift.
AB052910 mRNA. Translation: BAC53981.1 .
AK030111 mRNA. Translation: BAC26789.1 .
AC101915 Genomic DNA. No translation available.
CH466548 Genomic DNA. Translation: EDL00208.1 .
CH466548 Genomic DNA. Translation: EDL00209.1 .
AF005203 mRNA. Translation: AAC01953.1 .
CCDSi CCDS15008.1.
RefSeqi NP_001036124.1. NM_001042659.1.
NP_073558.2. NM_022721.3.
UniGenei Mm.150813.
Mm.470210.

3D structure databases

ProteinModelPortali Q9EQD0.
SMRi Q9EQD0. Positions 33-149, 197-536.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199778. 1 interaction.
DIPi DIP-41260N.
IntActi Q9EQD0. 4 interactions.
MINTi MINT-1783095.
STRINGi 10090.ENSMUSP00000067783.

Protein family/group databases

MEROPSi I93.001.
GPCRDBi Search...

PTM databases

PhosphoSitei Q9EQD0.

Proteomic databases

PRIDEi Q9EQD0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000063982 ; ENSMUSP00000067783 ; ENSMUSG00000045005 .
ENSMUST00000116133 ; ENSMUSP00000111828 ; ENSMUSG00000045005 .
GeneIDi 14367.
KEGGi mmu:14367.
UCSCi uc007bgy.1. mouse.

Organism-specific databases

CTDi 7855.
MGIi MGI:108571. Fzd5.

Phylogenomic databases

eggNOGi NOG257258.
GeneTreei ENSGT00750000117488.
HOGENOMi HOG000233236.
HOVERGENi HBG006977.
InParanoidi Q9EQD0.
KOi K02375.
OMAi AATYHKQ.
OrthoDBi EOG7M3J01.
TreeFami TF317907.

Enzyme and pathway databases

Reactomei REACT_221970. Ca2+ pathway.
REACT_222715. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.

Miscellaneous databases

NextBioi 285839.
PROi Q9EQD0.
SOURCEi Search...

Gene expression databases

CleanExi MM_FZD5.
Genevestigatori Q9EQD0.

Family and domain databases

Gene3Di 1.10.2000.10. 1 hit.
InterProi IPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026547. FZD5.
IPR017981. GPCR_2-like.
[Graphical view ]
PANTHERi PTHR11309. PTHR11309. 1 hit.
PTHR11309:SF29. PTHR11309:SF29. 1 hit.
Pfami PF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view ]
PRINTSi PR00489. FRIZZLED.
SMARTi SM00063. FRI. 1 hit.
[Graphical view ]
SUPFAMi SSF63501. SSF63501. 1 hit.
PROSITEi PS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis."
    Ishikawa T., Tamai Y., Zorn A.M., Yoshida H., Seldin M.F., Nishikawa S., Taketo M.M.
    Development 128:25-33(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6N.
    Tissue: Intestine.
  2. "Molecular cloning and characterization of a gene encoding for rat Frizzled 5."
    Ito S., Imamura T., Shiota K.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Johnson M.A., Greenberg N.M.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 211-300.
    Strain: C57BL/6.
    Tissue: Prostate.
  7. "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled."
    Wang Y., Macke J.P., Abella B.S., Andreasson K., Worley P., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.
    J. Biol. Chem. 271:4468-4476(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled."
    Yao R., Maeda T., Takada S., Noda T.
    Biochem. Biophys. Res. Commun. 286:771-778(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GOPC, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiFZD5_MOUSE
AccessioniPrimary (citable) accession number: Q9EQD0
Secondary accession number(s): G5E8F0
, O08975, Q8BMR2, Q8CHK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: October 3, 2012
Last modified: September 3, 2014
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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