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Q9EQD0

- FZD5_MOUSE

UniProt

Q9EQD0 - FZD5_MOUSE

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Protein

Frizzled-5

Gene

Fzd5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in yolk sac angiogenesis and in placental vascularization. Binds to Wnt2, Wnt10B, Wnt5A, but not to Wnt2B or Wnt4.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. PDZ domain binding Source: RefGenome
  3. Wnt-activated receptor activity Source: RefGenome
  4. Wnt-protein binding Source: MGI

GO - Biological processi

  1. angiogenesis Source: MGI
  2. anterior/posterior axis specification, embryo Source: Ensembl
  3. apoptotic process involved in morphogenesis Source: MGI
  4. axonogenesis Source: RefGenome
  5. brain development Source: RefGenome
  6. branching involved in labyrinthine layer morphogenesis Source: MGI
  7. canonical Wnt signaling pathway Source: MGI
  8. cell maturation Source: MGI
  9. cellular response to molecule of bacterial origin Source: Ensembl
  10. chorionic trophoblast cell differentiation Source: MGI
  11. embryonic camera-type eye development Source: MGI
  12. gonad development Source: RefGenome
  13. labyrinthine layer blood vessel development Source: MGI
  14. negative regulation of cell proliferation Source: MGI
  15. positive regulation of interferon-gamma production Source: Ensembl
  16. positive regulation of JUN kinase activity Source: MGI
  17. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  18. post-embryonic camera-type eye development Source: MGI
  19. regulation of canonical Wnt signaling pathway Source: MGI
  20. regulation of chorionic trophoblast cell proliferation Source: MGI
  21. regulation of tight junction assembly Source: MGI
  22. regulation of transcription from RNA polymerase II promoter Source: RefGenome
  23. Spemann organizer formation Source: Ensembl
  24. syncytiotrophoblast cell differentiation involved in labyrinthine layer development Source: MGI
  25. T cell differentiation in thymus Source: MGI
  26. vasculature development Source: MGI
  27. Wnt signaling pathway Source: MGI
  28. Wnt signaling pathway involved in dorsal/ventral axis specification Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Angiogenesis, Differentiation, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_221970. Ca2+ pathway.
REACT_222715. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.

Protein family/group databases

MEROPSiI93.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-5
Short name:
Fz-5
Short name:
mFz5
Gene namesi
Name:Fzd5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:108571. Fzd5.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication. Golgi apparatus membrane 1 Publication; Multi-pass membrane protein 1 Publication
Note: Localized at the plasma membrane and also found at the Golgi.

GO - Cellular componenti

  1. cell projection Source: RefGenome
  2. cell surface Source: Ensembl
  3. cytoplasm Source: RefGenome
  4. Golgi apparatus Source: BHF-UCL
  5. integral component of membrane Source: UniProtKB-KW
  6. perinuclear region of cytoplasm Source: BHF-UCL
  7. plasma membrane Source: BHF-UCL
  8. tight junction Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 585559Frizzled-5PRO_0000243936Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 94PROSITE-ProRule annotation
Disulfide bondi41 ↔ 87PROSITE-ProRule annotation
Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi78 ↔ 116PROSITE-ProRule annotation
Disulfide bondi105 ↔ 147PROSITE-ProRule annotation
Disulfide bondi109 ↔ 133PROSITE-ProRule annotation
Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Ubiquitinated by RNF43 and ZNRF3, leading to its degradation by the proteasome.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PRIDEiQ9EQD0.

PTM databases

PhosphoSiteiQ9EQD0.

Expressioni

Tissue specificityi

Expressed in eye, kidney, lung, chondrocytes, epithelial cells of the small intestine and gobelet cells of the colon.1 Publication

Developmental stagei

Expressed in the yolk sac, placenta, eye and lung bud at 9.5 dpc. At 10.5 dpc, also expressed in the placental blood vessel of embryonic origin.

Gene expression databases

CleanExiMM_FZD5.
GenevestigatoriQ9EQD0.

Interactioni

Subunit structurei

Interacts with GOPC.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
GopcQ8BH603EBI-7938232,EBI-296357

Protein-protein interaction databases

BioGridi199778. 1 interaction.
DIPiDIP-41260N.
IntActiQ9EQD0. 4 interactions.
MINTiMINT-1783095.
STRINGi10090.ENSMUSP00000067783.

Structurei

3D structure databases

ProteinModelPortaliQ9EQD0.
SMRiQ9EQD0. Positions 33-149, 197-536.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 238212ExtracellularSequence AnalysisAdd
BLAST
Topological domaini260 – 27011CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini292 – 31524ExtracellularSequence AnalysisAdd
BLAST
Topological domaini337 – 35822CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini380 – 40223ExtracellularSequence AnalysisAdd
BLAST
Topological domaini424 – 44926CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini471 – 50030ExtracellularSequence AnalysisAdd
BLAST
Topological domaini522 – 58564CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei239 – 25921Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei271 – 29121Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei316 – 33621Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei359 – 37921Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei403 – 42321Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei450 – 47021Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei501 – 52121Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 150123FZPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi582 – 5843PDZ-bindingBy similarity

Domaini

The PDZ-binding motif mediates interaction with GOPC.By similarity
The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG257258.
GeneTreeiENSGT00760000118864.
HOGENOMiHOG000233236.
HOVERGENiHBG006977.
InParanoidiQ9EQD0.
KOiK02375.
OMAiAATYHKQ.
OrthoDBiEOG7M3J01.
TreeFamiTF317907.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026547. FZD5.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF29. PTHR11309:SF29. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EQD0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARPDPSAPP SLLLLLLAQL VGRAAAASKA PVCQEITVPM CRGIGYNLTH
60 70 80 90 100
MPNQFNHDTQ DEAGLEVHQF WPLVEIHCSP DLRFFLCSMY TPICLPDYHK
110 120 130 140 150
PLPPCRSVCE RAKAGCSPLM RQYGFAWPER MSCDRLPVLG GDAEVLCMDY
160 170 180 190 200
NRSEATTASP KSFPAKPTLP GPPGAPSSGG ECPSGGPSVC TCREPFVPIL
210 220 230 240 250
KESHPLYNKV RTGQVPNCAV PCYQPSFSPD ERTFATFWIG LWSVLCFIST
260 270 280 290 300
STTVATFLID MERFRYPERP IIFLSACYLC VSLGFLVRLV VGHASVACSR
310 320 330 340 350
EHSHIHYETT GPALCTVVFL LVYFFGMASS IWWVILSLTW FLAAGMKWGN
360 370 380 390 400
EAIAGYAQYF HLAAWLIPSV KSITALALSS VDGDPVAGIC YVGNQNLNSL
410 420 430 440 450
RGFVLGPLVL YLLVGTLFLL AGFVSLFRIR SVIKQGGTKT DKLEKLMIRI
460 470 480 490 500
GIFTLLYTVP ASIVVACYLY EQHYRESWEA ALTCACPGPD AGQPRAKPEY
510 520 530 540 550
WVLMLKYFMC LVVGITSGVW IWSGKTLESW RRFTSRCCCS SRRGHKSGGA
560 570 580
MAAGDYAEAS AALTGRTGPP GPTAAYHKQV SLSHV
Length:585
Mass (Da):64,138
Last modified:October 3, 2012 - v3
Checksum:i5FC03620AF087733
GO

Sequence cautioni

The sequence AAG39355.1 differs from that shown. Reason: Frameshift at several positions.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41P → T in BAC26789. (PubMed:16141072)Curated
Sequence conflicti123 – 1242YG → S in BAC53981. 1 PublicationCurated
Sequence conflicti402 – 4021G → S in AAG39355. (PubMed:11092808)Curated
Sequence conflicti419 – 4191L → H in BAC53981. 1 PublicationCurated
Sequence conflicti444 – 4441E → G in BAC53981. 1 PublicationCurated
Sequence conflicti477 – 4771S → T in AAG39355. (PubMed:11092808)Curated
Sequence conflicti481 – 4811A → P in AAG39355. (PubMed:11092808)Curated
Sequence conflicti489 – 4891P → T in AAG39355. (PubMed:11092808)Curated
Sequence conflicti521 – 5211I → F in BAC53981. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF272146 mRNA. Translation: AAG39355.1. Frameshift.
AB052910 mRNA. Translation: BAC53981.1.
AK030111 mRNA. Translation: BAC26789.1.
AC101915 Genomic DNA. No translation available.
CH466548 Genomic DNA. Translation: EDL00208.1.
CH466548 Genomic DNA. Translation: EDL00209.1.
AF005203 mRNA. Translation: AAC01953.1.
CCDSiCCDS15008.1.
RefSeqiNP_001036124.1. NM_001042659.1.
NP_073558.2. NM_022721.3.
UniGeneiMm.150813.
Mm.470210.

Genome annotation databases

EnsembliENSMUST00000063982; ENSMUSP00000067783; ENSMUSG00000045005.
ENSMUST00000116133; ENSMUSP00000111828; ENSMUSG00000045005.
GeneIDi14367.
KEGGimmu:14367.
UCSCiuc007bgy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF272146 mRNA. Translation: AAG39355.1 . Frameshift.
AB052910 mRNA. Translation: BAC53981.1 .
AK030111 mRNA. Translation: BAC26789.1 .
AC101915 Genomic DNA. No translation available.
CH466548 Genomic DNA. Translation: EDL00208.1 .
CH466548 Genomic DNA. Translation: EDL00209.1 .
AF005203 mRNA. Translation: AAC01953.1 .
CCDSi CCDS15008.1.
RefSeqi NP_001036124.1. NM_001042659.1.
NP_073558.2. NM_022721.3.
UniGenei Mm.150813.
Mm.470210.

3D structure databases

ProteinModelPortali Q9EQD0.
SMRi Q9EQD0. Positions 33-149, 197-536.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199778. 1 interaction.
DIPi DIP-41260N.
IntActi Q9EQD0. 4 interactions.
MINTi MINT-1783095.
STRINGi 10090.ENSMUSP00000067783.

Protein family/group databases

MEROPSi I93.001.
GPCRDBi Search...

PTM databases

PhosphoSitei Q9EQD0.

Proteomic databases

PRIDEi Q9EQD0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000063982 ; ENSMUSP00000067783 ; ENSMUSG00000045005 .
ENSMUST00000116133 ; ENSMUSP00000111828 ; ENSMUSG00000045005 .
GeneIDi 14367.
KEGGi mmu:14367.
UCSCi uc007bgy.1. mouse.

Organism-specific databases

CTDi 7855.
MGIi MGI:108571. Fzd5.

Phylogenomic databases

eggNOGi NOG257258.
GeneTreei ENSGT00760000118864.
HOGENOMi HOG000233236.
HOVERGENi HBG006977.
InParanoidi Q9EQD0.
KOi K02375.
OMAi AATYHKQ.
OrthoDBi EOG7M3J01.
TreeFami TF317907.

Enzyme and pathway databases

Reactomei REACT_221970. Ca2+ pathway.
REACT_222715. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.

Miscellaneous databases

NextBioi 285839.
PROi Q9EQD0.
SOURCEi Search...

Gene expression databases

CleanExi MM_FZD5.
Genevestigatori Q9EQD0.

Family and domain databases

Gene3Di 1.10.2000.10. 1 hit.
InterProi IPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026547. FZD5.
IPR017981. GPCR_2-like.
[Graphical view ]
PANTHERi PTHR11309. PTHR11309. 1 hit.
PTHR11309:SF29. PTHR11309:SF29. 1 hit.
Pfami PF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view ]
PRINTSi PR00489. FRIZZLED.
SMARTi SM00063. FRI. 1 hit.
[Graphical view ]
SUPFAMi SSF63501. SSF63501. 1 hit.
PROSITEi PS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis."
    Ishikawa T., Tamai Y., Zorn A.M., Yoshida H., Seldin M.F., Nishikawa S., Taketo M.M.
    Development 128:25-33(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6N.
    Tissue: Intestine.
  2. "Molecular cloning and characterization of a gene encoding for rat Frizzled 5."
    Ito S., Imamura T., Shiota K.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Johnson M.A., Greenberg N.M.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 211-300.
    Strain: C57BL/6.
    Tissue: Prostate.
  7. "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled."
    Wang Y., Macke J.P., Abella B.S., Andreasson K., Worley P., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.
    J. Biol. Chem. 271:4468-4476(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled."
    Yao R., Maeda T., Takada S., Noda T.
    Biochem. Biophys. Res. Commun. 286:771-778(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GOPC, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiFZD5_MOUSE
AccessioniPrimary (citable) accession number: Q9EQD0
Secondary accession number(s): G5E8F0
, O08975, Q8BMR2, Q8CHK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: October 3, 2012
Last modified: October 29, 2014
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3