Reviewed, UniProtKB/Swiss-Prot Q9EQC9 (CXXC4_RAT)

Names and origin

Protein names

Recommended name:
    CXXC-type zinc finger protein 4
Alternative name(s):
    Inhibition of the Dvl and axin complex protein

Gene names

Name:	Cxxc4
Synonyms:	Idax

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1 By similarity.
Subunit structure	Interacts with the PDZ domain of DVL1. Ref.1 Ref.2
Subcellular location	Cytoplasm Ref.1.
Tissue specificity	Highest expression in cerebrum, cerebellum and heart, and lower expression in thymus and testis. Ref.1
Sequence similarities	Contains 1 CXXC-type zinc finger.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Cytoplasm
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Gene Ontology (GO)
Biological process	Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro PDZ domain binding Ref.1 Ref.2 Inferred from physical interaction. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 198	198	CXXC-type zinc finger protein 4		PRO_0000317544
Regions
	Zinc finger	132 – 173	42	CXXC-type
	Region	161 – 166	6	Interaction with DVL1
	Compositional bias	116 – 123	8	Poly-Ser

Sequences

	Sequence		Length	Mass (Da)
	Q9EQC9-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 9D9F7FAD11A9B759	FASTA	198	20,978
	10 20 30 40 50 60 MHHRNDSQRL GKAGCPPEPS LQMANTNFLS TLSPEHCRPL AGECMNKLKC GAAEAEIMNL 70 80 90 100 110 120 PERVGTFSAI PALGGISLPP GVIVMTALHS PAAASAAVTD SAFQIANLAD CPQNHSSSSS 130 140 150 160 170 180 SSSGGAGGAN PAKKKRKRCG VCVPCKRLIN CGVCSSCRNR KTGHQICKFR KCEELKKKPG 190 TSLERTPVPS AEAFRWFF

References

[1]	"Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein." Hino S., Kishida S., Michiue T., Fukui A., Sakamoto I., Takada S., Asashima M., Kikuchi A. Mol. Cell. Biol. 21:330-342(2001) [PubMed: 11113207] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH DVL1.
[2]	"Interaction between the internal motif KTXXXI of Idax and mDvl PDZ domain." London T.B.C., Lee H.-J., Shao Y., Zheng J. Biochem. Biophys. Res. Commun. 322:326-332(2004) [PubMed: 15313210] [Abstract] Cited for: INTERACTION WITH DVL1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF272158 mRNA. Translation: AAG42071.1.
IPI	IPI00189861.
RefSeq	NP_445794.1.
UniGene	Rn.209562
3D structure databases
SMR	Q9EQC9. Positions 127-181.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9EQC9.
Genome annotation databases
Ensembl	ENSRNOT00000016549; ENSRNOP00000016549; ENSRNOG00000012400; Rattus norvegicus. [Genome view]
GeneID	83824.
KEGG	rno:83824.
UCSC	NM_053342. rat.
Organism-specific databases
CTD	83824.
RGD	69228. Cxxc4.
Phylogenomic databases
eggNOG	maNOG14675.
HOVERGEN	Q9EQC9.
InParanoid	Q9EQC9.
OMA	MANTNSP.
OrthoDB	EOG9P5NW3.
PhylomeDB	Q9EQC9.
Gene expression databases
ArrayExpress	Q9EQC9.
Genevestigator	Q9EQC9.
Family and domain databases
InterPro	IPR002857. Znf_CXXC. [Graphical view]
Pfam	PF02008. zf-CXXC. 1 hit. [Graphical view]
PROSITE	PS51058. ZF_CXXC. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	616442.

Entry information

Entry name

CXXC4_RAT

Accession

Primary (citable) accession number: Q9EQC9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	March 1, 2001
Last modified:	January 19, 2010
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)