Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 287

Gene

Znf287

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri366 – 38823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri394 – 41623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri422 – 44423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri450 – 47223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri478 – 50023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri506 – 52823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri534 – 55623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri562 – 58423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri590 – 61223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri618 – 64023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri646 – 66823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri674 – 69623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri702 – 72423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri730 – 75223C2H2-type 14PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • positive regulation of transcription, DNA-templated Source: MGI
  • regulation of cytokine biosynthetic process Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 287
Short name:
Zfp-287
Alternative name(s):
Zinc finger protein SKAT-2
Gene namesi
Name:Znf287
Synonyms:Skat2, Zfp287
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2176561. Zfp287.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 759759Zinc finger protein 287PRO_0000047512Add
BLAST

Proteomic databases

PaxDbiQ9EQB9.
PRIDEiQ9EQB9.

PTM databases

iPTMnetiQ9EQB9.
PhosphoSiteiQ9EQB9.

Expressioni

Tissue specificityi

Expressed in brain and at low levels in kidney and spleen and few hematopoietic cell lines.

Gene expression databases

BgeeiENSMUSG00000005267.
CleanExiMM_ZFP287.
ExpressionAtlasiQ9EQB9. baseline and differential.
GenevisibleiQ9EQB9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000114531.

Structurei

3D structure databases

ProteinModelPortaliQ9EQB9.
SMRiQ9EQB9. Positions 39-120, 364-753.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 12483SCAN boxPROSITE-ProRule annotationAdd
BLAST
Domaini166 – 23469KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 14 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri366 – 38823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri394 – 41623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri422 – 44423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri450 – 47223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri478 – 50023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri506 – 52823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri534 – 55623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri562 – 58423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri590 – 61223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri618 – 64023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri646 – 66823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri674 – 69623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri702 – 72423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri730 – 75223C2H2-type 14PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00680000099963.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9EQB9.
KOiK09229.
OMAiGPSPEWE.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9EQB9.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EQB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANSSLSQVL LMWKPGKIQK GPCSAEQQTL TSRLLRDTET CRRNFRNFPY
60 70 80 90 100
PDVAGPRKAL CQLRELCLKW LRPEVHSKEQ ILELLVLEQF LSILPGEVRT
110 120 130 140 150
WVNSQYPESS EEVVALVEDL TQILEEEEAP QSSALPQDTP EDDPNHDPNP
160 170 180 190 200
ASQAGWLSDV VTKDLVTFND VAVDITQEDW ELMPPVQKEL YKTVTLQNYW
210 220 230 240 250
NMVSLGLTVY RPTVIPVLEE PWMVIKEIVE GPNPEWEPKA QAQCPAKHLP
260 270 280 290 300
ELKQDGTQTV KLEDSYDDDN DDSVESPPVC AFGMIHIDEE GFSVKSELSQ
310 320 330 340 350
EDPTEEYLSK CDIYRVTFEK HTNLGVQFDT QSDDKTALYN ESKPPFSNAS
360 370 380 390 400
SGGAVRGKIL PGDKPYSCNV CGKQFRKYPS LLAHRENHAK EKAYECEECG
410 420 430 440 450
KEFKHLSSLI AHQRMHTGEK PYECHQCGKA FSQRAHLTIH QRIHTGEKPY
460 470 480 490 500
KCEDCGKDFS QRAHLTIHQR THTGEKPYKC LECSKTFSHS SSLINHQRVH
510 520 530 540 550
TGEKPYICNE CGKTFSQSTH LLQHQKIHTG KKPYKCNECW KVFSQSTYLI
560 570 580 590 600
RHQRIHSGEK CYKCTACGKA FAHSSTLIQH QTTHTGEKSY ICNVCGKAFS
610 620 630 640 650
QSANLTQHHR THTGEKPYKC SVCGKAFSQS VHLTQHQRIH NGEKPFKCNT
660 670 680 690 700
CGKAYRQGAN LTQHQRVHTG EKPYKCHHCG KAFIYSSSLN QHRRTHTGER
710 720 730 740 750
PYKCSHCNKD FSQRTCLIQH QRIHTGEKPY GCRICGKAFT QSTNLIQHQR

VHTGARHRN
Length:759
Mass (Da):86,635
Last modified:July 27, 2011 - v2
Checksum:i36A0B0E1AB258368
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281Q → R in AAG37028 (PubMed:11093124).Curated
Sequence conflicti235 – 2351E → G in AAG37028 (PubMed:11093124).Curated
Sequence conflicti339 – 3391Y → H in AAG37028 (PubMed:11093124).Curated
Sequence conflicti672 – 6721K → R in AAG37028 (PubMed:11093124).Curated
Sequence conflicti736 – 7361G → E in AAG37028 (PubMed:11093124).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF281141 mRNA. Translation: AAG37028.1.
AK029572 mRNA. Translation: BAC26519.1.
BC117876 mRNA. Translation: AAI17877.1.
CCDSiCCDS24830.1.
RefSeqiNP_573471.2. NM_133208.2.
XP_006532443.1. XM_006532380.1.
UniGeneiMm.339982.
Mm.487192.

Genome annotation databases

EnsembliENSMUST00000149228; ENSMUSP00000114531; ENSMUSG00000005267.
ENSMUST00000185656; ENSMUSP00000141046; ENSMUSG00000005267.
GeneIDi170740.
KEGGimmu:170740.
UCSCiuc007jju.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF281141 mRNA. Translation: AAG37028.1.
AK029572 mRNA. Translation: BAC26519.1.
BC117876 mRNA. Translation: AAI17877.1.
CCDSiCCDS24830.1.
RefSeqiNP_573471.2. NM_133208.2.
XP_006532443.1. XM_006532380.1.
UniGeneiMm.339982.
Mm.487192.

3D structure databases

ProteinModelPortaliQ9EQB9.
SMRiQ9EQB9. Positions 39-120, 364-753.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000114531.

PTM databases

iPTMnetiQ9EQB9.
PhosphoSiteiQ9EQB9.

Proteomic databases

PaxDbiQ9EQB9.
PRIDEiQ9EQB9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000149228; ENSMUSP00000114531; ENSMUSG00000005267.
ENSMUST00000185656; ENSMUSP00000141046; ENSMUSG00000005267.
GeneIDi170740.
KEGGimmu:170740.
UCSCiuc007jju.1. mouse.

Organism-specific databases

CTDi170740.
MGIiMGI:2176561. Zfp287.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00680000099963.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9EQB9.
KOiK09229.
OMAiGPSPEWE.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9EQB9.

Miscellaneous databases

PROiQ9EQB9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005267.
CleanExiMM_ZFP287.
ExpressionAtlasiQ9EQB9. baseline and differential.
GenevisibleiQ9EQB9. MM.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN287_MOUSE
AccessioniPrimary (citable) accession number: Q9EQB9
Secondary accession number(s): Q8CDU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.