Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NIF3-like protein 1

Gene

Nif3l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.1 Publication

GO - Molecular functioni

GO - Biological processi

  • negative regulation of nucleic acid-templated transcription Source: UniProtKB
  • neuron differentiation Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
NIF3-like protein 11 Publication
Gene namesi
Name:Nif3l1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1929485. Nif3l1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • mitochondrion Source: MGI
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001473541 – 376NIF3-like protein 1Add BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei108N6-acetyllysineBy similarity1
Modified residuei254PhosphothreonineCombined sources1
Modified residuei258PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9EQ80.
MaxQBiQ9EQ80.
PaxDbiQ9EQ80.
PeptideAtlasiQ9EQ80.
PRIDEiQ9EQ80.

PTM databases

iPTMnetiQ9EQ80.
PhosphoSitePlusiQ9EQ80.

Expressioni

Tissue specificityi

Ubiquitous. Detected in all tissues tested with higher expression in cerebellum, heart and kidney and to a lower level in cerebrum, lung, liver, spleen and muscle.2 Publications

Developmental stagei

Expressed in the developping brain from E10.5 until E14.5. The expression decreases after E16.5, but an up-regulation is observed at P5 and the expression remains constant thereafter.1 Publication

Gene expression databases

BgeeiENSMUSG00000026036.
CleanExiMM_NIF3L1.
ExpressionAtlasiQ9EQ80. baseline and differential.
GenevisibleiQ9EQ80. MM.

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with COPS2 (PubMed:12522100). Interacts with THOC7 (PubMed:12951069).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9EQ80. 1 interactor.
MINTiMINT-4103434.
STRINGi10090.ENSMUSP00000084799.

Structurei

3D structure databases

ProteinModelPortaliQ9EQ80.
SMRiQ9EQ80.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni243 – 376Mediates interaction with COPS21 PublicationAdd BLAST134

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4131. Eukaryota.
COG0327. LUCA.
GeneTreeiENSGT00390000003590.
HOGENOMiHOG000014260.
HOVERGENiHBG029337.
InParanoidiQ9EQ80.
OMAiTNDLTEP.
OrthoDBiEOG091G0AAM.
TreeFamiTF324125.

Family and domain databases

InterProiIPR002678. GTP_cyclohydrolase_I/Nif3.
IPR017222. NIF3L1_animal.
[Graphical view]
PANTHERiPTHR13799. PTHR13799. 1 hit.
PfamiPF01784. NIF3. 1 hit.
[Graphical view]
PIRSFiPIRSF037490. UCP037490_NIF3_euk. 1 hit.
SUPFAMiSSF102705. SSF102705. 1 hit.
TIGRFAMsiTIGR00486. YbgI_SA1388. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9EQ80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSSAHLVPT SVQRAQSWIC RSSRSFMDLK ALLSSLNDFA SLSFAESWDN
60 70 80 90 100
VGLLVEPSPP HTVNTLFLTN DLTEEVMDEA LQKKADFILS YHPPIFRPMK
110 120 130 140 150
HITWKTWKEC LVIRALENRV AVYSPHTAYD AAPQGVNSWL AKGLGTCTTR
160 170 180 190 200
PIHPSRAPDY PTEGAHRLEF SVNRSQDLDK VMSTLRGVGG VSVTSFPARC
210 220 230 240 250
DGEEQTRISL NCTQKTLMQV LAFLSQDRQL YQKTEILSLE KPLLLHTGMG
260 270 280 290 300
RLCTLDESVS LAIMIERIKT HLKLSHLRLA LGVGRTLESQ VKVVALCAGS
310 320 330 340 350
GGSVLQGVEA DLYLTGEMSH HDVLDAASKG INVILCEHSN TERGFLSELQ
360 370
EMLGVHFENK INIILSETDR DPLRVV
Length:376
Mass (Da):41,746
Last modified:July 27, 2011 - v4
Checksum:i5B8693C5C621DC3D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7L → I in AAG45961 (PubMed:11124544).Curated1
Sequence conflicti190G → S in BAB27769 (PubMed:16141072).Curated1
Sequence conflicti204E → K in BAB27769 (PubMed:16141072).Curated1
Sequence conflicti217L → F in BAB27769 (PubMed:16141072).Curated1
Sequence conflicti221L → Q in BAB27769 (PubMed:16141072).Curated1
Sequence conflicti224L → F in BAB27769 (PubMed:16141072).Curated1
Sequence conflicti234T → I in BAB27769 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF284439 mRNA. Translation: AAG45961.1.
AK011670 mRNA. Translation: BAB27769.1.
AK154815 mRNA. Translation: BAE32848.1.
AK158616 mRNA. Translation: BAE34583.1.
CH466548 Genomic DNA. Translation: EDL00082.1.
BC065163 mRNA. Translation: AAH65163.1.
CCDSiCCDS14973.1.
RefSeqiNP_075364.2. NM_022988.3.
XP_006496249.1. XM_006496186.1.
UniGeneiMm.340248.

Genome annotation databases

EnsembliENSMUST00000087521; ENSMUSP00000084799; ENSMUSG00000026036.
ENSMUST00000171597; ENSMUSP00000127501; ENSMUSG00000026036.
GeneIDi65102.
KEGGimmu:65102.
UCSCiuc007bbz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF284439 mRNA. Translation: AAG45961.1.
AK011670 mRNA. Translation: BAB27769.1.
AK154815 mRNA. Translation: BAE32848.1.
AK158616 mRNA. Translation: BAE34583.1.
CH466548 Genomic DNA. Translation: EDL00082.1.
BC065163 mRNA. Translation: AAH65163.1.
CCDSiCCDS14973.1.
RefSeqiNP_075364.2. NM_022988.3.
XP_006496249.1. XM_006496186.1.
UniGeneiMm.340248.

3D structure databases

ProteinModelPortaliQ9EQ80.
SMRiQ9EQ80.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9EQ80. 1 interactor.
MINTiMINT-4103434.
STRINGi10090.ENSMUSP00000084799.

PTM databases

iPTMnetiQ9EQ80.
PhosphoSitePlusiQ9EQ80.

Proteomic databases

EPDiQ9EQ80.
MaxQBiQ9EQ80.
PaxDbiQ9EQ80.
PeptideAtlasiQ9EQ80.
PRIDEiQ9EQ80.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087521; ENSMUSP00000084799; ENSMUSG00000026036.
ENSMUST00000171597; ENSMUSP00000127501; ENSMUSG00000026036.
GeneIDi65102.
KEGGimmu:65102.
UCSCiuc007bbz.1. mouse.

Organism-specific databases

CTDi60491.
MGIiMGI:1929485. Nif3l1.

Phylogenomic databases

eggNOGiKOG4131. Eukaryota.
COG0327. LUCA.
GeneTreeiENSGT00390000003590.
HOGENOMiHOG000014260.
HOVERGENiHBG029337.
InParanoidiQ9EQ80.
OMAiTNDLTEP.
OrthoDBiEOG091G0AAM.
TreeFamiTF324125.

Miscellaneous databases

PROiQ9EQ80.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026036.
CleanExiMM_NIF3L1.
ExpressionAtlasiQ9EQ80. baseline and differential.
GenevisibleiQ9EQ80. MM.

Family and domain databases

InterProiIPR002678. GTP_cyclohydrolase_I/Nif3.
IPR017222. NIF3L1_animal.
[Graphical view]
PANTHERiPTHR13799. PTHR13799. 1 hit.
PfamiPF01784. NIF3. 1 hit.
[Graphical view]
PIRSFiPIRSF037490. UCP037490_NIF3_euk. 1 hit.
SUPFAMiSSF102705. SSF102705. 1 hit.
TIGRFAMsiTIGR00486. YbgI_SA1388. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNIF3L_MOUSE
AccessioniPrimary (citable) accession number: Q9EQ80
Secondary accession number(s): Q6P1B7, Q9D098
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 114 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.