Unreviewed, UniProtKB/TrEMBL Q9EQ78 (Q9EQ78_RAT)

Names and origin

Protein names

Submitted name:
    TEC kinase EMBL AAG00530.1

Gene names

Name:

Tec RGD 620973

Organism

Rattus norvegicus (Rat) EMBL AAG00530.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	553 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. Spearmint SPM000980
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. RuleBase RU000307V5 Contains 1 SH2 domain. Spearmint SPM020473 Contains 1 SH3 domain. RuleBase RU003338V3 Spearmint SPM020473 Contains 1 protein kinase domain. Spearmint SPM020473

Ontologies

Keywords
Domain	SH3 domain RuleBase RU003338V3
Ligand	ATP-binding RuleBase RU000304V2 Spearmint SPM020473 Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase Spearmint SPM000980 RuleBase RU000307V5
Gene Ontology (GO)
Biological process	intracellular signaling cascade Inferred from electronic annotation. Source: InterPro protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro tissue regeneration Ref.1 Inferred from expression pattern. Source: RGD
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from electronic annotation. Source: InterPro protein tyrosine kinase activity Ref.1 Traceable author statement. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAG00530.1

Sequences

	Sequence		Length	Mass (Da)
	Q9EQ78-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 24750BFCE3926A7C	FASTA	553	64,127
	10 20 30 40 50 60 GLLPSRCSDA NTLYIFAPSP QSRDRWVKKL KEEIKNNNNI MIKYHPKFWA DGSYQCCRQT 70 80 90 100 110 120 EKLAPGCEKY NLFESSIRKT LPPAPEIKRR PPPPIPPEEE NTEEIVVAMY DFQATEAHDL 130 140 150 160 170 180 RLERGQKYII LEKNDTHRWR ARDKYGSEGY IPSNYVTGKK SNNLDQYEWY CRNTNRSKAE 190 200 210 220 230 240 QLLRTEDKEG GFMVRDSSQP GLYTVSLYTK FGGEGSSGFR HYHIKETATS PKKYYLAKKH 250 260 270 280 290 300 AFGSIPEIIG YHKHNAAGLV TRLRYPVSTK GKNAPTTAGF SYDKWEINPQ ELTFMRELGS 310 320 330 340 350 360 GLFGVVRLGK RRAQYKVAIK AIREGAMCEE DFIEEAKVMM KLTHPELVQL YGVCTQQKPI 370 380 390 400 410 420 YIVTEFMERG CLLNFLRQRQ GHFSRDVLLS MCQDVCEGME YLERNSFIHR DLAARNCLVN 430 440 450 460 470 480 EAGVVKVSDF GMARYVLDDQ YTSSSGAKFP VKWCPPEVFN YSRFSSKSDV WSFGVLMWKI 490 500 510 520 530 540 FTEGRMPFEK NTNYEVVTMV TRGHRLPRPK LASKYLYEVM LRCWQERPEG RPSFEDLLRT 550 IDELVECEET FGR

References

[1]	"Identification and characterization of differentially expressed genes in the early response phase during liver regeneration." Xu W., Wang S., Wang G., Wei H., He F., Yang X. Biochem. Biophys. Res. Commun. 278:318-325(2000) [PubMed: 11097837] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Wistar EMBL AAG00530.1. Tissue: Liver EMBL AAG00530.1.
[2]	Wang S.Y., Xu W.Q., Yang X.M. Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Wistar EMBL AAG00530.1. Tissue: Liver EMBL AAG00530.1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF285881 mRNA. Translation: AAG00530.1.
IPI	IPI00189632.
UniGene	Rn.11797
3D structure databases
HSSP	HSSP built from PDB template 1GL5 based on UniProtKB P24604.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9EQ78.
Genome annotation databases
Ensembl	ENSRNOT00000003124; ENSRNOP00000003124; ENSRNOG00000002278; Rattus norvegicus. [Genome view] ENSRNOT00000003125; ENSRNOP00000003125; ENSRNOG00000002278; Rattus norvegicus. [Genome view] ENSRNOT00000049503; ENSRNOP00000046363; ENSRNOG00000002278; Rattus norvegicus. [Genome view] ENSRNOT00000066359; ENSRNOP00000059191; ENSRNOG00000002278; Rattus norvegicus. [Genome view]
Phylogenomic databases
HOVERGEN	Q9EQ78.
Gene expression databases
ArrayExpress	Q9EQ78.
Genevestigator	Q9EQ78.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR011993. PH_type. IPR001849. Pleckstrin_homology. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR000980. SH2. IPR001452. SH3_domain. IPR020473. SH3_region. IPR020755. Tyr_kinase_non-rcpt_Txk/Tec. IPR008266. Tyr_prot_kinase_AS. IPR001245. Tyr_prot_kinase_cat_dom. IPR020635. Tyr_prot_kinase_subgr_cat_dom. IPR001562. Znf_Btk_motif. [Graphical view]
Gene3D	G3DSA:2.30.29.30. PH_type. 1 hit. G3DSA:3.30.505.10. SH2. 1 hit.
PANTHER	PTHR23256:SF263. Tyr_kinase_non-rcpt_Txk/Tec. 1 hit.
Pfam	PF00779. BTK. 1 hit. PF07714. Pkinase_Tyr. 1 hit. PF00017. SH2. 1 hit. PF00018. SH3_1. 1 hit. [Graphical view]
PRINTS	PR00401. SH2DOMAIN. PR00452. SH3DOMAIN. PR00402. TECBTKDOMAIN.
ProDom	PD000001. Prot_kinase. 1 hit. PD000093. SH2. 1 hit. PD000066. SH3. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00107. BTK. 1 hit. SM00252. SH2. 1 hit. SM00326. SH3. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
PROSITE	PS50003. PH_DOMAIN. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS50001. SH2. 1 hit. PS50002. SH3. 1 hit. PS51113. ZF_BTK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9EQ78_RAT

Accession

Primary (citable) accession number: Q9EQ78

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2001
Last sequence update:	March 1, 2001
Last modified:	November 3, 2009
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)