UniProtKB - Q9EQ61 (PESC_MOUSE)
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Protein
Pescadillo homolog
Gene
Pes1
Organism
Mus musculus (Mouse)
Status
Functioni
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.UniRule annotation2 Publications
GO - Molecular functioni
- RNA binding Source: GO_Central
GO - Biological processi
- cell proliferation Source: UniProtKB
- maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: UniProtKB
- maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: MGI
- nucleolus organization Source: MGI
- protein localization to organelle Source: MGI
- regulation of cell cycle Source: MGI
- ribosome biogenesis Source: MGI
- rRNA processing Source: MGI
Keywordsi
Biological process | Ribosome biogenesis, rRNA processing |
Enzyme and pathway databases
Reactomei | R-MMU-6791226. Major pathway of rRNA processing in the nucleolus and cytosol. |
Names & Taxonomyi
Protein namesi | Recommended name: Pescadillo homologUniRule annotation |
Gene namesi | Name:Pes1 Synonyms:Pes |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1890613. Pes1. |
Pathology & Biotechi
Disruption phenotypei
Embryos die during preimplantation stages of development, with blastomeres failing to progress past morula stages. Within blastocysts the nucleoli fail to form correctly and the number of ribosomes appears dramatically reduced.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000186189 | 1 – 584 | Pescadillo homologAdd BLAST | 584 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 98 | N6-acetyllysineBy similarity | 1 | |
Cross-linki | 513 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity | ||
Cross-linki | 513 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity |
Post-translational modificationi
Sumoylated.UniRule annotation
Keywords - PTMi
Acetylation, Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q9EQ61. |
MaxQBi | Q9EQ61. |
PaxDbi | Q9EQ61. |
PRIDEi | Q9EQ61. |
PTM databases
iPTMneti | Q9EQ61. |
PhosphoSitePlusi | Q9EQ61. |
Expressioni
Tissue specificityi
Ubiquitous. Highest levels appear to be found in tissues that contain a population of proliferating cells, such as ovary and testis. Also appears to be highly expressed in kidney and liver. In the brain expression is restricted to neural progenitor cells and postmitotic neurons. Highly expressed in malignant astrocytes.2 Publications
Developmental stagei
In 2-cell and 4-cell stage interphase blastomeres expression is restricted to a sub-nuclear band that encircles one or more large vacuoles within the nucleus. These vacuoles may give rise to the mature nucleolus. Later in embryogenesis high levels are detected in developing liver. Is also widely and highly expressed throughout the developing brain and spinal cord at embryonic day 13.2 Publications
Inductioni
Induced in malignant astrocytes following the loss of p53. Induced in hepatocytes following partial hepatectomy.2 Publications
Gene expression databases
Bgeei | ENSMUSG00000020430. |
ExpressionAtlasi | Q9EQ61. baseline and differential. |
Genevisiblei | Q9EQ61. MM. |
Interactioni
Subunit structurei
Component of the PeBoW complex, composed of BOP1, PES1 and WDR12 (PubMed:15225545). The complex is held together by BOP1, which interacts with PES1 via its N-terminal domain and with WDR12 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The PeBoW complex associates with the 66S pre-ribosome (By similarity). The PeBoW complex also associates with DDX27, PES1 interacts directly with DDX27 (By similarity). Interacts with IRS1 and UBTF (PubMed:15169904). May interact with MAP1B (PubMed:17308336).UniRule annotation3 Publications
Protein-protein interaction databases
BioGridi | 211118. 2 interactors. |
CORUMi | Q9EQ61. |
IntActi | Q9EQ61. 1 interactor. |
MINTi | Q9EQ61. |
STRINGi | 10090.ENSMUSP00000020705. |
Structurei
3D structure databases
ProteinModelPortali | Q9EQ61. |
SMRi | Q9EQ61. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 321 – 414 | BRCTUniRule annotationAdd BLAST | 94 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 257 | Sufficient for nucleolar localizationBy similarityAdd BLAST | 257 | |
Regioni | 1 – 54 | Required for 28S ribosomal RNA processingBy similarityAdd BLAST | 54 | |
Regioni | 312 – 414 | Sufficient for interaction with MAP1B1 PublicationAdd BLAST | 103 | |
Regioni | 535 – 584 | Required for 28S ribosomal RNA processingBy similarityAdd BLAST | 50 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 454 – 527 | Glu-richAdd BLAST | 74 |
Sequence similaritiesi
Belongs to the pescadillo family.UniRule annotation
Phylogenomic databases
eggNOGi | KOG2481. Eukaryota. COG5163. LUCA. |
GeneTreei | ENSGT00390000002626. |
HOGENOMi | HOG000006022. |
HOVERGENi | HBG023409. |
InParanoidi | Q9EQ61. |
KOi | K14843. |
Family and domain databases
CDDi | cd00027. BRCT. 1 hit. |
Gene3Di | 3.40.50.10190. 1 hit. |
HAMAPi | MF_03028. Pescadillo. 1 hit. |
InterProi | View protein in InterPro IPR001357. BRCT_dom. IPR036420. BRCT_dom_sf. IPR010613. PES. |
PANTHERi | PTHR12221. PTHR12221. 1 hit. |
Pfami | View protein in Pfam PF16589. BRCT_2. 1 hit. PF06732. Pescadillo_N. 1 hit. |
SMARTi | View protein in SMART SM00292. BRCT. 1 hit. |
SUPFAMi | SSF52113. SSF52113. 1 hit. |
PROSITEi | View protein in PROSITE PS50172. BRCT. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q9EQ61-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGGLEKKKYE RGSATNYITR NKARKKLQLS LPDFRRLCIL KGIYPHEPKH
60 70 80 90 100
KKKVNKGSTA ARTFYLIKDI KFLLHEPIVN KFREYKVFVR KLRKAYGKSE
110 120 130 140 150
WNAVERLKDN KPCYKLDHIV KERYPTFIDA LRDLDDALSM CFLFSTFPRT
160 170 180 190 200
GKCHVQTIQL CRRLTVEFLH YVITARALRK VFLSIKGIYY QAEVLGQPIV
210 220 230 240 250
WIAPYAFSHD HPTDVDYRVM ATFTEFYTTL LGFVNFRLYQ SLNLHYPPKL
260 270 280 290 300
EGQAQAETKI SEDTYALDSE SSMEKLAALS ASLARVVVPA IEEAEADEFP
310 320 330 340 350
TDGEVTAQEE DRKKELEAQE KHKKLFEGLK FFLNREVPRE ALAFIIRSFG
360 370 380 390 400
GDVSWDKSLC IGATYDVTDS CITHQIVDRP GQQTPIIGRY YVQPQWVFDC
410 420 430 440 450
VNARLLLPVA EYFPGMQLPP HLSPFVSEKE GDYIPPEKLK LLALQRGEDP
460 470 480 490 500
GHLEEEEEED EDDDNEGDVA AENEEEDVEV ESEEEEEEEV HLSALEQHRL
510 520 530 540 550
EEKKPQVMAG TVKLEDKQRL AQEEESEAKR LAIMMMKKRE KYLYQKIMFG
560 570 580
KRRKIREANK LAEKRKAHDD AVRSEKKAKR TRPV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF289539 mRNA. Translation: AAG40734.1. AK029075 mRNA. Translation: BAC26278.1. AK088831 mRNA. Translation: BAC40599.1. BC004844 mRNA. Translation: AAH04844.1. BC011142 mRNA. Translation: AAH11142.1. |
CCDSi | CCDS24372.1. |
RefSeqi | NP_075027.1. NM_022889.3. |
UniGenei | Mm.28659. |
Genome annotation databases
Ensembli | ENSMUST00000020705; ENSMUSP00000020705; ENSMUSG00000020430. |
GeneIDi | 64934. |
KEGGi | mmu:64934. |
UCSCi | uc007hua.1. mouse. |
Similar proteinsi
Entry informationi
Entry namei | PESC_MOUSE | |
Accessioni | Q9EQ61Primary (citable) accession number: Q9EQ61 Secondary accession number(s): Q542F0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 20, 2002 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 28, 2018 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |