ID   V1R48_MOUSE             Reviewed;         302 AA.
AC   Q9EQ52;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   24-JAN-2024, entry version 129.
DE   RecName: Full=Vomeronasal type-1 receptor 48;
DE   AltName: Full=Vomeronasal type-1 receptor A3;
DE   AltName: Full=Vomeronasal type-1 receptor A6;
GN   Name=Vmn1r48; Synonyms=V1ra3, V1ra6 {ECO:0000312|EMBL:BAB79212.1};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1] {ECO:0000312|EMBL:AAG42076.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=129/SvJ {ECO:0000312|EMBL:AAG42076.1};
RX   PubMed=11116090; DOI=10.1101/gr.10.12.1958;
RA   Del Punta K., Rothman A., Rodriguez I., Mombaerts P.;
RT   "Sequence diversity and genomic organization of vomeronasal receptor genes
RT   in the mouse.";
RL   Genome Res. 10:1958-1967(2000).
RN   [2] {ECO:0000312|EMBL:BAB79212.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Sam M., Matsunami H., Buck L.;
RT   "Vomeronasal receptor gene diversity in the mammalian genome.";
RL   Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000305}
RP   PUTATIVE FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=12214233; DOI=10.1038/nature00955;
RA   Del Punta K., Leinders-Zufall T., Rodriguez I., Jukam D., Wysocki C.J.,
RA   Ogawa S., Zufall F., Mombaerts P.;
RT   "Deficient pheromone responses in mice lacking a cluster of vomeronasal
RT   receptor genes.";
RL   Nature 419:70-74(2002).
CC   -!- FUNCTION: Putative pheromone receptor implicated in the regulation of
CC       social and reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- DISRUPTION PHENOTYPE: Mice lacking all but one V1ra and V1rb gene (12%
CC       of the V1r repertoire) show a lack of chemosensory response to a subset
CC       of known pheromonal ligands and changes in maternal aggression as well
CC       as male reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF291482; AAG42076.1; -; Genomic_DNA.
DR   EMBL; AB062894; BAB79212.1; -; Genomic_DNA.
DR   CCDS; CCDS20350.1; -.
DR   RefSeq; NP_444448.1; NM_053218.1.
DR   AlphaFoldDB; Q9EQ52; -.
DR   SMR; Q9EQ52; -.
DR   GlyCosmos; Q9EQ52; 1 site, No reported glycans.
DR   GlyGen; Q9EQ52; 1 site.
DR   PaxDb; 10090-ENSMUSP00000073121; -.
DR   DNASU; 113845; -.
DR   Ensembl; ENSMUST00000073415.2; ENSMUSP00000073121.2; ENSMUSG00000057592.2.
DR   GeneID; 113845; -.
DR   KEGG; mmu:113845; -.
DR   UCSC; uc009cws.1; mouse.
DR   AGR; MGI:2148508; -.
DR   CTD; 113845; -.
DR   MGI; MGI:2148508; Vmn1r48.
DR   VEuPathDB; HostDB:ENSMUSG00000057592; -.
DR   eggNOG; ENOG502SNRJ; Eukaryota.
DR   GeneTree; ENSGT01030000234553; -.
DR   HOGENOM; CLU_058641_0_0_1; -.
DR   InParanoid; Q9EQ52; -.
DR   OMA; ATHISMM; -.
DR   OrthoDB; 4113734at2759; -.
DR   PhylomeDB; Q9EQ52; -.
DR   BioGRID-ORCS; 113845; 2 hits in 38 CRISPR screens.
DR   PRO; PR:Q9EQ52; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; Q9EQ52; Protein.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR   GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR   GO; GO:0007606; P:sensory perception of chemical stimulus; TAS:MGI.
DR   CDD; cd13949; 7tm_V1R_pheromone; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR004072; Vmron_rcpt_1.
DR   PANTHER; PTHR24062; VOMERONASAL TYPE-1 RECEPTOR; 1.
DR   PANTHER; PTHR24062:SF167; VOMERONASAL TYPE-1 RECEPTOR 42-RELATED; 1.
DR   Pfam; PF03402; V1R; 1.
DR   PRINTS; PR01534; VOMERONASL1R.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; Q9EQ52; MM.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Pheromone response; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..302
FT                   /note="Vomeronasal type-1 receptor 48"
FT                   /id="PRO_0000239958"
FT   TOPO_DOM        1..16
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        17..37
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        38..49
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..70
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        71..91
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..114
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        115..131
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..152
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        153..193
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..214
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        215..238
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..269
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        270..290
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        291..302
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        159
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        85..172
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   302 AA;  34263 MW;  EC0CB056AD9F9F0D CRC64;
     MNENSRLHTH SNIRNTFFSE IGIGISGNSF LLLFHIIKFF RGHRPRLTDL PIGLLSLIHL
     LMLLVAAVIA TDIFISWRGW NDIICKFLVY LYRSLRGLSL CTTSMLSVLQ AIILSPRSYC
     LAKFKRKSSH NISCAIIFLS VLYMSISSHL LISITATPNL TMNDFLYVSQ SCSLLPLSYL
     MQSIYSTLLV LREVFLIGLM VLSTSYMVAL LYMHRKQAQN LQGTSLSLKA SAEQRATQTI
     LMLMTFFVLM SIFDSIVSCS RTMFLDDPTS YSIHIFVMHI YATVSPFVFI STEKHIVNIL
     RG
//