ID   V1R48_MOUSE             Reviewed;         302 AA.
AC   Q9EQ52;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   16-NOV-2011, entry version 64.
DE   RecName: Full=Vomeronasal type-1 receptor 48;
DE   AltName: Full=Vomeronasal type-1 receptor A3;
DE   AltName: Full=Vomeronasal type-1 receptor A6;
GN   Name=Vmn1r48; Synonyms=V1ra3, V1ra6;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=129/SvJ;
RX   MEDLINE=20568485; PubMed=11116090; DOI=10.1101/gr.10.12.1958;
RA   Del Punta K., Rothman A., Rodriguez I., Mombaerts P.;
RT   "Sequence diversity and genomic organization of vomeronasal receptor
RT   genes in the mouse.";
RL   Genome Res. 10:1958-1967(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Sam M., Matsunami H., Buck L.;
RT   "Vomeronasal receptor gene diversity in the mammalian genome.";
RL   Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   PUTATIVE FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=12214233; DOI=10.1038/nature00955;
RA   Del Punta K., Leinders-Zufall T., Rodriguez I., Jukam D.,
RA   Wysocki C.J., Ogawa S., Zufall F., Mombaerts P.;
RT   "Deficient pheromone responses in mice lacking a cluster of
RT   vomeronasal receptor genes.";
RL   Nature 419:70-74(2002).
CC   -!- FUNCTION: Putative pheromone receptor implicated in the regulation
CC       of social and reproductive behavior.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC       (Potential).
CC   -!- DISRUPTION PHENOTYPE: Mice lacking all but one V1ra and V1rb gene
CC       (12% of the V1r repertoire) show a lack of chemosensory response
CC       to a subset of known pheromonal ligands and changes in maternal
CC       aggression as well as male reproductive behavior.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
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DR   EMBL; AF291482; AAG42076.1; -; Genomic_DNA.
DR   EMBL; AB062894; BAB79212.1; -; Genomic_DNA.
DR   IPI; IPI00110398; -.
DR   RefSeq; NP_444448.1; NM_053218.1.
DR   UniGene; Mm.425336; -.
DR   ProteinModelPortal; Q9EQ52; -.
DR   PRIDE; Q9EQ52; -.
DR   Ensembl; ENSMUST00000073415; ENSMUSP00000073121; ENSMUSG00000057592.
DR   GeneID; 113845; -.
DR   KEGG; mmu:113845; -.
DR   CTD; 113845; -.
DR   MGI; MGI:2148508; Vmn1r48.
DR   eggNOG; maNOG21825; -.
DR   GeneTree; ENSGT00530000062929; -.
DR   HOGENOM; HBG283597; -.
DR   HOVERGEN; HBG101191; -.
DR   InParanoid; Q9EQ52; -.
DR   OMA; IGILANS; -.
DR   OrthoDB; EOG4CNQS5; -.
DR   PhylomeDB; Q9EQ52; -.
DR   NextBio; 367959; -.
DR   CleanEx; MM_V1RA3; -.
DR   CleanEx; MM_V1RA6; -.
DR   Genevestigator; Q9EQ52; -.
DR   GermOnline; ENSMUSG00000057592; Mus musculus.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR   GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR   GO; GO:0007606; P:sensory perception of chemical stimulus; TAS:MGI.
DR   InterPro; IPR017452; GPCR_Rhodpsn_supfam.
DR   InterPro; IPR004072; Vmron_rcpt_1.
DR   KO; K04614; -.
DR   Pfam; PF03402; V1R; 1.
DR   PRINTS; PR01534; VOMERONASL1R.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Complete proteome; Disulfide bond;
KW   G-protein coupled receptor; Glycoprotein; Membrane;
KW   Pheromone response; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN         1    302       Vomeronasal type-1 receptor 48.
FT                                /FTId=PRO_0000239958.
FT   TOPO_DOM      1     16       Extracellular (Potential).
FT   TRANSMEM     17     37       Helical; Name=1; (Potential).
FT   TOPO_DOM     38     49       Cytoplasmic (Potential).
FT   TRANSMEM     50     70       Helical; Name=2; (Potential).
FT   TOPO_DOM     71     91       Extracellular (Potential).
FT   TRANSMEM     92    114       Helical; Name=3; (Potential).
FT   TOPO_DOM    115    131       Cytoplasmic (Potential).
FT   TRANSMEM    132    152       Helical; Name=4; (Potential).
FT   TOPO_DOM    153    193       Extracellular (Potential).
FT   TRANSMEM    194    214       Helical; Name=5; (Potential).
FT   TOPO_DOM    215    238       Cytoplasmic (Potential).
FT   TRANSMEM    239    259       Helical; Name=6; (Potential).
FT   TOPO_DOM    260    269       Extracellular (Potential).
FT   TRANSMEM    270    290       Helical; Name=7; (Potential).
FT   TOPO_DOM    291    302       Cytoplasmic (Potential).
FT   CARBOHYD    159    159       N-linked (GlcNAc...) (Potential).
FT   DISULFID     85    172       By similarity.
SQ   SEQUENCE   302 AA;  34263 MW;  EC0CB056AD9F9F0D CRC64;
     MNENSRLHTH SNIRNTFFSE IGIGISGNSF LLLFHIIKFF RGHRPRLTDL PIGLLSLIHL
     LMLLVAAVIA TDIFISWRGW NDIICKFLVY LYRSLRGLSL CTTSMLSVLQ AIILSPRSYC
     LAKFKRKSSH NISCAIIFLS VLYMSISSHL LISITATPNL TMNDFLYVSQ SCSLLPLSYL
     MQSIYSTLLV LREVFLIGLM VLSTSYMVAL LYMHRKQAQN LQGTSLSLKA SAEQRATQTI
     LMLMTFFVLM SIFDSIVSCS RTMFLDDPTS YSIHIFVMHI YATVSPFVFI STEKHIVNIL
     RG
//