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Q9EQ52

- V1R48_MOUSE

UniProt

Q9EQ52 - V1R48_MOUSE

Protein

Vomeronasal type-1 receptor 48

Gene

Vmn1r48

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Putative pheromone receptor implicated in the regulation of social and reproductive behavior.1 Publication

    GO - Molecular functioni

    1. pheromone receptor activity Source: InterPro
    2. receptor activity Source: MGI

    GO - Biological processi

    1. response to pheromone Source: UniProtKB-KW
    2. sensory perception of chemical stimulus Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Pheromone response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vomeronasal type-1 receptor 48
    Alternative name(s):
    Vomeronasal type-1 receptor A3
    Vomeronasal type-1 receptor A6
    Gene namesi
    Name:Vmn1r48
    Synonyms:V1ra3, V1ra6Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:2148508. Vmn1r48.

    Subcellular locationi

    Cell membrane Curated; Multi-pass membrane protein Sequence Analysis

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Mice lacking all but one V1ra and V1rb gene (12% of the V1r repertoire) show a lack of chemosensory response to a subset of known pheromonal ligands and changes in maternal aggression as well as male reproductive behavior.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 302302Vomeronasal type-1 receptor 48PRO_0000239958Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi85 ↔ 172PROSITE-ProRule annotation
    Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9EQ52.

    Expressioni

    Gene expression databases

    CleanExiMM_V1RA3.
    MM_V1RA6.
    GenevestigatoriQ9EQ52.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9EQ52.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1616ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini38 – 4912CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini71 – 9121ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini115 – 13117CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini153 – 19341ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini215 – 23824CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini260 – 26910ExtracellularSequence Analysis
    Topological domaini291 – 30212CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei50 – 7021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei92 – 11423Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei132 – 15221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei194 – 21421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei239 – 25921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei270 – 29021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG77521.
    GeneTreeiENSGT00530000062929.
    HOGENOMiHOG000231674.
    HOVERGENiHBG101191.
    InParanoidiQ9EQ52.
    KOiK04614.
    OMAiIGILANS.
    OrthoDBiEOG7F512Q.
    PhylomeDBiQ9EQ52.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR017452. GPCR_Rhodpsn_7TM.
    IPR004072. Vmron_rcpt_1.
    [Graphical view]
    PfamiPF03402. V1R. 1 hit.
    [Graphical view]
    PRINTSiPR01534. VOMERONASL1R.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9EQ52-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNENSRLHTH SNIRNTFFSE IGIGISGNSF LLLFHIIKFF RGHRPRLTDL    50
    PIGLLSLIHL LMLLVAAVIA TDIFISWRGW NDIICKFLVY LYRSLRGLSL 100
    CTTSMLSVLQ AIILSPRSYC LAKFKRKSSH NISCAIIFLS VLYMSISSHL 150
    LISITATPNL TMNDFLYVSQ SCSLLPLSYL MQSIYSTLLV LREVFLIGLM 200
    VLSTSYMVAL LYMHRKQAQN LQGTSLSLKA SAEQRATQTI LMLMTFFVLM 250
    SIFDSIVSCS RTMFLDDPTS YSIHIFVMHI YATVSPFVFI STEKHIVNIL 300
    RG 302
    Length:302
    Mass (Da):34,263
    Last modified:March 1, 2001 - v1
    Checksum:iEC0CB056AD9F9F0D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF291482 Genomic DNA. Translation: AAG42076.1.
    AB062894 Genomic DNA. Translation: BAB79212.1.
    CCDSiCCDS20350.1.
    RefSeqiNP_444448.1. NM_053218.1.
    UniGeneiMm.425336.

    Genome annotation databases

    EnsembliENSMUST00000073415; ENSMUSP00000073121; ENSMUSG00000057592.
    GeneIDi113845.
    KEGGimmu:113845.
    UCSCiuc009cws.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF291482 Genomic DNA. Translation: AAG42076.1 .
    AB062894 Genomic DNA. Translation: BAB79212.1 .
    CCDSi CCDS20350.1.
    RefSeqi NP_444448.1. NM_053218.1.
    UniGenei Mm.425336.

    3D structure databases

    ProteinModelPortali Q9EQ52.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi Q9EQ52.

    Protocols and materials databases

    DNASUi 113845.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000073415 ; ENSMUSP00000073121 ; ENSMUSG00000057592 .
    GeneIDi 113845.
    KEGGi mmu:113845.
    UCSCi uc009cws.1. mouse.

    Organism-specific databases

    CTDi 113845.
    MGIi MGI:2148508. Vmn1r48.

    Phylogenomic databases

    eggNOGi NOG77521.
    GeneTreei ENSGT00530000062929.
    HOGENOMi HOG000231674.
    HOVERGENi HBG101191.
    InParanoidi Q9EQ52.
    KOi K04614.
    OMAi IGILANS.
    OrthoDBi EOG7F512Q.
    PhylomeDBi Q9EQ52.

    Miscellaneous databases

    NextBioi 367959.
    PROi Q9EQ52.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_V1RA3.
    MM_V1RA6.
    Genevestigatori Q9EQ52.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR017452. GPCR_Rhodpsn_7TM.
    IPR004072. Vmron_rcpt_1.
    [Graphical view ]
    Pfami PF03402. V1R. 1 hit.
    [Graphical view ]
    PRINTSi PR01534. VOMERONASL1R.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence diversity and genomic organization of vomeronasal receptor genes in the mouse."
      Del Punta K., Rothman A., Rodriguez I., Mombaerts P.
      Genome Res. 10:1958-1967(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJImported.
    2. "Vomeronasal receptor gene diversity in the mammalian genome."
      Sam M., Matsunami H., Buck L.
      Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes."
      Del Punta K., Leinders-Zufall T., Rodriguez I., Jukam D., Wysocki C.J., Ogawa S., Zufall F., Mombaerts P.
      Nature 419:70-74(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: PUTATIVE FUNCTION, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiV1R48_MOUSE
    AccessioniPrimary (citable) accession number: Q9EQ52
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2006
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3