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Protein

Vomeronasal type-1 receptor 48

Gene

Vmn1r48

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Putative pheromone receptor implicated in the regulation of social and reproductive behavior.1 Publication

GO - Molecular functioni

  • pheromone receptor activity Source: InterPro
  • receptor activity Source: MGI

GO - Biological processi

  • response to pheromone Source: UniProtKB-KW
  • sensory perception of chemical stimulus Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Pheromone response

Names & Taxonomyi

Protein namesi
Recommended name:
Vomeronasal type-1 receptor 48
Alternative name(s):
Vomeronasal type-1 receptor A3
Vomeronasal type-1 receptor A6
Gene namesi
Name:Vmn1r48
Synonyms:V1ra3, V1ra6Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2148508. Vmn1r48.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616ExtracellularSequence AnalysisAdd
BLAST
Transmembranei17 – 3721Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini38 – 4912CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei50 – 7021Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini71 – 9121ExtracellularSequence AnalysisAdd
BLAST
Transmembranei92 – 11423Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini115 – 13117CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei132 – 15221Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini153 – 19341ExtracellularSequence AnalysisAdd
BLAST
Transmembranei194 – 21421Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini215 – 23824CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei239 – 25921Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini260 – 26910ExtracellularSequence Analysis
Transmembranei270 – 29021Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini291 – 30212CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice lacking all but one V1ra and V1rb gene (12% of the V1r repertoire) show a lack of chemosensory response to a subset of known pheromonal ligands and changes in maternal aggression as well as male reproductive behavior.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302Vomeronasal type-1 receptor 48PRO_0000239958Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi85 ↔ 172PROSITE-ProRule annotation
Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9EQ52.

Expressioni

Gene expression databases

CleanExiMM_V1RA3.
MM_V1RA6.
GenevisibleiQ9EQ52. MM.

Structurei

3D structure databases

ProteinModelPortaliQ9EQ52.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG77521.
GeneTreeiENSGT00530000062929.
HOGENOMiHOG000231674.
HOVERGENiHBG101191.
InParanoidiQ9EQ52.
KOiK04614.
OMAiIGILANS.
OrthoDBiEOG7F512Q.
PhylomeDBiQ9EQ52.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
[Graphical view]
PfamiPF03402. V1R. 1 hit.
[Graphical view]
PRINTSiPR01534. VOMERONASL1R.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EQ52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNENSRLHTH SNIRNTFFSE IGIGISGNSF LLLFHIIKFF RGHRPRLTDL
60 70 80 90 100
PIGLLSLIHL LMLLVAAVIA TDIFISWRGW NDIICKFLVY LYRSLRGLSL
110 120 130 140 150
CTTSMLSVLQ AIILSPRSYC LAKFKRKSSH NISCAIIFLS VLYMSISSHL
160 170 180 190 200
LISITATPNL TMNDFLYVSQ SCSLLPLSYL MQSIYSTLLV LREVFLIGLM
210 220 230 240 250
VLSTSYMVAL LYMHRKQAQN LQGTSLSLKA SAEQRATQTI LMLMTFFVLM
260 270 280 290 300
SIFDSIVSCS RTMFLDDPTS YSIHIFVMHI YATVSPFVFI STEKHIVNIL

RG
Length:302
Mass (Da):34,263
Last modified:March 1, 2001 - v1
Checksum:iEC0CB056AD9F9F0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF291482 Genomic DNA. Translation: AAG42076.1.
AB062894 Genomic DNA. Translation: BAB79212.1.
CCDSiCCDS20350.1.
RefSeqiNP_444448.1. NM_053218.1.
UniGeneiMm.425336.

Genome annotation databases

EnsembliENSMUST00000073415; ENSMUSP00000073121; ENSMUSG00000057592.
GeneIDi113845.
KEGGimmu:113845.
UCSCiuc009cws.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF291482 Genomic DNA. Translation: AAG42076.1.
AB062894 Genomic DNA. Translation: BAB79212.1.
CCDSiCCDS20350.1.
RefSeqiNP_444448.1. NM_053218.1.
UniGeneiMm.425336.

3D structure databases

ProteinModelPortaliQ9EQ52.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiQ9EQ52.

Protocols and materials databases

DNASUi113845.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073415; ENSMUSP00000073121; ENSMUSG00000057592.
GeneIDi113845.
KEGGimmu:113845.
UCSCiuc009cws.1. mouse.

Organism-specific databases

CTDi113845.
MGIiMGI:2148508. Vmn1r48.

Phylogenomic databases

eggNOGiNOG77521.
GeneTreeiENSGT00530000062929.
HOGENOMiHOG000231674.
HOVERGENiHBG101191.
InParanoidiQ9EQ52.
KOiK04614.
OMAiIGILANS.
OrthoDBiEOG7F512Q.
PhylomeDBiQ9EQ52.

Miscellaneous databases

NextBioi367959.
PROiQ9EQ52.
SOURCEiSearch...

Gene expression databases

CleanExiMM_V1RA3.
MM_V1RA6.
GenevisibleiQ9EQ52. MM.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
[Graphical view]
PfamiPF03402. V1R. 1 hit.
[Graphical view]
PRINTSiPR01534. VOMERONASL1R.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence diversity and genomic organization of vomeronasal receptor genes in the mouse."
    Del Punta K., Rothman A., Rodriguez I., Mombaerts P.
    Genome Res. 10:1958-1967(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJImported.
  2. "Vomeronasal receptor gene diversity in the mammalian genome."
    Sam M., Matsunami H., Buck L.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes."
    Del Punta K., Leinders-Zufall T., Rodriguez I., Jukam D., Wysocki C.J., Ogawa S., Zufall F., Mombaerts P.
    Nature 419:70-74(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PUTATIVE FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiV1R48_MOUSE
AccessioniPrimary (citable) accession number: Q9EQ52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 1, 2001
Last modified: June 24, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.