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Protein

Vomeronasal type-1 receptor 48

Gene

Vmn1r48

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Putative pheromone receptor implicated in the regulation of social and reproductive behavior.1 Publication

GO - Molecular functioni

  • pheromone receptor activity Source: InterPro
  • receptor activity Source: MGI

GO - Biological processi

  • response to pheromone Source: UniProtKB-KW
  • sensory perception of chemical stimulus Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Pheromone response

Names & Taxonomyi

Protein namesi
Recommended name:
Vomeronasal type-1 receptor 48
Alternative name(s):
Vomeronasal type-1 receptor A3
Vomeronasal type-1 receptor A6
Gene namesi
Name:Vmn1r48
Synonyms:V1ra3, V1ra6Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2148508. Vmn1r48.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16ExtracellularSequence analysisAdd BLAST16
Transmembranei17 – 37Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini38 – 49CytoplasmicSequence analysisAdd BLAST12
Transmembranei50 – 70Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini71 – 91ExtracellularSequence analysisAdd BLAST21
Transmembranei92 – 114Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini115 – 131CytoplasmicSequence analysisAdd BLAST17
Transmembranei132 – 152Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini153 – 193ExtracellularSequence analysisAdd BLAST41
Transmembranei194 – 214Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini215 – 238CytoplasmicSequence analysisAdd BLAST24
Transmembranei239 – 259Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini260 – 269ExtracellularSequence analysis10
Transmembranei270 – 290Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini291 – 302CytoplasmicSequence analysisAdd BLAST12

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice lacking all but one V1ra and V1rb gene (12% of the V1r repertoire) show a lack of chemosensory response to a subset of known pheromonal ligands and changes in maternal aggression as well as male reproductive behavior.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002399581 – 302Vomeronasal type-1 receptor 48Add BLAST302

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi85 ↔ 172PROSITE-ProRule annotation
Glycosylationi159N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9EQ52.
PRIDEiQ9EQ52.

Expressioni

Gene expression databases

CleanExiMM_V1RA3.
MM_V1RA6.
GenevisibleiQ9EQ52. MM.

Structurei

3D structure databases

ProteinModelPortaliQ9EQ52.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J99C. Eukaryota.
ENOG4111941. LUCA.
GeneTreeiENSGT00530000062929.
HOGENOMiHOG000231674.
HOVERGENiHBG101191.
InParanoidiQ9EQ52.
KOiK04614.
OMAiDECLNIP.
OrthoDBiEOG091G0B1U.
PhylomeDBiQ9EQ52.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
[Graphical view]
PfamiPF03402. V1R. 1 hit.
[Graphical view]
PRINTSiPR01534. VOMERONASL1R.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EQ52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNENSRLHTH SNIRNTFFSE IGIGISGNSF LLLFHIIKFF RGHRPRLTDL
60 70 80 90 100
PIGLLSLIHL LMLLVAAVIA TDIFISWRGW NDIICKFLVY LYRSLRGLSL
110 120 130 140 150
CTTSMLSVLQ AIILSPRSYC LAKFKRKSSH NISCAIIFLS VLYMSISSHL
160 170 180 190 200
LISITATPNL TMNDFLYVSQ SCSLLPLSYL MQSIYSTLLV LREVFLIGLM
210 220 230 240 250
VLSTSYMVAL LYMHRKQAQN LQGTSLSLKA SAEQRATQTI LMLMTFFVLM
260 270 280 290 300
SIFDSIVSCS RTMFLDDPTS YSIHIFVMHI YATVSPFVFI STEKHIVNIL

RG
Length:302
Mass (Da):34,263
Last modified:March 1, 2001 - v1
Checksum:iEC0CB056AD9F9F0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF291482 Genomic DNA. Translation: AAG42076.1.
AB062894 Genomic DNA. Translation: BAB79212.1.
CCDSiCCDS20350.1.
RefSeqiNP_444448.1. NM_053218.1.
UniGeneiMm.425336.

Genome annotation databases

EnsembliENSMUST00000073415; ENSMUSP00000073121; ENSMUSG00000057592.
GeneIDi113845.
KEGGimmu:113845.
UCSCiuc009cws.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF291482 Genomic DNA. Translation: AAG42076.1.
AB062894 Genomic DNA. Translation: BAB79212.1.
CCDSiCCDS20350.1.
RefSeqiNP_444448.1. NM_053218.1.
UniGeneiMm.425336.

3D structure databases

ProteinModelPortaliQ9EQ52.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ9EQ52.
PRIDEiQ9EQ52.

Protocols and materials databases

DNASUi113845.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073415; ENSMUSP00000073121; ENSMUSG00000057592.
GeneIDi113845.
KEGGimmu:113845.
UCSCiuc009cws.1. mouse.

Organism-specific databases

CTDi113845.
MGIiMGI:2148508. Vmn1r48.

Phylogenomic databases

eggNOGiENOG410J99C. Eukaryota.
ENOG4111941. LUCA.
GeneTreeiENSGT00530000062929.
HOGENOMiHOG000231674.
HOVERGENiHBG101191.
InParanoidiQ9EQ52.
KOiK04614.
OMAiDECLNIP.
OrthoDBiEOG091G0B1U.
PhylomeDBiQ9EQ52.

Miscellaneous databases

PROiQ9EQ52.
SOURCEiSearch...

Gene expression databases

CleanExiMM_V1RA3.
MM_V1RA6.
GenevisibleiQ9EQ52. MM.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
[Graphical view]
PfamiPF03402. V1R. 1 hit.
[Graphical view]
PRINTSiPR01534. VOMERONASL1R.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiV1R48_MOUSE
AccessioniPrimary (citable) accession number: Q9EQ52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.