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Protein

Vomeronasal type-1 receptor 48

Gene

Vmn1r48

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Putative pheromone receptor implicated in the regulation of social and reproductive behavior.1 Publication

GO - Molecular functioni

  • pheromone receptor activity Source: InterPro
  • receptor activity Source: MGI

GO - Biological processi

  • response to pheromone Source: UniProtKB-KW
  • sensory perception of chemical stimulus Source: MGI

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processPheromone response

Names & Taxonomyi

Protein namesi
Recommended name:
Vomeronasal type-1 receptor 48
Alternative name(s):
Vomeronasal type-1 receptor A3
Vomeronasal type-1 receptor A6
Gene namesi
Name:Vmn1r48
Synonyms:V1ra3, V1ra6Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2148508. Vmn1r48.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16ExtracellularSequence analysisAdd BLAST16
Transmembranei17 – 37Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini38 – 49CytoplasmicSequence analysisAdd BLAST12
Transmembranei50 – 70Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini71 – 91ExtracellularSequence analysisAdd BLAST21
Transmembranei92 – 114Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini115 – 131CytoplasmicSequence analysisAdd BLAST17
Transmembranei132 – 152Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini153 – 193ExtracellularSequence analysisAdd BLAST41
Transmembranei194 – 214Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini215 – 238CytoplasmicSequence analysisAdd BLAST24
Transmembranei239 – 259Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini260 – 269ExtracellularSequence analysis10
Transmembranei270 – 290Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini291 – 302CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice lacking all but one V1ra and V1rb gene (12% of the V1r repertoire) show a lack of chemosensory response to a subset of known pheromonal ligands and changes in maternal aggression as well as male reproductive behavior.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002399581 – 302Vomeronasal type-1 receptor 48Add BLAST302

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi85 ↔ 172PROSITE-ProRule annotation
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9EQ52.
PRIDEiQ9EQ52.

Expressioni

Gene expression databases

BgeeiENSMUSG00000057592.
CleanExiMM_V1RA3.
MM_V1RA6.
GenevisibleiQ9EQ52. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073121.

Structurei

3D structure databases

ProteinModelPortaliQ9EQ52.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J99C. Eukaryota.
ENOG4111941. LUCA.
GeneTreeiENSGT00900000141053.
HOGENOMiHOG000231674.
HOVERGENiHBG101191.
InParanoidiQ9EQ52.
KOiK04614.
OMAiCIFSASK.
OrthoDBiEOG091G0B1U.
PhylomeDBiQ9EQ52.

Family and domain databases

CDDicd13949. 7tm_V1R_pheromone. 1 hit.
InterProiView protein in InterPro
IPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
PANTHERiPTHR24062. PTHR24062. 1 hit.
PfamiView protein in Pfam
PF03402. V1R. 1 hit.
PRINTSiPR01534. VOMERONASL1R.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9EQ52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNENSRLHTH SNIRNTFFSE IGIGISGNSF LLLFHIIKFF RGHRPRLTDL
60 70 80 90 100
PIGLLSLIHL LMLLVAAVIA TDIFISWRGW NDIICKFLVY LYRSLRGLSL
110 120 130 140 150
CTTSMLSVLQ AIILSPRSYC LAKFKRKSSH NISCAIIFLS VLYMSISSHL
160 170 180 190 200
LISITATPNL TMNDFLYVSQ SCSLLPLSYL MQSIYSTLLV LREVFLIGLM
210 220 230 240 250
VLSTSYMVAL LYMHRKQAQN LQGTSLSLKA SAEQRATQTI LMLMTFFVLM
260 270 280 290 300
SIFDSIVSCS RTMFLDDPTS YSIHIFVMHI YATVSPFVFI STEKHIVNIL

RG
Length:302
Mass (Da):34,263
Last modified:March 1, 2001 - v1
Checksum:iEC0CB056AD9F9F0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF291482 Genomic DNA. Translation: AAG42076.1.
AB062894 Genomic DNA. Translation: BAB79212.1.
CCDSiCCDS20350.1.
RefSeqiNP_444448.1. NM_053218.1.
UniGeneiMm.425336.

Genome annotation databases

EnsembliENSMUST00000073415; ENSMUSP00000073121; ENSMUSG00000057592.
GeneIDi113845.
KEGGimmu:113845.
UCSCiuc009cws.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiV1R48_MOUSE
AccessioniPrimary (citable) accession number: Q9EQ52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 1, 2001
Last modified: November 22, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families