Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9EQ52

- V1R48_MOUSE

UniProt

Q9EQ52 - V1R48_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Vomeronasal type-1 receptor 48

Gene

Vmn1r48

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Putative pheromone receptor implicated in the regulation of social and reproductive behavior.1 Publication

GO - Molecular functioni

  1. pheromone receptor activity Source: InterPro
  2. receptor activity Source: MGI

GO - Biological processi

  1. response to pheromone Source: UniProtKB-KW
  2. sensory perception of chemical stimulus Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Pheromone response

Names & Taxonomyi

Protein namesi
Recommended name:
Vomeronasal type-1 receptor 48
Alternative name(s):
Vomeronasal type-1 receptor A3
Vomeronasal type-1 receptor A6
Gene namesi
Name:Vmn1r48
Synonyms:V1ra3, V1ra6Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:2148508. Vmn1r48.

Subcellular locationi

Cell membrane Curated; Multi-pass membrane protein Sequence Analysis

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice lacking all but one V1ra and V1rb gene (12% of the V1r repertoire) show a lack of chemosensory response to a subset of known pheromonal ligands and changes in maternal aggression as well as male reproductive behavior.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302Vomeronasal type-1 receptor 48PRO_0000239958Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi85 ↔ 172PROSITE-ProRule annotation
Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9EQ52.

Expressioni

Gene expression databases

CleanExiMM_V1RA3.
MM_V1RA6.
GenevestigatoriQ9EQ52.

Structurei

3D structure databases

ProteinModelPortaliQ9EQ52.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616ExtracellularSequence AnalysisAdd
BLAST
Topological domaini38 – 4912CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini71 – 9121ExtracellularSequence AnalysisAdd
BLAST
Topological domaini115 – 13117CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini153 – 19341ExtracellularSequence AnalysisAdd
BLAST
Topological domaini215 – 23824CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini260 – 26910ExtracellularSequence Analysis
Topological domaini291 – 30212CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei50 – 7021Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei92 – 11423Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei132 – 15221Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei194 – 21421Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei239 – 25921Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei270 – 29021Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG77521.
GeneTreeiENSGT00530000062929.
HOGENOMiHOG000231674.
HOVERGENiHBG101191.
InParanoidiQ9EQ52.
KOiK04614.
OMAiIGILANS.
OrthoDBiEOG7F512Q.
PhylomeDBiQ9EQ52.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
[Graphical view]
PfamiPF03402. V1R. 1 hit.
[Graphical view]
PRINTSiPR01534. VOMERONASL1R.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EQ52-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNENSRLHTH SNIRNTFFSE IGIGISGNSF LLLFHIIKFF RGHRPRLTDL
60 70 80 90 100
PIGLLSLIHL LMLLVAAVIA TDIFISWRGW NDIICKFLVY LYRSLRGLSL
110 120 130 140 150
CTTSMLSVLQ AIILSPRSYC LAKFKRKSSH NISCAIIFLS VLYMSISSHL
160 170 180 190 200
LISITATPNL TMNDFLYVSQ SCSLLPLSYL MQSIYSTLLV LREVFLIGLM
210 220 230 240 250
VLSTSYMVAL LYMHRKQAQN LQGTSLSLKA SAEQRATQTI LMLMTFFVLM
260 270 280 290 300
SIFDSIVSCS RTMFLDDPTS YSIHIFVMHI YATVSPFVFI STEKHIVNIL

RG
Length:302
Mass (Da):34,263
Last modified:March 1, 2001 - v1
Checksum:iEC0CB056AD9F9F0D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF291482 Genomic DNA. Translation: AAG42076.1.
AB062894 Genomic DNA. Translation: BAB79212.1.
CCDSiCCDS20350.1.
RefSeqiNP_444448.1. NM_053218.1.
UniGeneiMm.425336.

Genome annotation databases

EnsembliENSMUST00000073415; ENSMUSP00000073121; ENSMUSG00000057592.
GeneIDi113845.
KEGGimmu:113845.
UCSCiuc009cws.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF291482 Genomic DNA. Translation: AAG42076.1 .
AB062894 Genomic DNA. Translation: BAB79212.1 .
CCDSi CCDS20350.1.
RefSeqi NP_444448.1. NM_053218.1.
UniGenei Mm.425336.

3D structure databases

ProteinModelPortali Q9EQ52.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi Q9EQ52.

Protocols and materials databases

DNASUi 113845.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000073415 ; ENSMUSP00000073121 ; ENSMUSG00000057592 .
GeneIDi 113845.
KEGGi mmu:113845.
UCSCi uc009cws.1. mouse.

Organism-specific databases

CTDi 113845.
MGIi MGI:2148508. Vmn1r48.

Phylogenomic databases

eggNOGi NOG77521.
GeneTreei ENSGT00530000062929.
HOGENOMi HOG000231674.
HOVERGENi HBG101191.
InParanoidi Q9EQ52.
KOi K04614.
OMAi IGILANS.
OrthoDBi EOG7F512Q.
PhylomeDBi Q9EQ52.

Miscellaneous databases

NextBioi 367959.
PROi Q9EQ52.
SOURCEi Search...

Gene expression databases

CleanExi MM_V1RA3.
MM_V1RA6.
Genevestigatori Q9EQ52.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
[Graphical view ]
Pfami PF03402. V1R. 1 hit.
[Graphical view ]
PRINTSi PR01534. VOMERONASL1R.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence diversity and genomic organization of vomeronasal receptor genes in the mouse."
    Del Punta K., Rothman A., Rodriguez I., Mombaerts P.
    Genome Res. 10:1958-1967(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJImported.
  2. "Vomeronasal receptor gene diversity in the mammalian genome."
    Sam M., Matsunami H., Buck L.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes."
    Del Punta K., Leinders-Zufall T., Rodriguez I., Jukam D., Wysocki C.J., Ogawa S., Zufall F., Mombaerts P.
    Nature 419:70-74(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PUTATIVE FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiV1R48_MOUSE
AccessioniPrimary (citable) accession number: Q9EQ52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3