Reviewed, UniProtKB/Swiss-Prot Q9EQ52 (VN1A3_MOUSE)

Names and origin

Protein names

Recommended name:
Vomeronasal type-1 receptor A3

Alternative name(s):
Vomeronasal type-1 receptor A6

Gene names

Name:	V1ra3
Synonyms:	V1ra6

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	302 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Putative pheromone receptor implicated in the regulation of social and reproductive behavior. Ref.3
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Disruption phenotype	Mice lacking all but one V1ra and V1rb gene (12% of the V1r repertoire) show a lack of chemosensory response to a subset of known pheromonal ligands and changes in maternal aggression as well as male reproductive behavior. Ref.3
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Pheromone response
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW response to pheromone Inferred from electronic annotation. Source: UniProtKB-KW sensory perception of chemical stimulus Ref.1 Traceable author statement. Source: MGI
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	pheromone receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 302	302	Vomeronasal type-1 receptor A3		PRO_0000239958
Regions
	Topological domain	1 – 16	16	Extracellular Potential
	Transmembrane	17 – 37	21	1 Potential
	Topological domain	38 – 49	12	Cytoplasmic Potential
	Transmembrane	50 – 70	21	2 Potential
	Topological domain	71 – 91	21	Extracellular Potential
	Transmembrane	92 – 114	23	3 Potential
	Topological domain	115 – 131	17	Cytoplasmic Potential
	Transmembrane	132 – 152	21	4 Potential
	Topological domain	153 – 193	41	Extracellular Potential
	Transmembrane	194 – 214	21	5 Potential
	Topological domain	215 – 238	24	Cytoplasmic Potential
	Transmembrane	239 – 259	21	6 Potential
	Topological domain	260 – 269	10	Extracellular Potential
	Transmembrane	270 – 290	21	7 Potential
	Topological domain	291 – 302	12	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	159	1	N-linked (GlcNAc...) Potential
	Disulfide bond	85 ↔ 172		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9EQ52-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: EC0CB056AD9F9F0D	FASTA	302	34,263
	10 20 30 40 50 60 MNENSRLHTH SNIRNTFFSE IGIGISGNSF LLLFHIIKFF RGHRPRLTDL PIGLLSLIHL 70 80 90 100 110 120 LMLLVAAVIA TDIFISWRGW NDIICKFLVY LYRSLRGLSL CTTSMLSVLQ AIILSPRSYC 130 140 150 160 170 180 LAKFKRKSSH NISCAIIFLS VLYMSISSHL LISITATPNL TMNDFLYVSQ SCSLLPLSYL 190 200 210 220 230 240 MQSIYSTLLV LREVFLIGLM VLSTSYMVAL LYMHRKQAQN LQGTSLSLKA SAEQRATQTI 250 260 270 280 290 300 LMLMTFFVLM SIFDSIVSCS RTMFLDDPTS YSIHIFVMHI YATVSPFVFI STEKHIVNIL RG

References

[1]	"Sequence diversity and genomic organization of vomeronasal receptor genes in the mouse." Del Punta K., Rothman A., Rodriguez I., Mombaerts P. Genome Res. 10:1958-1967(2000) [PubMed: 11116090] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/SvJ.
[2]	"Vomeronasal receptor gene diversity in the mammalian genome." Sam M., Matsunami H., Buck L. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes." Del Punta K., Leinders-Zufall T., Rodriguez I., Jukam D., Wysocki C.J., Ogawa S., Zufall F., Mombaerts P. Nature 419:70-74(2002) [PubMed: 12214233] [Abstract] Cited for: PUTATIVE FUNCTION, DISRUPTION PHENOTYPE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF291482 Genomic DNA. Translation: AAG42076.1. AB062894 Genomic DNA. Translation: BAB79212.1.
IPI	IPI00110398.
RefSeq	NP_444448.1.
UniGene	Mm.425336
3D structure databases
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	Q9EQ52.
Genome annotation databases
Ensembl	ENSMUST00000073415; ENSMUSP00000073121; ENSMUSG00000057592; Mus musculus. [Genome view]
GeneID	113845.
KEGG	mmu:113845.
UCSC	uc009cws.1. mouse.
Organism-specific databases
CTD	113845.
MGI	MGI:2148508. V1ra3.
Phylogenomic databases
eggNOG	maNOG21825.
HOGENOM	HBG283597.
HOVERGEN	HBG101191.
InParanoid	Q9EQ52.
OMA	ISINLHI.
OrthoDB	EOG9Q5C85.
PhylomeDB	Q9EQ52.
Gene expression databases
CleanEx	MM_V1RA3. MM_V1RA6.
Genevestigator	Q9EQ52.
GermOnline	ENSMUSG00000057592. Mus musculus.
Family and domain databases
InterPro	IPR017452. GPCR_Rhodpsn_supfam. IPR004072. Vmron_rcpt_1. [Graphical view]
PANTHER	PTHR11391. Vmron_rcpt_1. 1 hit.
Pfam	PF03402. V1R. 1 hit. [Graphical view]
PRINTS	PR01534. VOMERONASL1R.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	367959.
SOURCE	Search...

Entry information

Entry name

VN1A3_MOUSE

Accession

Primary (citable) accession number: Q9EQ52

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
Last sequence update:	March 1, 2001
Last modified:	March 2, 2010
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)