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Q9EQ52 (V1R48_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vomeronasal type-1 receptor 48
Alternative name(s):
Vomeronasal type-1 receptor A3
Vomeronasal type-1 receptor A6
Gene names
Name:Vmn1r48
Synonyms:V1ra3, V1ra6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length302 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Putative pheromone receptor implicated in the regulation of social and reproductive behavior. Ref.3

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Disruption phenotype

Mice lacking all but one V1ra and V1rb gene (12% of the V1r repertoire) show a lack of chemosensory response to a subset of known pheromonal ligands and changes in maternal aggression as well as male reproductive behavior. Ref.3

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 302302Vomeronasal type-1 receptor 48
PRO_0000239958

Regions

Topological domain1 – 1616Extracellular Potential
Transmembrane17 – 3721Helical; Name=1; Potential
Topological domain38 – 4912Cytoplasmic Potential
Transmembrane50 – 7021Helical; Name=2; Potential
Topological domain71 – 9121Extracellular Potential
Transmembrane92 – 11423Helical; Name=3; Potential
Topological domain115 – 13117Cytoplasmic Potential
Transmembrane132 – 15221Helical; Name=4; Potential
Topological domain153 – 19341Extracellular Potential
Transmembrane194 – 21421Helical; Name=5; Potential
Topological domain215 – 23824Cytoplasmic Potential
Transmembrane239 – 25921Helical; Name=6; Potential
Topological domain260 – 26910Extracellular Potential
Transmembrane270 – 29021Helical; Name=7; Potential
Topological domain291 – 30212Cytoplasmic Potential

Amino acid modifications

Glycosylation1591N-linked (GlcNAc...) Potential
Disulfide bond85 ↔ 172 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9EQ52 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: EC0CB056AD9F9F0D

FASTA30234,263
        10         20         30         40         50         60 
MNENSRLHTH SNIRNTFFSE IGIGISGNSF LLLFHIIKFF RGHRPRLTDL PIGLLSLIHL 

        70         80         90        100        110        120 
LMLLVAAVIA TDIFISWRGW NDIICKFLVY LYRSLRGLSL CTTSMLSVLQ AIILSPRSYC 

       130        140        150        160        170        180 
LAKFKRKSSH NISCAIIFLS VLYMSISSHL LISITATPNL TMNDFLYVSQ SCSLLPLSYL 

       190        200        210        220        230        240 
MQSIYSTLLV LREVFLIGLM VLSTSYMVAL LYMHRKQAQN LQGTSLSLKA SAEQRATQTI 

       250        260        270        280        290        300 
LMLMTFFVLM SIFDSIVSCS RTMFLDDPTS YSIHIFVMHI YATVSPFVFI STEKHIVNIL 


RG 

« Hide

References

[1]"Sequence diversity and genomic organization of vomeronasal receptor genes in the mouse."
Del Punta K., Rothman A., Rodriguez I., Mombaerts P.
Genome Res. 10:1958-1967(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
[2]"Vomeronasal receptor gene diversity in the mammalian genome."
Sam M., Matsunami H., Buck L.
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes."
Del Punta K., Leinders-Zufall T., Rodriguez I., Jukam D., Wysocki C.J., Ogawa S., Zufall F., Mombaerts P.
Nature 419:70-74(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: PUTATIVE FUNCTION, DISRUPTION PHENOTYPE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF291482 Genomic DNA. Translation: AAG42076.1.
AB062894 Genomic DNA. Translation: BAB79212.1.
RefSeqNP_444448.1. NM_053218.1.
UniGeneMm.425336.

3D structure databases

ProteinModelPortalQ9EQ52.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEQ9EQ52.

Protocols and materials databases

DNASU113845.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000073415; ENSMUSP00000073121; ENSMUSG00000057592.
GeneID113845.
KEGGmmu:113845.
UCSCuc009cws.1. mouse.

Organism-specific databases

CTD113845.
MGIMGI:2148508. Vmn1r48.

Phylogenomic databases

eggNOGNOG77521.
GeneTreeENSGT00530000062929.
HOGENOMHOG000231674.
HOVERGENHBG101191.
InParanoidQ9EQ52.
KOK04614.
OMAIGILANS.
OrthoDBEOG7F512Q.
PhylomeDBQ9EQ52.

Gene expression databases

CleanExMM_V1RA3.
MM_V1RA6.
GenevestigatorQ9EQ52.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
[Graphical view]
PfamPF03402. V1R. 1 hit.
[Graphical view]
PRINTSPR01534. VOMERONASL1R.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio367959.
PROQ9EQ52.
SOURCESearch...

Entry information

Entry nameV1R48_MOUSE
AccessionPrimary (citable) accession number: Q9EQ52
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries