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Protein

Lysophosphatidic acid receptor 3

Gene

Lpar3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.

GO - Molecular functioni

  1. lysophosphatidic acid receptor activity Source: InterPro
  2. phospholipid binding Source: Ensembl

GO - Biological processi

  1. activation of MAPK activity Source: MGI
  2. bleb assembly Source: MGI
  3. G-protein coupled receptor signaling pathway Source: MGI
  4. positive regulation of calcium ion transport Source: Ensembl
  5. positive regulation of collateral sprouting Source: MGI
  6. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
  7. positive regulation of MAPK cascade Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.
REACT_232027. Lysosphingolipid and LPA receptors.
REACT_250376. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid receptor 3
Short name:
LPA receptor 3
Short name:
LPA-3
Alternative name(s):
Lysophosphatidic acid receptor Edg-7
Gene namesi
Name:Lpar3
Synonyms:Edg7, Lpa3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1929469. Lpar3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131ExtracellularSequence AnalysisAdd
BLAST
Transmembranei32 – 5221Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini53 – 6715CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei68 – 8821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini89 – 10113ExtracellularSequence AnalysisAdd
BLAST
Transmembranei102 – 12423Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini125 – 14622CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei147 – 16721Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini168 – 18619ExtracellularSequence AnalysisAdd
BLAST
Transmembranei187 – 20721Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini208 – 24033CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei241 – 26121Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini262 – 27615ExtracellularSequence AnalysisAdd
BLAST
Transmembranei277 – 29519Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini296 – 35459CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. axon Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Lysophosphatidic acid receptor 3PRO_0000069434Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi15 – 151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis
Lipidationi309 – 3091S-palmitoyl cysteineBy similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiQ9EQ31.

PTM databases

PhosphoSiteiQ9EQ31.

Expressioni

Tissue specificityi

Most abundantly expressed in testes, kidney, and lung, with moderate levels in small intestine, and low levels in heart, stomach, spleen, and adult and perinatal brain. Little or no expression in embryonic brain, liver, or thymus.

Gene expression databases

BgeeiQ9EQ31.
ExpressionAtlasiQ9EQ31. baseline and differential.
GenevestigatoriQ9EQ31.

Structurei

3D structure databases

ProteinModelPortaliQ9EQ31.
SMRiQ9EQ31. Positions 22-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG288678.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiQ9EQ31.
KOiK04294.
OMAiDISACSS.
OrthoDBiEOG7HTHH1.
PhylomeDBiQ9EQ31.
TreeFamiTF330052.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004065. LPA_rcpt.
IPR005385. LPA_rcpt_EDG7.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01560. EDG7RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01527. LPARECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EQ31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNECHYDKRM DFFYNRSNTD TADEWTGTKL VIVLCVGTFF CLFIFFSNSL
60 70 80 90 100
VIAAVITNRK FHFPFYYLLA NLAAADFFAG IAYVFLMFNT GPVSKTLTVN
110 120 130 140 150
RWFLRQGLLD TSLTASLANL LVIAVERHMS IMRMRVHSNL TKKRVTLLIL
160 170 180 190 200
LVWAIAIFMG AVPTLGWNCL CNISACSSLA PIYSRSYLIF WTVSNLLAFF
210 220 230 240 250
IMVAVYVRIY MYVKRKTNVL SPHTSGSISR RRAPMKLMKT VMTVLGAFVV
260 270 280 290 300
CWTPGLVVLL LDGLNCKQCN VQHVKRWFLL LALLNSVMNP IIYSYKDEDM
310 320 330 340 350
YNTMRKMICC ALQDSNTERR PSRNPSTIHS RSETGSQYLE DSISQGPVCN

KNGS
Length:354
Mass (Da):40,316
Last modified:March 1, 2001 - v1
Checksum:i8B6F9A3CA9C1F062
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF293845 mRNA. Translation: AAG13674.1.
AF272365, AF272364 Genomic DNA. Translation: AAK02017.1.
CCDSiCCDS17901.1.
RefSeqiNP_075359.1. NM_022983.4.
UniGeneiMm.155520.

Genome annotation databases

EnsembliENSMUST00000039164; ENSMUSP00000037712; ENSMUSG00000036832.
GeneIDi65086.
KEGGimmu:65086.
UCSCiuc008rra.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF293845 mRNA. Translation: AAG13674.1.
AF272365, AF272364 Genomic DNA. Translation: AAK02017.1.
CCDSiCCDS17901.1.
RefSeqiNP_075359.1. NM_022983.4.
UniGeneiMm.155520.

3D structure databases

ProteinModelPortaliQ9EQ31.
SMRiQ9EQ31. Positions 22-309.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

GuidetoPHARMACOLOGYi274.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9EQ31.

Proteomic databases

PRIDEiQ9EQ31.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039164; ENSMUSP00000037712; ENSMUSG00000036832.
GeneIDi65086.
KEGGimmu:65086.
UCSCiuc008rra.2. mouse.

Organism-specific databases

CTDi23566.
MGIiMGI:1929469. Lpar3.

Phylogenomic databases

eggNOGiNOG288678.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiQ9EQ31.
KOiK04294.
OMAiDISACSS.
OrthoDBiEOG7HTHH1.
PhylomeDBiQ9EQ31.
TreeFamiTF330052.

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.
REACT_232027. Lysosphingolipid and LPA receptors.
REACT_250376. G alpha (i) signalling events.

Miscellaneous databases

NextBioi320263.
PROiQ9EQ31.
SOURCEiSearch...

Gene expression databases

BgeeiQ9EQ31.
ExpressionAtlasiQ9EQ31. baseline and differential.
GenevestigatoriQ9EQ31.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004065. LPA_rcpt.
IPR005385. LPA_rcpt_EDG7.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01560. EDG7RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01527. LPARECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The mouse lp(A3)/Edg7 lysophosphatidic acid receptor gene: genomic structure, chromosomal localization, and expression pattern."
    Contos J.J.A., Chun J.
    Gene 267:243-253(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129/SvJ and Swiss Webster / NIH.
  2. Erratum
    Contos J.J.A., Chun J.
    Gene 272:345-345(2001)

Entry informationi

Entry nameiLPAR3_MOUSE
AccessioniPrimary (citable) accession number: Q9EQ31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: March 1, 2001
Last modified: January 7, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.