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Q9EQ31

- LPAR3_MOUSE

UniProt

Q9EQ31 - LPAR3_MOUSE

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Protein

Lysophosphatidic acid receptor 3

Gene
Lpar3, Edg7, Lpa3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.

GO - Molecular functioni

  1. lysophosphatidic acid receptor activity Source: InterPro
  2. phospholipid binding Source: Ensembl

GO - Biological processi

  1. activation of MAPK activity Source: MGI
  2. bleb assembly Source: MGI
  3. G-protein coupled receptor signaling pathway Source: MGI
  4. positive regulation of calcium ion transport Source: Ensembl
  5. positive regulation of collateral sprouting Source: MGI
  6. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
  7. positive regulation of MAPK cascade Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid receptor 3
Short name:
LPA receptor 3
Short name:
LPA-3
Alternative name(s):
Lysophosphatidic acid receptor Edg-7
Gene namesi
Name:Lpar3
Synonyms:Edg7, Lpa3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1929469. Lpar3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131Extracellular Reviewed predictionAdd
BLAST
Transmembranei32 – 5221Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini53 – 6715Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei68 – 8821Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini89 – 10113Extracellular Reviewed predictionAdd
BLAST
Transmembranei102 – 12423Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini125 – 14622Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei147 – 16721Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini168 – 18619Extracellular Reviewed predictionAdd
BLAST
Transmembranei187 – 20721Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini208 – 24033Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei241 – 26121Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini262 – 27615Extracellular Reviewed predictionAdd
BLAST
Transmembranei277 – 29519Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini296 – 35459Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. axon Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. intracellular membrane-bounded organelle Source: Ensembl
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Lysophosphatidic acid receptor 3PRO_0000069434Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi15 – 151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi172 – 1721N-linked (GlcNAc...) Reviewed prediction
Lipidationi309 – 3091S-palmitoyl cysteine By similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiQ9EQ31.

PTM databases

PhosphoSiteiQ9EQ31.

Expressioni

Tissue specificityi

Most abundantly expressed in testes, kidney, and lung, with moderate levels in small intestine, and low levels in heart, stomach, spleen, and adult and perinatal brain. Little or no expression in embryonic brain, liver, or thymus.

Gene expression databases

ArrayExpressiQ9EQ31.
BgeeiQ9EQ31.
GenevestigatoriQ9EQ31.

Structurei

3D structure databases

ProteinModelPortaliQ9EQ31.
SMRiQ9EQ31. Positions 22-309.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG288678.
GeneTreeiENSGT00740000115422.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiQ9EQ31.
KOiK04294.
OMAiDISACSS.
OrthoDBiEOG7HTHH1.
PhylomeDBiQ9EQ31.
TreeFamiTF330052.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004065. LPA_rcpt.
IPR005385. LPA_rcpt_EDG7.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01560. EDG7RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01527. LPARECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EQ31-1 [UniParc]FASTAAdd to Basket

« Hide

MNECHYDKRM DFFYNRSNTD TADEWTGTKL VIVLCVGTFF CLFIFFSNSL    50
VIAAVITNRK FHFPFYYLLA NLAAADFFAG IAYVFLMFNT GPVSKTLTVN 100
RWFLRQGLLD TSLTASLANL LVIAVERHMS IMRMRVHSNL TKKRVTLLIL 150
LVWAIAIFMG AVPTLGWNCL CNISACSSLA PIYSRSYLIF WTVSNLLAFF 200
IMVAVYVRIY MYVKRKTNVL SPHTSGSISR RRAPMKLMKT VMTVLGAFVV 250
CWTPGLVVLL LDGLNCKQCN VQHVKRWFLL LALLNSVMNP IIYSYKDEDM 300
YNTMRKMICC ALQDSNTERR PSRNPSTIHS RSETGSQYLE DSISQGPVCN 350
KNGS 354
Length:354
Mass (Da):40,316
Last modified:March 1, 2001 - v1
Checksum:i8B6F9A3CA9C1F062
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF293845 mRNA. Translation: AAG13674.1.
AF272365, AF272364 Genomic DNA. Translation: AAK02017.1.
CCDSiCCDS17901.1.
RefSeqiNP_075359.1. NM_022983.4.
UniGeneiMm.155520.

Genome annotation databases

EnsembliENSMUST00000039164; ENSMUSP00000037712; ENSMUSG00000036832.
GeneIDi65086.
KEGGimmu:65086.
UCSCiuc008rra.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF293845 mRNA. Translation: AAG13674.1 .
AF272365 , AF272364 Genomic DNA. Translation: AAK02017.1 .
CCDSi CCDS17901.1.
RefSeqi NP_075359.1. NM_022983.4.
UniGenei Mm.155520.

3D structure databases

ProteinModelPortali Q9EQ31.
SMRi Q9EQ31. Positions 22-309.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 274.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9EQ31.

Proteomic databases

PRIDEi Q9EQ31.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000039164 ; ENSMUSP00000037712 ; ENSMUSG00000036832 .
GeneIDi 65086.
KEGGi mmu:65086.
UCSCi uc008rra.2. mouse.

Organism-specific databases

CTDi 23566.
MGIi MGI:1929469. Lpar3.

Phylogenomic databases

eggNOGi NOG288678.
GeneTreei ENSGT00740000115422.
HOGENOMi HOG000233501.
HOVERGENi HBG103071.
InParanoidi Q9EQ31.
KOi K04294.
OMAi DISACSS.
OrthoDBi EOG7HTHH1.
PhylomeDBi Q9EQ31.
TreeFami TF330052.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 320263.
PROi Q9EQ31.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9EQ31.
Bgeei Q9EQ31.
Genevestigatori Q9EQ31.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004065. LPA_rcpt.
IPR005385. LPA_rcpt_EDG7.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01560. EDG7RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01527. LPARECEPTOR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The mouse lp(A3)/Edg7 lysophosphatidic acid receptor gene: genomic structure, chromosomal localization, and expression pattern."
    Contos J.J.A., Chun J.
    Gene 267:243-253(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129/SvJ and Swiss Webster / NIH.
  2. Erratum
    Contos J.J.A., Chun J.
    Gene 272:345-345(2001)

Entry informationi

Entry nameiLPAR3_MOUSE
AccessioniPrimary (citable) accession number: Q9EQ31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: March 1, 2001
Last modified: September 3, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi