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Q9EQ31

- LPAR3_MOUSE

UniProt

Q9EQ31 - LPAR3_MOUSE

Protein

Lysophosphatidic acid receptor 3

Gene

Lpar3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.

    GO - Molecular functioni

    1. lysophosphatidic acid receptor activity Source: InterPro
    2. phospholipid binding Source: Ensembl

    GO - Biological processi

    1. activation of MAPK activity Source: MGI
    2. bleb assembly Source: MGI
    3. G-protein coupled receptor signaling pathway Source: MGI
    4. positive regulation of calcium ion transport Source: Ensembl
    5. positive regulation of collateral sprouting Source: MGI
    6. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
    7. positive regulation of MAPK cascade Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophosphatidic acid receptor 3
    Short name:
    LPA receptor 3
    Short name:
    LPA-3
    Alternative name(s):
    Lysophosphatidic acid receptor Edg-7
    Gene namesi
    Name:Lpar3
    Synonyms:Edg7, Lpa3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1929469. Lpar3.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. intracellular membrane-bounded organelle Source: Ensembl
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 354354Lysophosphatidic acid receptor 3PRO_0000069434Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi15 – 151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis
    Lipidationi309 – 3091S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiQ9EQ31.

    PTM databases

    PhosphoSiteiQ9EQ31.

    Expressioni

    Tissue specificityi

    Most abundantly expressed in testes, kidney, and lung, with moderate levels in small intestine, and low levels in heart, stomach, spleen, and adult and perinatal brain. Little or no expression in embryonic brain, liver, or thymus.

    Gene expression databases

    ArrayExpressiQ9EQ31.
    BgeeiQ9EQ31.
    GenevestigatoriQ9EQ31.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9EQ31.
    SMRiQ9EQ31. Positions 22-309.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3131ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini53 – 6715CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini89 – 10113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini125 – 14622CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini168 – 18619ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini208 – 24033CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini262 – 27615ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini296 – 35459CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei32 – 5221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei68 – 8821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei102 – 12423Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei147 – 16721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei187 – 20721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei241 – 26121Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei277 – 29519Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG288678.
    GeneTreeiENSGT00740000115422.
    HOGENOMiHOG000233501.
    HOVERGENiHBG103071.
    InParanoidiQ9EQ31.
    KOiK04294.
    OMAiDISACSS.
    OrthoDBiEOG7HTHH1.
    PhylomeDBiQ9EQ31.
    TreeFamiTF330052.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR004065. LPA_rcpt.
    IPR005385. LPA_rcpt_EDG7.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01560. EDG7RECEPTOR.
    PR00237. GPCRRHODOPSN.
    PR01527. LPARECEPTOR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9EQ31-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNECHYDKRM DFFYNRSNTD TADEWTGTKL VIVLCVGTFF CLFIFFSNSL    50
    VIAAVITNRK FHFPFYYLLA NLAAADFFAG IAYVFLMFNT GPVSKTLTVN 100
    RWFLRQGLLD TSLTASLANL LVIAVERHMS IMRMRVHSNL TKKRVTLLIL 150
    LVWAIAIFMG AVPTLGWNCL CNISACSSLA PIYSRSYLIF WTVSNLLAFF 200
    IMVAVYVRIY MYVKRKTNVL SPHTSGSISR RRAPMKLMKT VMTVLGAFVV 250
    CWTPGLVVLL LDGLNCKQCN VQHVKRWFLL LALLNSVMNP IIYSYKDEDM 300
    YNTMRKMICC ALQDSNTERR PSRNPSTIHS RSETGSQYLE DSISQGPVCN 350
    KNGS 354
    Length:354
    Mass (Da):40,316
    Last modified:March 1, 2001 - v1
    Checksum:i8B6F9A3CA9C1F062
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF293845 mRNA. Translation: AAG13674.1.
    AF272365, AF272364 Genomic DNA. Translation: AAK02017.1.
    CCDSiCCDS17901.1.
    RefSeqiNP_075359.1. NM_022983.4.
    UniGeneiMm.155520.

    Genome annotation databases

    EnsembliENSMUST00000039164; ENSMUSP00000037712; ENSMUSG00000036832.
    GeneIDi65086.
    KEGGimmu:65086.
    UCSCiuc008rra.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF293845 mRNA. Translation: AAG13674.1 .
    AF272365 , AF272364 Genomic DNA. Translation: AAK02017.1 .
    CCDSi CCDS17901.1.
    RefSeqi NP_075359.1. NM_022983.4.
    UniGenei Mm.155520.

    3D structure databases

    ProteinModelPortali Q9EQ31.
    SMRi Q9EQ31. Positions 22-309.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 274.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9EQ31.

    Proteomic databases

    PRIDEi Q9EQ31.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000039164 ; ENSMUSP00000037712 ; ENSMUSG00000036832 .
    GeneIDi 65086.
    KEGGi mmu:65086.
    UCSCi uc008rra.2. mouse.

    Organism-specific databases

    CTDi 23566.
    MGIi MGI:1929469. Lpar3.

    Phylogenomic databases

    eggNOGi NOG288678.
    GeneTreei ENSGT00740000115422.
    HOGENOMi HOG000233501.
    HOVERGENi HBG103071.
    InParanoidi Q9EQ31.
    KOi K04294.
    OMAi DISACSS.
    OrthoDBi EOG7HTHH1.
    PhylomeDBi Q9EQ31.
    TreeFami TF330052.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 320263.
    PROi Q9EQ31.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9EQ31.
    Bgeei Q9EQ31.
    Genevestigatori Q9EQ31.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR004065. LPA_rcpt.
    IPR005385. LPA_rcpt_EDG7.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01560. EDG7RECEPTOR.
    PR00237. GPCRRHODOPSN.
    PR01527. LPARECEPTOR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mouse lp(A3)/Edg7 lysophosphatidic acid receptor gene: genomic structure, chromosomal localization, and expression pattern."
      Contos J.J.A., Chun J.
      Gene 267:243-253(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: 129/SvJ and Swiss Webster / NIH.
    2. Erratum
      Contos J.J.A., Chun J.
      Gene 272:345-345(2001)

    Entry informationi

    Entry nameiLPAR3_MOUSE
    AccessioniPrimary (citable) accession number: Q9EQ31
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3