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Q9EQ31 (LPAR3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophosphatidic acid receptor 3

Short name=LPA receptor 3
Short name=LPA-3
Alternative name(s):
Lysophosphatidic acid receptor Edg-7
Gene names
Name:Lpar3
Synonyms:Edg7, Lpa3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Most abundantly expressed in testes, kidney, and lung, with moderate levels in small intestine, and low levels in heart, stomach, spleen, and adult and perinatal brain. Little or no expression in embryonic brain, liver, or thymus.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Inferred from mutant phenotype PubMed 22465231. Source: MGI

activation of MAPK activity

Inferred from direct assay PubMed 15755723. Source: MGI

bleb assembly

Inferred from genetic interaction PubMed 17135244. Source: MGI

positive regulation of MAPK cascade

Inferred from direct assay PubMed 15755723. Source: MGI

positive regulation of calcium ion transport

Inferred from electronic annotation. Source: Ensembl

positive regulation of collateral sprouting

Inferred from mutant phenotype PubMed 22465231. Source: MGI

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentaxon

Inferred from direct assay PubMed 22465231. Source: MGI

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

intracellular membrane-bounded organelle

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionlysophosphatidic acid receptor activity

Inferred from electronic annotation. Source: InterPro

phospholipid binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 354354Lysophosphatidic acid receptor 3
PRO_0000069434

Regions

Topological domain1 – 3131Extracellular Potential
Transmembrane32 – 5221Helical; Name=1; Potential
Topological domain53 – 6715Cytoplasmic Potential
Transmembrane68 – 8821Helical; Name=2; Potential
Topological domain89 – 10113Extracellular Potential
Transmembrane102 – 12423Helical; Name=3; Potential
Topological domain125 – 14622Cytoplasmic Potential
Transmembrane147 – 16721Helical; Name=4; Potential
Topological domain168 – 18619Extracellular Potential
Transmembrane187 – 20721Helical; Name=5; Potential
Topological domain208 – 24033Cytoplasmic Potential
Transmembrane241 – 26121Helical; Name=6; Potential
Topological domain262 – 27615Extracellular Potential
Transmembrane277 – 29519Helical; Name=7; Potential
Topological domain296 – 35459Cytoplasmic Potential

Amino acid modifications

Lipidation3091S-palmitoyl cysteine By similarity
Glycosylation151N-linked (GlcNAc...) Potential
Glycosylation1721N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9EQ31 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 8B6F9A3CA9C1F062

FASTA35440,316
        10         20         30         40         50         60 
MNECHYDKRM DFFYNRSNTD TADEWTGTKL VIVLCVGTFF CLFIFFSNSL VIAAVITNRK 

        70         80         90        100        110        120 
FHFPFYYLLA NLAAADFFAG IAYVFLMFNT GPVSKTLTVN RWFLRQGLLD TSLTASLANL 

       130        140        150        160        170        180 
LVIAVERHMS IMRMRVHSNL TKKRVTLLIL LVWAIAIFMG AVPTLGWNCL CNISACSSLA 

       190        200        210        220        230        240 
PIYSRSYLIF WTVSNLLAFF IMVAVYVRIY MYVKRKTNVL SPHTSGSISR RRAPMKLMKT 

       250        260        270        280        290        300 
VMTVLGAFVV CWTPGLVVLL LDGLNCKQCN VQHVKRWFLL LALLNSVMNP IIYSYKDEDM 

       310        320        330        340        350 
YNTMRKMICC ALQDSNTERR PSRNPSTIHS RSETGSQYLE DSISQGPVCN KNGS 

« Hide

References

[1]"The mouse lp(A3)/Edg7 lysophosphatidic acid receptor gene: genomic structure, chromosomal localization, and expression pattern."
Contos J.J.A., Chun J.
Gene 267:243-253(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: 129/SvJ and Swiss Webster / NIH.
[2]Erratum
Contos J.J.A., Chun J.
Gene 272:345-345(2001)
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF293845 mRNA. Translation: AAG13674.1.
AF272365, AF272364 Genomic DNA. Translation: AAK02017.1.
CCDSCCDS17901.1.
RefSeqNP_075359.1. NM_022983.4.
UniGeneMm.155520.

3D structure databases

ProteinModelPortalQ9EQ31.
SMRQ9EQ31. Positions 22-309.
ModBaseSearch...
MobiDBSearch...

Chemistry

GuidetoPHARMACOLOGY274.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9EQ31.

Proteomic databases

PRIDEQ9EQ31.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000039164; ENSMUSP00000037712; ENSMUSG00000036832.
GeneID65086.
KEGGmmu:65086.
UCSCuc008rra.2. mouse.

Organism-specific databases

CTD23566.
MGIMGI:1929469. Lpar3.

Phylogenomic databases

eggNOGNOG288678.
GeneTreeENSGT00740000115422.
HOGENOMHOG000233501.
HOVERGENHBG103071.
InParanoidQ9EQ31.
KOK04294.
OMADISACSS.
OrthoDBEOG7HTHH1.
PhylomeDBQ9EQ31.
TreeFamTF330052.

Gene expression databases

ArrayExpressQ9EQ31.
BgeeQ9EQ31.
GenevestigatorQ9EQ31.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004065. LPA_rcpt.
IPR005385. LPA_rcpt_EDG7.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01560. EDG7RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01527. LPARECEPTOR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio320263.
PROQ9EQ31.
SOURCESearch...

Entry information

Entry nameLPAR3_MOUSE
AccessionPrimary (citable) accession number: Q9EQ31
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries