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Q9EQ28 (DPOD3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA polymerase delta subunit 3
Alternative name(s):
DNA polymerase delta subunit p66
Gene names
Name:Pold3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length462 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for optimal DNA polymerase delta activity By similarity. Ref.2

Subunit structure

Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. Interacts with POLD2. Interacts with PCNA By similarity.

Subcellular location

Nucleus.

Sequence caution

The sequence AAG45967.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 462461DNA polymerase delta subunit 3
PRO_0000186048

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue3061Phosphoserine Ref.3
Modified residue4031Phosphoserine By similarity
Modified residue4051Phosphoserine By similarity
Modified residue4071Phosphothreonine By similarity
Modified residue4091Phosphoserine By similarity
Modified residue4541Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9EQ28 [UniParc].

Last modified September 26, 2001. Version 2.
Checksum: FF3F67E065A08B36

FASTA46250,836
        10         20         30         40         50         60 
MAEQLYLENI DEFVTDQNKI VTYKWLSYTL GVHVNQAKQM LYEYVERKRK ENSGAQLHVT 

        70         80         90        100        110        120 
YLVSGSLIQN GHSCHKVAVV REDKLEAVKS KLAVTASIHV YSIQKAMLKD SGPLFNTDYD 

       130        140        150        160        170        180 
ILKSNLQNCS KFSAIQCAAA VPRAPAESPS SRKYEQSNLQ AASEAQASEL TTNGHGPPAS 

       190        200        210        220        230        240 
KQASQQPKGI MGMLISKAAT KTQDTNKETK PEAREVTSAS SAGGKAPGKG SVMSNFFGKA 

       250        260        270        280        290        300 
AMNKLKVNLD SEQAVKEEKT VEQPPVSVTE PKLAAPPAQK KSSRKSEPGK VQQKEKSSRG 

       310        320        330        340        350        360 
KRVDLSDEEA KETEHLKKKR RRIKLPQSDS SEDEVFEDSP EMYEADSPSP PPVSPPPDPM 

       370        380        390        400        410        420 
PKTEPPPVKR SSGETKRRRK RVLKSKTFVD EEGCIVTEKV YESESCTDSE EELKMKPASA 

       430        440        450        460 
HKPPAAAVKR EPREERKGPK KGAAALGKAN RQVSITGFFQ KK

« Hide

References

« Hide 'large scale' references
[1]"Identification of testicular germ cell gene expression by differential display analysis."
Anway M.D., Li Y., Griswold M.D.
Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Testis.
[2]"Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts."
Hughes P., Tratner I., Ducoux M., Piard K., Baldacci G.
Nucleic Acids Res. 27:2108-2114(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE, FUNCTION.
[3]"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry."
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M.
J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-306, MASS SPECTROMETRY.
Tissue: Melanoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF294329 mRNA. Translation: AAG45967.1. Different initiation.
IPIIPI00110298.
UniGeneMm.37562.

3D structure databases

ProteinModelPortalQ9EQ28.
SMRQ9EQ28. Positions 2-144.
ModBaseSearch...

PTM databases

PhosphoSiteQ9EQ28.

Proteomic databases

PaxDbQ9EQ28.
PRIDEQ9EQ28.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc009imk.1. mouse.

Organism-specific databases

MGIMGI:1915217. Pold3.

Phylogenomic databases

eggNOGNOG83700.
HOGENOMHOG000008055.
HOVERGENHBG051397.
InParanoidQ9EQ28.

Gene expression databases

ArrayExpressQ9EQ28.
BgeeQ9EQ28.
GenevestigatorQ9EQ28.
GermOnlineENSMUSG00000030726. Mus musculus.

Family and domain databases

InterProIPR019038. DNA_polymerase_subunit_Cdc27.
[Graphical view]
PfamPF09507. CDC27. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameDPOD3_MOUSE
AccessionPrimary (citable) accession number: Q9EQ28
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: September 26, 2001
Last modified: April 3, 2013
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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