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Q9EQ28

- DPOD3_MOUSE

UniProt

Q9EQ28 - DPOD3_MOUSE

Protein

DNA polymerase delta subunit 3

Gene

Pold3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (26 Sep 2001)
      Previous versions | rss
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    Functioni

    Required for optimal DNA polymerase delta activity.By similarity

    GO - Molecular functioni

    1. DNA-directed DNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. nucleotide-excision repair, DNA gap filling Source: Ensembl

    Keywords - Molecular functioni

    DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    DNA replication

    Enzyme and pathway databases

    ReactomeiREACT_209299. Repair synthesis of patch ~27-30 bases long by DNA polymerase.
    REACT_216529. Removal of the Flap Intermediate from the C-strand.
    REACT_219337. Removal of DNA patch containing abasic residue.
    REACT_219381. Repair synthesis for gap-filling by DNA polymerase in TC-NER.
    REACT_220175. Telomere C-strand (Lagging Strand) Synthesis.
    REACT_223154. Processive synthesis on the C-strand of the telomere.
    REACT_225604. Polymerase switching on the C-strand of the telomere.
    REACT_227394. Resolution of AP sites via the multiple-nucleotide patch replacement pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA polymerase delta subunit 3
    Alternative name(s):
    DNA polymerase delta subunit p66
    Gene namesi
    Name:Pold3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1915217. Pold3.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: Ensembl
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 462461DNA polymerase delta subunit 3PRO_0000186048Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei306 – 3061PhosphoserineBy similarity
    Modified residuei403 – 4031PhosphoserineBy similarity
    Modified residuei405 – 4051PhosphoserineBy similarity
    Modified residuei407 – 4071PhosphothreonineBy similarity
    Modified residuei409 – 4091PhosphoserineBy similarity
    Modified residuei454 – 4541PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9EQ28.
    PaxDbiQ9EQ28.
    PRIDEiQ9EQ28.

    PTM databases

    PhosphoSiteiQ9EQ28.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9EQ28.
    BgeeiQ9EQ28.
    GenevestigatoriQ9EQ28.

    Interactioni

    Subunit structurei

    Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. Interacts with POLD2. Interacts with PCNA By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9EQ28.
    SMRiQ9EQ28. Positions 2-144.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG83700.
    HOGENOMiHOG000008055.
    HOVERGENiHBG051397.
    InParanoidiQ9EQ28.
    PhylomeDBiQ9EQ28.

    Family and domain databases

    InterProiIPR019038. DNA_polymerase_subunit_Cdc27.
    [Graphical view]
    PfamiPF09507. CDC27. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9EQ28-1 [UniParc]FASTAAdd to Basket

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    MAEQLYLENI DEFVTDQNKI VTYKWLSYTL GVHVNQAKQM LYEYVERKRK    50
    ENSGAQLHVT YLVSGSLIQN GHSCHKVAVV REDKLEAVKS KLAVTASIHV 100
    YSIQKAMLKD SGPLFNTDYD ILKSNLQNCS KFSAIQCAAA VPRAPAESPS 150
    SRKYEQSNLQ AASEAQASEL TTNGHGPPAS KQASQQPKGI MGMLISKAAT 200
    KTQDTNKETK PEAREVTSAS SAGGKAPGKG SVMSNFFGKA AMNKLKVNLD 250
    SEQAVKEEKT VEQPPVSVTE PKLAAPPAQK KSSRKSEPGK VQQKEKSSRG 300
    KRVDLSDEEA KETEHLKKKR RRIKLPQSDS SEDEVFEDSP EMYEADSPSP 350
    PPVSPPPDPM PKTEPPPVKR SSGETKRRRK RVLKSKTFVD EEGCIVTEKV 400
    YESESCTDSE EELKMKPASA HKPPAAAVKR EPREERKGPK KGAAALGKAN 450
    RQVSITGFFQ KK 462
    Length:462
    Mass (Da):50,836
    Last modified:September 26, 2001 - v2
    Checksum:iFF3F67E065A08B36
    GO

    Sequence cautioni

    The sequence AAG45967.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF294329 mRNA. Translation: AAG45967.1. Different initiation.
    UniGeneiMm.37562.

    Genome annotation databases

    UCSCiuc009imk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF294329 mRNA. Translation: AAG45967.1 . Different initiation.
    UniGenei Mm.37562.

    3D structure databases

    ProteinModelPortali Q9EQ28.
    SMRi Q9EQ28. Positions 2-144.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9EQ28.

    Proteomic databases

    MaxQBi Q9EQ28.
    PaxDbi Q9EQ28.
    PRIDEi Q9EQ28.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc009imk.1. mouse.

    Organism-specific databases

    MGIi MGI:1915217. Pold3.

    Phylogenomic databases

    eggNOGi NOG83700.
    HOGENOMi HOG000008055.
    HOVERGENi HBG051397.
    InParanoidi Q9EQ28.
    PhylomeDBi Q9EQ28.

    Enzyme and pathway databases

    Reactomei REACT_209299. Repair synthesis of patch ~27-30 bases long by DNA polymerase.
    REACT_216529. Removal of the Flap Intermediate from the C-strand.
    REACT_219337. Removal of DNA patch containing abasic residue.
    REACT_219381. Repair synthesis for gap-filling by DNA polymerase in TC-NER.
    REACT_220175. Telomere C-strand (Lagging Strand) Synthesis.
    REACT_223154. Processive synthesis on the C-strand of the telomere.
    REACT_225604. Polymerase switching on the C-strand of the telomere.
    REACT_227394. Resolution of AP sites via the multiple-nucleotide patch replacement pathway.

    Miscellaneous databases

    PROi Q9EQ28.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9EQ28.
    Bgeei Q9EQ28.
    Genevestigatori Q9EQ28.

    Family and domain databases

    InterProi IPR019038. DNA_polymerase_subunit_Cdc27.
    [Graphical view ]
    Pfami PF09507. CDC27. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of testicular germ cell gene expression by differential display analysis."
      Anway M.D., Li Y., Griswold M.D.
      Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Testis.
    2. "Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts."
      Hughes P., Tratner I., Ducoux M., Piard K., Baldacci G.
      Nucleic Acids Res. 27:2108-2114(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE, FUNCTION.

    Entry informationi

    Entry nameiDPOD3_MOUSE
    AccessioniPrimary (citable) accession number: Q9EQ28
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: September 26, 2001
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3