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Q9EQ28

- DPOD3_MOUSE

UniProt

Q9EQ28 - DPOD3_MOUSE

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Protein
DNA polymerase delta subunit 3
Gene
Pold3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Required for optimal DNA polymerase delta activity By similarity.1 Publication

GO - Molecular functioni

  1. DNA-directed DNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. nucleotide-excision repair, DNA gap filling Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Enzyme and pathway databases

ReactomeiREACT_209299. Repair synthesis of patch ~27-30 bases long by DNA polymerase.
REACT_216529. Removal of the Flap Intermediate from the C-strand.
REACT_219337. Removal of DNA patch containing abasic residue.
REACT_219381. Repair synthesis for gap-filling by DNA polymerase in TC-NER.
REACT_220175. Telomere C-strand (Lagging Strand) Synthesis.
REACT_223154. Processive synthesis on the C-strand of the telomere.
REACT_225604. Polymerase switching on the C-strand of the telomere.
REACT_227394. Resolution of AP sites via the multiple-nucleotide patch replacement pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase delta subunit 3
Alternative name(s):
DNA polymerase delta subunit p66
Gene namesi
Name:Pold3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1915217. Pold3.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: Ensembl
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 462461DNA polymerase delta subunit 3
PRO_0000186048Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei306 – 3061Phosphoserine By similarity
Modified residuei403 – 4031Phosphoserine By similarity
Modified residuei405 – 4051Phosphoserine By similarity
Modified residuei407 – 4071Phosphothreonine By similarity
Modified residuei409 – 4091Phosphoserine By similarity
Modified residuei454 – 4541Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9EQ28.
PaxDbiQ9EQ28.
PRIDEiQ9EQ28.

PTM databases

PhosphoSiteiQ9EQ28.

Expressioni

Gene expression databases

ArrayExpressiQ9EQ28.
BgeeiQ9EQ28.
GenevestigatoriQ9EQ28.

Interactioni

Subunit structurei

Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. Interacts with POLD2. Interacts with PCNA By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9EQ28.
SMRiQ9EQ28. Positions 2-144.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG83700.
HOGENOMiHOG000008055.
HOVERGENiHBG051397.
InParanoidiQ9EQ28.
PhylomeDBiQ9EQ28.

Family and domain databases

InterProiIPR019038. DNA_polymerase_subunit_Cdc27.
[Graphical view]
PfamiPF09507. CDC27. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EQ28-1 [UniParc]FASTAAdd to Basket

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MAEQLYLENI DEFVTDQNKI VTYKWLSYTL GVHVNQAKQM LYEYVERKRK    50
ENSGAQLHVT YLVSGSLIQN GHSCHKVAVV REDKLEAVKS KLAVTASIHV 100
YSIQKAMLKD SGPLFNTDYD ILKSNLQNCS KFSAIQCAAA VPRAPAESPS 150
SRKYEQSNLQ AASEAQASEL TTNGHGPPAS KQASQQPKGI MGMLISKAAT 200
KTQDTNKETK PEAREVTSAS SAGGKAPGKG SVMSNFFGKA AMNKLKVNLD 250
SEQAVKEEKT VEQPPVSVTE PKLAAPPAQK KSSRKSEPGK VQQKEKSSRG 300
KRVDLSDEEA KETEHLKKKR RRIKLPQSDS SEDEVFEDSP EMYEADSPSP 350
PPVSPPPDPM PKTEPPPVKR SSGETKRRRK RVLKSKTFVD EEGCIVTEKV 400
YESESCTDSE EELKMKPASA HKPPAAAVKR EPREERKGPK KGAAALGKAN 450
RQVSITGFFQ KK 462
Length:462
Mass (Da):50,836
Last modified:September 26, 2001 - v2
Checksum:iFF3F67E065A08B36
GO

Sequence cautioni

The sequence AAG45967.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF294329 mRNA. Translation: AAG45967.1. Different initiation.
UniGeneiMm.37562.

Genome annotation databases

UCSCiuc009imk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF294329 mRNA. Translation: AAG45967.1 . Different initiation.
UniGenei Mm.37562.

3D structure databases

ProteinModelPortali Q9EQ28.
SMRi Q9EQ28. Positions 2-144.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9EQ28.

Proteomic databases

MaxQBi Q9EQ28.
PaxDbi Q9EQ28.
PRIDEi Q9EQ28.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc009imk.1. mouse.

Organism-specific databases

MGIi MGI:1915217. Pold3.

Phylogenomic databases

eggNOGi NOG83700.
HOGENOMi HOG000008055.
HOVERGENi HBG051397.
InParanoidi Q9EQ28.
PhylomeDBi Q9EQ28.

Enzyme and pathway databases

Reactomei REACT_209299. Repair synthesis of patch ~27-30 bases long by DNA polymerase.
REACT_216529. Removal of the Flap Intermediate from the C-strand.
REACT_219337. Removal of DNA patch containing abasic residue.
REACT_219381. Repair synthesis for gap-filling by DNA polymerase in TC-NER.
REACT_220175. Telomere C-strand (Lagging Strand) Synthesis.
REACT_223154. Processive synthesis on the C-strand of the telomere.
REACT_225604. Polymerase switching on the C-strand of the telomere.
REACT_227394. Resolution of AP sites via the multiple-nucleotide patch replacement pathway.

Miscellaneous databases

PROi Q9EQ28.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9EQ28.
Bgeei Q9EQ28.
Genevestigatori Q9EQ28.

Family and domain databases

InterProi IPR019038. DNA_polymerase_subunit_Cdc27.
[Graphical view ]
Pfami PF09507. CDC27. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of testicular germ cell gene expression by differential display analysis."
    Anway M.D., Li Y., Griswold M.D.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Testis.
  2. "Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts."
    Hughes P., Tratner I., Ducoux M., Piard K., Baldacci G.
    Nucleic Acids Res. 27:2108-2114(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, FUNCTION.

Entry informationi

Entry nameiDPOD3_MOUSE
AccessioniPrimary (citable) accession number: Q9EQ28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: September 26, 2001
Last modified: September 3, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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